LeishMANIAdb
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EamA domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
EamA domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania donovani
UniProt:
A0A451EJR5_LEIDO
TriTrypDb:
LdBPK_030630.1 * , LdCL_030011400 , LDHU3_03.0670
Length:
889

Annotations

LeishMANIAdb annotations

This highly expanded family of Kinetoplastid transporters is likely responsible for the uptake of critical nutrients. Might be a thiamine transporter if relate to human SLC35F proteins.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A0A451EJR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJR5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 213 217 PF00656 0.805
CLV_C14_Caspase3-7 598 602 PF00656 0.668
CLV_C14_Caspase3-7 629 633 PF00656 0.606
CLV_C14_Caspase3-7 876 880 PF00656 0.707
CLV_C14_Caspase3-7 93 97 PF00656 0.680
CLV_NRD_NRD_1 107 109 PF00675 0.504
CLV_NRD_NRD_1 295 297 PF00675 0.348
CLV_NRD_NRD_1 393 395 PF00675 0.321
CLV_NRD_NRD_1 526 528 PF00675 0.484
CLV_NRD_NRD_1 70 72 PF00675 0.508
CLV_NRD_NRD_1 859 861 PF00675 0.503
CLV_NRD_NRD_1 864 866 PF00675 0.495
CLV_PCSK_FUR_1 857 861 PF00082 0.504
CLV_PCSK_FUR_1 862 866 PF00082 0.498
CLV_PCSK_KEX2_1 107 109 PF00082 0.504
CLV_PCSK_KEX2_1 295 297 PF00082 0.363
CLV_PCSK_KEX2_1 393 395 PF00082 0.321
CLV_PCSK_KEX2_1 526 528 PF00082 0.484
CLV_PCSK_KEX2_1 69 71 PF00082 0.511
CLV_PCSK_KEX2_1 859 861 PF00082 0.503
CLV_PCSK_KEX2_1 862 864 PF00082 0.495
CLV_PCSK_PC7_1 859 865 PF00082 0.492
CLV_PCSK_SKI1_1 407 411 PF00082 0.389
CLV_PCSK_SKI1_1 451 455 PF00082 0.397
CLV_PCSK_SKI1_1 504 508 PF00082 0.576
DEG_APCC_DBOX_1 141 149 PF00400 0.707
DEG_SCF_FBW7_1 151 157 PF00400 0.655
DEG_SCF_FBW7_1 44 50 PF00400 0.706
DEG_SPOP_SBC_1 12 16 PF00917 0.685
DEG_SPOP_SBC_1 343 347 PF00917 0.470
DEG_SPOP_SBC_1 86 90 PF00917 0.647
DOC_ANK_TNKS_1 627 634 PF00023 0.611
DOC_CKS1_1 151 156 PF01111 0.662
DOC_CKS1_1 168 173 PF01111 0.655
DOC_CKS1_1 44 49 PF01111 0.707
DOC_CKS1_1 587 592 PF01111 0.665
DOC_CKS1_1 839 844 PF01111 0.628
DOC_CYCLIN_RxL_1 448 456 PF00134 0.323
DOC_CYCLIN_yCln2_LP_2 746 752 PF00134 0.304
DOC_MAPK_gen_1 393 399 PF00069 0.514
DOC_MAPK_gen_1 526 534 PF00069 0.261
DOC_MAPK_MEF2A_6 458 467 PF00069 0.575
DOC_PP1_RVXF_1 405 411 PF00149 0.484
DOC_PP2B_LxvP_1 535 538 PF13499 0.369
DOC_PP4_FxxP_1 25 28 PF00568 0.703
DOC_USP7_MATH_1 343 347 PF00917 0.466
DOC_USP7_MATH_1 363 367 PF00917 0.344
DOC_USP7_MATH_1 417 421 PF00917 0.369
DOC_USP7_MATH_1 477 481 PF00917 0.304
DOC_USP7_MATH_1 585 589 PF00917 0.659
DOC_USP7_MATH_1 595 599 PF00917 0.621
DOC_USP7_MATH_1 626 630 PF00917 0.645
