TNFR-Cys domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved in leishmania

Species:

Leishmania donovani

UniProt:

A0A451EJW4_LEIDO

TriTrypDb:

LdBPK_040160.1 , LdCL_040007100 , LDHU3_04.0200

Length:

525

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 8
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A451EJW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJW4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008233	peptidase activity	3	3
GO:0016787	hydrolase activity	2	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.381
CLV_C14_Caspase3-7	37	41	PF00656	0.322
CLV_PCSK_SKI1_1	34	38	PF00082	0.578
DEG_SPOP_SBC_1	457	461	PF00917	0.368
DOC_MAPK_FxFP_2	282	285	PF00069	0.374
DOC_PP4_FxxP_1	282	285	PF00568	0.374
DOC_USP7_MATH_1	110	114	PF00917	0.439
DOC_USP7_MATH_1	126	130	PF00917	0.291
DOC_USP7_MATH_1	137	141	PF00917	0.327
DOC_USP7_MATH_1	154	158	PF00917	0.468
DOC_USP7_MATH_1	224	228	PF00917	0.391
DOC_USP7_MATH_1	275	279	PF00917	0.414
DOC_USP7_MATH_1	319	323	PF00917	0.451
DOC_USP7_MATH_1	385	389	PF00917	0.384
DOC_USP7_MATH_1	470	474	PF00917	0.376
DOC_USP7_MATH_1	476	480	PF00917	0.358
DOC_USP7_MATH_1	79	83	PF00917	0.478
DOC_WW_Pin1_4	80	85	PF00397	0.524
LIG_14-3-3_CanoR_1	116	126	PF00244	0.428
LIG_14-3-3_CanoR_1	220	228	PF00244	0.326
LIG_14-3-3_CanoR_1	439	447	PF00244	0.465
LIG_14-3-3_CanoR_1	487	493	PF00244	0.417
LIG_14-3-3_CanoR_1	88	92	PF00244	0.466
LIG_BRCT_BRCA1_1	236	240	PF00533	0.402
LIG_FHA_1	119	125	PF00498	0.341
LIG_FHA_1	141	147	PF00498	0.417
LIG_FHA_1	158	164	PF00498	0.276
LIG_FHA_1	176	182	PF00498	0.335
LIG_FHA_1	31	37	PF00498	0.449
LIG_FHA_1	406	412	PF00498	0.353
LIG_FHA_1	45	51	PF00498	0.471
LIG_FHA_1	507	513	PF00498	0.452
LIG_FHA_1	59	65	PF00498	0.303
LIG_FHA_2	260	266	PF00498	0.353
LIG_FHA_2	284	290	PF00498	0.423
LIG_FHA_2	35	41	PF00498	0.498
LIG_FHA_2	357	363	PF00498	0.420
LIG_FHA_2	439	445	PF00498	0.332
LIG_LIR_Gen_1	44	52	PF02991	0.367
LIG_LIR_Gen_1	468	477	PF02991	0.316
LIG_LIR_Nem_3	132	136	PF02991	0.419
LIG_LIR_Nem_3	304	310	PF02991	0.433
LIG_LIR_Nem_3	40	46	PF02991	0.406
LIG_LIR_Nem_3	468	474	PF02991	0.313
LIG_PDZ_Class_2	520	525	PF00595	0.671
LIG_SH2_CRK	471	475	PF00017	0.309
LIG_SH2_SRC	269	272	PF00017	0.263
LIG_SH2_STAP1	46	50	PF00017	0.414
LIG_SH2_STAT5	269	272	PF00017	0.404
LIG_SH2_STAT5	46	49	PF00017	0.453
LIG_SH2_STAT5	471	474	PF00017	0.384
LIG_SH2_STAT5	490	493	PF00017	0.327
LIG_SH3_3	148	154	PF00018	0.454
LIG_SH3_3	407	413	PF00018	0.356
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.411
LIG_SUMO_SIM_par_1	101	106	PF11976	0.271
LIG_SUMO_SIM_par_1	142	147	PF11976	0.405
LIG_SUMO_SIM_par_1	162	167	PF11976	0.220
LIG_SUMO_SIM_par_1	193	199	PF11976	0.300
LIG_SUMO_SIM_par_1	230	235	PF11976	0.393
LIG_SUMO_SIM_par_1	47	56	PF11976	0.429
LIG_TRAF2_2	413	418	PF00917	0.372
MOD_CK1_1	101	107	PF00069	0.331
MOD_CK1_1	140	146	PF00069	0.372
MOD_CK1_1	157	163	PF00069	0.448
MOD_CK1_1	167	173	PF00069	0.378
MOD_CK1_1	193	199	PF00069	0.386
MOD_CK1_1	257	263	PF00069	0.352
MOD_CK1_1	264	270	PF00069	0.338
MOD_CK1_1	283	289	PF00069	0.341
MOD_CK1_1	300	306	PF00069	0.308
MOD_CK1_1	356	362	PF00069	0.403
MOD_CK1_1	367	373	PF00069	0.386
MOD_CK1_1	39	45	PF00069	0.465
MOD_CK1_1	53	59	PF00069	0.427
MOD_CK1_1	67	73	PF00069	0.372
MOD_CK1_1	82	88	PF00069	0.376
MOD_CK2_1	271	277	PF00069	0.398
