A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 65 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | yes | yes: 11, no: 8 |
NetGPI | no | yes: 0, no: 19 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005737 | cytoplasm | 2 | 3 |
GO:0110165 | cellular anatomical entity | 1 | 3 |
Related structures:
AlphaFold database: A0A451EJW1
Term | Name | Level | Count |
---|---|---|---|
GO:0003824 | catalytic activity | 1 | 3 |
GO:0008233 | peptidase activity | 3 | 3 |
GO:0016787 | hydrolase activity | 2 | 3 |
GO:0140096 | catalytic activity, acting on a protein | 2 | 3 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 359 | 363 | PF00656 | 0.387 |
CLV_C14_Caspase3-7 | 37 | 41 | PF00656 | 0.356 |
CLV_PCSK_SKI1_1 | 34 | 38 | PF00082 | 0.583 |
DEG_SPOP_SBC_1 | 457 | 461 | PF00917 | 0.369 |
DOC_MAPK_FxFP_2 | 282 | 285 | PF00069 | 0.371 |
DOC_PP4_FxxP_1 | 282 | 285 | PF00568 | 0.371 |
DOC_USP7_MATH_1 | 110 | 114 | PF00917 | 0.443 |
DOC_USP7_MATH_1 | 126 | 130 | PF00917 | 0.289 |
DOC_USP7_MATH_1 | 137 | 141 | PF00917 | 0.423 |
DOC_USP7_MATH_1 | 154 | 158 | PF00917 | 0.328 |
DOC_USP7_MATH_1 | 224 | 228 | PF00917 | 0.391 |
DOC_USP7_MATH_1 | 275 | 279 | PF00917 | 0.411 |
DOC_USP7_MATH_1 | 319 | 323 | PF00917 | 0.473 |
DOC_USP7_MATH_1 | 385 | 389 | PF00917 | 0.440 |
DOC_USP7_MATH_1 | 470 | 474 | PF00917 | 0.378 |
DOC_USP7_MATH_1 | 476 | 480 | PF00917 | 0.360 |
DOC_USP7_MATH_1 | 79 | 83 | PF00917 | 0.473 |
DOC_WW_Pin1_4 | 80 | 85 | PF00397 | 0.442 |
LIG_14-3-3_CanoR_1 | 116 | 126 | PF00244 | 0.428 |
LIG_14-3-3_CanoR_1 | 220 | 228 | PF00244 | 0.326 |
LIG_14-3-3_CanoR_1 | 439 | 447 | PF00244 | 0.471 |
LIG_14-3-3_CanoR_1 | 487 | 493 | PF00244 | 0.417 |
LIG_14-3-3_CanoR_1 | 88 | 92 | PF00244 | 0.470 |
LIG_BRCT_BRCA1_1 | 236 | 240 | PF00533 | 0.411 |
LIG_FHA_1 | 119 | 125 | PF00498 | 0.384 |
LIG_FHA_1 | 141 | 147 | PF00498 | 0.435 |
LIG_FHA_1 | 158 | 164 | PF00498 | 0.271 |
LIG_FHA_1 | 176 | 182 | PF00498 | 0.450 |
LIG_FHA_1 | 31 | 37 | PF00498 | 0.450 |
LIG_FHA_1 | 406 | 412 | PF00498 | 0.405 |
LIG_FHA_1 | 45 | 51 | PF00498 | 0.444 |
LIG_FHA_1 | 507 | 513 | PF00498 | 0.452 |
LIG_FHA_1 | 59 | 65 | PF00498 | 0.313 |
LIG_FHA_2 | 260 | 266 | PF00498 | 0.353 |
LIG_FHA_2 | 284 | 290 | PF00498 | 0.422 |
LIG_FHA_2 | 35 | 41 | PF00498 | 0.412 |
LIG_FHA_2 | 357 | 363 | PF00498 | 0.424 |
LIG_FHA_2 | 439 | 445 | PF00498 | 0.340 |
LIG_LIR_Apic_2 | 280 | 285 | PF02991 | 0.255 |
LIG_LIR_Gen_1 | 44 | 52 | PF02991 | 0.364 |
LIG_LIR_Gen_1 | 468 | 477 | PF02991 | 0.317 |
LIG_LIR_Nem_3 | 132 | 136 | PF02991 | 0.417 |
LIG_LIR_Nem_3 | 304 | 310 | PF02991 | 0.453 |
LIG_LIR_Nem_3 | 40 | 46 | PF02991 | 0.452 |
LIG_LIR_Nem_3 | 468 | 474 | PF02991 | 0.314 |
LIG_PDZ_Class_2 | 520 | 525 | PF00595 | 0.655 |
LIG_SH2_CRK | 471 | 475 | PF00017 | 0.310 |
LIG_SH2_SRC | 269 | 272 | PF00017 | 0.320 |
