PHB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H323_LEIBR

TriTrypDb:

LbrM.01.0110 , LBRM2903_010005700

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H323

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H323

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	191	193	PF00675	0.580
CLV_NRD_NRD_1	54	56	PF00675	0.596
CLV_PCSK_KEX2_1	191	193	PF00082	0.564
CLV_PCSK_KEX2_1	54	56	PF00082	0.614
CLV_PCSK_SKI1_1	111	115	PF00082	0.572
CLV_PCSK_SKI1_1	192	196	PF00082	0.644
CLV_PCSK_SKI1_1	45	49	PF00082	0.594
CLV_PCSK_SKI1_1	56	60	PF00082	0.532
DEG_APCC_DBOX_1	68	76	PF00400	0.507
DOC_CYCLIN_yCln2_LP_2	97	100	PF00134	0.432
DOC_PP2B_LxvP_1	96	99	PF13499	0.390
DOC_PP4_FxxP_1	107	110	PF00568	0.333
DOC_PP4_FxxP_1	114	117	PF00568	0.362
DOC_PP4_FxxP_1	196	199	PF00568	0.358
DOC_USP7_MATH_1	11	15	PF00917	0.610
DOC_USP7_MATH_1	117	121	PF00917	0.413
DOC_USP7_MATH_1	179	183	PF00917	0.435
DOC_USP7_MATH_1	73	77	PF00917	0.459
LIG_14-3-3_CanoR_1	10	19	PF00244	0.553
LIG_14-3-3_CanoR_1	45	50	PF00244	0.377
LIG_14-3-3_CanoR_1	54	59	PF00244	0.375
LIG_14-3-3_CanoR_1	74	82	PF00244	0.468
LIG_APCC_ABBA_1	197	202	PF00400	0.425
LIG_BRCT_BRCA1_1	100	104	PF00533	0.409
LIG_BRCT_BRCA1_1	80	84	PF00533	0.499
LIG_EVH1_2	99	103	PF00568	0.373
LIG_FHA_1	203	209	PF00498	0.404
LIG_FHA_1	92	98	PF00498	0.401
LIG_FHA_2	188	194	PF00498	0.456
LIG_FHA_2	59	65	PF00498	0.384
LIG_LIR_Apic_2	193	199	PF02991	0.369
LIG_LIR_Gen_1	144	155	PF02991	0.399
LIG_LIR_Gen_1	92	103	PF02991	0.379
LIG_LIR_Nem_3	101	107	PF02991	0.348
LIG_LIR_Nem_3	140	145	PF02991	0.362
LIG_LIR_Nem_3	92	98	PF02991	0.393
LIG_MLH1_MIPbox_1	100	104	PF16413	0.420
LIG_MLH1_MIPbox_1	80	84	PF16413	0.500
LIG_Pex14_2	103	107	PF04695	0.349
LIG_SH2_STAP1	143	147	PF00017	0.235
LIG_SH2_STAT5	143	146	PF00017	0.316
LIG_SH2_STAT5	153	156	PF00017	0.348
LIG_SH2_STAT5	83	86	PF00017	0.397
LIG_SH3_3	14	20	PF00018	0.537
LIG_SH3_3	156	162	PF00018	0.363
LIG_SH3_3	38	44	PF00018	0.403
LIG_SUMO_SIM_anti_2	222	228	PF11976	0.399
LIG_SUMO_SIM_par_1	222	228	PF11976	0.442
LIG_UBA3_1	28	33	PF00899	0.475
MOD_CK2_1	187	193	PF00069	0.434
MOD_GlcNHglycan	13	16	PF01048	0.518
MOD_GlcNHglycan	180	184	PF01048	0.618
MOD_GlcNHglycan	61	64	PF01048	0.622
MOD_GlcNHglycan	85	88	PF01048	0.646
MOD_GSK3_1	137	144	PF00069	0.385
MOD_GSK3_1	203	210	PF00069	0.339
MOD_GSK3_1	50	57	PF00069	0.351
MOD_LATS_1	43	49	PF00433	0.425
MOD_NEK2_1	187	192	PF00069	0.433
MOD_NEK2_1	78	83	PF00069	0.446
MOD_NEK2_1	89	94	PF00069	0.327
MOD_PK_1	131	137	PF00069	0.357
MOD_PKA_1	54	60	PF00069	0.363
MOD_PKA_2	54	60	PF00069	0.363
MOD_PKA_2	68	74	PF00069	0.428
MOD_PKA_2	9	15	PF00069	0.571
MOD_Plk_1	192	198	PF00069	0.358
MOD_Plk_4	137	143	PF00069	0.354
MOD_Plk_4	192	198	PF00069	0.316
MOD_Plk_4	220	226	PF00069	0.418
MOD_Plk_4	45	51	PF00069	0.325
MOD_Plk_4	54	60	PF00069	0.363
MOD_Plk_4	78	84	PF00069	0.448
MOD_Plk_4	99	105	PF00069	0.392
TRG_DiLeu_BaEn_1	211	216	PF01217	0.387
TRG_DiLeu_BaEn_1	222	227	PF01217	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU2	Leptomonas seymouri	76%	100%
A0A0S4JQK8	Bodo saltans	31%	87%
A0A1X0P2T1	Trypanosomatidae	46%	96%
A0A3S5ISA4	Trypanosoma rangeli	48%	97%
A0A451EJ66	Leishmania donovani	88%	97%
A4HRC9	Leishmania infantum	88%	97%
C9ZXG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	86%
E9ABZ7	Leishmania major	88%	100%
E9AJ94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
V5B2Q8	Trypanosoma cruzi	47%	88%