LeishMANIAdb
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Glucose-6-phosphate 1-dehydrogenase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glucose-6-phosphate 1-dehydrogenase
Gene product:
glucose-6-phosphate 1-dehydrogenase - putative
Species:
Leishmania infantum
UniProt:
A2CIJ8_LEIIN
TriTrypDb:
LINF_340005700 *
Length:
562

Annotations

Annotations by Jardim et al.

Pentose Phosphate Pathway, Glucose-6-phosphate 1-dehydrogenase g6pdh

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A2CIJ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A2CIJ8

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 13
GO:0005996 monosaccharide metabolic process 3 13
GO:0006006 glucose metabolic process 5 13
GO:0006091 generation of precursor metabolites and energy 3 13
GO:0006098 pentose-phosphate shunt 5 12
GO:0006139 nucleobase-containing compound metabolic process 3 13
GO:0006725 cellular aromatic compound metabolic process 3 13
GO:0006739 NADP metabolic process 7 13
GO:0006740 NADPH regeneration 4 13
GO:0006753 nucleoside phosphate metabolic process 4 13
GO:0006793 phosphorus metabolic process 3 13
GO:0006796 phosphate-containing compound metabolic process 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009117 nucleotide metabolic process 5 13
GO:0009987 cellular process 1 13
GO:0019318 hexose metabolic process 4 13
GO:0019362 pyridine nucleotide metabolic process 5 13
GO:0019637 organophosphate metabolic process 3 13
GO:0034641 cellular nitrogen compound metabolic process 3 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0044281 small molecule metabolic process 2 13
GO:0046483 heterocycle metabolic process 3 13
GO:0046496 nicotinamide nucleotide metabolic process 6 13
GO:0051156 glucose 6-phosphate metabolic process 4 13
GO:0055086 nucleobase-containing small molecule metabolic process 3 13
GO:0071704 organic substance metabolic process 2 13
GO:0072524 pyridine-containing compound metabolic process 4 13
GO:1901135 carbohydrate derivative metabolic process 3 13
GO:1901360 organic cyclic compound metabolic process 3 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:0000302 response to reactive oxygen species 4 1
GO:0006950 response to stress 2 1
GO:0006979 response to oxidative stress 3 1
GO:0008283 cell population proliferation 2 1
GO:0009051 pentose-phosphate shunt, oxidative branch 5 1
GO:0042221 response to chemical 2 1
GO:0050896 response to stimulus 1 1
GO:1901700 response to oxygen-containing compound 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0004345 glucose-6-phosphate dehydrogenase activity 5 13
GO:0005488 binding 1 13
GO:0016491 oxidoreductase activity 2 13
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 13
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 13
GO:0036094 small molecule binding 2 13
GO:0050661 NADP binding 4 13
GO:0097159 organic cyclic compound binding 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 30 32 PF00675 0.577
CLV_NRD_NRD_1 500 502 PF00675 0.336
CLV_PCSK_KEX2_1 161 163 PF00082 0.457
CLV_PCSK_PC1ET2_1 161 163 PF00082 0.466
CLV_PCSK_SKI1_1 42 46 PF00082 0.505
CLV_PCSK_SKI1_1 510 514 PF00082 0.456