LIG_SH2_STAP1 | 46 | 50 | PF00017 | 0.414 |
LIG_SH2_STAT5 | 269 | 272 | PF00017 | 0.400 |
LIG_SH2_STAT5 | 46 | 49 | PF00017 | 0.376 |
LIG_SH2_STAT5 | 471 | 474 | PF00017 | 0.385 |
LIG_SH2_STAT5 | 490 | 493 | PF00017 | 0.326 |
LIG_SH3_3 | 148 | 154 | PF00018 | 0.457 |
LIG_SH3_3 | 407 | 413 | PF00018 | 0.403 |
LIG_SUMO_SIM_anti_2 | 162 | 167 | PF11976 | 0.376 |
LIG_SUMO_SIM_par_1 | 101 | 106 | PF11976 | 0.271 |
LIG_SUMO_SIM_par_1 | 142 | 147 | PF11976 | 0.419 |
LIG_SUMO_SIM_par_1 | 162 | 167 | PF11976 | 0.219 |
LIG_SUMO_SIM_par_1 | 193 | 199 | PF11976 | 0.299 |
LIG_SUMO_SIM_par_1 | 230 | 235 | PF11976 | 0.389 |
LIG_SUMO_SIM_par_1 | 47 | 56 | PF11976 | 0.449 |
LIG_TRAF2_2 | 413 | 418 | PF00917 | 0.385 |
MOD_CK1_1 | 101 | 107 | PF00069 | 0.401 |
MOD_CK1_1 | 140 | 146 | PF00069 | 0.442 |
MOD_CK1_1 | 157 | 163 | PF00069 | 0.299 |
MOD_CK1_1 | 167 | 173 | PF00069 | 0.417 |
MOD_CK1_1 | 193 | 199 | PF00069 | 0.420 |
MOD_CK1_1 | 257 | 263 | PF00069 | 0.389 |
MOD_CK1_1 | 264 | 270 | PF00069 | 0.389 |
MOD_CK1_1 | 283 | 289 | PF00069 | 0.338 |
MOD_CK1_1 | 300 | 306 | PF00069 | 0.419 |
MOD_CK1_1 | 356 | 362 | PF00069 | 0.408 |
MOD_CK1_1 | 367 | 373 | PF00069 | 0.398 |
MOD_CK1_1 | 39 | 45 | PF00069 | 0.459 |
MOD_CK1_1 | 481 | 487 | PF00069 | 0.466 |
MOD_CK1_1 | 53 | 59 | PF00069 | 0.432 |
MOD_CK1_1 | 67 | 73 | PF00069 | 0.372 |
MOD_CK1_1 | 82 | 88 | PF00069 | 0.468 |
MOD_CK2_1 | 271 | 277 | PF00069 | 0.402 |
MOD_CK2_1 | 283 | 289 | PF00069 | 0.401 |
MOD_CK2_1 | 385 | 391 | PF00069 | 0.409 |
MOD_GlcNHglycan | 105 | 108 | PF01048 | 0.650 |
MOD_GlcNHglycan | 132 | 136 | PF01048 | 0.621 |
MOD_GlcNHglycan | 166 | 169 | PF01048 | 0.662 |
MOD_GlcNHglycan | 222 | 225 | PF01048 | 0.530 |
MOD_GlcNHglycan | 256 | 259 | PF01048 | 0.608 |
MOD_GlcNHglycan | 265 | 269 | PF01048 | 0.674 |
MOD_GlcNHglycan | 273 | 276 | PF01048 | 0.582 |
MOD_GlcNHglycan | 277 | 280 | PF01048 | 0.608 |
MOD_GlcNHglycan | 299 | 302 | PF01048 | 0.635 |
MOD_GlcNHglycan | 367 | 370 | PF01048 | 0.662 |
MOD_GlcNHglycan | 387 | 390 | PF01048 | 0.685 |
MOD_GlcNHglycan | 478 | 481 | PF01048 | 0.662 |
MOD_GlcNHglycan | 55 | 58 | PF01048 | 0.687 |
MOD_GlcNHglycan | 69 | 72 | PF01048 | 0.542 |
MOD_GlcNHglycan | 85 | 88 | PF01048 | 0.508 |
MOD_GSK3_1 | 199 | 206 | PF00069 | 0.443 |
MOD_GSK3_1 | 220 | 227 | PF00069 | 0.328 |
MOD_GSK3_1 | 253 | 260 | PF00069 | 0.407 |
MOD_GSK3_1 | 26 | 33 | PF00069 | 0.564 |
MOD_GSK3_1 | 271 | 278 | PF00069 | 0.459 |
MOD_GSK3_1 | 297 | 304 | PF00069 | 0.480 |
MOD_GSK3_1 | 345 | 352 | PF00069 | 0.381 |
MOD_GSK3_1 | 356 | 363 | PF00069 | 0.322 |
MOD_GSK3_1 | 383 | 390 | PF00069 | 0.441 |
MOD_GSK3_1 | 391 | 398 | PF00069 | 0.374 |
MOD_GSK3_1 | 434 | 441 | PF00069 | 0.459 |
MOD_GSK3_1 | 455 | 462 | PF00069 | 0.426 |
MOD_GSK3_1 | 478 | 485 | PF00069 | 0.403 |
