Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJT2_LEIDO

TriTrypDb:

LdBPK_013370.1 , LdCL_030013400 , LDHU3_03.0910

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.397
CLV_NRD_NRD_1	141	143	PF00675	0.409
CLV_NRD_NRD_1	165	167	PF00675	0.411
CLV_NRD_NRD_1	79	81	PF00675	0.381
CLV_PCSK_KEX2_1	141	143	PF00082	0.532
CLV_PCSK_KEX2_1	165	167	PF00082	0.485
CLV_PCSK_KEX2_1	293	295	PF00082	0.517
CLV_PCSK_KEX2_1	79	81	PF00082	0.381
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.461
CLV_PCSK_SKI1_1	116	120	PF00082	0.365
CLV_PCSK_SKI1_1	127	131	PF00082	0.364
CLV_PCSK_SKI1_1	165	169	PF00082	0.408
CLV_PCSK_SKI1_1	244	248	PF00082	0.375
CLV_PCSK_SKI1_1	251	255	PF00082	0.316
CLV_PCSK_SKI1_1	390	394	PF00082	0.529
CLV_PCSK_SKI1_1	46	50	PF00082	0.368
CLV_PCSK_SKI1_1	68	72	PF00082	0.355
CLV_PCSK_SKI1_1	79	83	PF00082	0.404
CLV_PCSK_SKI1_1	95	99	PF00082	0.355
DEG_APCC_DBOX_1	126	134	PF00400	0.498
DEG_APCC_DBOX_1	45	53	PF00400	0.365
DEG_APCC_DBOX_1	78	86	PF00400	0.418
DEG_Kelch_Keap1_1	224	229	PF01344	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DEG_SPOP_SBC_1	184	188	PF00917	0.389
DEG_SPOP_SBC_1	24	28	PF00917	0.563
DOC_CYCLIN_RxL_1	125	134	PF00134	0.419
DOC_CYCLIN_RxL_1	160	171	PF00134	0.420
DOC_CYCLIN_RxL_1	241	252	PF00134	0.471
DOC_CYCLIN_RxL_1	92	100	PF00134	0.355
DOC_MAPK_gen_1	127	135	PF00069	0.512
DOC_MAPK_MEF2A_6	323	330	PF00069	0.501
DOC_USP7_MATH_1	174	178	PF00917	0.447
DOC_USP7_MATH_1	184	188	PF00917	0.453
DOC_USP7_MATH_1	24	28	PF00917	0.686
DOC_USP7_MATH_1	89	93	PF00917	0.469
DOC_WW_Pin1_4	185	190	PF00397	0.410
DOC_WW_Pin1_4	25	30	PF00397	0.695
DOC_WW_Pin1_4	277	282	PF00397	0.445
LIG_14-3-3_CanoR_1	173	183	PF00244	0.427
LIG_14-3-3_CanoR_1	56	65	PF00244	0.430
LIG_14-3-3_CanoR_1	6	12	PF00244	0.556
LIG_APCC_ABBA_1	129	134	PF00400	0.402
LIG_APCC_ABBA_1	347	352	PF00400	0.467
LIG_APCC_ABBAyCdc20_2	128	134	PF00400	0.398
LIG_BIR_III_4	252	256	PF00653	0.348
LIG_Clathr_ClatBox_1	130	134	PF01394	0.439
LIG_Clathr_ClatBox_1	246	250	PF01394	0.446
LIG_FAT_LD_1	239	247	PF03623	0.417
LIG_FHA_1	335	341	PF00498	0.390
LIG_FHA_1	85	91	PF00498	0.341
LIG_FHA_2	384	390	PF00498	0.482
LIG_GBD_Chelix_1	238	246	PF00786	0.426
LIG_Integrin_RGD_1	262	264	PF01839	0.501
LIG_LIR_Gen_1	100	110	PF02991	0.382
LIG_LIR_Gen_1	154	164	PF02991	0.517
LIG_LIR_Gen_1	177	185	PF02991	0.469
LIG_LIR_Gen_1	283	292	PF02991	0.433
LIG_LIR_Nem_3	154	159	PF02991	0.478
LIG_LIR_Nem_3	177	182	PF02991	0.539
LIG_LIR_Nem_3	252	257	PF02991	0.370
LIG_LIR_Nem_3	386	391	PF02991	0.556
LIG_PCNA_PIPBox_1	112	121	PF02747	0.391
LIG_Pex14_1	388	392	PF04695	0.463
LIG_PTB_Apo_2	381	388	PF02174	0.468
LIG_SH2_CRK	179	183	PF00017	0.392
LIG_SH2_SRC	190	193	PF00017	0.374
LIG_SH2_SRC	351	354	PF00017	0.480
LIG_SH2_STAP1	179	183	PF00017	0.370
LIG_SH2_STAT5	190	193	PF00017	0.478
LIG_SH2_STAT5	391	394	PF00017	0.567
LIG_SH2_STAT5	66	69	PF00017	0.435
LIG_SH3_1	323	329	PF00018	0.515
LIG_SH3_3	186	192	PF00018	0.523
LIG_SH3_3	323	329	PF00018	0.538
LIG_SH3_3	85	91	PF00018	0.350
LIG_SUMO_SIM_anti_2	245	250	PF11976	0.450
LIG_SUMO_SIM_par_1	245	250	PF11976	0.386
LIG_TRAF2_1	363	366	PF00917	0.478
LIG_UBA3_1	129	137	PF00899	0.425
LIG_UBA3_1	7	15	PF00899	0.478
MOD_CDK_SPK_2	277	282	PF00069	0.408
MOD_CK1_1	27	33	PF00069	0.679
MOD_CK2_1	359	365	PF00069	0.499
MOD_CK2_1	383	389	PF00069	0.460
MOD_GlcNHglycan	29	32	PF01048	0.638
MOD_GlcNHglycan	59	62	PF01048	0.518
MOD_GSK3_1	196	203	PF00069	0.454
MOD_GSK3_1	23	30	PF00069	0.606
MOD_GSK3_1	330	337	PF00069	0.415
MOD_GSK3_1	57	64	PF00069	0.568
MOD_N-GLC_1	383	388	PF02516	0.575
MOD_NEK2_1	133	138	PF00069	0.465
MOD_NEK2_1	183	188	PF00069	0.433
MOD_NEK2_1	268	273	PF00069	0.493
MOD_NEK2_1	330	335	PF00069	0.410
MOD_NEK2_1	380	385	PF00069	0.617
MOD_NEK2_1	7	12	PF00069	0.569
MOD_PIKK_1	10	16	PF00454	0.485
MOD_PK_1	282	288	PF00069	0.469
MOD_Plk_1	383	389	PF00069	0.520
MOD_Plk_1	44	50	PF00069	0.481
MOD_Plk_4	330	336	PF00069	0.454
MOD_Plk_4	61	67	PF00069	0.421
MOD_ProDKin_1	185	191	PF00069	0.410
MOD_ProDKin_1	25	31	PF00069	0.697
MOD_ProDKin_1	277	283	PF00069	0.443
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.357
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.484
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.489
TRG_ENDOCYTIC_2	179	182	PF00928	0.348
TRG_ER_diArg_1	141	143	PF00400	0.515
TRG_ER_diArg_1	164	166	PF00400	0.422
TRG_ER_diArg_1	4	7	PF00400	0.578
TRG_ER_diArg_1	78	80	PF00400	0.384
TRG_Pf-PMV_PEXEL_1	104	109	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P542	Leptomonas seymouri	62%	100%
A0A0S4IVU1	Bodo saltans	39%	100%
A0A1X0P922	Trypanosomatidae	49%	100%
A4H3P5	Leishmania braziliensis	86%	99%
C9ZKH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E8NHC8	Leishmania infantum	100%	100%
E9ACM8	Leishmania major	94%	100%
E9AJW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5DTZ7	Trypanosoma cruzi	48%	99%