Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A451EJV0_LEIDO

TriTrypDb:

LdBPK_040040.1 , LdCL_040005500 , LDHU3_04.0060

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJV0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.628
CLV_PCSK_SKI1_1	396	400	PF00082	0.539
CLV_PCSK_SKI1_1	421	425	PF00082	0.637
DEG_Nend_UBRbox_3	1	3	PF02207	0.684
DEG_SPOP_SBC_1	124	128	PF00917	0.805
DEG_SPOP_SBC_1	176	180	PF00917	0.611
DOC_CKS1_1	432	437	PF01111	0.623
DOC_MAPK_gen_1	130	139	PF00069	0.768
DOC_MAPK_gen_1	182	190	PF00069	0.559
DOC_MAPK_gen_1	312	322	PF00069	0.597
DOC_MAPK_gen_1	366	376	PF00069	0.573
DOC_MAPK_MEF2A_6	267	275	PF00069	0.536
DOC_USP7_MATH_1	124	128	PF00917	0.815
DOC_USP7_MATH_1	183	187	PF00917	0.567
DOC_USP7_MATH_1	244	248	PF00917	0.636
DOC_USP7_MATH_1	401	405	PF00917	0.640
DOC_USP7_MATH_1	413	417	PF00917	0.485
DOC_USP7_MATH_1	72	76	PF00917	0.677
DOC_WW_Pin1_4	113	118	PF00397	0.793
DOC_WW_Pin1_4	423	428	PF00397	0.641
DOC_WW_Pin1_4	431	436	PF00397	0.578
DOC_WW_Pin1_4	61	66	PF00397	0.704
DOC_WW_Pin1_4	88	93	PF00397	0.791
LIG_14-3-3_CanoR_1	182	191	PF00244	0.558
LIG_14-3-3_CanoR_1	218	224	PF00244	0.576
LIG_14-3-3_CanoR_1	366	376	PF00244	0.488
LIG_14-3-3_CanoR_1	421	426	PF00244	0.585
LIG_Actin_WH2_2	351	368	PF00022	0.563
LIG_FHA_1	114	120	PF00498	0.696
LIG_FHA_1	164	170	PF00498	0.622
LIG_FHA_1	279	285	PF00498	0.528
LIG_FHA_1	333	339	PF00498	0.603
LIG_FHA_1	418	424	PF00498	0.641
LIG_FHA_2	339	345	PF00498	0.649
LIG_LIR_Nem_3	33	38	PF02991	0.706
LIG_LIR_Nem_3	353	358	PF02991	0.586
LIG_NRBOX	428	434	PF00104	0.592
LIG_PTB_Apo_2	227	234	PF02174	0.543
LIG_PTB_Phospho_1	227	233	PF10480	0.546
LIG_SH2_GRB2like	172	175	PF00017	0.623
LIG_SH2_SRC	18	21	PF00017	0.699
LIG_SH2_STAP1	172	176	PF00017	0.616
LIG_SH2_STAP1	233	237	PF00017	0.524
LIG_SH2_STAP1	251	255	PF00017	0.492
LIG_SH2_STAT3	213	216	PF00017	0.536
LIG_SH2_STAT3	232	235	PF00017	0.529
LIG_SH2_STAT5	18	21	PF00017	0.699
LIG_SH2_STAT5	213	216	PF00017	0.536
LIG_SH2_STAT5	269	272	PF00017	0.529
LIG_SH2_STAT5	294	297	PF00017	0.579
LIG_SH2_STAT5	367	370	PF00017	0.564
LIG_SH2_STAT5	67	70	PF00017	0.738
LIG_SH3_3	21	27	PF00018	0.599
LIG_SH3_3	9	15	PF00018	0.728
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.525
LIG_SUMO_SIM_anti_2	334	341	PF11976	0.696
LIG_SUMO_SIM_par_1	269	274	PF11976	0.622
LIG_SUMO_SIM_par_1	418	426	PF11976	0.630
LIG_SUMO_SIM_par_1	428	434	PF11976	0.570
LIG_TRAF2_1	341	344	PF00917	0.730
LIG_UBA3_1	429	436	PF00899	0.708
MOD_CDK_SPK_2	423	428	PF00069	0.641
MOD_CDK_SPK_2	431	436	PF00069	0.578
