Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJR4_LEIDO

TriTrypDb:

LdBPK_030620.1 , LdCL_030011300 , LDHU3_03.0660

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A451EJR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.634
CLV_C14_Caspase3-7	455	459	PF00656	0.571
CLV_C14_Caspase3-7	47	51	PF00656	0.444
CLV_NRD_NRD_1	3	5	PF00675	0.622
CLV_NRD_NRD_1	348	350	PF00675	0.473
CLV_NRD_NRD_1	500	502	PF00675	0.440
CLV_PCSK_KEX2_1	164	166	PF00082	0.561
CLV_PCSK_KEX2_1	3	5	PF00082	0.622
CLV_PCSK_KEX2_1	348	350	PF00082	0.521
CLV_PCSK_KEX2_1	499	501	PF00082	0.471
CLV_PCSK_KEX2_1	600	602	PF00082	0.517
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.561
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.565
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.538
CLV_PCSK_SKI1_1	113	117	PF00082	0.478
CLV_PCSK_SKI1_1	170	174	PF00082	0.443
CLV_PCSK_SKI1_1	256	260	PF00082	0.693
CLV_PCSK_SKI1_1	291	295	PF00082	0.565
CLV_PCSK_SKI1_1	318	322	PF00082	0.384
CLV_PCSK_SKI1_1	350	354	PF00082	0.636
CLV_PCSK_SKI1_1	465	469	PF00082	0.435
CLV_PCSK_SKI1_1	508	512	PF00082	0.413
CLV_PCSK_SKI1_1	555	559	PF00082	0.538
CLV_Separin_Metazoa	288	292	PF03568	0.515
DEG_APCC_DBOX_1	303	311	PF00400	0.568
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DEG_SPOP_SBC_1	239	243	PF00917	0.812
DEG_SPOP_SBC_1	245	249	PF00917	0.724
DEG_SPOP_SBC_1	476	480	PF00917	0.406
DEG_SPOP_SBC_1	68	72	PF00917	0.591
DOC_CYCLIN_RxL_1	313	322	PF00134	0.442
DOC_CYCLIN_RxL_1	347	355	PF00134	0.612
DOC_CYCLIN_RxL_1	462	469	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.502
DOC_MAPK_FxFP_2	29	32	PF00069	0.455
DOC_MAPK_gen_1	308	317	PF00069	0.445
DOC_MAPK_gen_1	348	354	PF00069	0.603
DOC_MAPK_JIP1_4	311	317	PF00069	0.453
DOC_MAPK_MEF2A_6	308	316	PF00069	0.370
DOC_MAPK_MEF2A_6	318	325	PF00069	0.369
DOC_MAPK_MEF2A_6	360	368	PF00069	0.432
DOC_MAPK_MEF2A_6	488	497	PF00069	0.483
DOC_PP2B_LxvP_1	321	324	PF13499	0.396
DOC_PP2B_LxvP_1	446	449	PF13499	0.378
DOC_PP4_FxxP_1	29	32	PF00568	0.455
DOC_SPAK_OSR1_1	428	432	PF12202	0.452
DOC_USP7_MATH_1	221	225	PF00917	0.689
DOC_USP7_MATH_1	227	231	PF00917	0.704
DOC_USP7_MATH_1	239	243	PF00917	0.805
DOC_USP7_MATH_1	245	249	PF00917	0.679
DOC_USP7_MATH_1	417	421	PF00917	0.637
DOC_USP7_MATH_1	477	481	PF00917	0.534
DOC_USP7_MATH_1	525	529	PF00917	0.352
DOC_USP7_MATH_1	68	72	PF00917	0.755
DOC_USP7_MATH_1	74	78	PF00917	0.752
DOC_USP7_UBL2_3	109	113	PF12436	0.497
DOC_WW_Pin1_4	250	255	PF00397	0.765
DOC_WW_Pin1_4	456	461	PF00397	0.494
LIG_14-3-3_CanoR_1	13	18	PF00244	0.512
LIG_14-3-3_CanoR_1	3	7	PF00244	0.603
LIG_14-3-3_CanoR_1	450	460	PF00244	0.466
LIG_14-3-3_CanoR_1	488	497	PF00244	0.540
LIG_14-3-3_CanoR_1	87	93	PF00244	0.572