CLV_PCSK_SKI1_1 70 74 PF00082 0.413
DEG_APCC_KENBOX_2 169 173 PF00400 0.378
DEG_APCC_KENBOX_2 348 352 PF00400 0.456
DOC_CKS1_1 511 516 PF01111 0.307
DOC_CYCLIN_yCln2_LP_2 100 103 PF00134 0.424
DOC_MAPK_gen_1 501 507 PF00069 0.456
DOC_MAPK_gen_1 68 77 PF00069 0.432
DOC_MAPK_MEF2A_6 411 419 PF00069 0.299
DOC_MAPK_MEF2A_6 68 76 PF00069 0.387
DOC_MAPK_RevD_3 72 87 PF00069 0.320
DOC_PP1_RVXF_1 414 420 PF00149 0.320
DOC_PP2B_LxvP_1 100 103 PF13499 0.424
DOC_PP2B_LxvP_1 187 190 PF13499 0.307
DOC_PP4_FxxP_1 174 177 PF00568 0.376
DOC_USP7_MATH_1 153 157 PF00917 0.242
DOC_USP7_MATH_1 361 365 PF00917 0.364
DOC_USP7_MATH_1 375 379 PF00917 0.226
DOC_USP7_MATH_1 439 443 PF00917 0.336
DOC_USP7_MATH_1 483 487 PF00917 0.307
DOC_USP7_UBL2_3 175 179 PF12436 0.391
DOC_USP7_UBL2_3 448 452 PF12436 0.376
DOC_USP7_UBL2_3 64 68 PF12436 0.470
DOC_WW_Pin1_4 510 515 PF00397 0.299
LIG_14-3-3_CanoR_1 461 468 PF00244 0.391
LIG_Actin_WH2_2 446 463 PF00022 0.366
LIG_APCC_ABBA_1 236 241 PF00400 0.434
LIG_APCC_ABBA_1 423 428 PF00400 0.354
LIG_BIR_II_1 1 5 PF00653 0.672
LIG_BRCT_BRCA1_1 495 499 PF00533 0.307
LIG_Clathr_ClatBox_1 319 323 PF01394 0.307
LIG_deltaCOP1_diTrp_1 393 400 PF00928 0.307
LIG_deltaCOP1_diTrp_1 506 512 PF00928 0.402
LIG_EVH1_2 190 194 PF00568 0.307
LIG_FHA_1 312 318 PF00498 0.307
LIG_FHA_1 380 386 PF00498 0.320
LIG_FHA_1 448 454 PF00498 0.363
LIG_FHA_1 495 501 PF00498 0.307
LIG_FHA_1 511 517 PF00498 0.280
LIG_FHA_1 71 77 PF00498 0.313
LIG_FHA_2 111 117 PF00498 0.434
LIG_FHA_2 283 289 PF00498 0.320
LIG_FHA_2 371 377 PF00498 0.428
LIG_FHA_2 464 470 PF00498 0.307
LIG_FHA_2 472 478 PF00498 0.307
LIG_LIR_Apic_2 171 177 PF02991 0.373
LIG_LIR_Gen_1 192 201 PF02991 0.468
LIG_LIR_Gen_1 34 45 PF02991 0.496
LIG_LIR_Gen_1 382 390 PF02991 0.307
LIG_LIR_Gen_1 409 419 PF02991 0.402
LIG_LIR_Gen_1 443 454 PF02991 0.307
LIG_LIR_Gen_1 482 492 PF02991 0.307
LIG_LIR_Nem_3 158 163 PF02991 0.296
LIG_LIR_Nem_3 192 197 PF02991 0.460
LIG_LIR_Nem_3 34 40 PF02991 0.495
LIG_LIR_Nem_3 393 398 PF02991 0.328
LIG_LIR_Nem_3 409 415 PF02991 0.336
LIG_LIR_Nem_3 443 449 PF02991 0.307
LIG_LIR_Nem_3 482 487 PF02991 0.307
LIG_LIR_Nem_3 506 512 PF02991 0.298
LIG_LIR_Nem_3 88 92 PF02991 0.320
LIG_Pex14_2 270 274 PF04695 0.307
LIG_Pex14_2 89 93 PF04695 0.320
LIG_PTB_Apo_2 264 271 PF02174 0.307
LIG_PTB_Apo_2 542 549 PF02174 0.332
LIG_Rb_LxCxE_1 336 350 PF01857 0.402
LIG_SH2_NCK_1 154 158 PF00017 0.336
LIG_SH2_PTP2 412 415 PF00017 0.434
LIG_SH2_PTP2 446 449 PF00017 0.359
LIG_SH2_STAP1 357 361 PF00017 0.402
LIG_SH2_STAP1 476 480 PF00017 0.324
LIG_SH2_STAP1 484 488 PF00017 0.315
LIG_SH2_STAT5 129 132 PF00017 0.402
LIG_SH2_STAT5 13 16 PF00017 0.535
LIG_SH2_STAT5 149 152 PF00017 0.320
LIG_SH2_STAT5 186 189 PF00017 0.336
LIG_SH2_STAT5 251 254 PF00017 0.308
LIG_SH2_STAT5 298 301 PF00017 0.307
LIG_SH2_STAT5 357 360 PF00017 0.307
LIG_SH2_STAT5 368 371 PF00017 0.307
LIG_SH2_STAT5 412 415 PF00017 0.402
LIG_SH2_STAT5 446 449 PF00017 0.321
LIG_SH2_STAT5 96 99 PF00017 0.354
LIG_SH3_3 369 375 PF00018 0.282
LIG_SH3_3 475 481 PF00018 0.337
LIG_SUMO_SIM_anti_2 335 342 PF11976 0.376
LIG_TYR_ITIM 184 189 PF00017 0.307
LIG_UBA3_1 316 324 PF00899 0.307
LIG_UBA3_1 36 42 PF00899 0.345
