Amidohydrolase/Amidohydrolase family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amidohydrolase family, putative

Species:

Leishmania donovani

UniProt:

A0A451EJU1_LEIDO

TriTrypDb:

LdBPK_030910.1 , LdCL_030014400 , LDHU3_03.1020

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJU1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.451
CLV_C14_Caspase3-7	553	557	PF00656	0.451
CLV_NRD_NRD_1	11	13	PF00675	0.378
CLV_NRD_NRD_1	250	252	PF00675	0.334
CLV_NRD_NRD_1	523	525	PF00675	0.264
CLV_NRD_NRD_1	601	603	PF00675	0.305
CLV_PCSK_KEX2_1	11	13	PF00082	0.330
CLV_PCSK_KEX2_1	237	239	PF00082	0.251
CLV_PCSK_KEX2_1	250	252	PF00082	0.251
CLV_PCSK_KEX2_1	493	495	PF00082	0.305
CLV_PCSK_KEX2_1	523	525	PF00082	0.264
CLV_PCSK_KEX2_1	601	603	PF00082	0.305
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.305
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.271
CLV_PCSK_SKI1_1	111	115	PF00082	0.305
CLV_PCSK_SKI1_1	250	254	PF00082	0.251
CLV_PCSK_SKI1_1	317	321	PF00082	0.232
CLV_PCSK_SKI1_1	490	494	PF00082	0.287
DOC_CDC14_PxL_1	112	120	PF14671	0.505
DOC_MAPK_gen_1	296	305	PF00069	0.436
DOC_MAPK_MEF2A_6	291	299	PF00069	0.471
DOC_PP1_RVXF_1	39	45	PF00149	0.377
DOC_PP2B_LxvP_1	113	116	PF13499	0.455
DOC_PP4_FxxP_1	332	335	PF00568	0.451
DOC_PP4_MxPP_1	340	343	PF00568	0.451
DOC_USP7_MATH_1	191	195	PF00917	0.505
DOC_USP7_MATH_1	323	327	PF00917	0.505
DOC_USP7_MATH_1	359	363	PF00917	0.505
DOC_USP7_MATH_2	609	615	PF00917	0.488
DOC_WW_Pin1_4	157	162	PF00397	0.477
DOC_WW_Pin1_4	242	247	PF00397	0.450
DOC_WW_Pin1_4	338	343	PF00397	0.505
DOC_WW_Pin1_4	67	72	PF00397	0.466
LIG_14-3-3_CanoR_1	124	134	PF00244	0.505
LIG_14-3-3_CanoR_1	15	24	PF00244	0.528
LIG_14-3-3_CanoR_1	317	324	PF00244	0.410
LIG_14-3-3_CanoR_1	337	341	PF00244	0.451
LIG_14-3-3_CanoR_1	41	45	PF00244	0.406
LIG_14-3-3_CanoR_1	422	432	PF00244	0.553
LIG_14-3-3_CanoR_1	439	445	PF00244	0.391
LIG_14-3-3_CanoR_1	524	530	PF00244	0.376
LIG_14-3-3_CanoR_1	620	625	PF00244	0.469
LIG_14-3-3_CanoR_1	78	83	PF00244	0.442
LIG_AP2alpha_1	311	315	PF02296	0.428
LIG_APCC_ABBA_1	355	360	PF00400	0.505
LIG_BRCT_BRCA1_1	261	265	PF00533	0.500
LIG_BRCT_BRCA1_1	328	332	PF00533	0.505
LIG_deltaCOP1_diTrp_1	142	152	PF00928	0.451
LIG_eIF4E_1	529	535	PF01652	0.451
LIG_FHA_1	126	132	PF00498	0.448
LIG_FHA_1	187	193	PF00498	0.558
LIG_FHA_1	255	261	PF00498	0.474
LIG_FHA_1	275	281	PF00498	0.368
LIG_FHA_1	319	325	PF00498	0.410
LIG_FHA_1	46	52	PF00498	0.381
LIG_FHA_1	487	493	PF00498	0.471
LIG_FHA_1	636	642	PF00498	0.451
LIG_FHA_2	207	213	PF00498	0.463
LIG_FHA_2	273	279	PF00498	0.464
LIG_FHA_2	378	384	PF00498	0.462
LIG_GBD_Chelix_1	535	543	PF00786	0.305
LIG_HCF-1_HBM_1	136	139	PF13415	0.505
LIG_LIR_Apic_2	329	335	PF02991	0.454
LIG_LIR_Gen_1	125	135	PF02991	0.451
LIG_LIR_Gen_1	262	272	PF02991	0.464
LIG_LIR_Gen_1	512	520	PF02991	0.410
LIG_LIR_Nem_3	125	130	PF02991	0.451
LIG_LIR_Nem_3	262	268	PF02991	0.505
LIG_LIR_Nem_3	313	318	PF02991	0.436
LIG_LIR_Nem_3	528	534	PF02991	0.436
LIG_LIR_Nem_3	81	87	PF02991	0.337
LIG_LYPXL_S_1	95	99	PF13949	0.251
LIG_NRP_CendR_1	695	697	PF00754	0.376
LIG_Pex14_2	265	269	PF04695	0.505
LIG_Pex14_2	311	315	PF04695	0.432
LIG_SH2_CRK	301	305	PF00017	0.451
LIG_SH2_CRK	498	502	PF00017	0.505
LIG_SH2_CRK	55	59	PF00017	0.407
LIG_SH2_CRK	684	688	PF00017	0.451
LIG_SH2_NCK_1	644	648	PF00017	0.505
LIG_SH2_NCK_1	684	688	PF00017	0.451
LIG_SH2_SRC	644	647	PF00017	0.505
LIG_SH2_STAP1	178	182	PF00017	0.451
LIG_SH2_STAP1	276	280	PF00017	0.428
LIG_SH2_STAT3	579	582	PF00017	0.471
LIG_SH2_STAT5	276	279	PF00017	0.521
LIG_SH2_STAT5	349	352	PF00017	0.451
LIG_SH2_STAT5	515	518	PF00017	0.472
LIG_SH2_STAT5	622	625	PF00017	0.468
LIG_SH2_STAT5	635	638	PF00017	0.503
LIG_SH2_STAT5	684	687	PF00017	0.451
LIG_SH3_3	19	25	PF00018	0.438
LIG_SH3_3	545	551	PF00018	0.451
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.335
LIG_SUMO_SIM_par_1	188	194	PF11976	0.410
LIG_SUMO_SIM_par_1	214	220	PF11976	0.488
LIG_TYR_ITIM	682	687	PF00017	0.288
LIG_TYR_ITIM	82	87	PF00017	0.326
MOD_CK1_1	120	126	PF00069	0.268
MOD_CK1_1	160	166	PF00069	0.258
MOD_CK1_1	267	273	PF00069	0.328
MOD_CK1_1	326	332	PF00069	0.424
MOD_CK1_1	362	368	PF00069	0.302
MOD_CK1_1	486	492	PF00069	0.316
MOD_CK2_1	206	212	PF00069	0.442
MOD_CK2_1	410	416	PF00069	0.291
MOD_CK2_1	44	50	PF00069	0.362
MOD_CK2_1	474	480	PF00069	0.307
MOD_GlcNHglycan	119	122	PF01048	0.370
MOD_GlcNHglycan	17	20	PF01048	0.536
MOD_GlcNHglycan	183	186	PF01048	0.288
MOD_GlcNHglycan	325	328	PF01048	0.439
MOD_GlcNHglycan	393	396	PF01048	0.361
MOD_GlcNHglycan	399	403	PF01048	0.300
MOD_GlcNHglycan	418	421	PF01048	0.169
MOD_GlcNHglycan	450	453	PF01048	0.288
MOD_GSK3_1	20	27	PF00069	0.624
MOD_GSK3_1	259	266	PF00069	0.345
MOD_GSK3_1	267	274	PF00069	0.300
MOD_GSK3_1	326	333	PF00069	0.316
MOD_GSK3_1	40	47	PF00069	0.274
MOD_N-GLC_1	278	283	PF02516	0.255
MOD_N-GLC_1	376	381	PF02516	0.316
MOD_N-GLC_1	486	491	PF02516	0.255
MOD_NEK2_1	263	268	PF00069	0.328
MOD_NEK2_1	271	276	PF00069	0.255
MOD_NEK2_1	410	415	PF00069	0.291
MOD_NEK2_1	44	49	PF00069	0.372
MOD_NEK2_1	530	535	PF00069	0.319
MOD_NEK2_1	99	104	PF00069	0.288
MOD_NEK2_2	191	196	PF00069	0.364
MOD_NEK2_2	264	269	PF00069	0.364
MOD_PIKK_1	122	128	PF00454	0.364
MOD_PIKK_1	578	584	PF00454	0.316
MOD_PKA_1	524	530	PF00069	0.288
MOD_PKA_2	336	342	PF00069	0.288
MOD_PKA_2	40	46	PF00069	0.369
MOD_PKB_1	78	86	PF00069	0.418
MOD_Plk_1	330	336	PF00069	0.291
MOD_Plk_1	645	651	PF00069	0.379
MOD_Plk_2-3	278	284	PF00069	0.231
MOD_Plk_2-3	383	389	PF00069	0.318
MOD_Plk_2-3	611	617	PF00069	0.288
MOD_Plk_4	264	270	PF00069	0.364
MOD_Plk_4	525	531	PF00069	0.314
MOD_Plk_4	682	688	PF00069	0.322
MOD_ProDKin_1	157	163	PF00069	0.324
MOD_ProDKin_1	242	248	PF00069	0.287
MOD_ProDKin_1	338	344	PF00069	0.364
MOD_ProDKin_1	67	73	PF00069	0.466
MOD_SUMO_rev_2	486	495	PF00179	0.291
TRG_DiLeu_BaEn_1	31	36	PF01217	0.426
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.364
TRG_ENDOCYTIC_2	316	319	PF00928	0.288
TRG_ENDOCYTIC_2	349	352	PF00928	0.328
TRG_ENDOCYTIC_2	498	501	PF00928	0.364
TRG_ENDOCYTIC_2	515	518	PF00928	0.189
TRG_ENDOCYTIC_2	55	58	PF00928	0.452
TRG_ENDOCYTIC_2	644	647	PF00928	0.438
TRG_ENDOCYTIC_2	684	687	PF00928	0.288
TRG_ENDOCYTIC_2	84	87	PF00928	0.405
TRG_ENDOCYTIC_2	96	99	PF00928	0.269
TRG_ER_diArg_1	11	13	PF00400	0.378
TRG_ER_diArg_1	295	298	PF00400	0.288
TRG_ER_diArg_1	475	478	PF00400	0.325
TRG_ER_diArg_1	600	602	PF00400	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P539	Leptomonas seymouri	70%	99%
A0A1I9LN01	Arabidopsis thaliana	28%	100%
A4H3Q5	Leishmania braziliensis	88%	100%
A4HRX9	Leishmania infantum	100%	100%
E9ACN8	Leishmania major	95%	100%
E9AJX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O34355	Bacillus subtilis (strain 168)	24%	100%
Q68AP4	Arthrobacter pascens	24%	100%