MOD_GSK3_1 | 79 | 86 | PF00069 | 0.448 |
MOD_GSK3_1 | 94 | 101 | PF00069 | 0.370 |
MOD_N-GLC_1 | 140 | 145 | PF02516 | 0.628 |
MOD_N-GLC_1 | 184 | 189 | PF02516 | 0.522 |
MOD_N-GLC_2 | 438 | 440 | PF02516 | 0.672 |
MOD_NEK2_1 | 131 | 136 | PF00069 | 0.417 |
MOD_NEK2_1 | 184 | 189 | PF00069 | 0.347 |
MOD_NEK2_1 | 254 | 259 | PF00069 | 0.419 |
MOD_NEK2_1 | 297 | 302 | PF00069 | 0.433 |
MOD_NEK2_1 | 310 | 315 | PF00069 | 0.340 |
MOD_NEK2_1 | 327 | 332 | PF00069 | 0.286 |
MOD_NEK2_1 | 406 | 411 | PF00069 | 0.421 |
MOD_NEK2_1 | 50 | 55 | PF00069 | 0.441 |
MOD_NEK2_1 | 64 | 69 | PF00069 | 0.305 |
MOD_NEK2_1 | 93 | 98 | PF00069 | 0.352 |
MOD_NEK2_2 | 126 | 131 | PF00069 | 0.341 |
MOD_PIKK_1 | 196 | 202 | PF00454 | 0.389 |
MOD_PIKK_1 | 360 | 366 | PF00454 | 0.377 |
MOD_PIKK_1 | 64 | 70 | PF00454 | 0.432 |
MOD_PKA_2 | 219 | 225 | PF00069 | 0.333 |
MOD_PKA_2 | 438 | 444 | PF00069 | 0.465 |
MOD_PKA_2 | 79 | 85 | PF00069 | 0.500 |
MOD_PKA_2 | 87 | 93 | PF00069 | 0.445 |
MOD_Plk_1 | 140 | 146 | PF00069 | 0.452 |
MOD_Plk_1 | 184 | 190 | PF00069 | 0.328 |
MOD_Plk_1 | 234 | 240 | PF00069 | 0.369 |
MOD_Plk_1 | 264 | 270 | PF00069 | 0.410 |
MOD_Plk_1 | 34 | 40 | PF00069 | 0.462 |
MOD_Plk_1 | 44 | 50 | PF00069 | 0.261 |
MOD_Plk_4 | 126 | 132 | PF00069 | 0.418 |
MOD_Plk_4 | 140 | 146 | PF00069 | 0.395 |
MOD_Plk_4 | 159 | 165 | PF00069 | 0.313 |
MOD_Plk_4 | 190 | 196 | PF00069 | 0.453 |
MOD_Plk_4 | 235 | 241 | PF00069 | 0.371 |
MOD_Plk_4 | 277 | 283 | PF00069 | 0.293 |
MOD_Plk_4 | 303 | 309 | PF00069 | 0.388 |
MOD_Plk_4 | 356 | 362 | PF00069 | 0.451 |
MOD_Plk_4 | 406 | 412 | PF00069 | 0.445 |
MOD_Plk_4 | 44 | 50 | PF00069 | 0.357 |
MOD_Plk_4 | 98 | 104 | PF00069 | 0.450 |
MOD_ProDKin_1 | 80 | 86 | PF00069 | 0.441 |
TRG_ENDOCYTIC_2 | 46 | 49 | PF00928 | 0.347 |
TRG_ENDOCYTIC_2 | 471 | 474 | PF00928 | 0.315 |
TRG_NES_CRM1_1 | 128 | 139 | PF08389 | 0.414 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N0P251 | Leptomonas seymouri | 23% | 100% |
A0A381M9M8 | Leishmania infantum | 97% | 100% |
A0A3S5H581 | Leishmania donovani | 99% | 100% |
A0A3S5H583 | Leishmania donovani | 99% | 100% |
A0A451EJW4 | Leishmania donovani | 99% | 100% |
A0A451EJW6 | Leishmania donovani | 22% | 74% |
A4H3T7 | Leishmania braziliensis | 75% | 100% |
A4H3T8 | Leishmania braziliensis | 68% | 100% |
A4H3T9 | Leishmania braziliensis | 69% | 100% |
A4H3U0 | Leishmania braziliensis | 67% | 100% |
A4H3U1 | Leishmania braziliensis | 67% | 100% |
A4HS14 | Leishmania infantum | 22% | 74% |
E9AJZ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 86% | 100% |
E9AK01 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 23% | 74% |
Q9N852 | Leishmania major | 91% | 100% |
Q9N853 | Leishmania major | 91% | 100% |
Q9N856 | Leishmania major | 91% | 100% |
Q9XZX9 | Leishmania major | 24% | 74% |