Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJS2_LEIDO

TriTrypDb:

LdBPK_030710.1 , LdCL_030012300 , LDHU3_03.0800

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.518
CLV_NRD_NRD_1	156	158	PF00675	0.608
CLV_NRD_NRD_1	219	221	PF00675	0.470
CLV_NRD_NRD_1	302	304	PF00675	0.600
CLV_NRD_NRD_1	96	98	PF00675	0.569
CLV_PCSK_FUR_1	300	304	PF00082	0.606
CLV_PCSK_KEX2_1	158	160	PF00082	0.595
CLV_PCSK_KEX2_1	25	27	PF00082	0.624
CLV_PCSK_KEX2_1	302	304	PF00082	0.600
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.580
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.691
CLV_PCSK_SKI1_1	158	162	PF00082	0.565
CLV_PCSK_SKI1_1	289	293	PF00082	0.646
CLV_PCSK_SKI1_1	29	33	PF00082	0.667
CLV_PCSK_SKI1_1	392	396	PF00082	0.579
CLV_Separin_Metazoa	128	132	PF03568	0.545
DEG_APCC_DBOX_1	156	164	PF00400	0.597
DEG_APCC_DBOX_1	219	227	PF00400	0.523
DOC_CKS1_1	395	400	PF01111	0.600
DOC_MAPK_gen_1	220	228	PF00069	0.568
DOC_MAPK_MEF2A_6	203	212	PF00069	0.429
DOC_MAPK_NFAT4_5	209	217	PF00069	0.367
DOC_MAPK_RevD_3	206	221	PF00069	0.486
DOC_PP2B_LxvP_1	139	142	PF13499	0.653
DOC_PP4_FxxP_1	373	376	PF00568	0.522
DOC_USP7_MATH_1	177	181	PF00917	0.662
DOC_USP7_MATH_1	18	22	PF00917	0.596
DOC_USP7_MATH_1	227	231	PF00917	0.478
DOC_USP7_MATH_1	345	349	PF00917	0.705
DOC_USP7_MATH_1	354	358	PF00917	0.635
DOC_USP7_MATH_1	4	8	PF00917	0.621
DOC_USP7_MATH_1	52	56	PF00917	0.649
DOC_USP7_MATH_1	70	74	PF00917	0.469
DOC_USP7_UBL2_3	154	158	PF12436	0.584
DOC_USP7_UBL2_3	37	41	PF12436	0.669
DOC_USP7_UBL2_3	94	98	PF12436	0.465
DOC_WW_Pin1_4	290	295	PF00397	0.572
DOC_WW_Pin1_4	350	355	PF00397	0.695
DOC_WW_Pin1_4	394	399	PF00397	0.585
DOC_WW_Pin1_4	45	50	PF00397	0.665
DOC_WW_Pin1_4	66	71	PF00397	0.418
LIG_14-3-3_CanoR_1	203	210	PF00244	0.550
LIG_14-3-3_CanoR_1	220	224	PF00244	0.382
LIG_14-3-3_CanoR_1	289	294	PF00244	0.687
LIG_14-3-3_CanoR_1	29	34	PF00244	0.671
LIG_Actin_WH2_1	209	226	PF00022	0.436
LIG_Actin_WH2_2	210	226	PF00022	0.437
LIG_APCC_ABBA_1	56	61	PF00400	0.547
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_1	1	5	PF00653	0.586
LIG_BIR_III_2	349	353	PF00653	0.540
LIG_BIR_III_3	1	5	PF00653	0.586
LIG_BRCT_BRCA1_1	112	116	PF00533	0.531
LIG_BRCT_BRCA1_1	52	56	PF00533	0.528
LIG_deltaCOP1_diTrp_1	169	174	PF00928	0.537
LIG_FHA_1	223	229	PF00498	0.555
LIG_FHA_1	26	32	PF00498	0.537
LIG_FHA_1	275	281	PF00498	0.539
LIG_FHA_2	119	125	PF00498	0.460
LIG_LIR_Apic_2	173	177	PF02991	0.581
LIG_LIR_Apic_2	370	376	PF02991	0.522
LIG_LIR_Gen_1	237	248	PF02991	0.466
LIG_LIR_Gen_1	53	63	PF02991	0.553
LIG_LIR_Nem_3	237	243	PF02991	0.503
LIG_LIR_Nem_3	53	59	PF02991	0.509
LIG_SH2_CRK	240	244	PF00017	0.505
LIG_SH2_PTP2	377	380	PF00017	0.557
LIG_SH2_SRC	110	113	PF00017	0.443
LIG_SH2_STAP1	80	84	PF00017	0.423
LIG_SH2_STAT3	238	241	PF00017	0.435
LIG_SH2_STAT5	238	241	PF00017	0.435
LIG_SH2_STAT5	377	380	PF00017	0.589
LIG_SH2_STAT5	80	83	PF00017	0.438
LIG_SH3_3	240	246	PF00018	0.507
LIG_SH3_3	281	287	PF00018	0.525
LIG_SH3_3	375	381	PF00018	0.646
LIG_SH3_3	44	50	PF00018	0.688
LIG_TRAF2_1	121	124	PF00917	0.520
LIG_TRAF2_1	309	312	PF00917	0.490
MOD_CDC14_SPxK_1	353	356	PF00782	0.523
MOD_CDK_SPxK_1	350	356	PF00069	0.532
MOD_CDK_SPxK_1	394	400	PF00069	0.567
MOD_CK1_1	119	125	PF00069	0.569
MOD_CK1_1	152	158	PF00069	0.645
MOD_CK1_1	219	225	PF00069	0.488
MOD_CK1_1	48	54	PF00069	0.626
MOD_CK1_1	6	12	PF00069	0.609
MOD_CK1_1	83	89	PF00069	0.511
MOD_CK2_1	118	124	PF00069	0.545
MOD_CMANNOS	171	174	PF00535	0.535
MOD_Cter_Amidation	23	26	PF01082	0.599
MOD_GlcNHglycan	133	136	PF01048	0.560
MOD_GlcNHglycan	151	154	PF01048	0.605
MOD_GlcNHglycan	199	202	PF01048	0.531
MOD_GlcNHglycan	20	23	PF01048	0.655
MOD_GlcNHglycan	204	207	PF01048	0.415
MOD_GlcNHglycan	246	249	PF01048	0.566
MOD_GlcNHglycan	327	330	PF01048	0.587
MOD_GlcNHglycan	33	36	PF01048	0.656
MOD_GlcNHglycan	337	340	PF01048	0.597
MOD_GlcNHglycan	43	46	PF01048	0.615
MOD_GlcNHglycan	6	9	PF01048	0.641
MOD_GSK3_1	14	21	PF00069	0.767
MOD_GSK3_1	148	155	PF00069	0.603
MOD_GSK3_1	246	253	PF00069	0.579
MOD_GSK3_1	25	32	PF00069	0.660
MOD_GSK3_1	270	277	PF00069	0.455
MOD_GSK3_1	325	332	PF00069	0.619
MOD_GSK3_1	350	357	PF00069	0.705
MOD_GSK3_1	37	44	PF00069	0.657
MOD_GSK3_1	48	55	PF00069	0.589
MOD_GSK3_1	66	73	PF00069	0.548
MOD_GSK3_1	80	87	PF00069	0.387
MOD_N-GLC_1	18	23	PF02516	0.597
MOD_N-GLC_1	323	328	PF02516	0.595
MOD_NEK2_1	116	121	PF00069	0.637
MOD_NEK2_1	14	19	PF00069	0.662
MOD_NEK2_1	167	172	PF00069	0.403
MOD_NEK2_1	358	363	PF00069	0.527
MOD_PIKK_1	246	252	PF00454	0.669
MOD_PIKK_1	329	335	PF00454	0.582
MOD_PIKK_1	358	364	PF00454	0.472
MOD_PKA_1	158	164	PF00069	0.677
MOD_PKA_1	25	31	PF00069	0.647
MOD_PKA_2	158	164	PF00069	0.575
MOD_PKA_2	167	173	PF00069	0.390
MOD_PKA_2	202	208	PF00069	0.468
MOD_PKA_2	219	225	PF00069	0.457
MOD_PKA_2	244	250	PF00069	0.567
MOD_PKA_2	25	31	PF00069	0.647
MOD_Plk_1	275	281	PF00069	0.474
MOD_Plk_1	323	329	PF00069	0.547
MOD_Plk_1	388	394	PF00069	0.628
MOD_Plk_1	70	76	PF00069	0.570
MOD_Plk_4	275	281	PF00069	0.482
MOD_Plk_4	70	76	PF00069	0.479
MOD_Plk_4	80	86	PF00069	0.466
MOD_Plk_4	9	15	PF00069	0.630
MOD_ProDKin_1	290	296	PF00069	0.573
MOD_ProDKin_1	350	356	PF00069	0.694
MOD_ProDKin_1	394	400	PF00069	0.591
MOD_ProDKin_1	45	51	PF00069	0.662
MOD_ProDKin_1	66	72	PF00069	0.454
MOD_SUMO_for_1	93	96	PF00179	0.396
MOD_SUMO_rev_2	152	160	PF00179	0.568
MOD_SUMO_rev_2	190	200	PF00179	0.476
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.533
TRG_ENDOCYTIC_2	240	243	PF00928	0.531
TRG_ENDOCYTIC_2	288	291	PF00928	0.594
TRG_ENDOCYTIC_2	366	369	PF00928	0.649
TRG_ENDOCYTIC_2	377	380	PF00928	0.518
TRG_ER_diArg_1	157	160	PF00400	0.607
TRG_ER_diArg_1	228	231	PF00400	0.540
TRG_ER_diArg_1	299	302	PF00400	0.589
TRG_NES_CRM1_1	260	274	PF08389	0.479
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW0	Leptomonas seymouri	42%	84%
A0A3R7KL86	Trypanosoma rangeli	24%	100%
A4H3N4	Leishmania braziliensis	63%	100%
A4HRW1	Leishmania infantum	100%	100%
C9ZKG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ACL8	Leishmania major	91%	99%
E9AJV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%