A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 75 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 16, no: 5 |
NetGPI | no | yes: 0, no: 21 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005737 | cytoplasm | 2 | 3 |
GO:0110165 | cellular anatomical entity | 1 | 3 |
Related structures:
AlphaFold database: A0A451EJW6
Term | Name | Level | Count |
---|---|---|---|
GO:0003824 | catalytic activity | 1 | 3 |
GO:0008233 | peptidase activity | 3 | 3 |
GO:0016787 | hydrolase activity | 2 | 3 |
GO:0140096 | catalytic activity, acting on a protein | 2 | 3 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 108 | 112 | PF00656 | 0.291 |
CLV_C14_Caspase3-7 | 419 | 423 | PF00656 | 0.285 |
CLV_PCSK_SKI1_1 | 192 | 196 | PF00082 | 0.478 |
CLV_PCSK_SKI1_1 | 221 | 225 | PF00082 | 0.493 |
DEG_MDM2_SWIB_1 | 215 | 223 | PF02201 | 0.277 |
DEG_SCF_FBW7_1 | 522 | 527 | PF00400 | 0.338 |
DOC_CKS1_1 | 521 | 526 | PF01111 | 0.336 |
DOC_CKS1_1 | 543 | 548 | PF01111 | 0.347 |
DOC_PP1_SILK_1 | 80 | 85 | PF00149 | 0.291 |
DOC_PP2B_PxIxI_1 | 237 | 243 | PF00149 | 0.277 |
DOC_USP7_MATH_1 | 147 | 151 | PF00917 | 0.335 |
DOC_USP7_MATH_1 | 175 | 179 | PF00917 | 0.287 |
DOC_USP7_MATH_1 | 246 | 250 | PF00917 | 0.314 |
DOC_USP7_MATH_1 | 288 | 292 | PF00917 | 0.335 |
DOC_USP7_MATH_1 | 315 | 319 | PF00917 | 0.398 |
DOC_USP7_MATH_1 | 321 | 325 | PF00917 | 0.383 |
DOC_USP7_MATH_1 | 581 | 585 | PF00917 | 0.286 |
DOC_USP7_MATH_1 | 68 | 72 | PF00917 | 0.404 |
DOC_WW_Pin1_4 | 261 | 266 | PF00397 | 0.355 |
DOC_WW_Pin1_4 | 520 | 525 | PF00397 | 0.339 |
DOC_WW_Pin1_4 | 526 | 531 | PF00397 | 0.312 |
DOC_WW_Pin1_4 | 542 | 547 | PF00397 | 0.283 |
DOC_WW_Pin1_4 | 602 | 607 | PF00397 | 0.352 |
LIG_14-3-3_CanoR_1 | 149 | 155 | PF00244 | 0.280 |
LIG_14-3-3_CanoR_1 | 225 | 231 | PF00244 | 0.284 |
LIG_14-3-3_CanoR_1 | 245 | 251 | PF00244 | 0.266 |
LIG_14-3-3_CanoR_1 | 338 | 348 | PF00244 | 0.378 |
LIG_14-3-3_CanoR_1 | 434 | 438 | PF00244 | 0.309 |
LIG_14-3-3_CanoR_1 | 566 | 574 | PF00244 | 0.318 |
LIG_14-3-3_CanoR_1 | 84 | 89 | PF00244 | 0.388 |
LIG_Actin_WH2_2 | 209 | 227 | PF00022 | 0.270 |
LIG_Actin_WH2_2 | 75 | 91 | PF00022 | 0.281 |