MOD_CK2_1	283	289	PF00069	0.404
MOD_CK2_1	385	391	PF00069	0.395
MOD_GlcNHglycan	105	108	PF01048	0.625
MOD_GlcNHglycan	132	136	PF01048	0.588
MOD_GlcNHglycan	166	169	PF01048	0.624
MOD_GlcNHglycan	222	225	PF01048	0.531
MOD_GlcNHglycan	256	259	PF01048	0.572
MOD_GlcNHglycan	265	269	PF01048	0.649
MOD_GlcNHglycan	273	276	PF01048	0.536
MOD_GlcNHglycan	277	280	PF01048	0.570
MOD_GlcNHglycan	299	302	PF01048	0.611
MOD_GlcNHglycan	367	370	PF01048	0.651
MOD_GlcNHglycan	387	390	PF01048	0.555
MOD_GlcNHglycan	478	481	PF01048	0.660
MOD_GlcNHglycan	55	58	PF01048	0.642
MOD_GlcNHglycan	69	72	PF01048	0.574
MOD_GlcNHglycan	85	88	PF01048	0.532
MOD_GSK3_1	199	206	PF00069	0.405
MOD_GSK3_1	220	227	PF00069	0.328
MOD_GSK3_1	253	260	PF00069	0.370
MOD_GSK3_1	26	33	PF00069	0.563
MOD_GSK3_1	271	278	PF00069	0.434
MOD_GSK3_1	297	304	PF00069	0.385
MOD_GSK3_1	319	326	PF00069	0.474
MOD_GSK3_1	345	352	PF00069	0.380
MOD_GSK3_1	356	363	PF00069	0.318
MOD_GSK3_1	383	390	PF00069	0.450
MOD_GSK3_1	391	398	PF00069	0.361
MOD_GSK3_1	434	441	PF00069	0.456
MOD_GSK3_1	455	462	PF00069	0.425
MOD_GSK3_1	478	485	PF00069	0.403
MOD_GSK3_1	79	86	PF00069	0.451
MOD_GSK3_1	94	101	PF00069	0.280
MOD_N-GLC_1	140	145	PF02516	0.625
MOD_N-GLC_1	184	189	PF02516	0.523
MOD_N-GLC_2	438	440	PF02516	0.636
MOD_N-GLC_2	484	486	PF02516	0.461
MOD_NEK2_1	131	136	PF00069	0.382
MOD_NEK2_1	184	189	PF00069	0.429
MOD_NEK2_1	254	259	PF00069	0.394
MOD_NEK2_1	297	302	PF00069	0.410
MOD_NEK2_1	310	315	PF00069	0.330
MOD_NEK2_1	327	332	PF00069	0.313
MOD_NEK2_1	406	411	PF00069	0.365
MOD_NEK2_1	50	55	PF00069	0.367
MOD_NEK2_1	64	69	PF00069	0.307
MOD_NEK2_1	93	98	PF00069	0.333
MOD_NEK2_2	126	131	PF00069	0.340
MOD_PIKK_1	196	202	PF00454	0.388
MOD_PIKK_1	360	366	PF00454	0.371
MOD_PIKK_1	64	70	PF00454	0.434
MOD_PKA_2	219	225	PF00069	0.334
MOD_PKA_2	438	444	PF00069	0.457
MOD_PKA_2	79	85	PF00069	0.504
MOD_PKA_2	87	93	PF00069	0.405
MOD_Plk_1	140	146	PF00069	0.446
MOD_Plk_1	184	190	PF00069	0.329
MOD_Plk_1	234	240	PF00069	0.361
MOD_Plk_1	264	270	PF00069	0.401
MOD_Plk_1	34	40	PF00069	0.460
MOD_Plk_1	44	50	PF00069	0.280
MOD_Plk_4	126	132	PF00069	0.432
MOD_Plk_4	140	146	PF00069	0.321
MOD_Plk_4	159	165	PF00069	0.349
MOD_Plk_4	190	196	PF00069	0.448
MOD_Plk_4	235	241	PF00069	0.320
MOD_Plk_4	303	309	PF00069	0.344
MOD_Plk_4	356	362	PF00069	0.447
MOD_Plk_4	406	412	PF00069	0.350
MOD_Plk_4	44	50	PF00069	0.351
MOD_Plk_4	98	104	PF00069	0.327
MOD_ProDKin_1	80	86	PF00069	0.522
TRG_ENDOCYTIC_2	46	49	PF00928	0.338
TRG_ENDOCYTIC_2	471	474	PF00928	0.314
TRG_NES_CRM1_1	128	139	PF08389	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P251	Leptomonas seymouri	22%	100%
A0A381M9M8	Leishmania infantum	98%	100%
A0A3S5H581	Leishmania donovani	99%	100%
A0A3S5H583	Leishmania donovani	100%	100%
A0A451EJW1	Leishmania donovani	99%	100%
A0A451EJW6	Leishmania donovani	23%	74%
A4H3T7	Leishmania braziliensis	75%	100%
A4H3T8	Leishmania braziliensis	68%	100%
A4H3T9	Leishmania braziliensis	69%	100%
A4H3U0	Leishmania braziliensis	67%	100%
A4H3U1	Leishmania braziliensis	67%	100%
A4HS14	Leishmania infantum	23%	74%
E9AJZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AK01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	74%
Q9N852	Leishmania major	91%	100%
Q9N853	Leishmania major	91%	100%
Q9N856	Leishmania major	91%	100%
Q9XZX9	Leishmania major	24%	74%