Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJR6_LEIDO

TriTrypDb:

LdBPK_030640.1 , LdCL_030011500 , LDHU3_03.0680

Length:

798

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A451EJR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.704
CLV_C14_Caspase3-7	555	559	PF00656	0.748
CLV_C14_Caspase3-7	677	681	PF00656	0.358
CLV_NRD_NRD_1	101	103	PF00675	0.541
CLV_NRD_NRD_1	359	361	PF00675	0.383
CLV_PCSK_KEX2_1	101	103	PF00082	0.539
CLV_PCSK_KEX2_1	359	361	PF00082	0.383
CLV_PCSK_SKI1_1	113	117	PF00082	0.499
CLV_PCSK_SKI1_1	230	234	PF00082	0.303
CLV_PCSK_SKI1_1	352	356	PF00082	0.474
CLV_PCSK_SKI1_1	435	439	PF00082	0.373
CLV_PCSK_SKI1_1	519	523	PF00082	0.514
CLV_PCSK_SKI1_1	673	677	PF00082	0.587
DEG_SCF_FBW7_1	456	461	PF00400	0.680
DEG_SCF_FBW7_2	135	142	PF00400	0.687
DEG_SPOP_SBC_1	86	90	PF00917	0.624
DOC_CYCLIN_RxL_1	110	121	PF00134	0.688
DOC_CYCLIN_yCln2_LP_2	403	409	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	716	722	PF00134	0.525
DOC_MAPK_DCC_7	178	187	PF00069	0.621
DOC_MAPK_gen_1	359	366	PF00069	0.585
DOC_MAPK_gen_1	6	14	PF00069	0.716
DOC_MAPK_HePTP_8	4	16	PF00069	0.717
DOC_MAPK_MEF2A_6	230	239	PF00069	0.503
DOC_MAPK_MEF2A_6	395	402	PF00069	0.346
DOC_MAPK_MEF2A_6	7	16	PF00069	0.722
DOC_PP1_RVXF_1	228	235	PF00149	0.503
DOC_PP2B_LxvP_1	403	406	PF13499	0.525
DOC_PP4_FxxP_1	103	106	PF00568	0.665
DOC_PP4_FxxP_1	122	125	PF00568	0.692
DOC_PP4_FxxP_1	272	275	PF00568	0.405
DOC_USP7_MATH_1	106	110	PF00917	0.711
DOC_USP7_MATH_1	165	169	PF00917	0.674
DOC_USP7_MATH_1	172	176	PF00917	0.642
DOC_USP7_MATH_1	318	322	PF00917	0.525
DOC_USP7_MATH_1	41	45	PF00917	0.798
DOC_USP7_MATH_1	458	462	PF00917	0.734
DOC_USP7_MATH_1	486	490	PF00917	0.674
DOC_USP7_MATH_1	551	555	PF00917	0.775
DOC_USP7_MATH_1	576	580	PF00917	0.773
DOC_USP7_MATH_1	58	62	PF00917	0.692
DOC_USP7_MATH_1	708	712	PF00917	0.405
DOC_USP7_UBL2_3	226	230	PF12436	0.509
DOC_WW_Pin1_4	121	126	PF00397	0.705
DOC_WW_Pin1_4	135	140	PF00397	0.658
DOC_WW_Pin1_4	180	185	PF00397	0.688
DOC_WW_Pin1_4	262	267	PF00397	0.431
DOC_WW_Pin1_4	454	459	PF00397	0.749
DOC_WW_Pin1_4	474	479	PF00397	0.605
DOC_WW_Pin1_4	569	574	PF00397	0.747
DOC_WW_Pin1_4	715	720	PF00397	0.405
DOC_WW_Pin1_4	736	741	PF00397	0.516
DOC_WW_Pin1_4	90	95	PF00397	0.706
LIG_14-3-3_CanoR_1	101	106	PF00244	0.696
LIG_14-3-3_CanoR_1	118	123	PF00244	0.750
LIG_14-3-3_CanoR_1	151	159	PF00244	0.715
LIG_14-3-3_CanoR_1	208	213	PF00244	0.573
LIG_14-3-3_CanoR_1	784	791	PF00244	0.689
LIG_Actin_WH2_2	103	120	PF00022	0.641
LIG_Actin_WH2_2	586	602	PF00022	0.695
LIG_AP2alpha_1	315	319	PF02296	0.356
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BIR_III_2	650	654	PF00653	0.482
LIG_BIR_III_4	540	544	PF00653	0.746
LIG_BRCT_BRCA1_1	296	300	PF00533	0.587
LIG_BRCT_BRCA1_1	403	407	PF00533	0.405
LIG_BRCT_BRCA1_1	460	464	PF00533	0.726
LIG_deltaCOP1_diTrp_1	393	402	PF00928	0.346
LIG_eIF4E_1	493	499	PF01652	0.745
LIG_FHA_1	207	213	PF00498	0.570
LIG_FHA_1	329	335	PF00498	0.479
LIG_FHA_1	576	582	PF00498	0.696
LIG_FHA_1	641	647	PF00498	0.405
LIG_FHA_1	77	83	PF00498	0.725
LIG_FHA_2	159	165	PF00498	0.740
LIG_FHA_2	17	23	PF00498	0.743
LIG_FHA_2	436	442	PF00498	0.624
LIG_FHA_2	675	681	PF00498	0.389
LIG_FHA_2	763	769	PF00498	0.645
LIG_LIR_Apic_2	120	125	PF02991	0.694
LIG_LIR_Apic_2	270	275	PF02991	0.346
LIG_LIR_Apic_2	595	601	PF02991	0.698
LIG_LIR_Gen_1	197	206	PF02991	0.609
LIG_LIR_Gen_1	358	369	PF02991	0.550
LIG_LIR_Gen_1	416	426	PF02991	0.565
LIG_LIR_Nem_3	197	201	PF02991	0.619
LIG_LIR_Nem_3	228	232	PF02991	0.539
LIG_LIR_Nem_3	358	364	PF02991	0.602
LIG_LIR_Nem_3	381	386	PF02991	0.512
LIG_LIR_Nem_3	393	399	PF02991	0.346
LIG_LIR_Nem_3	404	410	PF02991	0.292
LIG_LIR_Nem_3	416	421	PF02991	0.467
LIG_NRBOX	281	287	PF00104	0.405
LIG_PCNA_PIPBox_1	249	258	PF02747	0.446
LIG_Pex14_1	256	260	PF04695	0.463
LIG_Pex14_1	322	326	PF04695	0.435
LIG_Pex14_1	397	401	PF04695	0.525
LIG_Pex14_1	414	418	PF04695	0.447
LIG_Pex14_2	279	283	PF04695	0.525
LIG_Pex14_2	315	319	PF04695	0.386
LIG_Pex14_2	349	353	PF04695	0.405
LIG_Pex14_2	682	686	PF04695	0.405
LIG_REV1ctd_RIR_1	462	470	PF16727	0.680
LIG_SH2_CRK	361	365	PF00017	0.540
LIG_SH2_CRK	383	387	PF00017	0.473
LIG_SH2_CRK	418	422	PF00017	0.553
LIG_SH2_CRK	684	688	PF00017	0.525
LIG_SH2_CRK	743	747	PF00017	0.320
LIG_SH2_GRB2like	361	364	PF00017	0.654
LIG_SH2_GRB2like	701	704	PF00017	0.554
LIG_SH2_GRB2like	742	745	PF00017	0.329
LIG_SH2_NCK_1	361	365	PF00017	0.540
LIG_SH2_NCK_1	743	747	PF00017	0.320
LIG_SH2_PTP2	198	201	PF00017	0.585
LIG_SH2_SRC	361	364	PF00017	0.654
LIG_SH2_SRC	701	704	PF00017	0.434
LIG_SH2_STAP1	269	273	PF00017	0.432
LIG_SH2_STAP1	290	294	PF00017	0.334
LIG_SH2_STAP1	326	330	PF00017	0.372
LIG_SH2_STAP1	346	350	PF00017	0.320
LIG_SH2_STAP1	361	365	PF00017	0.457
LIG_SH2_STAP1	705	709	PF00017	0.632
LIG_SH2_STAP1	774	778	PF00017	0.588
LIG_SH2_STAT5	198	201	PF00017	0.619
LIG_SH2_STAT5	269	272	PF00017	0.431
LIG_SH2_STAT5	290	293	PF00017	0.461
LIG_SH2_STAT5	330	333	PF00017	0.390
LIG_SH2_STAT5	365	368	PF00017	0.525
LIG_SH2_STAT5	422	425	PF00017	0.656
LIG_SH2_STAT5	598	601	PF00017	0.705
LIG_SH2_STAT5	684	687	PF00017	0.525
LIG_SH2_STAT5	688	691	PF00017	0.460
LIG_SH2_STAT5	696	699	PF00017	0.330
LIG_SH2_STAT5	701	704	PF00017	0.277
LIG_SH2_STAT5	758	761	PF00017	0.410
LIG_SH3_1	178	184	PF00018	0.639
LIG_SH3_3	178	184	PF00018	0.699
LIG_SH3_3	209	215	PF00018	0.627
LIG_SH3_3	469	475	PF00018	0.685
LIG_SH3_3	570	576	PF00018	0.760
LIG_SH3_3	604	610	PF00018	0.708
LIG_SH3_3	723	729	PF00018	0.405
LIG_SUMO_SIM_anti_2	197	204	PF11976	0.582
LIG_SUMO_SIM_anti_2	721	727	PF11976	0.525
LIG_SUMO_SIM_par_1	124	130	PF11976	0.655
LIG_SUMO_SIM_par_1	477	482	PF11976	0.680
LIG_SUMO_SIM_par_1	724	730	PF11976	0.405
LIG_TRAF2_1	34	37	PF00917	0.739
LIG_TRAF2_1	438	441	PF00917	0.574
LIG_WW_2	607	610	PF00397	0.663
MOD_CK1_1	121	127	PF00069	0.729
MOD_CK1_1	183	189	PF00069	0.635
MOD_CK1_1	204	210	PF00069	0.671
MOD_CK1_1	259	265	PF00069	0.442
MOD_CK1_1	329	335	PF00069	0.392
MOD_CK1_1	44	50	PF00069	0.836
MOD_CK1_1	554	560	PF00069	0.741
MOD_CK1_1	711	717	PF00069	0.525
MOD_CK1_1	718	724	PF00069	0.411
MOD_CK1_1	76	82	PF00069	0.792
MOD_CK2_1	31	37	PF00069	0.725
MOD_CK2_1	435	441	PF00069	0.597
MOD_CK2_1	569	575	PF00069	0.723
MOD_CK2_1	588	594	PF00069	0.584
MOD_CK2_1	762	768	PF00069	0.645
MOD_CK2_1	783	789	PF00069	0.730
MOD_GlcNHglycan	446	449	PF01048	0.496
MOD_GlcNHglycan	47	50	PF01048	0.567
MOD_GlcNHglycan	590	593	PF01048	0.495
MOD_GlcNHglycan	60	63	PF01048	0.516
MOD_GlcNHglycan	661	664	PF01048	0.592
MOD_GlcNHglycan	705	708	PF01048	0.427
MOD_GSK3_1	117	124	PF00069	0.735
MOD_GSK3_1	150	157	PF00069	0.678
MOD_GSK3_1	197	204	PF00069	0.627
MOD_GSK3_1	318	325	PF00069	0.405
MOD_GSK3_1	41	48	PF00069	0.836
MOD_GSK3_1	450	457	PF00069	0.705
MOD_GSK3_1	550	557	PF00069	0.714
MOD_GSK3_1	655	662	PF00069	0.402
MOD_GSK3_1	711	718	PF00069	0.507
MOD_GSK3_1	86	93	PF00069	0.685
MOD_N-GLC_1	267	272	PF02516	0.571
MOD_N-GLC_1	76	81	PF02516	0.556
MOD_N-GLC_2	341	343	PF02516	0.405
MOD_NEK2_1	117	122	PF00069	0.704
MOD_NEK2_1	126	131	PF00069	0.708
MOD_NEK2_1	201	206	PF00069	0.680
MOD_NEK2_1	355	360	PF00069	0.596
MOD_NEK2_1	370	375	PF00069	0.359
MOD_NEK2_1	378	383	PF00069	0.407
MOD_NEK2_1	401	406	PF00069	0.525
MOD_NEK2_1	640	645	PF00069	0.435
MOD_NEK2_1	686	691	PF00069	0.519
MOD_NEK2_1	692	697	PF00069	0.433
MOD_NEK2_1	96	101	PF00069	0.718
MOD_NEK2_2	225	230	PF00069	0.512
MOD_NEK2_2	365	370	PF00069	0.447
MOD_NEK2_2	610	615	PF00069	0.669
MOD_NEK2_2	674	679	PF00069	0.401
MOD_PIKK_1	158	164	PF00454	0.730
MOD_PIKK_1	608	614	PF00454	0.661
MOD_PIKK_1	711	717	PF00454	0.525
MOD_PK_1	208	214	PF00069	0.620
MOD_PK_1	530	536	PF00069	0.730
MOD_PKA_1	101	107	PF00069	0.698
MOD_PKA_2	101	107	PF00069	0.698
MOD_PKA_2	117	123	PF00069	0.729
MOD_PKA_2	150	156	PF00069	0.749
MOD_PKA_2	294	300	PF00069	0.663
MOD_PKA_2	41	47	PF00069	0.801
MOD_PKA_2	450	456	PF00069	0.667
MOD_PKA_2	599	605	PF00069	0.700
MOD_PKA_2	783	789	PF00069	0.672
MOD_PKB_1	433	441	PF00069	0.616
MOD_PKB_1	782	790	PF00069	0.637
MOD_Plk_1	267	273	PF00069	0.368
MOD_Plk_1	42	48	PF00069	0.733
MOD_Plk_1	622	628	PF00069	0.658
MOD_Plk_1	76	82	PF00069	0.723
MOD_Plk_2-3	762	768	PF00069	0.679
MOD_Plk_4	197	203	PF00069	0.645
MOD_Plk_4	208	214	PF00069	0.589
MOD_Plk_4	318	324	PF00069	0.405
MOD_Plk_4	365	371	PF00069	0.519
MOD_Plk_4	378	384	PF00069	0.320
MOD_Plk_4	413	419	PF00069	0.491
MOD_Plk_4	460	466	PF00069	0.728
MOD_Plk_4	576	582	PF00069	0.694
MOD_Plk_4	610	616	PF00069	0.676
MOD_Plk_4	622	628	PF00069	0.514
MOD_Plk_4	633	639	PF00069	0.292
MOD_Plk_4	708	714	PF00069	0.525
MOD_Plk_4	76	82	PF00069	0.757
MOD_ProDKin_1	121	127	PF00069	0.705
MOD_ProDKin_1	135	141	PF00069	0.658
MOD_ProDKin_1	180	186	PF00069	0.687
MOD_ProDKin_1	262	268	PF00069	0.426
MOD_ProDKin_1	454	460	PF00069	0.751
MOD_ProDKin_1	474	480	PF00069	0.607
MOD_ProDKin_1	569	575	PF00069	0.748
MOD_ProDKin_1	715	721	PF00069	0.405
MOD_ProDKin_1	736	742	PF00069	0.513
MOD_ProDKin_1	90	96	PF00069	0.709
MOD_SUMO_rev_2	762	770	PF00179	0.654
MOD_SUMO_rev_2	773	778	PF00179	0.571
TRG_ENDOCYTIC_2	198	201	PF00928	0.619
TRG_ENDOCYTIC_2	269	272	PF00928	0.449
TRG_ENDOCYTIC_2	290	293	PF00928	0.461
TRG_ENDOCYTIC_2	346	349	PF00928	0.514
TRG_ENDOCYTIC_2	361	364	PF00928	0.519
TRG_ENDOCYTIC_2	383	386	PF00928	0.483
TRG_ENDOCYTIC_2	418	421	PF00928	0.554
TRG_ENDOCYTIC_2	684	687	PF00928	0.503
TRG_ENDOCYTIC_2	742	745	PF00928	0.432
TRG_ER_diArg_1	100	102	PF00400	0.732
TRG_ER_diArg_1	359	361	PF00400	0.548
TRG_ER_diArg_1	432	435	PF00400	0.602
TRG_ER_diArg_1	781	784	PF00400	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3M7	Leishmania braziliensis	72%	100%
E9ACL1	Leishmania major	88%	95%
E9AG55	Leishmania infantum	99%	100%
E9AJU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%