DOC_USP7_MATH_1 81 85 PF00917 0.784
DOC_USP7_MATH_1 844 848 PF00917 0.647
DOC_USP7_MATH_1 880 884 PF00917 0.707
DOC_USP7_UBL2_3 451 455 PF12436 0.368
DOC_WW_Pin1_4 150 155 PF00397 0.755
DOC_WW_Pin1_4 167 172 PF00397 0.644
DOC_WW_Pin1_4 234 239 PF00397 0.668
DOC_WW_Pin1_4 266 271 PF00397 0.672
DOC_WW_Pin1_4 278 283 PF00397 0.628
DOC_WW_Pin1_4 33 38 PF00397 0.685
DOC_WW_Pin1_4 427 432 PF00397 0.314
DOC_WW_Pin1_4 43 48 PF00397 0.684
DOC_WW_Pin1_4 517 522 PF00397 0.505
DOC_WW_Pin1_4 57 62 PF00397 0.712
DOC_WW_Pin1_4 586 591 PF00397 0.660
DOC_WW_Pin1_4 604 609 PF00397 0.663
DOC_WW_Pin1_4 765 770 PF00397 0.389
DOC_WW_Pin1_4 77 82 PF00397 0.602
DOC_WW_Pin1_4 811 816 PF00397 0.589
DOC_WW_Pin1_4 838 843 PF00397 0.625
LIG_14-3-3_CanoR_1 107 115 PF00244 0.743
LIG_14-3-3_CanoR_1 142 151 PF00244 0.682
LIG_14-3-3_CanoR_1 197 201 PF00244 0.638
LIG_14-3-3_CanoR_1 553 561 PF00244 0.540
LIG_14-3-3_CanoR_1 69 77 PF00244 0.704
LIG_14-3-3_CanoR_1 734 740 PF00244 0.495
LIG_14-3-3_CanoR_1 863 873 PF00244 0.646
LIG_Actin_WH2_2 384 400 PF00022 0.345
LIG_APCC_ABBA_1 786 791 PF00400 0.339
LIG_BIR_II_1 1 5 PF00653 0.715
LIG_BIR_III_2 680 684 PF00653 0.427
LIG_BIR_III_2 766 770 PF00653 0.338
LIG_BRCT_BRCA1_1 445 449 PF00533 0.304
LIG_BRCT_BRCA1_1 718 722 PF00533 0.304
LIG_BRCT_BRCA1_2 445 451 PF00533 0.304
LIG_Clathr_ClatBox_1 676 680 PF01394 0.284
LIG_deltaCOP1_diTrp_1 402 410 PF00928 0.521
LIG_EVH1_2 285 289 PF00568 0.586
LIG_FHA_1 1 7 PF00498 0.694
LIG_FHA_1 155 161 PF00498 0.719
LIG_FHA_1 298 304 PF00498 0.540
LIG_FHA_1 367 373 PF00498 0.269
LIG_FHA_1 386 392 PF00498 0.313
LIG_FHA_1 428 434 PF00498 0.315
LIG_FHA_1 448 454 PF00498 0.346
LIG_FHA_1 46 52 PF00498 0.661
LIG_FHA_1 587 593 PF00498 0.683
LIG_FHA_1 718 724 PF00498 0.369
LIG_FHA_1 749 755 PF00498 0.304
LIG_FHA_2 130 136 PF00498 0.684
LIG_FHA_2 151 157 PF00498 0.686
LIG_FHA_2 171 177 PF00498 0.651
LIG_FHA_2 211 217 PF00498 0.693
LIG_FHA_2 235 241 PF00498 0.703
LIG_FHA_2 286 292 PF00498 0.565
LIG_FHA_2 553 559 PF00498 0.513
LIG_FHA_2 792 798 PF00498 0.521
LIG_GBD_Chelix_1 383 391 PF00786 0.369
LIG_IBAR_NPY_1 462 464 PF08397 0.563
LIG_LIR_Apic_2 165 171 PF02991 0.706
LIG_LIR_Apic_2 459 463 PF02991 0.562
LIG_LIR_Gen_1 155 166 PF02991 0.682
LIG_LIR_Gen_1 288 297 PF02991 0.614
LIG_LIR_Gen_1 366 376 PF02991 0.272
LIG_LIR_Gen_1 468 477 PF02991 0.292
LIG_LIR_Gen_1 480 487 PF02991 0.401
LIG_LIR_Gen_1 719 730 PF02991 0.304
LIG_LIR_Gen_1 768 779 PF02991 0.286
LIG_LIR_Gen_1 867 877 PF02991 0.677
LIG_LIR_LC3C_4 291 294 PF02991 0.559
LIG_LIR_Nem_3 203 207 PF02991 0.668
LIG_LIR_Nem_3 288 292 PF02991 0.622
LIG_LIR_Nem_3 366 371 PF02991 0.305
LIG_LIR_Nem_3 468 472 PF02991 0.304
