Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJV6_LEIDO

TriTrypDb:

LdBPK_040110.1 , LdCL_040006200 , LDHU3_04.0130

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A451EJV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.578
CLV_C14_Caspase3-7	510	514	PF00656	0.814
CLV_NRD_NRD_1	11	13	PF00675	0.527
CLV_NRD_NRD_1	20	22	PF00675	0.283
CLV_NRD_NRD_1	432	434	PF00675	0.453
CLV_NRD_NRD_1	50	52	PF00675	0.702
CLV_NRD_NRD_1	539	541	PF00675	0.572
CLV_NRD_NRD_1	562	564	PF00675	0.612
CLV_NRD_NRD_1	574	576	PF00675	0.563
CLV_PCSK_FUR_1	430	434	PF00082	0.409
CLV_PCSK_FUR_1	560	564	PF00082	0.608
CLV_PCSK_KEX2_1	102	104	PF00082	0.606
CLV_PCSK_KEX2_1	11	13	PF00082	0.529
CLV_PCSK_KEX2_1	19	21	PF00082	0.418
CLV_PCSK_KEX2_1	311	313	PF00082	0.745
CLV_PCSK_KEX2_1	430	432	PF00082	0.441
CLV_PCSK_KEX2_1	49	51	PF00082	0.692
CLV_PCSK_KEX2_1	541	543	PF00082	0.575
CLV_PCSK_KEX2_1	562	564	PF00082	0.594
CLV_PCSK_KEX2_1	574	576	PF00082	0.580
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.606
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.745
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.560
CLV_PCSK_SKI1_1	124	128	PF00082	0.577
CLV_PCSK_SKI1_1	20	24	PF00082	0.405
CLV_PCSK_SKI1_1	395	399	PF00082	0.728
CLV_PCSK_SKI1_1	544	548	PF00082	0.616
DEG_Nend_UBRbox_2	1	3	PF02207	0.763
DEG_SPOP_SBC_1	507	511	PF00917	0.785
DOC_CYCLIN_RxL_1	392	402	PF00134	0.516
DOC_MAPK_gen_1	19	25	PF00069	0.548
DOC_MAPK_gen_1	431	442	PF00069	0.634
DOC_MAPK_MEF2A_6	122	129	PF00069	0.392
DOC_MAPK_NFAT4_5	122	130	PF00069	0.392
DOC_PP2B_LxvP_1	525	528	PF13499	0.671
DOC_USP7_MATH_1	140	144	PF00917	0.496
DOC_USP7_MATH_1	244	248	PF00917	0.508
DOC_USP7_MATH_1	262	266	PF00917	0.296
DOC_USP7_MATH_1	298	302	PF00917	0.473
DOC_USP7_MATH_1	403	407	PF00917	0.513
DOC_USP7_MATH_1	481	485	PF00917	0.815
DOC_USP7_MATH_1	512	516	PF00917	0.820
DOC_USP7_MATH_2	528	534	PF00917	0.836
DOC_WW_Pin1_4	421	426	PF00397	0.680
DOC_WW_Pin1_4	496	501	PF00397	0.707
DOC_WW_Pin1_4	534	539	PF00397	0.826
DOC_WW_Pin1_4	66	71	PF00397	0.525
DOC_WW_Pin1_4	95	100	PF00397	0.490
LIG_14-3-3_CanoR_1	212	220	PF00244	0.513
LIG_14-3-3_CanoR_1	275	284	PF00244	0.501
LIG_14-3-3_CanoR_1	370	376	PF00244	0.513
LIG_Actin_WH2_2	259	277	PF00022	0.452
LIG_CSL_BTD_1	490	493	PF09270	0.751
LIG_EVH1_2	70	74	PF00568	0.511
LIG_FHA_1	29	35	PF00498	0.494
LIG_FHA_1	318	324	PF00498	0.459
LIG_FHA_2	400	406	PF00498	0.385
LIG_FHA_2	422	428	PF00498	0.666
LIG_FHA_2	508	514	PF00498	0.781
LIG_FHA_2	545	551	PF00498	0.826
LIG_LIR_Gen_1	170	181	PF02991	0.400
LIG_LIR_Gen_1	401	412	PF02991	0.365
LIG_LIR_Nem_3	170	176	PF02991	0.403
LIG_LIR_Nem_3	308	313	PF02991	0.419
LIG_LIR_Nem_3	401	407	PF02991	0.365
LIG_MYND_1	71	75	PF01753	0.619
LIG_NRBOX	332	338	PF00104	0.545
LIG_SH2_STAP1	173	177	PF00017	0.395
LIG_SH2_STAT3	460	463	PF00017	0.806
LIG_SH2_STAT5	189	192	PF00017	0.399
LIG_SH2_STAT5	418	421	PF00017	0.419
LIG_SH2_STAT5	47	50	PF00017	0.508
LIG_SH3_3	456	462	PF00018	0.721
LIG_SH3_3	494	500	PF00018	0.715
LIG_SUMO_SIM_anti_2	226	234	PF11976	0.517
LIG_SUMO_SIM_anti_2	374	380	PF11976	0.519
