C6H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJT3_LEIDO

TriTrypDb:

LdBPK_013360.1 , LdCL_030013500 , LDHU3_03.0920

Length:

969

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.656
CLV_C14_Caspase3-7	345	349	PF00656	0.570
CLV_C14_Caspase3-7	477	481	PF00656	0.525
CLV_C14_Caspase3-7	613	617	PF00656	0.557
CLV_NRD_NRD_1	526	528	PF00675	0.735
CLV_NRD_NRD_1	62	64	PF00675	0.627
CLV_NRD_NRD_1	668	670	PF00675	0.473
CLV_NRD_NRD_1	709	711	PF00675	0.775
CLV_NRD_NRD_1	855	857	PF00675	0.467
CLV_NRD_NRD_1	886	888	PF00675	0.598
CLV_NRD_NRD_1	915	917	PF00675	0.516
CLV_NRD_NRD_1	951	953	PF00675	0.628
CLV_PCSK_FUR_1	916	920	PF00082	0.631
CLV_PCSK_KEX2_1	525	527	PF00082	0.699
CLV_PCSK_KEX2_1	66	68	PF00082	0.787
CLV_PCSK_KEX2_1	668	670	PF00082	0.450
CLV_PCSK_KEX2_1	855	857	PF00082	0.467
CLV_PCSK_KEX2_1	91	93	PF00082	0.679
CLV_PCSK_KEX2_1	918	920	PF00082	0.631
CLV_PCSK_KEX2_1	947	949	PF00082	0.645
CLV_PCSK_KEX2_1	951	953	PF00082	0.655
CLV_PCSK_KEX2_1	962	964	PF00082	0.577
CLV_PCSK_KEX2_1	966	968	PF00082	0.522
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.737
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.733
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.679
CLV_PCSK_PC1ET2_1	918	920	PF00082	0.631
CLV_PCSK_PC1ET2_1	947	949	PF00082	0.634
CLV_PCSK_PC1ET2_1	962	964	PF00082	0.606
CLV_PCSK_PC1ET2_1	966	968	PF00082	0.578
CLV_PCSK_PC7_1	914	920	PF00082	0.635
CLV_PCSK_SKI1_1	261	265	PF00082	0.567
CLV_PCSK_SKI1_1	326	330	PF00082	0.483
CLV_PCSK_SKI1_1	474	478	PF00082	0.573
CLV_PCSK_SKI1_1	710	714	PF00082	0.759
CLV_PCSK_SKI1_1	892	896	PF00082	0.607
CLV_PCSK_SKI1_1	919	923	PF00082	0.546
CLV_PCSK_SKI1_1	951	955	PF00082	0.624
CLV_PCSK_SKI1_1	963	967	PF00082	0.646
DEG_SIAH_1	147	155	PF03145	0.632
DEG_SPOP_SBC_1	283	287	PF00917	0.624
DEG_SPOP_SBC_1	378	382	PF00917	0.763
DEG_SPOP_SBC_1	383	387	PF00917	0.789
DOC_CDC14_PxL_1	572	580	PF14671	0.462
DOC_CKS1_1	138	143	PF01111	0.659
DOC_MAPK_gen_1	668	676	PF00069	0.456
DOC_MAPK_MEF2A_6	826	835	PF00069	0.475
DOC_MAPK_MEF2A_6	860	868	PF00069	0.652
DOC_PP1_RVXF_1	324	331	PF00149	0.497
DOC_PP1_RVXF_1	464	471	PF00149	0.482
DOC_PP1_RVXF_1	666	673	PF00149	0.542
DOC_PP1_RVXF_1	863	869	PF00149	0.715
DOC_PP2B_LxvP_1	145	148	PF13499	0.665
DOC_PP2B_LxvP_1	375	378	PF13499	0.637
DOC_PP2B_LxvP_1	699	702	PF13499	0.702
DOC_PP4_FxxP_1	23	26	PF00568	0.460
DOC_PP4_FxxP_1	330	333	PF00568	0.607
DOC_PP4_FxxP_1	470	473	PF00568	0.523
DOC_USP7_MATH_1	160	164	PF00917	0.624
DOC_USP7_MATH_1	191	195	PF00917	0.684
DOC_USP7_MATH_1	232	236	PF00917	0.723
DOC_USP7_MATH_1	257	261	PF00917	0.566
DOC_USP7_MATH_1	283	287	PF00917	0.642
DOC_USP7_MATH_1	303	307	PF00917	0.438
DOC_USP7_MATH_1	378	382	PF00917	0.710
