TatD related DNase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TatD related DNase, putative

Species:

Leishmania donovani

UniProt:

A0A451EJS4_LEIDO

TriTrypDb:

LdBPK_030730.1 , LdCL_030012500 , LDHU3_03.0820

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A451EJS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJS4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0008297	single-stranded DNA exodeoxyribonuclease activity	7	1
GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	8	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.522
CLV_C14_Caspase3-7	402	406	PF00656	0.474
CLV_C14_Caspase3-7	412	416	PF00656	0.362
CLV_C14_Caspase3-7	598	602	PF00656	0.615
CLV_C14_Caspase3-7	614	618	PF00656	0.692
CLV_NRD_NRD_1	109	111	PF00675	0.277
CLV_NRD_NRD_1	121	123	PF00675	0.293
CLV_NRD_NRD_1	18	20	PF00675	0.650
CLV_NRD_NRD_1	556	558	PF00675	0.512
CLV_NRD_NRD_1	667	669	PF00675	0.611
CLV_PCSK_FUR_1	554	558	PF00082	0.572
CLV_PCSK_KEX2_1	121	123	PF00082	0.321
CLV_PCSK_KEX2_1	18	20	PF00082	0.699
CLV_PCSK_KEX2_1	514	516	PF00082	0.574
CLV_PCSK_KEX2_1	553	555	PF00082	0.472
CLV_PCSK_KEX2_1	556	558	PF00082	0.504
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.574
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.482
CLV_PCSK_SKI1_1	10	14	PF00082	0.658
CLV_PCSK_SKI1_1	166	170	PF00082	0.250
CLV_PCSK_SKI1_1	261	265	PF00082	0.308
CLV_PCSK_SKI1_1	295	299	PF00082	0.274
CLV_PCSK_SKI1_1	32	36	PF00082	0.675
CLV_PCSK_SKI1_1	561	565	PF00082	0.552
DEG_SPOP_SBC_1	606	610	PF00917	0.624
DOC_CKS1_1	38	43	PF01111	0.524
DOC_CKS1_1	431	436	PF01111	0.454
DOC_CKS1_1	463	468	PF01111	0.457
DOC_CYCLIN_yCln2_LP_2	393	396	PF00134	0.521
DOC_MAPK_gen_1	556	565	PF00069	0.466
DOC_MAPK_MEF2A_6	268	277	PF00069	0.508
DOC_MAPK_MEF2A_6	348	356	PF00069	0.593
DOC_PP1_RVXF_1	172	179	PF00149	0.521
DOC_PP2B_LxvP_1	393	396	PF13499	0.521
DOC_USP7_MATH_1	192	196	PF00917	0.503
DOC_USP7_MATH_1	316	320	PF00917	0.599
DOC_USP7_MATH_1	409	413	PF00917	0.454
DOC_USP7_MATH_1	581	585	PF00917	0.648
DOC_USP7_MATH_1	607	611	PF00917	0.657
DOC_USP7_MATH_1	613	617	PF00917	0.579
DOC_USP7_MATH_1	62	66	PF00917	0.505
DOC_USP7_UBL2_3	32	36	PF12436	0.657
DOC_USP7_UBL2_3	560	564	PF12436	0.556
DOC_WW_Pin1_4	194	199	PF00397	0.584
DOC_WW_Pin1_4	37	42	PF00397	0.602
DOC_WW_Pin1_4	43	48	PF00397	0.515
DOC_WW_Pin1_4	430	435	PF00397	0.458
DOC_WW_Pin1_4	462	467	PF00397	0.410
DOC_WW_Pin1_4	95	100	PF00397	0.480
LIG_14-3-3_CanoR_1	141	145	PF00244	0.605
LIG_14-3-3_CanoR_1	668	676	PF00244	0.685
LIG_BRCT_BRCA1_1	196	200	PF00533	0.379
LIG_BRCT_BRCA1_1	352	356	PF00533	0.414
LIG_eIF4E_1	257	263	PF01652	0.521
LIG_FHA_1	288	294	PF00498	0.595
LIG_FHA_1	470	476	PF00498	0.415
LIG_FHA_2	167	173	PF00498	0.455
LIG_FHA_2	456	462	PF00498	0.521
LIG_FHA_2	474	480	PF00498	0.506
LIG_FHA_2	596	602	PF00498	0.728
LIG_FHA_2	78	84	PF00498	0.478
LIG_GBD_Chelix_1	455	463	PF00786	0.295
LIG_LIR_Apic_2	37	41	PF02991	0.541
LIG_LIR_Gen_1	458	468	PF02991	0.481
LIG_LIR_Gen_1	569	579	PF02991	0.567
LIG_LIR_Nem_3	197	203	PF02991	0.463
LIG_LIR_Nem_3	353	359	PF02991	0.461
LIG_LIR_Nem_3	569	574	PF02991	0.553
LIG_LYPXL_SIV_4	99	107	PF13949	0.319
LIG_NRBOX	299	305	PF00104	0.509
LIG_NRBOX	419	425	PF00104	0.454
LIG_NRBOX	516	522	PF00104	0.504
LIG_Pex14_2	263	267	PF04695	0.541
LIG_PTB_Apo_2	573	580	PF02174	0.576
LIG_Rb_pABgroove_1	454	462	PF01858	0.491
LIG_SH2_CRK	206	210	PF00017	0.454
LIG_SH2_CRK	38	42	PF00017	0.546
LIG_SH2_CRK	452	456	PF00017	0.482
LIG_SH2_NCK_1	38	42	PF00017	0.546
LIG_SH2_SRC	100	103	PF00017	0.319
LIG_SH2_SRC	452	455	PF00017	0.505
LIG_SH2_STAP1	452	456	PF00017	0.509
LIG_SH2_STAT3	454	457	PF00017	0.509
LIG_SH2_STAT5	100	103	PF00017	0.380
LIG_SH2_STAT5	357	360	PF00017	0.439
LIG_SH2_STAT5	38	41	PF00017	0.538
LIG_SH2_STAT5	441	444	PF00017	0.507
LIG_SH2_STAT5	454	457	PF00017	0.443
LIG_SH3_1	21	27	PF00018	0.584
LIG_SH3_1	44	50	PF00018	0.410
LIG_SH3_3	21	27	PF00018	0.598
LIG_SH3_3	270	276	PF00018	0.513
LIG_SH3_3	349	355	PF00018	0.483
LIG_SH3_3	44	50	PF00018	0.433
LIG_SH3_3	443	449	PF00018	0.499
LIG_SH3_3	463	469	PF00018	0.362
LIG_TRAF2_1	123	126	PF00917	0.479
LIG_TRAF2_1	584	587	PF00917	0.647
LIG_TYR_ITIM	204	209	PF00017	0.505
LIG_WW_3	394	398	PF00397	0.514
MOD_CDK_SPxxK_3	37	44	PF00069	0.521
MOD_CK1_1	383	389	PF00069	0.531
MOD_CK1_1	569	575	PF00069	0.556
MOD_CK1_1	608	614	PF00069	0.742
MOD_CK1_1	700	706	PF00069	0.759
MOD_CK1_1	77	83	PF00069	0.462
MOD_CK2_1	285	291	PF00069	0.509
MOD_CK2_1	370	376	PF00069	0.534
MOD_CK2_1	552	558	PF00069	0.567
MOD_CK2_1	581	587	PF00069	0.670
MOD_CK2_1	77	83	PF00069	0.521
MOD_GlcNHglycan	166	169	PF01048	0.340
MOD_GlcNHglycan	307	310	PF01048	0.333
MOD_GlcNHglycan	318	321	PF01048	0.386
MOD_GlcNHglycan	32	35	PF01048	0.624
MOD_GlcNHglycan	382	385	PF01048	0.324
MOD_GlcNHglycan	405	408	PF01048	0.335
MOD_GlcNHglycan	411	414	PF01048	0.186
MOD_GlcNHglycan	479	483	PF01048	0.381
MOD_GlcNHglycan	610	613	PF01048	0.663
MOD_GlcNHglycan	619	622	PF01048	0.611
MOD_GlcNHglycan	64	67	PF01048	0.428
MOD_GlcNHglycan	672	675	PF01048	0.734
MOD_GlcNHglycan	677	680	PF01048	0.793
MOD_GSK3_1	13	20	PF00069	0.613
MOD_GSK3_1	140	147	PF00069	0.531
MOD_GSK3_1	186	193	PF00069	0.566
MOD_GSK3_1	26	33	PF00069	0.623
MOD_GSK3_1	285	292	PF00069	0.521
MOD_GSK3_1	36	43	PF00069	0.580
MOD_GSK3_1	399	406	PF00069	0.517
MOD_GSK3_1	469	476	PF00069	0.424
MOD_GSK3_1	607	614	PF00069	0.637
MOD_GSK3_1	71	78	PF00069	0.671
MOD_N-GLC_1	247	252	PF02516	0.328
MOD_N-GLC_1	30	35	PF02516	0.652
MOD_N-GLC_1	566	571	PF02516	0.544
MOD_NEK2_1	144	149	PF00069	0.541
MOD_NEK2_1	17	22	PF00069	0.587
MOD_NEK2_1	289	294	PF00069	0.521
MOD_NEK2_1	304	309	PF00069	0.521
MOD_NEK2_1	330	335	PF00069	0.479
MOD_NEK2_1	424	429	PF00069	0.479
MOD_NEK2_1	664	669	PF00069	0.635
MOD_NEK2_1	71	76	PF00069	0.676
MOD_PIKK_1	418	424	PF00454	0.454
MOD_PKA_2	140	146	PF00069	0.605
MOD_PKA_2	156	162	PF00069	0.391
MOD_PKA_2	17	23	PF00069	0.615
MOD_PKA_2	347	353	PF00069	0.414
MOD_PKA_2	581	587	PF00069	0.648
MOD_PKB_1	603	611	PF00069	0.614
MOD_Plk_1	473	479	PF00069	0.500
MOD_Plk_1	569	575	PF00069	0.556
MOD_Plk_2-3	285	291	PF00069	0.521
MOD_Plk_4	140	146	PF00069	0.576
MOD_Plk_4	455	461	PF00069	0.518
MOD_ProDKin_1	194	200	PF00069	0.584
MOD_ProDKin_1	37	43	PF00069	0.603
MOD_ProDKin_1	430	436	PF00069	0.458
MOD_ProDKin_1	45	51	PF00069	0.483
MOD_ProDKin_1	462	468	PF00069	0.410
MOD_ProDKin_1	95	101	PF00069	0.470
MOD_SUMO_for_1	368	371	PF00179	0.474
MOD_SUMO_rev_2	125	130	PF00179	0.509
MOD_SUMO_rev_2	5	15	PF00179	0.623
MOD_SUMO_rev_2	672	678	PF00179	0.618
TRG_DiLeu_BaEn_1	140	145	PF01217	0.509
TRG_DiLeu_BaLyEn_6	630	635	PF01217	0.539
TRG_ENDOCYTIC_2	206	209	PF00928	0.454
TRG_ENDOCYTIC_2	452	455	PF00928	0.468
TRG_ENDOCYTIC_2	460	463	PF00928	0.457
TRG_ER_diArg_1	120	122	PF00400	0.521
TRG_ER_diArg_1	17	19	PF00400	0.694
TRG_ER_diArg_1	554	557	PF00400	0.497
TRG_ER_FFAT_2	33	43	PF00635	0.552
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E3	Leptomonas seymouri	56%	89%
A0A1X0P9U8	Trypanosomatidae	31%	90%
A4H3N6	Leishmania braziliensis	67%	100%
A4HRW3	Leishmania infantum	99%	100%
C9ZKG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	98%
E9ACM0	Leishmania major	86%	100%
E9AJV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	97%