LIG_LIR_Nem_3 480 485 PF02991 0.370
LIG_LIR_Nem_3 719 725 PF02991 0.304
LIG_LIR_Nem_3 768 774 PF02991 0.286
LIG_LIR_Nem_3 867 872 PF02991 0.670
LIG_LYPXL_SIV_4 463 471 PF13949 0.469
LIG_Pex14_1 329 333 PF04695 0.317
LIG_Pex14_1 406 410 PF04695 0.484
LIG_Pex14_1 529 533 PF04695 0.304
LIG_Pex14_1 546 550 PF04695 0.493
LIG_Pex14_2 321 325 PF04695 0.496
LIG_Pex14_2 378 382 PF04695 0.304
LIG_Pex14_2 399 403 PF04695 0.527
LIG_RPA_C_Fungi 291 303 PF08784 0.470
LIG_SH2_CRK 168 172 PF00017 0.635
LIG_SH2_CRK 445 449 PF00017 0.347
LIG_SH2_CRK 460 464 PF00017 0.431
LIG_SH2_CRK 714 718 PF00017 0.304
LIG_SH2_CRK 869 873 PF00017 0.613
LIG_SH2_GRB2like 460 463 PF00017 0.365
LIG_SH2_GRB2like 731 734 PF00017 0.334
LIG_SH2_NCK_1 425 429 PF00017 0.417
LIG_SH2_NCK_1 445 449 PF00017 0.347
LIG_SH2_NCK_1 460 464 PF00017 0.366
LIG_SH2_PTP2 464 467 PF00017 0.304
LIG_SH2_PTP2 771 774 PF00017 0.304
LIG_SH2_SRC 207 210 PF00017 0.560
LIG_SH2_SRC 460 463 PF00017 0.401
LIG_SH2_SRC 573 576 PF00017 0.518
LIG_SH2_STAP1 200 204 PF00017 0.610
LIG_SH2_STAP1 368 372 PF00017 0.304
LIG_SH2_STAP1 445 449 PF00017 0.304
LIG_SH2_STAP1 735 739 PF00017 0.338
LIG_SH2_STAP1 869 873 PF00017 0.613
LIG_SH2_STAP1 98 102 PF00017 0.688
LIG_SH2_STAT5 368 371 PF00017 0.326
LIG_SH2_STAT5 464 467 PF00017 0.338
LIG_SH2_STAT5 484 487 PF00017 0.389
LIG_SH2_STAT5 554 557 PF00017 0.346
LIG_SH2_STAT5 563 566 PF00017 0.427
LIG_SH2_STAT5 714 717 PF00017 0.304
LIG_SH2_STAT5 726 729 PF00017 0.304
LIG_SH2_STAT5 731 734 PF00017 0.334
LIG_SH2_STAT5 771 774 PF00017 0.304
LIG_SH2_STAT5 787 790 PF00017 0.337
LIG_SH3_1 235 241 PF00018 0.555
LIG_SH3_3 148 154 PF00018 0.572
LIG_SH3_3 235 241 PF00018 0.625
LIG_SH3_3 257 263 PF00018 0.752
LIG_SH3_3 279 285 PF00018 0.502
LIG_SH3_3 32 38 PF00018 0.640
LIG_SH3_3 373 379 PF00018 0.445
LIG_SH3_3 615 621 PF00018 0.586
LIG_SH3_3 638 644 PF00018 0.525
LIG_SH3_3 672 678 PF00018 0.347
LIG_SH3_3 843 849 PF00018 0.626
LIG_SUMO_SIM_anti_2 288 294 PF11976 0.413
LIG_SUMO_SIM_anti_2 751 757 PF11976 0.304
LIG_SUMO_SIM_par_1 146 153 PF11976 0.674
LIG_SUMO_SIM_par_1 505 512 PF11976 0.436
LIG_SUMO_SIM_par_1 520 525 PF11976 0.333
LIG_SUMO_SIM_par_1 658 667 PF11976 0.402
LIG_TRAF2_1 237 240 PF00917 0.629
LIG_TRAF2_1 794 797 PF00917 0.383
LIG_TRFH_1 674 678 PF08558 0.248
LIG_WRC_WIRS_1 368 373 PF05994 0.304
LIG_WRC_WIRS_1 466 471 PF05994 0.369
MOD_CDK_SPK_2 811 816 PF00069 0.472
MOD_CDK_SPxxK_3 167 174 PF00069 0.640
MOD_CDK_SPxxK_3 57 64 PF00069 0.606
MOD_CK1_1 129 135 PF00069 0.622
MOD_CK1_1 141 147 PF00069 0.560
MOD_CK1_1 278 284 PF00069 0.537
MOD_CK1_1 345 351 PF00069 0.599
MOD_CK1_1 36 42 PF00069 0.640
MOD_CK1_1 366 372 PF00069 0.364
