LeishMANIAdb
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Surface antigen-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein (fragment)
Species:
Leishmania donovani
UniProt:
A0A451EJW6_LEIDO
TriTrypDb:
LdBPK_040180.1 * , LdCL_040007300 , LDHU3_04.0250
Length:
709

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 75
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 16, no: 5
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A0A451EJW6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJW6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008233 peptidase activity 3 3
GO:0016787 hydrolase activity 2 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 108 112 PF00656 0.291
CLV_C14_Caspase3-7 419 423 PF00656 0.285
CLV_PCSK_SKI1_1 192 196 PF00082 0.478
CLV_PCSK_SKI1_1 221 225 PF00082 0.493
DEG_MDM2_SWIB_1 215 223 PF02201 0.277
DEG_SCF_FBW7_1 522 527 PF00400 0.338
DOC_CKS1_1 521 526 PF01111 0.336
DOC_CKS1_1 543 548 PF01111 0.347
DOC_PP1_SILK_1 80 85 PF00149 0.291
DOC_PP2B_PxIxI_1 237 243 PF00149 0.277
DOC_USP7_MATH_1 147 151 PF00917 0.335
DOC_USP7_MATH_1 175 179 PF00917 0.287
DOC_USP7_MATH_1 246 250 PF00917 0.314
DOC_USP7_MATH_1 288 292 PF00917 0.335
DOC_USP7_MATH_1 315 319 PF00917 0.398
DOC_USP7_MATH_1 321 325 PF00917 0.383
DOC_USP7_MATH_1 581 585 PF00917 0.286
DOC_USP7_MATH_1 68 72 PF00917 0.404
DOC_WW_Pin1_4 261 266 PF00397 0.355
DOC_WW_Pin1_4 520 525 PF00397 0.339
DOC_WW_Pin1_4 526 531 PF00397 0.312
DOC_WW_Pin1_4 542 547 PF00397 0.283
DOC_WW_Pin1_4 602 607 PF00397 0.352
LIG_14-3-3_CanoR_1 149 155 PF00244 0.280
LIG_14-3-3_CanoR_1 225 231 PF00244 0.284
LIG_14-3-3_CanoR_1 245 251 PF00244 0.266
LIG_14-3-3_CanoR_1 338 348 PF00244 0.378
LIG_14-3-3_CanoR_1 434 438 PF00244 0.309
LIG_14-3-3_CanoR_1 566 574 PF00244 0.318
LIG_14-3-3_CanoR_1 84 89 PF00244 0.388
LIG_Actin_WH2_2 209 227 PF00022 0.270
LIG_Actin_WH2_2 75 91 PF00022 0.281
LIG_BIR_III_4 111 115 PF00653 0.290
LIG_BRCT_BRCA1_1 164 168 PF00533 0.266
LIG_BRCT_BRCA1_1 37 41 PF00533 0.378
LIG_Clathr_ClatBox_1 256 260 PF01394 0.289
LIG_CtBP_PxDLS_1 273 277 PF00389 0.295
LIG_eIF4E_1 520 526 PF01652 0.324
LIG_FHA_1 158 164 PF00498 0.330
LIG_FHA_1 211 217 PF00498 0.306
LIG_FHA_1 264 270 PF00498 0.306
LIG_FHA_1 299 305 PF00498 0.396
LIG_FHA_1 330 336 PF00498 0.420
LIG_FHA_1 377 383 PF00498 0.342
LIG_FHA_1 393 399 PF00498 0.374
LIG_FHA_1 521 527 PF00498 0.323
LIG_FHA_1 581 587 PF00498 0.320
LIG_FHA_1 85 91 PF00498 0.266
LIG_FHA_2 106 112 PF00498 0.289
LIG_FHA_2 304 310 PF00498 0.427
LIG_FHA_2 55 61 PF00498 0.291
LIG_GBD_Chelix_1 531 539 PF00786 0.539
LIG_LIR_Gen_1 213 223 PF02991 0.275
LIG_LIR_Gen_1 361 370 PF02991 0.335
LIG_LIR_Gen_1 387 394 PF02991 0.329
LIG_LIR_Gen_1 91 102 PF02991 0.273
LIG_LIR_Nem_3 213 218 PF02991 0.269
LIG_LIR_Nem_3 358 363 PF02991 0.355
LIG_LIR_Nem_3 387 391 PF02991 0.345
LIG_LIR_Nem_3 559 564 PF02991 0.313
LIG_LIR_Nem_3 673 679 PF02991 0.328
LIG_LIR_Nem_3 91 97 PF02991 0.269
LIG_Pex14_2 215 219 PF04695 0.271
LIG_PTB_Apo_2 251 258 PF02174 0.280
LIG_PTB_Apo_2 346 353 PF02174 0.383
LIG_PTB_Apo_2 359 366 PF02174 0.333
LIG_PTB_Apo_2 628 635 PF02174 0.346
LIG_PTB_Phospho_1 359 365 PF10480 0.349
LIG_PTB_Phospho_1 628 634 PF10480 0.346
LIG_SH2_CRK 363 367 PF00017 0.333
LIG_SH2_CRK 561 565 PF00017 0.310
LIG_SH2_CRK 676 680 PF00017 0.320
LIG_SH2_GRB2like 360 363 PF00017 0.354
LIG_SH2_PTP2 94 97 PF00017 0.258
LIG_SH2_STAP1 360 364 PF00017 0.351
LIG_SH2_STAP1 594 598 PF00017 0.337
LIG_SH2_STAP1 691 695 PF00017 0.284
LIG_SH2_STAT5 100 103 PF00017 0.278
LIG_SH2_STAT5 211 214 PF00017 0.242
LIG_SH2_STAT5 360 363 PF00017 0.362
LIG_SH2_STAT5 365 368 PF00017 0.323
LIG_SH2_STAT5 521 524 PF00017 0.341
LIG_SH2_STAT5 556 559 PF00017 0.312
LIG_SH2_STAT5 594 597 PF00017 0.291
LIG_SH2_STAT5 629 632 PF00017 0.349
LIG_SH2_STAT5 635 638 PF00017 0.330
LIG_SH2_STAT5 648 651 PF00017 0.287
LIG_SH2_STAT5 670 673 PF00017 0.327
LIG_SH2_STAT5 94 97 PF00017 0.258
LIG_SH3_2 543 548 PF14604 0.341
LIG_SH3_3 152 158 PF00018 0.320
LIG_SH3_3 180 186 PF00018 0.285
LIG_SH3_3 259 265 PF00018 0.312
LIG_SH3_3 540 546 PF00018 0.332
LIG_SUMO_SIM_anti_2 131 142 PF11976 0.271
LIG_SUMO_SIM_anti_2 316 324 PF11976 0.407
LIG_SUMO_SIM_par_1 178 184 PF11976 0.307
LIG_TRAF2_1 48 51 PF00917 0.347
LIG_TRFH_1 520 524 PF08558 0.335
LIG_Vh1_VBS_1 9 27 PF01044 0.227
MOD_CDK_SPxK_1 542 548 PF00069 0.343
MOD_CK1_1 141 147 PF00069 0.372
MOD_CK1_1 150 156 PF00069 0.277
MOD_CK1_1 187 193 PF00069 0.298
MOD_CK1_1 227 233 PF00069 0.349
MOD_CK1_1 263 269 PF00069 0.333
MOD_CK1_1 275 281 PF00069 0.391
MOD_CK1_1 37 43 PF00069 0.488
MOD_CK1_1 45 51 PF00069 0.392
MOD_CK1_1 473 479 PF00069 0.364
MOD_CK1_1 505 511 PF00069 0.316
MOD_CK1_1 52 58 PF00069 0.392
MOD_CK1_1 602 608 PF00069 0.356
MOD_CK1_1 70 76 PF00069 0.363
MOD_CK1_1 703 709 PF00069 0.481
MOD_CK2_1 176 182 PF00069 0.270
MOD_CK2_1 45 51 PF00069 0.365
MOD_CK2_1 54 60 PF00069 0.291
MOD_GlcNHglycan 111 115 PF01048 0.524
MOD_GlcNHglycan 149 152 PF01048 0.586
MOD_GlcNHglycan 192 195 PF01048 0.510
MOD_GlcNHglycan 2 5 PF01048 0.397
MOD_GlcNHglycan 429 432 PF01048 0.480
MOD_GlcNHglycan 45 48 PF01048 0.687
MOD_GSK3_1 124 131 PF00069 0.285
MOD_GSK3_1 132 139 PF00069 0.309
MOD_GSK3_1 157 164 PF00069 0.294
MOD_GSK3_1 181 188 PF00069 0.391
MOD_GSK3_1 260 267 PF00069 0.413
MOD_GSK3_1 288 295 PF00069 0.379
MOD_GSK3_1 366 373 PF00069 0.321
MOD_GSK3_1 390 397 PF00069 0.365
MOD_GSK3_1 45 52 PF00069 0.366
MOD_GSK3_1 473 480 PF00069 0.364
MOD_GSK3_1 520 527 PF00069 0.334
MOD_GSK3_1 565 572 PF00069 0.316
MOD_GSK3_1 594 601 PF00069 0.333
MOD_GSK3_1 657 664 PF00069 0.345
MOD_GSK3_1 70 77 PF00069 0.455
MOD_GSK3_1 84 91 PF00069 0.305
MOD_N-GLC_1 105 110 PF02516 0.486
MOD_N-GLC_1 260 265 PF02516 0.517
MOD_N-GLC_1 376 381 PF02516 0.529
MOD_N-GLC_2 351 353 PF02516 0.620
MOD_N-GLC_2 448 450 PF02516 0.487
MOD_N-GLC_2 462 464 PF02516 0.501
MOD_N-GLC_2 511 513 PF02516 0.501
MOD_N-GLC_2 617 619 PF02516 0.536
MOD_NEK2_1 163 168 PF00069 0.336
MOD_NEK2_1 170 175 PF00069 0.356
MOD_NEK2_1 224 229 PF00069 0.369
MOD_NEK2_1 366 371 PF00069 0.318
MOD_NEK2_1 376 381 PF00069 0.344
MOD_NEK2_1 394 399 PF00069 0.382
MOD_NEK2_1 426 431 PF00069 0.310
MOD_NEK2_1 657 662 PF00069 0.354
MOD_NEK2_1 671 676 PF00069 0.295
MOD_NEK2_1 700 705 PF00069 0.284
MOD_NEK2_1 83 88 PF00069 0.389
MOD_NEK2_2 280 285 PF00069 0.314
MOD_NEK2_2 371 376 PF00069 0.306
MOD_OFUCOSY 368 375 PF10250 0.503
MOD_OFUCOSY 474 481 PF10250 0.560
MOD_PIKK_1 187 193 PF00454 0.345
MOD_PIKK_1 28 34 PF00454 0.351
MOD_PIKK_1 479 485 PF00454 0.328
MOD_PIKK_1 511 517 PF00454 0.303
MOD_PIKK_1 605 611 PF00454 0.377
MOD_PIKK_1 677 683 PF00454 0.333
MOD_PKA_2 102 108 PF00069 0.260
MOD_PKA_2 224 230 PF00069 0.348
MOD_PKA_2 384 390 PF00069 0.343
MOD_PKA_2 433 439 PF00069 0.310
MOD_PKA_2 565 571 PF00069 0.316
MOD_PKA_2 83 89 PF00069 0.348
MOD_Plk_1 105 111 PF00069 0.291
MOD_Plk_1 139 145 PF00069 0.371
MOD_Plk_1 219 225 PF00069 0.373
MOD_Plk_1 252 258 PF00069 0.403
MOD_Plk_1 49 55 PF00069 0.386
MOD_Plk_1 581 587 PF00069 0.300
MOD_Plk_1 74 80 PF00069 0.335
MOD_Plk_4 132 138 PF00069 0.316
MOD_Plk_4 150 156 PF00069 0.308
MOD_Plk_4 163 169 PF00069 0.252
MOD_Plk_4 176 182 PF00069 0.404
MOD_Plk_4 252 258 PF00069 0.350
MOD_Plk_4 315 321 PF00069 0.391
MOD_Plk_4 689 695 PF00069 0.284
MOD_Plk_4 700 706 PF00069 0.237
MOD_ProDKin_1 261 267 PF00069 0.350
MOD_ProDKin_1 520 526 PF00069 0.337
MOD_ProDKin_1 542 548 PF00069 0.343
MOD_ProDKin_1 602 608 PF00069 0.360
TRG_DiLeu_BaEn_2 252 258 PF01217 0.289
TRG_DiLeu_BaLyEn_6 235 240 PF01217 0.305
TRG_DiLeu_BaLyEn_6 521 526 PF01217 0.325
TRG_ENDOCYTIC_2 363 366 PF00928 0.332
TRG_ENDOCYTIC_2 388 391 PF00928 0.349
TRG_ENDOCYTIC_2 488 491 PF00928 0.307
TRG_ENDOCYTIC_2 561 564 PF00928 0.315
TRG_ENDOCYTIC_2 676 679 PF00928 0.317
TRG_ENDOCYTIC_2 94 97 PF00928 0.258
TRG_NES_CRM1_1 207 220 PF08389 0.265

Homologs

Protein Taxonomy Sequence identity Coverage
A0A381M9M8 Leishmania infantum 23% 100%
A0A3S5H581 Leishmania donovani 22% 100%
A0A3S5H583 Leishmania donovani 22% 100%
A0A3S5H584 Leishmania donovani 75% 100%
A0A451EJW1 Leishmania donovani 22% 100%
A0A451EJW4 Leishmania donovani 23% 100%
A4H3T9 Leishmania braziliensis 24% 98%
A4H3U0 Leishmania braziliensis 25% 100%
A4H3U1 Leishmania braziliensis 25% 100%
A4H3Y2 Leishmania braziliensis 32% 100%
A4HS13 Leishmania infantum 74% 100%
A4HS14 Leishmania infantum 99% 100%
E9AJZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AK00 Leishmania mexicana (strain MHOM/GT/2001/U1103) 69% 100%
E9AK01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q9N852 Leishmania major 23% 100%
Q9N853 Leishmania major 23% 100%
Q9N856 Leishmania major 22% 100%
Q9XZX8 Leishmania major 71% 100%
Q9XZX9 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS