BSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BSD domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H322_LEIBR

TriTrypDb:

LbrM.01.0100 , LBRM2903_010005600

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H322

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H322

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.744
CLV_NRD_NRD_1	46	48	PF00675	0.547
CLV_PCSK_KEX2_1	131	133	PF00082	0.670
CLV_PCSK_KEX2_1	442	444	PF00082	0.554
CLV_PCSK_KEX2_1	46	48	PF00082	0.355
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.554
CLV_PCSK_SKI1_1	142	146	PF00082	0.583
CLV_PCSK_SKI1_1	181	185	PF00082	0.522
CLV_PCSK_SKI1_1	425	429	PF00082	0.469
CLV_PCSK_SKI1_1	462	466	PF00082	0.573
CLV_PCSK_SKI1_1	51	55	PF00082	0.397
CLV_PCSK_SKI1_1	576	580	PF00082	0.570
CLV_Separin_Metazoa	422	426	PF03568	0.522
DEG_SCF_FBW7_1	255	260	PF00400	0.526
DEG_SPOP_SBC_1	143	147	PF00917	0.607
DEG_SPOP_SBC_1	41	45	PF00917	0.511
DEG_SPOP_SBC_1	94	98	PF00917	0.764
DOC_CYCLIN_RxL_1	51	63	PF00134	0.323
DOC_MAPK_gen_1	29	38	PF00069	0.426
DOC_MAPK_gen_1	459	467	PF00069	0.317
DOC_MAPK_gen_1	46	54	PF00069	0.402
DOC_MAPK_HePTP_8	394	406	PF00069	0.524
DOC_MAPK_MEF2A_6	181	189	PF00069	0.520
DOC_MAPK_MEF2A_6	397	406	PF00069	0.485
DOC_PP1_RVXF_1	593	599	PF00149	0.588
DOC_PP2B_LxvP_1	406	409	PF13499	0.415
DOC_PP2B_LxvP_1	541	544	PF13499	0.519
DOC_PP4_FxxP_1	38	41	PF00568	0.456
DOC_PP4_FxxP_1	75	78	PF00568	0.341
DOC_USP7_MATH_1	116	120	PF00917	0.641
DOC_USP7_MATH_1	143	147	PF00917	0.579
DOC_USP7_MATH_1	157	161	PF00917	0.360
DOC_USP7_MATH_1	240	244	PF00917	0.629
DOC_USP7_MATH_1	246	250	PF00917	0.669
DOC_USP7_MATH_1	257	261	PF00917	0.703
DOC_USP7_MATH_1	273	277	PF00917	0.744
DOC_USP7_MATH_1	574	578	PF00917	0.654
DOC_USP7_MATH_1	591	595	PF00917	0.522
DOC_USP7_MATH_1	86	90	PF00917	0.784
DOC_USP7_MATH_1	94	98	PF00917	0.740
DOC_WW_Pin1_4	118	123	PF00397	0.716
DOC_WW_Pin1_4	253	258	PF00397	0.752
DOC_WW_Pin1_4	319	324	PF00397	0.575
DOC_WW_Pin1_4	559	564	PF00397	0.690
DOC_WW_Pin1_4	578	583	PF00397	0.783
DOC_WW_Pin1_4	60	65	PF00397	0.607
DOC_WW_Pin1_4	96	101	PF00397	0.632
LIG_14-3-3_CanoR_1	299	309	PF00244	0.335
LIG_AP2alpha_2	67	69	PF02296	0.541
LIG_BIR_II_1	1	5	PF00653	0.514
LIG_BRCT_BRCA1_1	2	6	PF00533	0.568
LIG_BRCT_BRCA1_1	34	38	PF00533	0.420
LIG_Clathr_ClatBox_1	345	349	PF01394	0.575