LIG_Actin_RPEL_3	353	372	PF02755	0.579
LIG_Actin_WH2_2	275	293	PF00022	0.491
LIG_APCC_ABBA_1	395	400	PF00400	0.562
LIG_BIR_III_2	603	607	PF00653	0.577
LIG_BIR_III_4	400	404	PF00653	0.534
LIG_BIR_III_4	50	54	PF00653	0.580
LIG_BRCT_BRCA1_1	458	462	PF00533	0.558
LIG_BRCT_BRCA1_1	480	484	PF00533	0.601
LIG_BRCT_BRCA1_1	65	69	PF00533	0.562
LIG_Clathr_ClatBox_1	115	119	PF01394	0.519
LIG_CtBP_PxDLS_1	24	28	PF00389	0.511
LIG_EH1_1	592	600	PF00400	0.488
LIG_FHA_1	193	199	PF00498	0.381
LIG_FHA_1	276	282	PF00498	0.475
LIG_FHA_1	320	326	PF00498	0.387
LIG_FHA_1	433	439	PF00498	0.385
LIG_FHA_1	87	93	PF00498	0.632
LIG_FHA_2	301	307	PF00498	0.567
LIG_FHA_2	409	415	PF00498	0.579
LIG_FHA_2	453	459	PF00498	0.584
LIG_FHA_2	562	568	PF00498	0.501
LIG_LIR_Apic_2	26	32	PF02991	0.445
LIG_LIR_Apic_2	306	312	PF02991	0.446
LIG_LIR_Gen_1	273	282	PF02991	0.528
LIG_LIR_Gen_1	440	449	PF02991	0.468
LIG_LIR_Gen_1	481	490	PF02991	0.519
LIG_LIR_Nem_3	273	279	PF02991	0.529
LIG_LIR_Nem_3	440	444	PF02991	0.381
LIG_LIR_Nem_3	481	487	PF02991	0.521
LIG_LYPXL_S_1	516	520	PF13949	0.550
LIG_NRBOX	316	322	PF00104	0.489
LIG_NRBOX	367	373	PF00104	0.492
LIG_PCNA_yPIPBox_3	132	140	PF02747	0.456
LIG_PCNA_yPIPBox_3	283	291	PF02747	0.543
LIG_PDZ_Class_2	602	607	PF00595	0.568
LIG_Pex14_2	203	207	PF04695	0.385
LIG_SH2_CRK	369	373	PF00017	0.516
LIG_SH2_NCK_1	405	409	PF00017	0.571
LIG_SH2_SRC	342	345	PF00017	0.558
LIG_SH2_SRC	405	408	PF00017	0.605
LIG_SH2_SRC	543	546	PF00017	0.405
LIG_SH2_STAP1	144	148	PF00017	0.439
LIG_SH2_STAP1	162	166	PF00017	0.502
LIG_SH2_STAP1	434	438	PF00017	0.363
LIG_SH2_STAP1	441	445	PF00017	0.359
LIG_SH2_STAP1	576	580	PF00017	0.406
LIG_SH2_STAT5	276	279	PF00017	0.520
LIG_SH2_STAT5	30	33	PF00017	0.420
LIG_SH2_STAT5	342	345	PF00017	0.502
LIG_SH2_STAT5	434	437	PF00017	0.381
LIG_SH2_STAT5	543	546	PF00017	0.405
LIG_SH3_3	128	134	PF00018	0.587
LIG_SH3_3	211	217	PF00018	0.610
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.517
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.497
LIG_SUMO_SIM_par_1	114	119	PF11976	0.517
LIG_SUMO_SIM_par_1	472	481	PF11976	0.509
LIG_TRAF2_1	584	587	PF00917	0.467
LIG_TRFH_1	468	472	PF08558	0.536
LIG_TYR_ITIM	574	579	PF00017	0.393
LIG_UBA3_1	314	318	PF00899	0.378
LIG_UBA3_1	353	358	PF00899	0.609
LIG_WRC_WIRS_1	17	22	PF05994	0.544
MOD_CDC14_SPxK_1	253	256	PF00782	0.669
MOD_CDK_SPxK_1	250	256	PF00069	0.678
MOD_CK1_1	16	22	PF00069	0.539
MOD_CK1_1	229	235	PF00069	0.777
MOD_CK1_1	240	246	PF00069	0.784
MOD_CK1_1	247	253	PF00069	0.556
MOD_CK1_1	59	65	PF00069	0.699
MOD_CK1_1	77	83	PF00069	0.733
MOD_CK2_1	300	306	PF00069	0.572
MOD_CK2_1	561	567	PF00069	0.480
MOD_CK2_1	581	587	PF00069	0.263
MOD_CK2_1	59	65	PF00069	0.693
MOD_CK2_1	70	76	PF00069	0.738
MOD_GlcNHglycan	223	226	PF01048	0.704
MOD_GlcNHglycan	249	252	PF01048	0.694
MOD_GlcNHglycan	551	554	PF01048	0.399
MOD_GlcNHglycan	72	75	PF01048	0.757
MOD_GlcNHglycan	76	79	PF01048	0.732
MOD_GlcNHglycan	92	95	PF01048	0.437
MOD_GSK3_1	12	19	PF00069	0.511
MOD_GSK3_1	226	233	PF00069	0.746
MOD_GSK3_1	234	241	PF00069	0.746
MOD_GSK3_1	243	250	PF00069	0.742
MOD_GSK3_1	319	326	PF00069	0.376
MOD_GSK3_1	452	459	PF00069	0.580
MOD_GSK3_1	472	479	PF00069	0.333
MOD_GSK3_1	525	532	PF00069	0.435
MOD_GSK3_1	59	66	PF00069	0.722
MOD_GSK3_1	70	77	PF00069	0.743
MOD_GSK3_1	83	90	PF00069	0.613
MOD_GSK3_1	92	99	PF00069	0.669
MOD_N-GLC_1	151	156	PF02516	0.577
MOD_N-GLC_1	243	248	PF02516	0.783
MOD_N-GLC_1	409	414	PF02516	0.654
MOD_N-GLC_1	488	493	PF02516	0.514
MOD_NEK2_1	193	198	PF00069	0.410
MOD_NEK2_1	2	7	PF00069	0.630
MOD_NEK2_1	277	282	PF00069	0.425
MOD_NEK2_1	419	424	PF00069	0.552
MOD_NEK2_1	544	549	PF00069	0.396
MOD_NEK2_1	561	566	PF00069	0.393
MOD_NEK2_1	69	74	PF00069	0.513
MOD_PIKK_1	227	233	PF00454	0.722
MOD_PK_1	13	19	PF00069	0.598
MOD_PKA_1	499	505	PF00069	0.435
MOD_PKA_2	12	18	PF00069	0.492
MOD_PKA_2	2	8	PF00069	0.599
MOD_PKA_2	499	505	PF00069	0.504
MOD_PKA_2	56	62	PF00069	0.641
MOD_PKA_2	86	92	PF00069	0.540
MOD_Plk_1	193	199	PF00069	0.416
MOD_Plk_1	409	415	PF00069	0.688
MOD_Plk_1	562	568	PF00069	0.398
MOD_Plk_1	64	70	PF00069	0.715
MOD_Plk_4	111	117	PF00069	0.525
MOD_Plk_4	16	22	PF00069	0.497
MOD_Plk_4	277	283	PF00069	0.444
MOD_Plk_4	478	484	PF00069	0.573
MOD_Plk_4	526	532	PF00069	0.408
MOD_ProDKin_1	250	256	PF00069	0.764
MOD_ProDKin_1	456	462	PF00069	0.481
MOD_SUMO_rev_2	416	425	PF00179	0.621
MOD_SUMO_rev_2	584	591	PF00179	0.441
TRG_DiLeu_BaEn_1	594	599	PF01217	0.457
TRG_DiLeu_BaEn_4	287	293	PF01217	0.517
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.477
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.510
TRG_ENDOCYTIC_2	276	279	PF00928	0.520
TRG_ENDOCYTIC_2	369	372	PF00928	0.521
TRG_ENDOCYTIC_2	441	444	PF00928	0.383
TRG_ENDOCYTIC_2	517	520	PF00928	0.556
TRG_ENDOCYTIC_2	576	579	PF00928	0.404
TRG_ER_diArg_1	2	4	PF00400	0.634
TRG_ER_diArg_1	499	501	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	514	519	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q3	Leptomonas seymouri	65%	99%
A0A0S4JDH1	Bodo saltans	29%	100%
A0A1X0P9P0	Trypanosomatidae	48%	100%
A0A422NMG4	Trypanosoma rangeli	48%	100%
A4H3M5	Leishmania braziliensis	87%	100%
D0A267	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
E9ACK9	Leishmania major	95%	100%
E9AG53	Leishmania infantum	100%	100%
E9AJU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
V5BSR7	Trypanosoma cruzi	47%	100%