DOC_USP7_MATH_1	383	387	PF00917	0.705
DOC_USP7_MATH_1	396	400	PF00917	0.722
DOC_USP7_MATH_1	508	512	PF00917	0.637
DOC_USP7_MATH_1	520	524	PF00917	0.683
DOC_USP7_MATH_1	610	614	PF00917	0.501
DOC_USP7_MATH_1	702	706	PF00917	0.760
DOC_USP7_MATH_1	747	751	PF00917	0.637
DOC_USP7_MATH_1	759	763	PF00917	0.521
DOC_USP7_UBL2_3	47	51	PF12436	0.542
DOC_USP7_UBL2_3	902	906	PF12436	0.673
DOC_USP7_UBL2_3	918	922	PF12436	0.416
DOC_USP7_UBL2_3	954	958	PF12436	0.693
DOC_USP7_UBL2_3	962	966	PF12436	0.622
DOC_WW_Pin1_4	137	142	PF00397	0.581
DOC_WW_Pin1_4	255	260	PF00397	0.622
DOC_WW_Pin1_4	379	384	PF00397	0.729
DOC_WW_Pin1_4	547	552	PF00397	0.713
DOC_WW_Pin1_4	589	594	PF00397	0.510
LIG_14-3-3_CanoR_1	261	271	PF00244	0.475
LIG_14-3-3_CanoR_1	284	291	PF00244	0.650
LIG_14-3-3_CanoR_1	53	57	PF00244	0.510
LIG_14-3-3_CanoR_1	717	722	PF00244	0.705
LIG_BIR_III_4	654	658	PF00653	0.555
LIG_BRCT_BRCA1_1	259	263	PF00533	0.608
LIG_BRCT_BRCA1_1	466	470	PF00533	0.461
LIG_CSL_BTD_1	121	124	PF09270	0.626
LIG_deltaCOP1_diTrp_1	770	776	PF00928	0.549
LIG_EVH1_1	122	126	PF00568	0.686
LIG_FHA_1	138	144	PF00498	0.594
LIG_FHA_1	221	227	PF00498	0.558
LIG_FHA_1	271	277	PF00498	0.417
LIG_FHA_1	323	329	PF00498	0.539
LIG_FHA_1	548	554	PF00498	0.743
LIG_FHA_1	632	638	PF00498	0.533
LIG_FHA_1	738	744	PF00498	0.630
LIG_FHA_1	773	779	PF00498	0.526
LIG_FHA_1	828	834	PF00498	0.522
LIG_FHA_1	859	865	PF00498	0.588
LIG_FHA_2	101	107	PF00498	0.751
LIG_FHA_2	308	314	PF00498	0.581
LIG_FHA_2	335	341	PF00498	0.707
LIG_FHA_2	354	360	PF00498	0.626
LIG_FHA_2	475	481	PF00498	0.432
LIG_LIR_Apic_2	20	26	PF02991	0.463
LIG_LIR_Apic_2	467	473	PF02991	0.514
LIG_LIR_Gen_1	352	361	PF02991	0.686
LIG_LIR_Nem_3	352	358	PF02991	0.701
LIG_LIR_Nem_3	434	440	PF02991	0.488
LIG_LIR_Nem_3	763	769	PF02991	0.559
LIG_LIR_Nem_3	770	776	PF02991	0.425
LIG_LIR_Nem_3	844	849	PF02991	0.416
LIG_MLH1_MIPbox_1	259	263	PF16413	0.608
LIG_PCNA_yPIPBox_3	784	798	PF02747	0.605
LIG_Pex14_2	45	49	PF04695	0.479
LIG_Pex14_2	599	603	PF04695	0.436
LIG_Pex14_2	823	827	PF04695	0.433
LIG_RPA_C_Fungi	617	629	PF08784	0.526
LIG_SH2_CRK	606	610	PF00017	0.546
LIG_SH2_CRK	653	657	PF00017	0.393
LIG_SH2_CRK	659	663	PF00017	0.452
LIG_SH2_GRB2like	568	571	PF00017	0.543
LIG_SH2_NCK_1	653	657	PF00017	0.393
LIG_SH2_PTP2	182	185	PF00017	0.515
LIG_SH2_PTP2	645	648	PF00017	0.422
LIG_SH2_SRC	539	542	PF00017	0.740
LIG_SH2_SRC	608	611	PF00017	0.505
LIG_SH2_STAP1	568	572	PF00017	0.556
LIG_SH2_STAT3	425	428	PF00017	0.541
LIG_SH2_STAT5	182	185	PF00017	0.540
LIG_SH2_STAT5	262	265	PF00017	0.535
LIG_SH2_STAT5	353	356	PF00017	0.698
LIG_SH2_STAT5	438	441	PF00017	0.556
LIG_SH2_STAT5	458	461	PF00017	0.189
LIG_SH2_STAT5	572	575	PF00017	0.505
LIG_SH2_STAT5	608	611	PF00017	0.500
LIG_SH2_STAT5	645	648	PF00017	0.347
LIG_SH2_STAT5	686	689	PF00017	0.506
LIG_SH2_STAT5	809	812	PF00017	0.465
LIG_SH2_STAT5	945	948	PF00017	0.576
LIG_SH3_3	118	124	PF00018	0.604
LIG_SH3_3	138	144	PF00018	0.432
LIG_SH3_3	148	154	PF00018	0.501
LIG_SH3_3	306	312	PF00018	0.478
LIG_SH3_3	330	336	PF00018	0.733
LIG_SH3_3	535	541	PF00018	0.743
LIG_SH3_3	554	560	PF00018	0.453
LIG_SH3_3	799	805	PF00018	0.467
LIG_SH3_3	906	912	PF00018	0.653
LIG_SUMO_SIM_anti_2	356	364	PF11976	0.720
LIG_SUMO_SIM_par_1	306	313	PF11976	0.571
LIG_TRAF2_1	511	514	PF00917	0.614
LIG_TRAF2_1	561	564	PF00917	0.645
LIG_TRAF2_1	793	796	PF00917	0.456
LIG_TYR_ITIM	643	648	PF00017	0.492
LIG_TYR_ITIM	651	656	PF00017	0.471
LIG_WRC_WIRS_1	596	601	PF05994	0.508
LIG_WW_2	123	126	PF00397	0.715
MOD_CDC14_SPxK_1	258	261	PF00782	0.531
MOD_CDK_SPxK_1	255	261	PF00069	0.612
MOD_CK1_1	16	22	PF00069	0.421
MOD_CK1_1	245	251	PF00069	0.738
MOD_CK1_1	286	292	PF00069	0.666
MOD_CK1_1	381	387	PF00069	0.697
MOD_CK1_1	542	548	PF00069	0.693
MOD_CK1_1	555	561	PF00069	0.533
MOD_CK1_1	732	738	PF00069	0.749
MOD_CK2_1	353	359	PF00069	0.708
MOD_CK2_1	508	514	PF00069	0.667
MOD_CK2_1	558	564	PF00069	0.521
MOD_CK2_1	735	741	PF00069	0.622
MOD_Cter_Amidation	89	92	PF01082	0.738
MOD_Cter_Amidation	956	959	PF01082	0.639
MOD_GlcNHglycan	100	103	PF01048	0.791
MOD_GlcNHglycan	162	165	PF01048	0.637
MOD_GlcNHglycan	185	188	PF01048	0.502
MOD_GlcNHglycan	193	196	PF01048	0.568
MOD_GlcNHglycan	206	209	PF01048	0.417
MOD_GlcNHglycan	273	276	PF01048	0.511
MOD_GlcNHglycan	279	282	PF01048	0.538
MOD_GlcNHglycan	291	294	PF01048	0.370
MOD_GlcNHglycan	375	378	PF01048	0.700
MOD_GlcNHglycan	510	513	PF01048	0.688
MOD_GlcNHglycan	554	557	PF01048	0.686
MOD_GlcNHglycan	560	563	PF01048	0.547
MOD_GlcNHglycan	58	61	PF01048	0.641
MOD_GlcNHglycan	622	625	PF01048	0.537
MOD_GlcNHglycan	638	641	PF01048	0.414
MOD_GlcNHglycan	762	765	PF01048	0.696
MOD_GlcNHglycan	902	905	PF01048	0.587
MOD_GlcNHglycan	937	941	PF01048	0.592
MOD_GSK3_1	100	107	PF00069	0.751
MOD_GSK3_1	13	20	PF00069	0.443
MOD_GSK3_1	238	245	PF00069	0.725
MOD_GSK3_1	248	255	PF00069	0.535
MOD_GSK3_1	257	264	PF00069	0.391
MOD_GSK3_1	282	289	PF00069	0.648
MOD_GSK3_1	293	300	PF00069	0.466
MOD_GSK3_1	303	310	PF00069	0.404
MOD_GSK3_1	349	356	PF00069	0.687
MOD_GSK3_1	373	380	PF00069	0.707
MOD_GSK3_1	52	59	PF00069	0.369
MOD_GSK3_1	539	546	PF00069	0.681
MOD_GSK3_1	729	736	PF00069	0.742
MOD_GSK3_1	747	754	PF00069	0.375
MOD_GSK3_1	772	779	PF00069	0.538
MOD_GSK3_1	854	861	PF00069	0.517
MOD_GSK3_1	876	883	PF00069	0.747
MOD_GSK3_1	932	939	PF00069	0.693
MOD_N-GLC_1	242	247	PF02516	0.688
MOD_N-GLC_1	474	479	PF02516	0.635
MOD_N-GLC_1	508	513	PF02516	0.665
MOD_N-GLC_1	520	525	PF02516	0.513
MOD_NEK2_1	1	6	PF00069	0.665
MOD_NEK2_1	220	225	PF00069	0.530
MOD_NEK2_1	282	287	PF00069	0.642
MOD_NEK2_1	297	302	PF00069	0.466
MOD_NEK2_1	307	312	PF00069	0.403
MOD_NEK2_1	436	441	PF00069	0.468
MOD_NEK2_1	543	548	PF00069	0.664
MOD_NEK2_1	56	61	PF00069	0.614
MOD_NEK2_1	580	585	PF00069	0.367
MOD_NEK2_1	751	756	PF00069	0.670
MOD_NEK2_1	827	832	PF00069	0.429
MOD_NEK2_1	900	905	PF00069	0.532
MOD_NEK2_2	464	469	PF00069	0.555
MOD_PIKK_1	14	20	PF00454	0.383
MOD_PIKK_1	38	44	PF00454	0.404
MOD_PIKK_1	733	739	PF00454	0.749
MOD_PK_1	717	723	PF00069	0.547
MOD_PKA_2	277	283	PF00069	0.589
MOD_PKA_2	52	58	PF00069	0.349
MOD_PKA_2	62	68	PF00069	0.650
MOD_PKA_2	631	637	PF00069	0.571
MOD_PKA_2	732	738	PF00069	0.729
MOD_PKA_2	854	860	PF00069	0.483
MOD_PKA_2	886	892	PF00069	0.687
MOD_PKA_2	898	904	PF00069	0.578
MOD_Plk_1	464	470	PF00069	0.566
MOD_Plk_1	474	480	PF00069	0.515
MOD_Plk_1	672	678	PF00069	0.554
MOD_Plk_2-3	679	685	PF00069	0.518
MOD_Plk_4	293	299	PF00069	0.503
MOD_Plk_4	303	309	PF00069	0.433
MOD_Plk_4	445	451	PF00069	0.472
MOD_ProDKin_1	137	143	PF00069	0.581
MOD_ProDKin_1	255	261	PF00069	0.625
MOD_ProDKin_1	379	385	PF00069	0.732
MOD_ProDKin_1	547	553	PF00069	0.718
MOD_ProDKin_1	589	595	PF00069	0.502
MOD_SUMO_rev_2	106	114	PF00179	0.688
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.562
TRG_ENDOCYTIC_2	182	185	PF00928	0.592
TRG_ENDOCYTIC_2	355	358	PF00928	0.693
TRG_ENDOCYTIC_2	437	440	PF00928	0.558
TRG_ENDOCYTIC_2	572	575	PF00928	0.452
TRG_ENDOCYTIC_2	606	609	PF00928	0.557
TRG_ENDOCYTIC_2	645	648	PF00928	0.354
TRG_ENDOCYTIC_2	653	656	PF00928	0.411
TRG_ENDOCYTIC_2	766	769	PF00928	0.639
TRG_ENDOCYTIC_2	933	936	PF00928	0.585
TRG_ER_diArg_1	526	528	PF00400	0.747
TRG_ER_diArg_1	629	632	PF00400	0.475
TRG_ER_diArg_1	668	670	PF00400	0.546
TRG_ER_diArg_1	864	867	PF00400	0.647
TRG_ER_diArg_1	950	952	PF00400	0.740
TRG_NLS_MonoCore_2	523	528	PF00514	0.782
TRG_NLS_MonoCore_2	915	920	PF00514	0.629
TRG_NLS_MonoExtC_3	62	67	PF00514	0.545
TRG_NLS_MonoExtC_3	709	714	PF00514	0.660
TRG_NLS_MonoExtN_4	522	529	PF00514	0.782
TRG_NLS_MonoExtN_4	708	714	PF00514	0.753
TRG_NLS_MonoExtN_4	88	95	PF00514	0.670
TRG_NLS_MonoExtN_4	914	921	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	668	673	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	919	923	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW4	Leptomonas seymouri	59%	100%
A0A1X0P9W0	Trypanosomatidae	40%	100%
A0A422NHM2	Trypanosoma rangeli	42%	100%
A4H3P6	Leishmania braziliensis	79%	99%
C9ZKH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E8NHC7	Leishmania infantum	100%	100%
E9ACM9	Leishmania major	93%	100%
E9AJW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BC86	Trypanosoma cruzi	41%	100%