MOD_CDK_SPK_2	88	93	PF00069	0.791
MOD_CDK_SPxxK_3	88	95	PF00069	0.795
MOD_CK1_1	101	107	PF00069	0.684
MOD_CK1_1	109	115	PF00069	0.697
MOD_CK1_1	118	124	PF00069	0.704
MOD_CK1_1	178	184	PF00069	0.714
MOD_CK1_1	348	354	PF00069	0.669
MOD_CK1_1	361	367	PF00069	0.519
MOD_CK1_1	416	422	PF00069	0.704
MOD_CK2_1	109	115	PF00069	0.697
MOD_CK2_1	338	344	PF00069	0.641
MOD_CK2_1	347	353	PF00069	0.527
MOD_GlcNHglycan	111	114	PF01048	0.607
MOD_GlcNHglycan	122	125	PF01048	0.696
MOD_GlcNHglycan	246	249	PF01048	0.584
MOD_GlcNHglycan	350	353	PF01048	0.687
MOD_GlcNHglycan	369	372	PF01048	0.377
MOD_GlcNHglycan	403	406	PF01048	0.462
MOD_GlcNHglycan	74	77	PF01048	0.578
MOD_GlcNHglycan	86	89	PF01048	0.658
MOD_GlcNHglycan	98	101	PF01048	0.661
MOD_GSK3_1	109	116	PF00069	0.776
MOD_GSK3_1	120	127	PF00069	0.760
MOD_GSK3_1	163	170	PF00069	0.623
MOD_GSK3_1	334	341	PF00069	0.657
MOD_GSK3_1	343	350	PF00069	0.609
MOD_GSK3_1	412	419	PF00069	0.647
MOD_GSK3_1	57	64	PF00069	0.567
MOD_GSK3_1	84	91	PF00069	0.732
MOD_N-GLC_1	276	281	PF02516	0.508
MOD_N-GLC_1	416	421	PF02516	0.497
MOD_N-GLC_1	57	62	PF02516	0.567
MOD_NEK2_1	120	125	PF00069	0.810
MOD_NEK2_1	167	172	PF00069	0.615
MOD_NEK2_1	177	182	PF00069	0.625
MOD_NEK2_1	207	212	PF00069	0.632
MOD_NEK2_1	276	281	PF00069	0.514
MOD_NEK2_1	59	64	PF00069	0.780
MOD_NEK2_1	96	101	PF00069	0.713
MOD_NEK2_2	125	130	PF00069	0.761
MOD_NEK2_2	30	35	PF00069	0.601
MOD_PIKK_1	104	110	PF00454	0.700
MOD_PIKK_1	231	237	PF00454	0.533
MOD_PIKK_1	399	405	PF00454	0.538
MOD_PKA_2	217	223	PF00069	0.573
MOD_PKA_2	344	350	PF00069	0.509
MOD_Plk_1	135	141	PF00069	0.528
MOD_Plk_1	271	277	PF00069	0.602
MOD_Plk_1	361	367	PF00069	0.571
MOD_Plk_1	417	423	PF00069	0.503
MOD_Plk_4	115	121	PF00069	0.795
MOD_Plk_4	135	141	PF00069	0.411
MOD_Plk_4	271	277	PF00069	0.623
MOD_Plk_4	30	36	PF00069	0.610
MOD_Plk_4	334	340	PF00069	0.692
MOD_Plk_4	372	378	PF00069	0.535
MOD_Plk_4	8	14	PF00069	0.670
MOD_ProDKin_1	113	119	PF00069	0.793
MOD_ProDKin_1	423	429	PF00069	0.635
MOD_ProDKin_1	431	437	PF00069	0.581
MOD_ProDKin_1	61	67	PF00069	0.706
MOD_ProDKin_1	88	94	PF00069	0.792
TRG_DiLeu_BaEn_1	115	120	PF01217	0.717
TRG_DiLeu_BaEn_1	266	271	PF01217	0.660
TRG_ENDOCYTIC_2	31	34	PF00928	0.614
TRG_ENDOCYTIC_2	355	358	PF00928	0.583
TRG_ENDOCYTIC_2	67	70	PF00928	0.683
TRG_NES_CRM1_1	272	285	PF08389	0.528
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X9	Leptomonas seymouri	64%	95%
A4H3S4	Leishmania braziliensis	83%	100%
A4HRZ9	Leishmania infantum	100%	100%
E9AJY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q95Z91	Leishmania major	92%	100%