MOD_CK1_1 131 137 PF00069 0.448
MOD_CK1_1 43 49 PF00069 0.571
MOD_CK2_1 193 199 PF00069 0.339
MOD_CK2_1 225 231 PF00069 0.376
MOD_CK2_1 282 288 PF00069 0.320
MOD_CK2_1 370 376 PF00069 0.443
MOD_GlcNHglycan 228 231 PF01048 0.361
MOD_GlcNHglycan 270 273 PF01048 0.328
MOD_GlcNHglycan 359 362 PF01048 0.393
MOD_GlcNHglycan 42 45 PF01048 0.550
MOD_GlcNHglycan 456 459 PF01048 0.378
MOD_GlcNHglycan 520 523 PF01048 0.415
MOD_GlcNHglycan 79 82 PF01048 0.336
MOD_GSK3_1 189 196 PF00069 0.351
MOD_GSK3_1 226 233 PF00069 0.307
MOD_GSK3_1 282 289 PF00069 0.305
MOD_GSK3_1 357 364 PF00069 0.326
MOD_GSK3_1 375 382 PF00069 0.207
MOD_GSK3_1 66 73 PF00069 0.470
MOD_N-GLC_1 131 136 PF02516 0.320
MOD_N-GLC_1 274 279 PF02516 0.380
MOD_N-GLC_1 494 499 PF02516 0.335
MOD_NEK2_1 240 245 PF00069 0.369
MOD_NEK2_1 286 291 PF00069 0.340
MOD_NEK2_1 460 465 PF00069 0.346
MOD_NEK2_1 468 473 PF00069 0.299
MOD_NEK2_1 493 498 PF00069 0.347
MOD_PIKK_1 230 236 PF00454 0.350
MOD_PIKK_1 240 246 PF00454 0.324
MOD_PIKK_1 311 317 PF00454 0.307
MOD_PIKK_1 427 433 PF00454 0.313
MOD_PKA_1 85 91 PF00069 0.320
MOD_PKA_2 223 229 PF00069 0.424
MOD_PKA_2 460 466 PF00069 0.383
MOD_Plk_1 240 246 PF00069 0.376
MOD_Plk_1 370 376 PF00069 0.434
MOD_Plk_1 468 474 PF00069 0.320
MOD_Plk_2-3 370 376 PF00069 0.339
MOD_Plk_4 122 128 PF00069 0.456
MOD_Plk_4 189 195 PF00069 0.402
MOD_Plk_4 336 342 PF00069 0.456
MOD_Plk_4 483 489 PF00069 0.307
MOD_Plk_4 70 76 PF00069 0.335
MOD_ProDKin_1 510 516 PF00069 0.299
MOD_SUMO_for_1 63 66 PF00179 0.476
MOD_SUMO_rev_2 155 163 PF00179 0.437
MOD_SUMO_rev_2 219 229 PF00179 0.378
MOD_SUMO_rev_2 329 339 PF00179 0.309
MOD_SUMO_rev_2 520 527 PF00179 0.284
MOD_SUMO_rev_2 65 69 PF00179 0.472
TRG_DiLeu_BaEn_2 537 543 PF01217 0.336
TRG_DiLeu_BaLyEn_6 511 516 PF01217 0.320
TRG_ENDOCYTIC_2 154 157 PF00928 0.434
TRG_ENDOCYTIC_2 186 189 PF00928 0.307
TRG_ENDOCYTIC_2 412 415 PF00928 0.402
TRG_ENDOCYTIC_2 446 449 PF00928 0.297
TRG_ENDOCYTIC_2 484 487 PF00928 0.313
TRG_ENDOCYTIC_2 554 557 PF00928 0.562
TRG_NES_CRM1_1 307 323 PF08389 0.376
TRG_Pf-PMV_PEXEL_1 215 219 PF00026 0.318
TRG_Pf-PMV_PEXEL_1 326 331 PF00026 0.291

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY68 Leptomonas seymouri 79% 100%
A0A0S4IKV7 Bodo saltans 60% 100%
A0A0S4JKV9 Bodo saltans 63% 92%
A0A1X0P8S6 Trypanosomatidae 67% 99%
A0A1X0P9F7 Trypanosomatidae 67% 99%
A0A3R7JXC4 Trypanosoma rangeli 65% 100%
A0QP90 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 36% 100%
A2CIK6 Leishmania donovani 100% 100%
A4HAD3 Leishmania braziliensis 86% 100%
D0A1T2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
E9B4H4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O00091 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 47% 100%
O14137 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
O24357 Spinacia oleracea 46% 98%
O51581 Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) 32% 100%
O54537 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 35% 100%
O55044 Cricetulus griseus 51% 100%
O59812 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 100%
O68282 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 39% 100%
