Putative lanosterol 14-alpha-demethylase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sterol 14-alpha-demethylase - putative

Species:

Leishmania infantum

UniProt:

A2TEF2_LEIIN

TriTrypDb:

LINF_110017200

Length:

480

Annotations

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, lanosterol 14-alpha-demethylase CYP51

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A2TEF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A2TEF2

PDB structure(s): 3l4d_A , 3l4d_B , 3l4d_C , 3l4d_D

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	12
GO:0032259	methylation	2	12
GO:0006629	lipid metabolic process	3	1
GO:0008202	steroid metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016125	sterol metabolic process	4	1
GO:0044085	cellular component biogenesis	3	1
GO:0044091	membrane biogenesis	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004497	monooxygenase activity	3	12
GO:0005488	binding	1	12
GO:0005506	iron ion binding	6	12
GO:0008168	methyltransferase activity	4	12
GO:0016491	oxidoreductase activity	2	12
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0020037	heme binding	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046906	tetrapyrrole binding	3	12
GO:0046914	transition metal ion binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008398	sterol 14-demethylase activity	3	3
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	3
GO:0032451	demethylase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.306
CLV_NRD_NRD_1	187	189	PF00675	0.309
CLV_NRD_NRD_1	350	352	PF00675	0.308
CLV_NRD_NRD_1	359	361	PF00675	0.308
CLV_PCSK_FUR_1	310	314	PF00082	0.378
CLV_PCSK_KEX2_1	189	191	PF00082	0.308
CLV_PCSK_KEX2_1	312	314	PF00082	0.417
CLV_PCSK_KEX2_1	350	352	PF00082	0.308
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.313
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.417
CLV_PCSK_PC7_1	346	352	PF00082	0.308
CLV_PCSK_SKI1_1	151	155	PF00082	0.455
CLV_PCSK_SKI1_1	360	364	PF00082	0.343
CLV_PCSK_SKI1_1	403	407	PF00082	0.369
CLV_PCSK_SKI1_1	433	437	PF00082	0.314
CLV_PCSK_SKI1_1	471	475	PF00082	0.457
CLV_PCSK_SKI1_1	87	91	PF00082	0.421
DEG_APCC_DBOX_1	122	130	PF00400	0.324
DEG_APCC_DBOX_1	231	239	PF00400	0.295
DEG_APCC_DBOX_1	359	367	PF00400	0.429
DEG_Nend_Nbox_1	1	3	PF02207	0.444
DOC_CKS1_1	88	93	PF01111	0.455
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.324
DOC_MAPK_DCC_7	350	358	PF00069	0.316
DOC_MAPK_DCC_7	360	368	PF00069	0.295
DOC_MAPK_gen_1	121	128	PF00069	0.308
DOC_MAPK_gen_1	350	358	PF00069	0.308
DOC_MAPK_gen_1	360	368	PF00069	0.308
DOC_MAPK_MEF2A_6	350	358	PF00069	0.308
DOC_PP2B_LxvP_1	218	221	PF13499	0.317
DOC_PP4_FxxP_1	104	107	PF00568	0.308
DOC_PP4_FxxP_1	393	396	PF00568	0.324
DOC_PP4_FxxP_1	88	91	PF00568	0.308
DOC_USP7_MATH_1	345	349	PF00917	0.324
DOC_USP7_MATH_1	463	467	PF00917	0.468
DOC_USP7_MATH_2	98	104	PF00917	0.343
DOC_USP7_UBL2_3	471	475	PF12436	0.408
DOC_USP7_UBL2_3	58	62	PF12436	0.240
DOC_WW_Pin1_4	36	41	PF00397	0.413
DOC_WW_Pin1_4	379	384	PF00397	0.301
DOC_WW_Pin1_4	87	92	PF00397	0.338
DOC_WW_Pin1_4	94	99	PF00397	0.276
LIG_14-3-3_CanoR_1	274	280	PF00244	0.393
LIG_14-3-3_CanoR_1	75	79	PF00244	0.408
LIG_APCC_ABBA_1	106	111	PF00400	0.343
LIG_BRCT_BRCA1_1	85	89	PF00533	0.265
LIG_CtBP_PxDLS_1	184	189	PF00389	0.308
LIG_EH1_1	277	285	PF00400	0.308
LIG_FHA_1	255	261	PF00498	0.308
LIG_FHA_1	292	298	PF00498	0.298
LIG_FHA_1	37	43	PF00498	0.370
LIG_FHA_1	456	462	PF00498	0.402
LIG_FHA_1	66	72	PF00498	0.303
LIG_HP1_1	354	358	PF01393	0.370
LIG_LIR_Apic_2	103	107	PF02991	0.386
LIG_LIR_Apic_2	390	396	PF02991	0.344
LIG_LIR_Apic_2	86	91	PF02991	0.283
LIG_LIR_Gen_1	100	109	PF02991	0.308
LIG_LIR_Gen_1	298	309	PF02991	0.308
LIG_LIR_Gen_1	442	452	PF02991	0.320
LIG_LIR_Gen_1	453	463	PF02991	0.264
LIG_LIR_Nem_3	298	304	PF02991	0.308
LIG_LIR_Nem_3	409	415	PF02991	0.316
LIG_LIR_Nem_3	425	430	PF02991	0.258
LIG_LIR_Nem_3	442	448	PF02991	0.188
LIG_LYPXL_yS_3	119	122	PF13949	0.324
LIG_MLH1_MIPbox_1	85	89	PF16413	0.278
LIG_NRBOX	260	266	PF00104	0.324
LIG_NRBOX	4	10	PF00104	0.472
LIG_PCNA_yPIPBox_3	146	159	PF02747	0.308
LIG_PCNA_yPIPBox_3	270	284	PF02747	0.429
LIG_Pex14_2	20	24	PF04695	0.454
LIG_SH2_CRK	115	119	PF00017	0.324
LIG_SH2_CRK	331	335	PF00017	0.308
LIG_SH2_CRK	63	67	PF00017	0.429
LIG_SH2_GRB2like	331	334	PF00017	0.365
LIG_SH2_NCK_1	115	119	PF00017	0.343
LIG_SH2_PTP2	371	374	PF00017	0.294
LIG_SH2_SRC	331	334	PF00017	0.365
LIG_SH2_STAP1	102	106	PF00017	0.343
LIG_SH2_STAP1	331	335	PF00017	0.343
LIG_SH2_STAP1	443	447	PF00017	0.324
LIG_SH2_STAT5	19	22	PF00017	0.445
LIG_SH2_STAT5	371	374	PF00017	0.278
LIG_SH2_STAT5	472	475	PF00017	0.374
LIG_SH3_3	209	215	PF00018	0.308
LIG_SH3_3	26	32	PF00018	0.411
LIG_SH3_3	359	365	PF00018	0.429
LIG_SH3_3	457	463	PF00018	0.425
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.491
LIG_TYR_ITIM	329	334	PF00017	0.308
LIG_UBA3_1	303	312	PF00899	0.324
LIG_WRC_WIRS_1	101	106	PF05994	0.343
MOD_CDK_SPK_2	87	92	PF00069	0.338
MOD_CDK_SPK_2	94	99	PF00069	0.276
MOD_CK1_1	23	29	PF00069	0.489
MOD_CK1_1	295	301	PF00069	0.308
MOD_CK2_1	273	279	PF00069	0.308
MOD_CK2_1	94	100	PF00069	0.308
MOD_GlcNHglycan	168	173	PF01048	0.365
MOD_GSK3_1	20	27	PF00069	0.439
MOD_GSK3_1	291	298	PF00069	0.307
MOD_GSK3_1	379	386	PF00069	0.295
MOD_GSK3_1	431	438	PF00069	0.308
MOD_GSK3_1	83	90	PF00069	0.377
MOD_N-GLC_1	24	29	PF02516	0.465
MOD_N-GLC_1	255	260	PF02516	0.327
MOD_N-GLC_2	70	72	PF02516	0.429
MOD_NEK2_1	20	25	PF00069	0.447
MOD_NEK2_2	345	350	PF00069	0.324
MOD_PIKK_1	273	279	PF00454	0.429
MOD_PIKK_1	463	469	PF00454	0.414
MOD_PKA_2	27	33	PF00069	0.422
MOD_PKA_2	273	279	PF00069	0.393
MOD_PKA_2	345	351	PF00069	0.308
MOD_PKA_2	74	80	PF00069	0.308
MOD_Plk_1	131	137	PF00069	0.299
MOD_Plk_1	168	174	PF00069	0.343
MOD_Plk_4	100	106	PF00069	0.322
MOD_Plk_4	431	437	PF00069	0.308
MOD_Plk_4	455	461	PF00069	0.308
MOD_ProDKin_1	36	42	PF00069	0.413
MOD_ProDKin_1	379	385	PF00069	0.301
MOD_ProDKin_1	87	93	PF00069	0.338
MOD_ProDKin_1	94	100	PF00069	0.276
MOD_SUMO_for_1	201	204	PF00179	0.320
TRG_DiLeu_BaEn_1	4	9	PF01217	0.571
TRG_DiLeu_BaEn_1	425	430	PF01217	0.393
TRG_DiLeu_BaEn_2	123	129	PF01217	0.324
TRG_DiLeu_BaEn_2	147	153	PF01217	0.308
TRG_DiLeu_BaEn_2	99	105	PF01217	0.324
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.324
TRG_ENDOCYTIC_2	102	105	PF00928	0.308
TRG_ENDOCYTIC_2	119	122	PF00928	0.308
TRG_ENDOCYTIC_2	331	334	PF00928	0.308
TRG_ENDOCYTIC_2	456	459	PF00928	0.306
TRG_ENDOCYTIC_2	63	66	PF00928	0.429
TRG_ER_diArg_1	120	123	PF00400	0.324
TRG_ER_diArg_1	187	190	PF00400	0.308
TRG_ER_diArg_1	226	229	PF00400	0.429
TRG_ER_diArg_1	349	351	PF00400	0.308
TRG_ER_diLys_1	475	480	PF00400	0.549
TRG_NES_CRM1_1	124	139	PF08389	0.308
TRG_NLS_MonoCore_2	473	478	PF00514	0.365
TRG_NLS_MonoExtN_4	471	478	PF00514	0.432
TRG_NLS_MonoExtN_4	58	64	PF00514	0.241

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A068Q609	Prunus mume	21%	91%
A0A068Q6L2	Prunus mume	20%	93%
A0A068Q721	Prunus mume	22%	93%
A0A084API1	Stachybotrys chartarum (strain CBS 109288 / IBT 7711)	23%	91%
A0A0B4L1W8	Maesa lanceolata	24%	99%
A0A0D1DMJ7	Ustilago maydis (strain 521 / FGSC 9021)	21%	75%
A0A0N1I4H1	Leptomonas seymouri	89%	100%
A0A0N1PC71	Leptomonas seymouri	22%	87%
A0A0S1TPC7	Salvia pomifera	21%	96%
A0A0S2IHL2	Kalopanax septemlobus	24%	92%
A0A0S2II38	Kalopanax septemlobus	22%	100%
A0A0S4IJW0	Bodo saltans	69%	100%
A0A0S4JHW8	Bodo saltans	22%	95%
A0A159AKG3	Thymus vulgaris	23%	97%
A0A1B4XBH0	Sordaria araneosa	23%	93%
A0A1D8QMD1	Salvia fruticosa	21%	96%
A0A1I9Q5Z0	Platycodon grandiflorus	21%	100%
A0A1U8QFC3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	21%	87%
A0A1X0NUW4	Trypanosomatidae	79%	100%
A0A1X0P1I7	Trypanosomatidae	23%	94%
A0A2V5GZ95	Aspergillus violaceofuscus (strain CBS 115571)	27%	99%
A0A2Z5D850	Pastinaca sativa	23%	95%
A0A2Z5D852	Pastinaca sativa	23%	95%
A0A343URW6	Catharanthus roseus	20%	95%
A0A3Q7HBJ5	Solanum lycopersicum	21%	100%
A0A3Q7HS74	Solanum lycopersicum	22%	100%
A0A3S7WRS7	Leishmania donovani	100%	100%
A0A3S7X3X6	Leishmania donovani	22%	94%
A0A422NRN3	Trypanosoma rangeli	79%	100%
A0A481NR20	Barbarea vulgaris	22%	94%
A0A517FNC9	Trigonella foenum-graecum	22%	91%
A0A517FND3	Trigonella foenum-graecum	20%	100%
A0A5A4DV62	Paris polyphylla	22%	99%
A1YJE3	Nicotiana tomentosiformis	20%	93%
A2RRT9	Rattus norvegicus	21%	91%
A2Z212	Oryza sativa subsp. indica	22%	96%
A4H6N4	Leishmania braziliensis	96%	100%
A4HB52	Leishmania braziliensis	21%	88%
A4HIU1	Leishmania braziliensis	22%	100%
A4I646	Leishmania infantum	22%	94%
A5ABG2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	100%
A5BFI4	Vitis vinifera	21%	100%
A6YIH8	Hyoscyamus muticus	22%	96%
A9QNE7	Solanum lycopersicum	23%	100%
B4FVP3	Zea mays	23%	95%
B5BSX1	Glycyrrhiza uralensis	22%	97%
B8N2C8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	30%	94%
B8NFL5	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	27%	98%
B8NUK6	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	29%	94%
B9G934	Oryza sativa subsp. japonica	24%	94%
C0SJS2	Pastinaca sativa	21%	100%
C0SJS4	Apium graveolens	21%	100%
C9K1X6	Streptomyces melanosporofaciens	25%	100%
C9K1X7	Streptomyces melanosporofaciens	23%	100%
D0A7D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
D2CGS0	Ammi majus	22%	94%
D5J9U8	Lactuca sativa	23%	98%
D5JBW8	Cichorium intybus	23%	98%
D5JBW9	Saussurea costus	23%	98%
D5JBX0	Helianthus annuus	22%	98%
D5JBX1	Barnadesia spinosa	22%	97%
E1B2Z9	Cichorium intybus	22%	97%
E9ANQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9B1C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B5C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	87%
E9KBR8	Glycine max	21%	91%
E9QY26	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	30%	92%
F1RE08	Danio rerio	20%	100%
F1SYD1	Postia placenta (strain ATCC 44394 / Madison 698-R)	23%	97%
F2Z9C1	Eschscholzia californica	21%	92%
F6H9N6	Vitis vinifera	21%	100%
F8S1I0	Lactuca sativa	23%	98%
G3GBK0	Cichorium intybus	23%	97%
G4XV71	Glycyrrhiza uralensis	23%	92%
H1A988	Glycyrrhiza uralensis	24%	92%
H2DH16	Panax ginseng	22%	99%
H2DH17	Panax ginseng	23%	92%
H2DH18	Panax ginseng	23%	96%
H2DH21	Panax ginseng	24%	93%
I1GQE7	Brachypodium distachyon	23%	100%
I1RBR4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	29%	91%
I1RJR2	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	27%	95%
I1S2M5	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	29%	93%
I1TEM0	Catharanthus roseus	22%	96%
I1TEM1	Catharanthus roseus	22%	95%
K4CI52	Solanum lycopersicum	21%	100%
K7NBR2	Siraitia grosvenorii	23%	100%
L7X0L7	Papaver somniferum	23%	89%
O02766	Oryctolagus cuniculus	23%	96%
O14442	Uncinula necator	30%	92%
O18596	Drosophila mettleri	21%	94%
O22307	Lotus japonicus	21%	98%
O23051	Arabidopsis thaliana	23%	98%
O35074	Mus musculus	22%	96%
O35728	Mus musculus	22%	95%
O43174	Homo sapiens	22%	97%
O44221	Drosophila mettleri	22%	92%
O46420	Sus scrofa	34%	95%
O46515	Equus caballus	22%	92%
O48786	Arabidopsis thaliana	26%	92%
O48923	Glycine max	23%	94%
O48928	Glycine max	21%	94%
O49858	Glycine max	23%	91%
O55127	Mus musculus	21%	97%
O57525	Rana dybowskii	22%	92%
O64635	Arabidopsis thaliana	23%	94%
O64636	Arabidopsis thaliana	21%	94%
O64637	Arabidopsis thaliana	23%	94%
O64638	Arabidopsis thaliana	21%	93%
O65782	Arabidopsis thaliana	24%	96%
O65790	Arabidopsis thaliana	24%	96%
O73853	Ictalurus punctatus	24%	93%
O81077	Arabidopsis thaliana	21%	100%
O81970	Glycine max	21%	96%
O81972	Glycine max	22%	92%
O81974	Glycine max	21%	95%
O87605	Streptomyces venezuelae	21%	100%
O88833	Mus musculus	22%	94%
O93323	Xenopus laevis	23%	98%
P00184	Mus musculus	21%	92%
P00185	Rattus norvegicus	21%	92%
P05176	Oryctolagus cuniculus	22%	93%
P08516	Rattus norvegicus	21%	94%
P0A513	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	100%
P0DO13	Rauvolfia serpentina	21%	95%
P0DO14	Gelsemium sempervirens	22%	96%
P0DO35	Origanum vulgare	22%	97%
P0DO36	Thymus vulgaris	22%	97%
P0DO37	Origanum vulgare	21%	97%
P0DO38	Thymus vulgaris	24%	97%
P0DO39	Origanum vulgare	23%	97%
P0DO40	Origanum majorana	23%	97%
P0DO41	Origanum vulgare	24%	97%
P0DO42	Thymus vulgaris	24%	97%
P10611	Oryctolagus cuniculus	22%	94%
P10613	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	91%
P10614	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	91%
P11707	Oryctolagus cuniculus	22%	96%
P11711	Rattus norvegicus	22%	98%
P11714	Mus musculus	21%	95%
P12394	Gallus gallus	22%	94%
P13584	Homo sapiens	23%	94%
P14263	Candida tropicalis	29%	91%
P14579	Oryctolagus cuniculus	22%	94%
P14580	Oryctolagus cuniculus	22%	94%
P14581	Oryctolagus cuniculus	22%	94%
P15128	Oryctolagus cuniculus	22%	95%
P15129	Rattus norvegicus	23%	94%
P15392	Mus musculus	25%	97%
P20812	Rattus norvegicus	24%	97%
P20816	Rattus norvegicus	23%	95%
P20817	Rattus norvegicus	23%	95%
P20852	Mus musculus	24%	97%
P22680	Homo sapiens	22%	95%
P24456	Mus musculus	21%	95%
P24464	Rattus norvegicus	23%	94%
P29980	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	25%	100%
P33274	Rattus norvegicus	23%	92%
P37118	Solanum melongena	21%	95%
P37120	Solanum melongena	21%	94%
P37121	Solanum melongena	23%	100%
P37122	Solanum melongena	24%	95%
P48421	Arabidopsis thaliana	22%	96%
P49264	Thlaspi arvense	22%	97%
P49602	Ustilago maydis (strain 521 / FGSC 9021)	28%	86%
P50859	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	30%	90%
P51542	Oryctolagus cuniculus	21%	96%
P51869	Rattus norvegicus	22%	92%
P51870	Rattus norvegicus	22%	91%
P51871	Rattus norvegicus	24%	89%
P55540	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	25%	100%
P56593	Mus musculus	22%	98%
P58048	Arabidopsis thaliana	22%	95%
P58049	Arabidopsis thaliana	23%	97%
P58050	Arabidopsis thaliana	21%	97%
P58051	Arabidopsis thaliana	24%	97%
P63718	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	25%	100%
P78329	Homo sapiens	25%	92%
P79739	Danio rerio	21%	98%
P82711	Drosophila melanogaster	24%	95%
P93149	Glycyrrhiza echinata	22%	92%
P93596	Triticum aestivum	32%	100%
P93846	Sorghum bicolor	31%	98%
P98183	Catharanthus roseus	22%	95%
P98187	Homo sapiens	23%	92%
P9WPM2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	100%
P9WPM3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	100%
P9WPM4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	23%	100%
P9WPM5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	23%	100%
P9WPM6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	22%	98%
P9WPM7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	22%	98%
P9WPN0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	22%	100%
P9WPN1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	22%	100%
P9WPP8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	100%
P9WPP9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
Q00557	Mesocricetus auratus	21%	92%
Q02315	Pichia kudriavzevii	30%	100%
Q02928	Homo sapiens	23%	92%
Q05047	Catharanthus roseus	21%	92%
Q05556	Oryctolagus cuniculus	23%	97%
Q05JG2	Oryza sativa subsp. japonica	21%	100%
Q08477	Homo sapiens	24%	92%
Q09736	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	97%
Q09J78	Oryza sativa subsp. indica	22%	95%
Q09J79	Oryza sativa subsp. indica	21%	100%
Q0CZG8	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	100%
Q0IIF9	Bos taurus	23%	88%
Q0J185	Oryza sativa subsp. japonica	22%	96%
Q0WTF4	Arabidopsis thaliana	22%	96%
Q12664	Penicillium italicum	29%	93%
Q16647	Homo sapiens	22%	96%
Q16696	Homo sapiens	24%	97%
Q16850	Homo sapiens	34%	94%
Q1JPY5	Danio rerio	34%	96%
Q1ZXH9	Dictyostelium discoideum	34%	100%
Q27589	Drosophila melanogaster	21%	96%
Q27606	Drosophila melanogaster	23%	91%
Q27902	Papilio glaucus	23%	96%
Q2MJ20	Medicago truncatula	21%	100%
Q2MJ21	Medicago truncatula	22%	92%
Q38Q87	Nicotiana tabacum	21%	93%
Q3MID2	Rattus norvegicus	23%	92%
Q42716	Mentha piperita	22%	96%
Q42798	Glycine max	21%	94%
Q42799	Glycine max	24%	96%
Q43068	Pisum sativum	21%	88%
Q43147	Solanum lycopersicum	23%	100%
Q43250	Zea mays	23%	90%
Q43255	Zea mays	22%	90%
Q4PJW3	Bos taurus	34%	96%
Q4QGX0	Leishmania major	97%	100%
Q4R8S6	Macaca fascicularis	34%	94%
Q4V8D1	Rattus norvegicus	22%	91%
Q4WNT5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	30%	93%
Q50EK0	Picea sitchensis	22%	97%
Q50EK1	Picea sitchensis	22%	97%
Q50EK4	Pinus taeda	23%	91%
Q50LE0	Solanum lycopersicum	21%	100%
Q54KV0	Dictyostelium discoideum	22%	99%
Q54NY3	Dictyostelium discoideum	22%	96%
Q55EK2	Dictyostelium discoideum	23%	90%
Q59205	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	24%	100%
Q59990	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
Q5IZM4	Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1)	32%	100%
Q5KQH7	Oryza sativa subsp. japonica	21%	83%
Q5KQT6	Felis catus	20%	94%
Q5RCN6	Pongo abelii	20%	91%
Q5RE72	Pongo abelii	34%	94%
Q5TCH4	Homo sapiens	23%	92%
Q5UQI3	Acanthamoeba polyphaga mimivirus	23%	68%
Q5VRM7	Oryza sativa subsp. japonica	23%	95%
Q5Z5S6	Oryza sativa subsp. japonica	22%	95%
Q62969	Rattus norvegicus	22%	96%
Q64462	Mus musculus	23%	94%
Q64654	Rattus norvegicus	34%	95%
Q69F95	Phaseolus vulgaris	22%	100%
Q6A152	Mus musculus	21%	95%
Q6IV13	Mentha spicata	22%	97%
Q6NKZ8	Arabidopsis thaliana	23%	91%
Q6NT55	Homo sapiens	22%	90%
Q6WG30	Taxus cuspidata	23%	96%
Q6WKY9	Mentha gracilis	22%	97%
Q6WKZ0	Mentha gracilis	22%	97%
Q6WKZ1	Mentha gracilis	22%	97%
Q6WNR0	Medicago truncatula	20%	96%
Q6XQ14	Manihot esculenta	22%	94%
Q6ZDE3	Oryza sativa subsp. japonica	22%	94%
Q6ZWL3	Homo sapiens	21%	91%
Q759W0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	91%
Q7G602	Oryza sativa subsp. japonica	22%	91%
Q7Z1V1	Trypanosoma cruzi (strain CL Brener)	76%	100%
Q7Z449	Homo sapiens	23%	88%
Q82IY3	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	25%	100%
Q8AXY5	Fundulus heteroclitus	22%	97%
Q8GSQ1	Oryza sativa subsp. japonica	23%	100%
Q8K0C4	Mus musculus	33%	95%
Q8K4D6	Rattus norvegicus	22%	95%
Q8LM92	Oryza sativa subsp. japonica	21%	90%
Q8SPK0	Sus scrofa	22%	95%
Q8SPK1	Sus scrofa	22%	95%
Q8VWZ7	Catharanthus roseus	22%	97%
Q92113	Squalus acanthias	22%	94%
Q947B7	Mentha piperita	20%	97%
Q949P1	Arabidopsis thaliana	22%	100%
Q94FM7	Nicotiana tabacum	21%	95%
Q94IA6	Arabidopsis thaliana	23%	98%
Q95036	Papilio glaucus	23%	100%
Q95078	Drosophila melanogaster	20%	89%
Q964R0	Blattella germanica	23%	92%
Q964R1	Blattella germanica	21%	96%
Q96514	Arabidopsis thaliana	22%	95%
Q99N16	Mus musculus	23%	92%
Q9AXM6	Taxus cuspidata	22%	97%
Q9CA60	Arabidopsis thaliana	22%	99%
Q9CX98	Mus musculus	22%	91%
Q9DBW0	Mus musculus	23%	91%
Q9EP75	Mus musculus	22%	92%
Q9FG65	Arabidopsis thaliana	21%	96%
Q9FH76	Arabidopsis thaliana	21%	100%
Q9FMA5	Arabidopsis thaliana	23%	100%
Q9GJX5	Sus scrofa	23%	95%
Q9GLL1	Ovis aries	23%	91%
Q9HCS2	Homo sapiens	22%	92%
Q9JKJ9	Mus musculus	24%	100%
Q9K498	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	24%	100%
Q9LIP5	Arabidopsis thaliana	21%	96%
Q9LJK2	Arabidopsis thaliana	22%	100%
Q9LJY5	Arabidopsis thaliana	20%	93%
Q9LJY7	Arabidopsis thaliana	20%	94%
Q9LSF8	Arabidopsis thaliana	22%	93%
Q9LTL0	Arabidopsis thaliana	23%	96%
Q9LTM0	Arabidopsis thaliana	22%	96%
Q9LTM4	Arabidopsis thaliana	21%	96%
Q9LUC5	Arabidopsis thaliana	24%	94%
Q9LUC6	Arabidopsis thaliana	26%	94%
Q9LUC8	Arabidopsis thaliana	25%	94%
Q9LUC9	Arabidopsis thaliana	23%	94%
Q9LVD2	Arabidopsis thaliana	22%	96%
Q9LVD6	Arabidopsis thaliana	22%	98%
Q9M066	Arabidopsis thaliana	22%	92%
Q9NYL5	Homo sapiens	24%	100%
Q9PUB4	Gallus gallus	22%	98%
Q9PVE8	Fundulus heteroclitus	22%	97%
Q9QXF7	Rattus norvegicus	22%	96%
Q9SAA9	Arabidopsis thaliana	32%	98%
Q9SAE4	Arabidopsis thaliana	22%	98%
Q9SBQ9	Petunia hybrida	23%	94%
Q9SD85	Arabidopsis thaliana	21%	94%
Q9SHG5	Arabidopsis thaliana	21%	92%
Q9SWR5	Glycine max	22%	92%
Q9SXS3	Glycyrrhiza echinata	23%	92%
Q9T0K0	Arabidopsis thaliana	20%	98%
Q9T0K2	Arabidopsis thaliana	24%	97%
Q9UNU6	Homo sapiens	22%	96%
Q9UVC3	Cunninghamella elegans	34%	94%
Q9V4T5	Drosophila melanogaster	22%	90%
Q9V4U7	Drosophila melanogaster	26%	94%
Q9V558	Drosophila melanogaster	22%	94%
Q9V559	Drosophila melanogaster	22%	93%
Q9V770	Drosophila melanogaster	23%	96%
Q9V771	Drosophila melanogaster	23%	96%
Q9V773	Drosophila melanogaster	22%	96%
Q9VB31	Drosophila melanogaster	23%	95%
Q9VFP1	Drosophila melanogaster	26%	94%
Q9VGB5	Drosophila melanogaster	23%	99%
Q9VL92	Drosophila melanogaster	21%	91%
Q9VLZ7	Drosophila melanogaster	20%	94%
Q9VMS7	Drosophila melanogaster	22%	94%
Q9VMS8	Drosophila melanogaster	20%	94%
Q9VMS9	Drosophila melanogaster	21%	94%
Q9VWR5	Drosophila melanogaster	22%	84%
Q9VXY0	Drosophila melanogaster	23%	97%
Q9XGT9	Gerbera hybrida	23%	94%
Q9XHE6	Mentha piperita	22%	96%
Q9XHE7	Mentha piperita	22%	96%
Q9XHE8	Mentha spicata	22%	97%
U5NDT8	Catharanthus roseus	20%	91%
U5NE19	Catharanthus roseus	23%	92%
V5BSB7	Trypanosoma cruzi	25%	95%
V5C1C6	Trypanosoma cruzi	76%	100%
W8JDE2	Catharanthus roseus	22%	93%
W8JIS5	Catharanthus roseus	23%	93%
W8JMU7	Catharanthus roseus	21%	96%
W8JMV1	Catharanthus roseus	23%	96%
W8JWW3	Catharanthus roseus	22%	89%
X2EVQ5	Tanacetum parthenium	23%	97%
X2EW55	Tanacetum parthenium	22%	96%
X2JE85	Tanacetum parthenium	22%	97%
X2JI34	Tanacetum parthenium	22%	98%