LIG_SUMO_SIM_par_1	356	361	PF11976	0.405
LIG_TRAF2_1	435	438	PF00917	0.631
LIG_WW_3	69	73	PF00397	0.518
MOD_CDK_SPK_2	496	501	PF00069	0.822
MOD_CDK_SPxK_1	534	540	PF00069	0.843
MOD_CDK_SPxK_1	66	72	PF00069	0.435
MOD_CDK_SPxxK_3	534	541	PF00069	0.843
MOD_CDK_SPxxK_3	95	102	PF00069	0.485
MOD_CK1_1	148	154	PF00069	0.525
MOD_CK1_1	277	283	PF00069	0.500
MOD_CK1_1	306	312	PF00069	0.540
MOD_CK1_1	515	521	PF00069	0.753
MOD_CK1_1	533	539	PF00069	0.783
MOD_CK1_1	7	13	PF00069	0.770
MOD_CK2_1	220	226	PF00069	0.434
MOD_CK2_1	399	405	PF00069	0.492
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.433
MOD_GlcNHglycan	147	150	PF01048	0.742
MOD_GlcNHglycan	155	159	PF01048	0.613
MOD_GlcNHglycan	170	173	PF01048	0.639
MOD_GlcNHglycan	222	225	PF01048	0.629
MOD_GlcNHglycan	270	273	PF01048	0.642
MOD_GlcNHglycan	532	535	PF01048	0.589
MOD_GSK3_1	211	218	PF00069	0.512
MOD_GSK3_1	273	280	PF00069	0.484
MOD_GSK3_1	399	406	PF00069	0.525
MOD_GSK3_1	421	428	PF00069	0.698
MOD_GSK3_1	492	499	PF00069	0.709
MOD_GSK3_1	508	515	PF00069	0.827
MOD_GSK3_1	517	524	PF00069	0.638
MOD_GSK3_1	529	536	PF00069	0.830
MOD_GSK3_1	558	565	PF00069	0.807
MOD_GSK3_1	566	573	PF00069	0.776
MOD_NEK2_1	168	173	PF00069	0.407
MOD_NEK2_1	210	215	PF00069	0.472
MOD_NEK2_1	220	225	PF00069	0.392
MOD_NEK2_1	231	236	PF00069	0.448
MOD_NEK2_1	274	279	PF00069	0.486
MOD_NEK2_1	358	363	PF00069	0.411
MOD_NEK2_1	399	404	PF00069	0.529
MOD_NEK2_1	407	412	PF00069	0.418
MOD_NEK2_2	425	430	PF00069	0.634
MOD_NEK2_2	566	571	PF00069	0.792
MOD_OFUCOSY	355	362	PF10250	0.436
MOD_PIKK_1	148	154	PF00454	0.518
MOD_PIKK_1	231	237	PF00454	0.521
MOD_PIKK_1	303	309	PF00454	0.481
MOD_PKA_1	562	568	PF00069	0.793
MOD_PKA_2	211	217	PF00069	0.512
MOD_PKA_2	274	280	PF00069	0.489
MOD_PKA_2	561	567	PF00069	0.791
MOD_PKA_2	570	576	PF00069	0.789
MOD_PKA_2	7	13	PF00069	0.703
MOD_PKB_1	542	550	PF00069	0.767
MOD_PKB_1	560	568	PF00069	0.791
MOD_Plk_1	117	123	PF00069	0.483
MOD_Plk_1	481	487	PF00069	0.743
MOD_Plk_4	244	250	PF00069	0.507
MOD_Plk_4	371	377	PF00069	0.524
MOD_Plk_4	492	498	PF00069	0.749
MOD_ProDKin_1	421	427	PF00069	0.681
MOD_ProDKin_1	496	502	PF00069	0.708
MOD_ProDKin_1	534	540	PF00069	0.828
MOD_ProDKin_1	66	72	PF00069	0.527
MOD_ProDKin_1	95	101	PF00069	0.483
TRG_DiLeu_BaEn_1	226	231	PF01217	0.443
TRG_DiLeu_BaEn_4	437	443	PF01217	0.568
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.411
TRG_ENDOCYTIC_2	173	176	PF00928	0.396
TRG_ER_diArg_1	121	124	PF00400	0.394
TRG_ER_diArg_1	18	21	PF00400	0.683
TRG_ER_diArg_1	339	342	PF00400	0.560
TRG_ER_diArg_1	343	346	PF00400	0.478
TRG_ER_diArg_1	393	396	PF00400	0.376
TRG_ER_diArg_1	430	433	PF00400	0.691
TRG_ER_diArg_1	48	51	PF00400	0.494
TRG_ER_diArg_1	542	545	PF00400	0.769
TRG_ER_diArg_1	560	563	PF00400	0.792
TRG_NLS_MonoExtC_3	539	544	PF00514	0.764
TRG_NLS_MonoExtN_4	538	545	PF00514	0.759
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X8	Leptomonas seymouri	47%	92%
A4H3T1	Leishmania braziliensis	77%	100%
A4HS06	Leishmania infantum	100%	100%
E9AJZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q9N858	Leishmania major	94%	100%