MOD_CK1_1 45 51 PF00069 0.692
MOD_CK1_1 495 501 PF00069 0.558
MOD_CK1_1 512 518 PF00069 0.499
MOD_CK1_1 622 628 PF00069 0.540
MOD_CK1_1 664 670 PF00069 0.270
MOD_CK1_1 73 79 PF00069 0.800
MOD_CK1_1 741 747 PF00069 0.304
MOD_CK1_1 781 787 PF00069 0.369
MOD_CK1_1 838 844 PF00069 0.636
MOD_CK1_1 84 90 PF00069 0.695
MOD_CK1_1 878 884 PF00069 0.649
MOD_CK2_1 170 176 PF00069 0.620
MOD_CK2_1 234 240 PF00069 0.677
MOD_CK2_1 285 291 PF00069 0.447
MOD_CK2_1 687 693 PF00069 0.391
MOD_CK2_1 791 797 PF00069 0.375
MOD_CK2_1 817 823 PF00069 0.619
MOD_CMANNOS 403 406 PF00535 0.380
MOD_GlcNHglycan 145 148 PF01048 0.685
MOD_GlcNHglycan 203 207 PF01048 0.680
MOD_GlcNHglycan 229 232 PF01048 0.619
MOD_GlcNHglycan 25 28 PF01048 0.580
MOD_GlcNHglycan 277 280 PF01048 0.566
MOD_GlcNHglycan 347 350 PF01048 0.624
MOD_GlcNHglycan 352 355 PF01048 0.639
MOD_GlcNHglycan 356 359 PF01048 0.440
MOD_GlcNHglycan 373 376 PF01048 0.425
MOD_GlcNHglycan 419 422 PF01048 0.304
MOD_GlcNHglycan 445 448 PF01048 0.304
MOD_GlcNHglycan 493 498 PF01048 0.567
MOD_GlcNHglycan 511 514 PF01048 0.441
MOD_GlcNHglycan 621 624 PF01048 0.602
MOD_GlcNHglycan 728 731 PF01048 0.363
MOD_GlcNHglycan 746 749 PF01048 0.200
MOD_GlcNHglycan 820 823 PF01048 0.620
MOD_GlcNHglycan 84 87 PF01048 0.634
MOD_GlcNHglycan 879 883 PF01048 0.589
MOD_GSK3_1 134 141 PF00069 0.602
MOD_GSK3_1 150 157 PF00069 0.544
MOD_GSK3_1 343 350 PF00069 0.580
MOD_GSK3_1 363 370 PF00069 0.356
MOD_GSK3_1 43 50 PF00069 0.713
MOD_GSK3_1 443 450 PF00069 0.343
MOD_GSK3_1 489 496 PF00069 0.543
MOD_GSK3_1 509 516 PF00069 0.488
MOD_GSK3_1 533 540 PF00069 0.503
MOD_GSK3_1 622 629 PF00069 0.570
MOD_GSK3_1 660 667 PF00069 0.300
MOD_GSK3_1 7 14 PF00069 0.640
MOD_GSK3_1 73 80 PF00069 0.740
MOD_GSK3_1 744 751 PF00069 0.304
MOD_GSK3_1 757 764 PF00069 0.391
MOD_GSK3_1 81 88 PF00069 0.600
MOD_GSK3_1 834 841 PF00069 0.617
MOD_N-GLC_1 761 766 PF02516 0.397
MOD_N-GLC_1 834 839 PF02516 0.602
MOD_N-GLC_2 20 22 PF02516 0.642
MOD_NEK2_1 275 280 PF00069 0.582
MOD_NEK2_1 297 302 PF00069 0.385
MOD_NEK2_1 364 369 PF00069 0.371
MOD_NEK2_1 371 376 PF00069 0.304
MOD_NEK2_1 385 390 PF00069 0.304
MOD_NEK2_1 437 442 PF00069 0.304
MOD_NEK2_1 471 476 PF00069 0.369
MOD_NEK2_1 533 538 PF00069 0.304
MOD_NEK2_1 685 690 PF00069 0.440
MOD_NEK2_1 7 12 PF00069 0.594
MOD_NEK2_1 717 722 PF00069 0.308
MOD_NEK2_1 778 783 PF00069 0.369
MOD_NEK2_1 82 87 PF00069 0.559
MOD_NEK2_2 123 128 PF00069 0.617
MOD_NEK2_2 477 482 PF00069 0.304
MOD_NEK2_2 687 692 PF00069 0.434
MOD_NEK2_2 770 775 PF00069 0.304
MOD_PIKK_1 160 166 PF00454 0.679
MOD_PIKK_1 741 747 PF00454 0.304
MOD_PIKK_1 844 850 PF00454 0.584