O83491 Treponema pallidum (strain Nichols) 36% 100%
O84188 Chlamydia trachomatis (strain D/UW-3/Cx) 36% 100%
O95479 Homo sapiens 31% 71%
P05370 Rattus norvegicus 51% 100%
P0A585 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 39% 100%
P0A587 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 31% 100%
P0AC53 Escherichia coli (strain K12) 38% 100%
P0AC54 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 38% 100%
P11410 Cyberlindnera jadinii 51% 100%
P11411 Leuconostoc mesenteroides 33% 100%
P11412 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 50% 100%
P11413 Homo sapiens 51% 100%
P12646 Drosophila melanogaster 53% 100%
P21907 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) 33% 100%
P29686 Synechococcus elongatus (strain PCC 7942 / FACHB-805) 36% 100%
P37830 Solanum tuberosum 54% 100%
P37986 Dickeya dadantii (strain 3937) 35% 100%
P41571 Ceratitis capitata 51% 100%
P41764 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 51% 100%
P44311 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 37% 100%
P48826 Aspergillus niger 52% 100%
P48828 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 50% 100%
P48848 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 37% 100%
P48992 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 37% 100%
P54547 Bacillus subtilis (strain 168) 36% 100%
P54996 Takifugu rubripes 49% 100%
P56110 Helicobacter pylori (strain ATCC 700392 / 26695) 31% 100%
P56201 Oryctolagus cuniculus 28% 71%
P57405 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 31% 100%
P73411 Synechocystis sp. (strain PCC 6803 / Kazusa) 37% 100%
P77809 Aggregatibacter actinomycetemcomitans 38% 100%
P97324 Mus musculus 49% 100%
P9WN70 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 31% 100%
P9WN71 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 31% 100%
P9WN72 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 39% 100%
P9WN73 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 39% 100%
Q00612 Mus musculus 51% 100%
Q27464 Caenorhabditis elegans 49% 100%
Q27638 Drosophila yakuba 52% 100%
Q29492 Osphranter robustus 50% 100%
Q42919 Medicago sativa 52% 100%
Q43727 Arabidopsis thaliana 48% 98%
Q43793 Nicotiana tabacum 47% 95%
Q43839 Solanum tuberosum 47% 97%
Q4Q3K1 Leishmania major 96% 100%
Q557D2 Dictyostelium discoideum 50% 100%
Q5FUK8 Gluconobacter oxydans (strain 621H) 34% 100%
Q7YS37 Bos indicus 46% 100%
Q89AI7 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 34% 100%
Q8CFX1 Mus musculus 31% 71%
Q8K9M2 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 31% 100%
Q8L743 Arabidopsis thaliana 47% 94%
Q8SR89 Encephalitozoon cuniculi (strain GB-M1) 27% 100%
Q8XCJ6 Escherichia coli O157:H7 38% 100%
Q93ZW0 Arabidopsis thaliana 37% 90%
Q9FJI5 Arabidopsis thaliana 54% 100%
Q9FY99 Arabidopsis thaliana 47% 94%
Q9LK23 Arabidopsis thaliana 54% 100%
Q9PKK8 Chlamydia muridarum (strain MoPn / Nigg) 35% 100%
Q9X0N9 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 39% 100%
Q9Z3S2 Rhizobium meliloti (strain 1021) 36% 100%
Q9Z8U6 Chlamydia pneumoniae 37% 100%
Q9ZKB2 Helicobacter pylori (strain J99 / ATCC 700824) 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS