NAD-dependent protein deacetylase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Silent information regulator 2 related protein 1 - putative

Species:

Leishmania infantum

UniProt:

A0A6L0XH39_LEIIN

TriTrypDb:

LINF_260007100

Length:

373

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: ipemberton@photeomix.com
Publication title: The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design
Publication 1st author(s): Ronin
Publication Identifier(s): 29543820
Host organism: -1
Interaction detection method(s): x-ray crystallography
Interaction type: direct interaction
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: A0A6L0XH39
ID(s) interactor B: P04637
Taxid interactor A: Leishmania infantum
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A6L0XH39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

PDB structure(s): 5ol0_A , 5ol0_B

Function

Biological processes
Term	Name	Level	Count
GO:0001775	cell activation	2	1
GO:0002274	myeloid leukocyte activation	3	1
GO:0002376	immune system process	1	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009605	response to external stimulus	2	1
GO:0009607	response to biotic stimulus	2	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042113	B cell activation	4	1
GO:0042116	macrophage activation	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043207	response to external biotic stimulus	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0045321	leukocyte activation	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046649	lymphocyte activation	3	1
GO:0050896	response to stimulus	1	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0051707	response to other organism	2	1
GO:0051716	cellular response to stimulus	2	1
GO:0052167	modulation by symbiont of host innate immune response	7	1
GO:0052173	response to defenses of other organism	3	1
GO:0052200	response to host defenses	4	1
GO:0052553	modulation by symbiont of host immune response	6	1
GO:0052572	response to host immune response	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0075136	response to host	3	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004407	histone deacetylase activity	4	9
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	8
GO:0016740	transferase activity	2	11
GO:0016757	glycosyltransferase activity	3	5
GO:0016787	hydrolase activity	2	10
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	9
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	9
GO:0017136	NAD-dependent histone deacetylase activity	5	9
GO:0019213	deacetylase activity	3	9
GO:0033558	protein lysine deacetylase activity	3	9
GO:0034979	NAD-dependent protein deacetylase activity	4	9
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	8
GO:0051287	NAD binding	4	11
GO:0070403	NAD+ binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003950	NAD+ ADP-ribosyltransferase activity	5	1
GO:0016763	pentosyltransferase activity	4	1
GO:0042903	tubulin deacetylase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.627
CLV_NRD_NRD_1	284	286	PF00675	0.626
CLV_NRD_NRD_1	32	34	PF00675	0.397
CLV_PCSK_KEX2_1	284	286	PF00082	0.590
CLV_PCSK_KEX2_1	32	34	PF00082	0.352
CLV_PCSK_KEX2_1	354	356	PF00082	0.521
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.524
CLV_PCSK_SKI1_1	32	36	PF00082	0.442
CLV_PCSK_SKI1_1	327	331	PF00082	0.398
DEG_APCC_DBOX_1	31	39	PF00400	0.402
DEG_SPOP_SBC_1	304	308	PF00917	0.731
DOC_MAPK_FxFP_2	250	253	PF00069	0.377
DOC_MAPK_gen_1	242	250	PF00069	0.379
DOC_MAPK_gen_1	27	36	PF00069	0.420
DOC_MAPK_HePTP_8	26	38	PF00069	0.319
DOC_MAPK_MEF2A_6	233	240	PF00069	0.362
DOC_MAPK_MEF2A_6	29	38	PF00069	0.316
DOC_PP1_RVXF_1	325	332	PF00149	0.394
DOC_PP4_FxxP_1	250	253	PF00568	0.377
DOC_PP4_FxxP_1	51	54	PF00568	0.409
DOC_USP7_MATH_1	143	147	PF00917	0.406
DOC_USP7_MATH_1	304	308	PF00917	0.666
DOC_USP7_MATH_1	40	44	PF00917	0.498
DOC_WW_Pin1_4	1	6	PF00397	0.639
DOC_WW_Pin1_4	133	138	PF00397	0.429
DOC_WW_Pin1_4	154	159	PF00397	0.469
DOC_WW_Pin1_4	275	280	PF00397	0.740
DOC_WW_Pin1_4	290	295	PF00397	0.736
DOC_WW_Pin1_4	50	55	PF00397	0.381
LIG_14-3-3_CanoR_1	120	129	PF00244	0.444
LIG_14-3-3_CanoR_1	175	183	PF00244	0.462
LIG_14-3-3_CanoR_1	270	279	PF00244	0.742
LIG_14-3-3_CanoR_1	355	363	PF00244	0.534
LIG_BIR_III_2	360	364	PF00653	0.587
LIG_FHA_1	121	127	PF00498	0.413
LIG_FHA_2	257	263	PF00498	0.448
LIG_FHA_2	339	345	PF00498	0.335
LIG_GBD_Chelix_1	211	219	PF00786	0.301
LIG_HP1_1	236	240	PF01393	0.370
LIG_Integrin_RGD_1	332	334	PF01839	0.512
LIG_LIR_Apic_2	50	54	PF02991	0.381
LIG_LIR_Gen_1	196	207	PF02991	0.470
LIG_LIR_Gen_1	56	67	PF02991	0.402
LIG_LIR_Nem_3	196	202	PF02991	0.426
LIG_LIR_Nem_3	310	316	PF02991	0.599
LIG_LIR_Nem_3	344	348	PF02991	0.411
LIG_LIR_Nem_3	56	62	PF02991	0.437
LIG_LIR_Nem_3	84	89	PF02991	0.439
LIG_Pex14_1	96	100	PF04695	0.413
LIG_RPA_C_Fungi	237	249	PF08784	0.374
LIG_SH2_CRK	59	63	PF00017	0.284
LIG_SH2_GRB2like	59	62	PF00017	0.239
LIG_SH2_SRC	165	168	PF00017	0.317
LIG_SH2_STAT5	165	168	PF00017	0.420
LIG_SH2_STAT5	25	28	PF00017	0.321
LIG_SH2_STAT5	345	348	PF00017	0.410
LIG_SH3_3	2	8	PF00018	0.558
LIG_SH3_3	250	256	PF00018	0.517
LIG_SH3_3	291	297	PF00018	0.526
LIG_SH3_CIN85_PxpxPR_1	279	284	PF14604	0.542
LIG_SUMO_SIM_anti_2	210	218	PF11976	0.269
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.275
LIG_SUMO_SIM_par_1	210	218	PF11976	0.354
LIG_SUMO_SIM_par_1	337	344	PF11976	0.327
LIG_TRAF2_1	297	300	PF00917	0.601
LIG_TRAF2_1	8	11	PF00917	0.509
LIG_TRFH_1	224	228	PF08558	0.345
MOD_CDC14_SPxK_1	282	285	PF00782	0.542
MOD_CDK_SPK_2	1	6	PF00069	0.518
MOD_CDK_SPK_2	279	284	PF00069	0.542
MOD_CDK_SPxK_1	279	285	PF00069	0.542
MOD_CK1_1	174	180	PF00069	0.416
MOD_CK1_1	271	277	PF00069	0.812
MOD_CK1_1	293	299	PF00069	0.562
MOD_CK1_1	305	311	PF00069	0.624
MOD_CK1_1	53	59	PF00069	0.234
MOD_CK2_1	256	262	PF00069	0.352
MOD_CK2_1	293	299	PF00069	0.710
MOD_CK2_1	338	344	PF00069	0.493
MOD_GlcNHglycan	169	172	PF01048	0.317
MOD_GlcNHglycan	279	282	PF01048	0.715
MOD_GSK3_1	167	174	PF00069	0.317
MOD_GSK3_1	269	276	PF00069	0.671
MOD_GSK3_1	302	309	PF00069	0.635
MOD_GSK3_1	68	75	PF00069	0.275
MOD_NEK2_1	169	174	PF00069	0.271
MOD_NEK2_1	74	79	PF00069	0.297
MOD_NEK2_2	256	261	PF00069	0.421
MOD_PIKK_1	120	126	PF00454	0.249
MOD_PIKK_1	271	277	PF00454	0.666
MOD_PKA_2	174	180	PF00069	0.416
MOD_PKA_2	269	275	PF00069	0.742
MOD_PKA_2	356	362	PF00069	0.544
MOD_Plk_2-3	287	293	PF00069	0.585
MOD_Plk_4	74	80	PF00069	0.259
MOD_ProDKin_1	1	7	PF00069	0.635
MOD_ProDKin_1	133	139	PF00069	0.271
MOD_ProDKin_1	154	160	PF00069	0.327
MOD_ProDKin_1	275	281	PF00069	0.740
MOD_ProDKin_1	290	296	PF00069	0.735
MOD_ProDKin_1	50	56	PF00069	0.203
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.293
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.240
TRG_ENDOCYTIC_2	345	348	PF00928	0.410
TRG_ENDOCYTIC_2	59	62	PF00928	0.284
TRG_ER_diArg_1	283	285	PF00400	0.542
TRG_ER_diArg_1	31	33	PF00400	0.392
TRG_ER_diArg_1	355	358	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVQ5	Leptomonas seymouri	67%	98%
A0A1X0NT02	Trypanosomatidae	56%	100%
A0A3Q8IDH7	Leishmania donovani	99%	100%
A0A422NVE3	Trypanosoma rangeli	56%	100%
A8NWP2	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	28%	100%
B0RM75	Xanthomonas campestris pv. campestris (strain B100)	28%	100%
C8V3W5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	39%	76%
C9ZS62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E1BRE2	Gallus gallus	28%	100%
E2RDZ6	Canis lupus familiaris	31%	100%
E9AIR9	Leishmania braziliensis	80%	100%
E9AY03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
F7DKV7	Xenopus tropicalis	30%	100%
F7EZ75	Macaca mulatta	29%	100%
O94640	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	79%
P06700	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	66%
P53685	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	74%
P53686	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P53687	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	83%
Q0P595	Bos taurus	26%	93%
Q25337	Leishmania major	92%	100%
Q3ZBQ0	Bos taurus	30%	100%
Q4UZX0	Xanthomonas campestris pv. campestris (strain 8004)	28%	100%
Q54QE6	Dictyostelium discoideum	46%	73%
Q57V41	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	50%	100%
Q5A1W9	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	77%
Q5AW69	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	46%	100%
Q5R6G3	Pongo abelii	29%	100%
Q68F47	Xenopus laevis	29%	100%
Q68FX9	Rattus norvegicus	29%	100%
Q6DHI5	Danio rerio	29%	100%
Q6FWI7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	73%
Q757M7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	37%	67%
Q882K4	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	27%	100%
Q89EA6	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	29%	100%
Q8BKJ9	Mus musculus	25%	93%
Q8K2C6	Mus musculus	29%	100%
Q8PDM9	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	28%	100%
Q8PQK3	Xanthomonas axonopodis pv. citri (strain 306)	31%	100%
Q9NRC8	Homo sapiens	25%	93%
Q9NXA8	Homo sapiens	29%	100%
V5BZF3	Trypanosoma cruzi	56%	100%