LIG_BIR_III_4 | 111 | 115 | PF00653 | 0.290 |
LIG_BRCT_BRCA1_1 | 164 | 168 | PF00533 | 0.266 |
LIG_BRCT_BRCA1_1 | 37 | 41 | PF00533 | 0.378 |
LIG_Clathr_ClatBox_1 | 256 | 260 | PF01394 | 0.289 |
LIG_CtBP_PxDLS_1 | 273 | 277 | PF00389 | 0.295 |
LIG_eIF4E_1 | 520 | 526 | PF01652 | 0.324 |
LIG_FHA_1 | 158 | 164 | PF00498 | 0.330 |
LIG_FHA_1 | 211 | 217 | PF00498 | 0.306 |
LIG_FHA_1 | 264 | 270 | PF00498 | 0.306 |
LIG_FHA_1 | 299 | 305 | PF00498 | 0.396 |
LIG_FHA_1 | 330 | 336 | PF00498 | 0.420 |
LIG_FHA_1 | 377 | 383 | PF00498 | 0.342 |
LIG_FHA_1 | 393 | 399 | PF00498 | 0.374 |
LIG_FHA_1 | 521 | 527 | PF00498 | 0.323 |
LIG_FHA_1 | 581 | 587 | PF00498 | 0.320 |
LIG_FHA_1 | 85 | 91 | PF00498 | 0.266 |
LIG_FHA_2 | 106 | 112 | PF00498 | 0.289 |
LIG_FHA_2 | 304 | 310 | PF00498 | 0.427 |
LIG_FHA_2 | 55 | 61 | PF00498 | 0.291 |
LIG_GBD_Chelix_1 | 531 | 539 | PF00786 | 0.539 |
LIG_LIR_Gen_1 | 213 | 223 | PF02991 | 0.275 |
LIG_LIR_Gen_1 | 361 | 370 | PF02991 | 0.335 |
LIG_LIR_Gen_1 | 387 | 394 | PF02991 | 0.329 |
LIG_LIR_Gen_1 | 91 | 102 | PF02991 | 0.273 |
LIG_LIR_Nem_3 | 213 | 218 | PF02991 | 0.269 |
LIG_LIR_Nem_3 | 358 | 363 | PF02991 | 0.355 |
LIG_LIR_Nem_3 | 387 | 391 | PF02991 | 0.345 |
LIG_LIR_Nem_3 | 559 | 564 | PF02991 | 0.313 |
LIG_LIR_Nem_3 | 673 | 679 | PF02991 | 0.328 |
LIG_LIR_Nem_3 | 91 | 97 | PF02991 | 0.269 |
LIG_Pex14_2 | 215 | 219 | PF04695 | 0.271 |
LIG_PTB_Apo_2 | 251 | 258 | PF02174 | 0.280 |
LIG_PTB_Apo_2 | 346 | 353 | PF02174 | 0.383 |
LIG_PTB_Apo_2 | 359 | 366 | PF02174 | 0.333 |
LIG_PTB_Apo_2 | 628 | 635 | PF02174 | 0.346 |
LIG_PTB_Phospho_1 | 359 | 365 | PF10480 | 0.349 |
LIG_PTB_Phospho_1 | 628 | 634 | PF10480 | 0.346 |
LIG_SH2_CRK | 363 | 367 | PF00017 | 0.333 |
LIG_SH2_CRK | 561 | 565 | PF00017 | 0.310 |
LIG_SH2_CRK | 676 | 680 | PF00017 | 0.320 |
LIG_SH2_GRB2like | 360 | 363 | PF00017 | 0.354 |
LIG_SH2_PTP2 | 94 | 97 | PF00017 | 0.258 |
LIG_SH2_STAP1 | 360 | 364 | PF00017 | 0.351 |
LIG_SH2_STAP1 | 594 | 598 | PF00017 | 0.337 |
LIG_SH2_STAP1 | 691 | 695 | PF00017 | 0.284 |
LIG_SH2_STAT5 | 100 | 103 | PF00017 | 0.278 |
LIG_SH2_STAT5 | 211 | 214 | PF00017 | 0.242 |
LIG_SH2_STAT5 | 360 | 363 | PF00017 | 0.362 |
LIG_SH2_STAT5 | 365 | 368 | PF00017 | 0.323 |
LIG_SH2_STAT5 | 521 | 524 | PF00017 | 0.341 |
LIG_SH2_STAT5 | 556 | 559 | PF00017 | 0.312 |
LIG_SH2_STAT5 | 594 | 597 | PF00017 | 0.291 |
LIG_SH2_STAT5 | 629 | 632 | PF00017 | 0.349 |
LIG_SH2_STAT5 | 635 | 638 | PF00017 | 0.330 |
LIG_SH2_STAT5 | 648 | 651 | PF00017 | 0.287 |
LIG_SH2_STAT5 | 670 | 673 | PF00017 | 0.327 |
LIG_SH2_STAT5 | 94 | 97 | PF00017 | 0.258 |
LIG_SH3_2 | 543 | 548 | PF14604 | 0.341 |
LIG_SH3_3 | 152 | 158 | PF00018 | 0.320 |
LIG_SH3_3 | 180 | 186 | PF00018 | 0.285 |
LIG_SH3_3 | 259 | 265 | PF00018 | 0.312 |
LIG_SH3_3 | 540 | 546 | PF00018 | 0.332 |
LIG_SUMO_SIM_anti_2 | 131 | 142 | PF11976 | 0.271 |
LIG_SUMO_SIM_anti_2 | 316 | 324 | PF11976 | 0.407 |
LIG_SUMO_SIM_par_1 | 178 | 184 | PF11976 | 0.307 |
LIG_TRAF2_1 | 48 | 51 | PF00917 | 0.347 |
LIG_TRFH_1 | 520 | 524 | PF08558 | 0.335 |
LIG_Vh1_VBS_1 | 9 | 27 | PF01044 | 0.227 |
MOD_CDK_SPxK_1 | 542 | 548 | PF00069 | 0.343 |
MOD_CK1_1 | 141 | 147 | PF00069 | 0.372 |
MOD_CK1_1 | 150 | 156 | PF00069 | 0.277 |
MOD_CK1_1 | 187 | 193 | PF00069 | 0.298 |
MOD_CK1_1 | 227 | 233 | PF00069 | 0.349 |
MOD_CK1_1 | 263 | 269 | PF00069 | 0.333 |
MOD_CK1_1 | 275 | 281 | PF00069 | 0.391 |
MOD_CK1_1 | 37 | 43 | PF00069 | 0.488 |
MOD_CK1_1 | 45 | 51 | PF00069 | 0.392 |
MOD_CK1_1 | 473 | 479 | PF00069 | 0.364 |
MOD_CK1_1 | 505 | 511 | PF00069 | 0.316 |
MOD_CK1_1 | 52 | 58 | PF00069 | 0.392 |
MOD_CK1_1 | 602 | 608 | PF00069 | 0.356 |
MOD_CK1_1 | 70 | 76 | PF00069 | 0.363 |
MOD_CK1_1 | 703 | 709 | PF00069 | 0.481 |
MOD_CK2_1 | 176 | 182 | PF00069 | 0.270 |
MOD_CK2_1 | 45 | 51 | PF00069 | 0.365 |
MOD_CK2_1 | 54 | 60 | PF00069 | 0.291 |
MOD_GlcNHglycan | 111 | 115 | PF01048 | 0.524 |
MOD_GlcNHglycan | 149 | 152 | PF01048 | 0.586 |
MOD_GlcNHglycan | 192 | 195 | PF01048 | 0.510 |
MOD_GlcNHglycan | 2 | 5 | PF01048 | 0.397 |
MOD_GlcNHglycan | 429 | 432 | PF01048 | 0.480 |
MOD_GlcNHglycan | 45 | 48 | PF01048 | 0.687 |
MOD_GSK3_1 | 124 | 131 | PF00069 | 0.285 |
MOD_GSK3_1 | 132 | 139 | PF00069 | 0.309 |
MOD_GSK3_1 | 157 | 164 | PF00069 | 0.294 |
MOD_GSK3_1 | 181 | 188 | PF00069 | 0.391 |
MOD_GSK3_1 | 260 | 267 | PF00069 | 0.413 |
MOD_GSK3_1 | 288 | 295 | PF00069 | 0.379 |
MOD_GSK3_1 | 366 | 373 | PF00069 | 0.321 |
MOD_GSK3_1 | 390 | 397 | PF00069 | 0.365 |
MOD_GSK3_1 | 45 | 52 | PF00069 | 0.366 |
MOD_GSK3_1 | 473 | 480 | PF00069 | 0.364 |
MOD_GSK3_1 | 520 | 527 | PF00069 | 0.334 |
MOD_GSK3_1 | 565 | 572 | PF00069 | 0.316 |
MOD_GSK3_1 | 594 | 601 | PF00069 | 0.333 |
MOD_GSK3_1 | 657 | 664 | PF00069 | 0.345 |
MOD_GSK3_1 | 70 | 77 | PF00069 | 0.455 |
MOD_GSK3_1 | 84 | 91 | PF00069 | 0.305 |
MOD_N-GLC_1 | 105 | 110 | PF02516 | 0.486 |
MOD_N-GLC_1 | 260 | 265 | PF02516 | 0.517 |
MOD_N-GLC_1 | 376 | 381 | PF02516 | 0.529 |
MOD_N-GLC_2 | 351 | 353 | PF02516 | 0.620 |
MOD_N-GLC_2 | 448 | 450 | PF02516 | 0.487 |
MOD_N-GLC_2 | 462 | 464 | PF02516 | 0.501 |
MOD_N-GLC_2 | 511 | 513 | PF02516 | 0.501 |
MOD_N-GLC_2 | 617 | 619 | PF02516 | 0.536 |
MOD_NEK2_1 | 163 | 168 | PF00069 | 0.336 |
MOD_NEK2_1 | 170 | 175 | PF00069 | 0.356 |
MOD_NEK2_1 | 224 | 229 | PF00069 | 0.369 |
MOD_NEK2_1 | 366 | 371 | PF00069 | 0.318 |
MOD_NEK2_1 | 376 | 381 | PF00069 | 0.344 |
MOD_NEK2_1 | 394 | 399 | PF00069 | 0.382 |
MOD_NEK2_1 | 426 | 431 | PF00069 | 0.310 |
MOD_NEK2_1 | 657 | 662 | PF00069 | 0.354 |
MOD_NEK2_1 | 671 | 676 | PF00069 | 0.295 |
MOD_NEK2_1 | 700 | 705 | PF00069 | 0.284 |
MOD_NEK2_1 | 83 | 88 | PF00069 | 0.389 |
MOD_NEK2_2 | 280 | 285 | PF00069 | 0.314 |
MOD_NEK2_2 | 371 | 376 | PF00069 | 0.306 |
MOD_OFUCOSY | 368 | 375 | PF10250 | 0.503 |
MOD_OFUCOSY | 474 | 481 | PF10250 | 0.560 |
MOD_PIKK_1 | 187 | 193 | PF00454 | 0.345 |
MOD_PIKK_1 | 28 | 34 | PF00454 | 0.351 |
MOD_PIKK_1 | 479 | 485 | PF00454 | 0.328 |
MOD_PIKK_1 | 511 | 517 | PF00454 | 0.303 |
MOD_PIKK_1 | 605 | 611 | PF00454 | 0.377 |
MOD_PIKK_1 | 677 | 683 | PF00454 | 0.333 |
MOD_PKA_2 | 102 | 108 | PF00069 | 0.260 |
MOD_PKA_2 | 224 | 230 | PF00069 | 0.348 |
MOD_PKA_2 | 384 | 390 | PF00069 | 0.343 |
MOD_PKA_2 | 433 | 439 | PF00069 | 0.310 |
MOD_PKA_2 | 565 | 571 | PF00069 | 0.316 |
MOD_PKA_2 | 83 | 89 | PF00069 | 0.348 |
MOD_Plk_1 | 105 | 111 | PF00069 | 0.291 |
MOD_Plk_1 | 139 | 145 | PF00069 | 0.371 |
MOD_Plk_1 | 219 | 225 | PF00069 | 0.373 |
MOD_Plk_1 | 252 | 258 | PF00069 | 0.403 |
MOD_Plk_1 | 49 | 55 | PF00069 | 0.386 |
MOD_Plk_1 | 581 | 587 | PF00069 | 0.300 |
MOD_Plk_1 | 74 | 80 | PF00069 | 0.335 |
MOD_Plk_4 | 132 | 138 | PF00069 | 0.316 |
MOD_Plk_4 | 150 | 156 | PF00069 | 0.308 |
MOD_Plk_4 | 163 | 169 | PF00069 | 0.252 |
MOD_Plk_4 | 176 | 182 | PF00069 | 0.404 |
MOD_Plk_4 | 252 | 258 | PF00069 | 0.350 |
MOD_Plk_4 | 315 | 321 | PF00069 | 0.391 |
MOD_Plk_4 | 689 | 695 | PF00069 | 0.284 |
MOD_Plk_4 | 700 | 706 | PF00069 | 0.237 |
MOD_ProDKin_1 | 261 | 267 | PF00069 | 0.350 |
MOD_ProDKin_1 | 520 | 526 | PF00069 | 0.337 |
MOD_ProDKin_1 | 542 | 548 | PF00069 | 0.343 |
MOD_ProDKin_1 | 602 | 608 | PF00069 | 0.360 |
TRG_DiLeu_BaEn_2 | 252 | 258 | PF01217 | 0.289 |
TRG_DiLeu_BaLyEn_6 | 235 | 240 | PF01217 | 0.305 |
TRG_DiLeu_BaLyEn_6 | 521 | 526 | PF01217 | 0.325 |
TRG_ENDOCYTIC_2 | 363 | 366 | PF00928 | 0.332 |
TRG_ENDOCYTIC_2 | 388 | 391 | PF00928 | 0.349 |
TRG_ENDOCYTIC_2 | 488 | 491 | PF00928 | 0.307 |
TRG_ENDOCYTIC_2 | 561 | 564 | PF00928 | 0.315 |
TRG_ENDOCYTIC_2 | 676 | 679 | PF00928 | 0.317 |
TRG_ENDOCYTIC_2 | 94 | 97 | PF00928 | 0.258 |
TRG_NES_CRM1_1 | 207 | 220 | PF08389 | 0.265 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A381M9M8 | Leishmania infantum | 23% | 100% |
A0A3S5H581 | Leishmania donovani | 22% | 100% |
A0A3S5H583 | Leishmania donovani | 22% | 100% |
A0A3S5H584 | Leishmania donovani | 75% | 100% |
A0A451EJW1 | Leishmania donovani | 22% | 100% |
A0A451EJW4 | Leishmania donovani | 23% | 100% |
A4H3T9 | Leishmania braziliensis | 24% | 98% |
A4H3U0 | Leishmania braziliensis | 25% | 100% |
A4H3U1 | Leishmania braziliensis | 25% | 100% |
A4H3Y2 | Leishmania braziliensis | 32% | 100% |
A4HS13 | Leishmania infantum | 74% | 100% |
A4HS14 | Leishmania infantum | 99% | 100% |
E9AJZ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 23% | 100% |
E9AK00 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 69% | 100% |
E9AK01 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 90% | 100% |
Q9N852 | Leishmania major | 23% | 100% |
Q9N853 | Leishmania major | 23% | 100% |
Q9N856 | Leishmania major | 22% | 100% |
Q9XZX8 | Leishmania major | 71% | 100% |
Q9XZX9 | Leishmania major | 93% | 100% |