MOD_PKA_1 70 76 PF00069 0.626
MOD_PKA_1 864 870 PF00069 0.577
MOD_PKA_2 106 112 PF00069 0.713
MOD_PKA_2 141 147 PF00069 0.604
MOD_PKA_2 196 202 PF00069 0.531
MOD_PKA_2 397 403 PF00069 0.388
MOD_PKA_2 552 558 PF00069 0.362
MOD_PKA_2 595 601 PF00069 0.600
MOD_PKA_2 70 76 PF00069 0.635
MOD_PKA_2 733 739 PF00069 0.339
MOD_PKA_2 864 870 PF00069 0.649
MOD_PKB_1 69 77 PF00069 0.629
MOD_PKB_1 862 870 PF00069 0.522
MOD_Plk_1 202 208 PF00069 0.575
MOD_Plk_1 297 303 PF00069 0.395
MOD_Plk_1 653 659 PF00069 0.366
MOD_Plk_1 664 670 PF00069 0.314
MOD_Plk_1 7 13 PF00069 0.636
MOD_Plk_1 791 797 PF00069 0.439
MOD_Plk_2-3 791 797 PF00069 0.379
MOD_Plk_4 111 117 PF00069 0.791
MOD_Plk_4 285 291 PF00069 0.427
MOD_Plk_4 298 304 PF00069 0.390
MOD_Plk_4 367 373 PF00069 0.304
MOD_Plk_4 437 443 PF00069 0.304
MOD_Plk_4 465 471 PF00069 0.369
MOD_Plk_4 477 483 PF00069 0.304
MOD_Plk_4 537 543 PF00069 0.335
MOD_Plk_4 545 551 PF00069 0.403
MOD_Plk_4 738 744 PF00069 0.304
MOD_Plk_4 770 776 PF00069 0.369
MOD_Plk_4 781 787 PF00069 0.266
MOD_ProDKin_1 150 156 PF00069 0.705
MOD_ProDKin_1 167 173 PF00069 0.552
MOD_ProDKin_1 234 240 PF00069 0.583
MOD_ProDKin_1 266 272 PF00069 0.584
MOD_ProDKin_1 278 284 PF00069 0.512
MOD_ProDKin_1 33 39 PF00069 0.608
MOD_ProDKin_1 427 433 PF00069 0.366
MOD_ProDKin_1 43 49 PF00069 0.608
MOD_ProDKin_1 517 523 PF00069 0.627
MOD_ProDKin_1 57 63 PF00069 0.636
MOD_ProDKin_1 586 592 PF00069 0.572
MOD_ProDKin_1 604 610 PF00069 0.576
MOD_ProDKin_1 765 771 PF00069 0.469
MOD_ProDKin_1 77 83 PF00069 0.488
MOD_ProDKin_1 811 817 PF00069 0.483
MOD_ProDKin_1 838 844 PF00069 0.525
MOD_SUMO_rev_2 791 800 PF00179 0.442
TRG_DiLeu_BaEn_1 298 303 PF01217 0.358
TRG_DiLeu_BaLyEn_6 404 409 PF01217 0.367
TRG_DiLeu_BaLyEn_6 587 592 PF01217 0.578
TRG_ENDOCYTIC_2 368 371 PF00928 0.335
TRG_ENDOCYTIC_2 445 448 PF00928 0.294
TRG_ENDOCYTIC_2 464 467 PF00928 0.304
TRG_ENDOCYTIC_2 714 717 PF00928 0.304
TRG_ENDOCYTIC_2 771 774 PF00928 0.304
TRG_ENDOCYTIC_2 827 830 PF00928 0.634
TRG_ENDOCYTIC_2 869 872 PF00928 0.593
TRG_ER_diArg_1 294 296 PF00400 0.415
TRG_ER_diArg_1 392 394 PF00400 0.399
TRG_ER_diArg_1 526 528 PF00400 0.325
TRG_ER_diArg_1 640 643 PF00400 0.475
TRG_ER_diArg_1 69 71 PF00400 0.643
TRG_ER_diArg_1 857 860 PF00400 0.632
TRG_ER_diArg_1 861 864 PF00400 0.626
TRG_NES_CRM1_1 669 680 PF08389 0.304
TRG_Pf-PMV_PEXEL_1 53 57 PF00026 0.618
TRG_Pf-PMV_PEXEL_1 628 632 PF00026 0.505

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I037 Leptomonas seymouri 57% 91%
A4H3M6 Leishmania braziliensis 68% 96%
E9ACL0 Leishmania major 90% 100%
E9AG54 Leishmania infantum 100% 100%
E9AJU8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS