Serine/threonine-protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A451EJS7_LEIDO

TriTrypDb:

LdBPK_030760.1 , LdCL_030012800 , LDHU3_03.0850

Length:

3171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1009	1013	PF00656	0.457
CLV_C14_Caspase3-7	1315	1319	PF00656	0.492
CLV_C14_Caspase3-7	1428	1432	PF00656	0.601
CLV_C14_Caspase3-7	1864	1868	PF00656	0.455
CLV_C14_Caspase3-7	1979	1983	PF00656	0.523
CLV_C14_Caspase3-7	21	25	PF00656	0.600
CLV_C14_Caspase3-7	2105	2109	PF00656	0.602
CLV_C14_Caspase3-7	2387	2391	PF00656	0.628
CLV_C14_Caspase3-7	2396	2400	PF00656	0.559
CLV_C14_Caspase3-7	2479	2483	PF00656	0.531

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4H3N9	Leishmania braziliensis	52%	100%
E9ACM3	Leishmania major	86%	97%
E9AJW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	95%

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