LIG_CSL_BTD_1	38	41	PF09270	0.475
LIG_deltaCOP1_diTrp_1	289	298	PF00928	0.487
LIG_deltaCOP1_diTrp_1	338	346	PF00928	0.516
LIG_deltaCOP1_diTrp_1	376	385	PF00928	0.308
LIG_EVH1_1	541	545	PF00568	0.513
LIG_EVH1_2	100	104	PF00568	0.432
LIG_FHA_1	109	115	PF00498	0.427
LIG_FHA_1	182	188	PF00498	0.467
LIG_FHA_1	210	216	PF00498	0.684
LIG_FHA_1	220	226	PF00498	0.656
LIG_FHA_1	418	424	PF00498	0.470
LIG_FHA_2	417	423	PF00498	0.531
LIG_FHA_2	525	531	PF00498	0.636
LIG_FXI_DFP_1	345	349	PF00024	0.575
LIG_LIR_Apic_2	35	41	PF02991	0.441
LIG_LIR_Apic_2	74	78	PF02991	0.339
LIG_LIR_Gen_1	202	211	PF02991	0.536
LIG_LIR_Gen_1	448	458	PF02991	0.510
LIG_LIR_Gen_1	597	602	PF02991	0.636
LIG_LIR_Nem_3	160	164	PF02991	0.502
LIG_LIR_Nem_3	202	208	PF02991	0.510
LIG_LIR_Nem_3	297	301	PF02991	0.482
LIG_LIR_Nem_3	337	343	PF02991	0.391
LIG_LIR_Nem_3	377	383	PF02991	0.334
LIG_LIR_Nem_3	448	453	PF02991	0.488
LIG_LIR_Nem_3	66	72	PF02991	0.454
LIG_Pex14_1	380	384	PF04695	0.335
LIG_PTAP_UEV_1	266	271	PF05743	0.535
LIG_PTB_Apo_2	169	176	PF02174	0.448
LIG_PTB_Phospho_1	169	175	PF10480	0.535
LIG_Rb_pABgroove_1	340	348	PF01858	0.557
LIG_SH2_CRK	367	371	PF00017	0.335
LIG_SH2_STAP1	496	500	PF00017	0.487
LIG_SH2_STAT5	175	178	PF00017	0.560
LIG_SH2_STAT5	383	386	PF00017	0.335
LIG_SH3_3	156	162	PF00018	0.481
LIG_SH3_3	264	270	PF00018	0.792
LIG_SH3_3	539	545	PF00018	0.733
LIG_SH3_3	566	572	PF00018	0.721
LIG_SH3_3	74	80	PF00018	0.560
LIG_SUMO_SIM_anti_2	418	425	PF11976	0.440
LIG_SUMO_SIM_anti_2	431	439	PF11976	0.218
LIG_SUMO_SIM_par_1	431	439	PF11976	0.278
LIG_SUMO_SIM_par_1	463	469	PF11976	0.328
LIG_TRAF2_1	287	290	PF00917	0.602
LIG_TRAF2_1	488	491	PF00917	0.319
LIG_TRAF2_1	602	605	PF00917	0.614
LIG_TRFH_1	367	371	PF08558	0.335
MOD_CK1_1	206	212	PF00069	0.553
MOD_CK1_1	259	265	PF00069	0.772
MOD_CK1_1	300	306	PF00069	0.402
MOD_CK1_1	469	475	PF00069	0.452
MOD_CK1_1	494	500	PF00069	0.565
MOD_CK1_1	577	583	PF00069	0.686
MOD_CK1_1	63	69	PF00069	0.320
MOD_CK1_1	89	95	PF00069	0.764
MOD_CK1_1	96	102	PF00069	0.709
MOD_CK2_1	157	163	PF00069	0.385
MOD_CK2_1	19	25	PF00069	0.300
MOD_CK2_1	319	325	PF00069	0.420
MOD_CK2_1	416	422	PF00069	0.550
MOD_CK2_1	484	490	PF00069	0.524
MOD_CK2_1	591	597	PF00069	0.593
MOD_GlcNHglycan	165	168	PF01048	0.499
MOD_GlcNHglycan	2	5	PF01048	0.566
MOD_GlcNHglycan	20	24	PF01048	0.539
MOD_GlcNHglycan	242	245	PF01048	0.701
MOD_GlcNHglycan	259	262	PF01048	0.698
MOD_GlcNHglycan	264	267	PF01048	0.573
MOD_GlcNHglycan	358	361	PF01048	0.480
MOD_GlcNHglycan	576	579	PF01048	0.810
MOD_GlcNHglycan	586	589	PF01048	0.739
MOD_GlcNHglycan	591	594	PF01048	0.681
MOD_GlcNHglycan	60	63	PF01048	0.490
MOD_GlcNHglycan	86	89	PF01048	0.736
MOD_GSK3_1	116	123	PF00069	0.642
MOD_GSK3_1	181	188	PF00069	0.530
MOD_GSK3_1	199	206	PF00069	0.400
MOD_GSK3_1	207	214	PF00069	0.573
MOD_GSK3_1	229	236	PF00069	0.579
MOD_GSK3_1	253	260	PF00069	0.784
MOD_GSK3_1	265	272	PF00069	0.721
MOD_GSK3_1	273	280	PF00069	0.726
MOD_GSK3_1	412	419	PF00069	0.507
MOD_GSK3_1	465	472	PF00069	0.446
MOD_GSK3_1	559	566	PF00069	0.764
MOD_GSK3_1	574	581	PF00069	0.664
MOD_GSK3_1	84	91	PF00069	0.683
MOD_GSK3_1	95	102	PF00069	0.707
MOD_N-GLC_1	152	157	PF02516	0.512
MOD_N-GLC_1	233	238	PF02516	0.511
MOD_N-GLC_1	41	46	PF02516	0.511
MOD_NEK2_1	152	157	PF00069	0.474
MOD_NEK2_1	207	212	PF00069	0.624
MOD_NEK2_1	218	223	PF00069	0.644
MOD_NEK2_1	309	314	PF00069	0.516
MOD_NEK2_1	465	470	PF00069	0.400
MOD_NEK2_1	58	63	PF00069	0.569
MOD_NEK2_2	12	17	PF00069	0.564
MOD_PIKK_1	466	472	PF00454	0.571
MOD_PIKK_1	477	483	PF00454	0.563
MOD_PKA_2	229	235	PF00069	0.719
MOD_Plk_1	317	323	PF00069	0.539
MOD_Plk_1	375	381	PF00069	0.434
MOD_Plk_4	12	18	PF00069	0.560
MOD_Plk_4	233	239	PF00069	0.572
MOD_Plk_4	375	381	PF00069	0.474
MOD_Plk_4	491	497	PF00069	0.540
MOD_ProDKin_1	118	124	PF00069	0.724
MOD_ProDKin_1	253	259	PF00069	0.754
MOD_ProDKin_1	319	325	PF00069	0.568
MOD_ProDKin_1	559	565	PF00069	0.691
MOD_ProDKin_1	578	584	PF00069	0.783
MOD_ProDKin_1	60	66	PF00069	0.606
MOD_ProDKin_1	96	102	PF00069	0.621
MOD_SUMO_for_1	374	377	PF00179	0.290
TRG_DiLeu_BaEn_1	297	302	PF01217	0.441
TRG_ENDOCYTIC_2	343	346	PF00928	0.467
TRG_ENDOCYTIC_2	367	370	PF00928	0.323
TRG_ENDOCYTIC_2	461	464	PF00928	0.487
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ7	Leptomonas seymouri	48%	98%
A0A1X0P2Y2	Trypanosomatidae	28%	100%
A0A3R7LAJ1	Trypanosoma rangeli	29%	100%
A0A451EJ65	Leishmania donovani	70%	100%
A4HRC8	Leishmania infantum	70%	100%
C9ZXG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ABZ6	Leishmania major	70%	98%
E9AJ93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
V5AME8	Trypanosoma cruzi	29%	100%