LeishMANIAdb
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Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat/DHHC palmitoyltransferase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat/DHHC palmitoyltransferase, putative
Gene product:
Ankyrin repeats (3 copies)/DHHC palmitoyltransferase, putative
Species:
Leishmania donovani
UniProt:
A0A451EJQ0_LEIDO
TriTrypDb:
LdBPK_030460.1 * , LdCL_030009700 , LDHU3_03.0480
Length:
1009

Annotations

LeishMANIAdb annotations

This small but fast-evolving family of Kinetoplastid proteins likely serves either as a transporter or a lipid-related enzyme (e.g. palmitoyltransferase).

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A451EJQ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJQ0

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 3
GO:0006796 phosphate-containing compound metabolic process 4 3
GO:0008152 metabolic process 1 3
GO:0009987 cellular process 1 3
GO:0016310 phosphorylation 5 3
GO:0044237 cellular metabolic process 2 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016740 transferase activity 2 7
GO:0016409 palmitoyltransferase activity 5 3
GO:0016746 acyltransferase activity 3 3
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 3
GO:0016301 kinase activity 4 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016417 S-acyltransferase activity 5 1
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4 1
GO:0019707 protein-cysteine S-acyltransferase activity 3 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 282 286 PF00656 0.453
CLV_C14_Caspase3-7 317 321 PF00656 0.575
CLV_C14_Caspase3-7 355 359 PF00656 0.729
CLV_C14_Caspase3-7 368 372 PF00656 0.671
CLV_C14_Caspase3-7 528 532 PF00656 0.409
CLV_C14_Caspase3-7 555 559 PF00656 0.456
CLV_C14_Caspase3-7 700 704 PF00656 0.615
CLV_NRD_NRD_1 106 108 PF00675 0.282
CLV_NRD_NRD_1 400 402 PF00675 0.405
CLV_NRD_NRD_1 73 75 PF00675 0.362
CLV_PCSK_FUR_1 398 402 PF00082 0.481
CLV_PCSK_KEX2_1 106 108 PF00082 0.321
CLV_PCSK_KEX2_1 400 402 PF00082 0.402
CLV_PCSK_KEX2_1 72 74 PF00082 0.367
CLV_PCSK_KEX2_1 988 990 PF00082 0.431
CLV_PCSK_PC1ET2_1 988 990 PF00082 0.525
CLV_PCSK_SKI1_1 164 168 PF00082 0.242
CLV_PCSK_SKI1_1 314 318 PF00082 0.201
CLV_PCSK_SKI1_1 374 378 PF00082 0.478
CLV_PCSK_SKI1_1 451 455 PF00082 0.416
CLV_PCSK_SKI1_1 575 579 PF00082 0.667
CLV_PCSK_SKI1_1 614 618 PF00082 0.412
CLV_PCSK_SKI1_1 737 741 PF00082 0.650
CLV_PCSK_SKI1_1 750 754 PF00082 0.609
CLV_PCSK_SKI1_1 852 856 PF00082 0.649
CLV_PCSK_SKI1_1 950 954 PF00082 0.446
DEG_APCC_DBOX_1 613 621 PF00400 0.337
DEG_SCF_FBW7_1 1002 1009 PF00400 0.668
DEG_SCF_FBW7_2 20 27 PF00400 0.651
DEG_SPOP_SBC_1 353 357 PF00917 0.678
DOC_CKS1_1 1003 1008 PF01111 0.749
DOC_CKS1_1 21 26 PF01111 0.725
DOC_CYCLIN_RxL_1 159 168 PF00134 0.453
DOC_CYCLIN_RxL_1 572 582 PF00134 0.436
DOC_CYCLIN_RxL_1 734 744 PF00134 0.377
DOC_CYCLIN_yClb1_LxF_4 709 715 PF00134 0.536
DOC_CYCLIN_yClb1_LxF_4 976 982 PF00134 0.674
DOC_CYCLIN_yCln2_LP_2 496 502 PF00134 0.496
DOC_MAPK_gen_1 493 502 PF00069 0.638
DOC_MAPK_gen_1 988 996 PF00069 0.643
DOC_MAPK_MEF2A_6 495 504 PF00069 0.480
DOC_MAPK_MEF2A_6 614 622 PF00069 0.401
DOC_MAPK_MEF2A_6 865 873 PF00069 0.336
DOC_MAPK_NFAT4_5 614 622 PF00069 0.355
DOC_PP1_RVXF_1 449 456 PF00149 0.620
DOC_PP1_RVXF_1 573 580 PF00149 0.473
DOC_PP4_FxxP_1 219 222 PF00568 0.653
DOC_SPAK_OSR1_1 131 135 PF12202 0.543
DOC_USP7_MATH_1 171 175 PF00917 0.551
DOC_USP7_MATH_1 187 191 PF00917 0.609
DOC_USP7_MATH_1 283 287 PF00917 0.423
DOC_USP7_MATH_1 344 348 PF00917 0.656
DOC_USP7_MATH_1 354 358 PF00917 0.674
DOC_USP7_MATH_1 438 442 PF00917 0.629
DOC_USP7_MATH_1 515 519 PF00917 0.585
DOC_USP7_MATH_1 635 639 PF00917 0.629
DOC_USP7_MATH_1 785 789 PF00917 0.400
DOC_USP7_MATH_1 832 836 PF00917 0.401
DOC_USP7_MATH_1 909 913 PF00917 0.640
DOC_WW_Pin1_4 1002 1007 PF00397 0.674
DOC_WW_Pin1_4 20 25 PF00397 0.725
DOC_WW_Pin1_4 263 268 PF00397 0.555
DOC_WW_Pin1_4 287 292 PF00397 0.461
DOC_WW_Pin1_4 456 461 PF00397 0.668
DOC_WW_Pin1_4 579 584 PF00397 0.444
DOC_WW_Pin1_4 592 597 PF00397 0.362
DOC_WW_Pin1_4 648 653 PF00397 0.597
DOC_WW_Pin1_4 701 706 PF00397 0.684
DOC_WW_Pin1_4 783 788 PF00397 0.475
LIG_14-3-3_CanoR_1 208 218 PF00244 0.724
LIG_14-3-3_CanoR_1 314 322 PF00244 0.418
LIG_14-3-3_CanoR_1 410 416 PF00244 0.632
LIG_14-3-3_CanoR_1 461 471 PF00244 0.702
LIG_14-3-3_CanoR_1 538 548 PF00244 0.502
LIG_14-3-3_CanoR_1 56 65 PF00244 0.761
LIG_14-3-3_CanoR_1 575 580 PF00244 0.474
LIG_14-3-3_CanoR_1 641 648 PF00244 0.696
LIG_14-3-3_CanoR_1 668 676 PF00244 0.654
LIG_14-3-3_CanoR_1 865 869 PF00244 0.472
LIG_14-3-3_CanoR_1 939 945 PF00244 0.751
LIG_Dynein_DLC8_1 459 465 PF01221 0.651
LIG_eIF4E_1 568 574 PF01652 0.420
LIG_FHA_1 1003 1009 PF00498 0.752
LIG_FHA_1 158 164 PF00498 0.478
LIG_FHA_1 288 294 PF00498 0.442
LIG_FHA_1 427 433 PF00498 0.634
LIG_FHA_1 505 511 PF00498 0.325
LIG_FHA_1 624 630 PF00498 0.384
LIG_FHA_1 648 654 PF00498 0.624
LIG_FHA_1 734 740 PF00498 0.410
LIG_FHA_1 98 104 PF00498 0.508
LIG_FHA_2 315 321 PF00498 0.401
LIG_FHA_2 353 359 PF00498 0.647
LIG_FHA_2 57 63 PF00498 0.704
LIG_FHA_2 773 779 PF00498 0.387
LIG_FHA_2 802 808 PF00498 0.428
LIG_FHA_2 898 904 PF00498 0.585
LIG_GBD_Chelix_1 975 983 PF00786 0.437
LIG_LIR_Gen_1 117 127 PF02991 0.512
LIG_LIR_Gen_1 182 193 PF02991 0.554
LIG_LIR_Gen_1 298 308 PF02991 0.470
LIG_LIR_Gen_1 319 330 PF02991 0.536
LIG_LIR_Gen_1 363 373 PF02991 0.618
LIG_LIR_Gen_1 37 48 PF02991 0.672
LIG_LIR_Gen_1 413 423 PF02991 0.572
LIG_LIR_Gen_1 429 438 PF02991 0.642
LIG_LIR_Gen_1 507 515 PF02991 0.292
LIG_LIR_Gen_1 696 706 PF02991 0.604
LIG_LIR_Gen_1 719 729 PF02991 0.396
LIG_LIR_Gen_1 798 806 PF02991 0.447
LIG_LIR_Gen_1 938 949 PF02991 0.745
LIG_LIR_LC3C_4 507 511 PF02991 0.306
LIG_LIR_Nem_3 117 123 PF02991 0.518
LIG_LIR_Nem_3 182 188 PF02991 0.549
LIG_LIR_Nem_3 298 303 PF02991 0.467
LIG_LIR_Nem_3 319 325 PF02991 0.543
LIG_LIR_Nem_3 441 445 PF02991 0.598
LIG_LIR_Nem_3 507 511 PF02991 0.284
LIG_LIR_Nem_3 651 657 PF02991 0.623
LIG_LIR_Nem_3 659 665 PF02991 0.634
LIG_LIR_Nem_3 696 701 PF02991 0.643
LIG_LIR_Nem_3 719 724 PF02991 0.396
LIG_LIR_Nem_3 751 756 PF02991 0.497
LIG_LIR_Nem_3 798 802 PF02991 0.453
LIG_LIR_Nem_3 938 944 PF02991 0.747
LIG_MYND_1 222 226 PF01753 0.552
LIG_MYND_2 471 475 PF01753 0.645
LIG_NRBOX 192 198 PF00104 0.643
LIG_NRBOX 427 433 PF00104 0.507
LIG_NRBOX 572 578 PF00104 0.412
LIG_NRBOX 616 622 PF00104 0.432
LIG_NRBOX 629 635 PF00104 0.420
LIG_NRBOX 722 728 PF00104 0.355
LIG_NRBOX 978 984 PF00104 0.636
LIG_PCNA_PIPBox_1 13 22 PF02747 0.681
LIG_PCNA_PIPBox_1 677 686 PF02747 0.666
LIG_PCNA_yPIPBox_3 674 684 PF02747 0.706
LIG_PCNA_yPIPBox_3 7 20 PF02747 0.672
LIG_Pex14_1 872 876 PF04695 0.258
LIG_Pex14_2 181 185 PF04695 0.588
LIG_Pex14_2 445 449 PF04695 0.610
LIG_Pex14_2 76 80 PF04695 0.622
LIG_Rb_LxCxE_1 736 758 PF01857 0.467
LIG_REV1ctd_RIR_1 446 455 PF16727 0.558
LIG_SH2_CRK 31 35 PF00017 0.737
LIG_SH2_CRK 698 702 PF00017 0.602
LIG_SH2_CRK 86 90 PF00017 0.439
LIG_SH2_CRK 876 880 PF00017 0.299
LIG_SH2_CRK 941 945 PF00017 0.777
LIG_SH2_GRB2like 31 34 PF00017 0.658
LIG_SH2_NCK_1 876 880 PF00017 0.391
LIG_SH2_PTP2 394 397 PF00017 0.646
LIG_SH2_PTP2 860 863 PF00017 0.335
LIG_SH2_SRC 19 22 PF00017 0.705
LIG_SH2_SRC 969 972 PF00017 0.641
LIG_SH2_STAP1 279 283 PF00017 0.522
LIG_SH2_STAP1 698 702 PF00017 0.641
LIG_SH2_STAP1 876 880 PF00017 0.334
LIG_SH2_STAT3 605 608 PF00017 0.474
LIG_SH2_STAT5 165 168 PF00017 0.527
LIG_SH2_STAT5 19 22 PF00017 0.680
LIG_SH2_STAT5 243 246 PF00017 0.536
LIG_SH2_STAT5 272 275 PF00017 0.492
LIG_SH2_STAT5 338 341 PF00017 0.597
LIG_SH2_STAT5 394 397 PF00017 0.603
LIG_SH2_STAT5 425 428 PF00017 0.583
LIG_SH2_STAT5 442 445 PF00017 0.557
LIG_SH2_STAT5 568 571 PF00017 0.481
LIG_SH2_STAT5 684 687 PF00017 0.606
LIG_SH2_STAT5 828 831 PF00017 0.469
LIG_SH2_STAT5 860 863 PF00017 0.364
LIG_SH3_1 467 473 PF00018 0.663
LIG_SH3_3 1000 1006 PF00018 0.746
LIG_SH3_3 18 24 PF00018 0.700
LIG_SH3_3 432 438 PF00018 0.663
LIG_SH3_3 467 473 PF00018 0.725
LIG_SH3_3 98 104 PF00018 0.536
LIG_SUMO_SIM_anti_2 725 730 PF11976 0.410
LIG_SUMO_SIM_par_1 195 202 PF11976 0.508
LIG_SUMO_SIM_par_1 617 624 PF11976 0.427
LIG_SUMO_SIM_par_1 714 719 PF11976 0.431
LIG_SUMO_SIM_par_1 99 105 PF11976 0.518
LIG_TRAF2_1 534 537 PF00917 0.417
LIG_TRAF2_1 642 645 PF00917 0.686
LIG_TRFH_1 243 247 PF08558 0.498
LIG_TYR_ITIM 566 571 PF00017 0.484
LIG_TYR_ITIM 874 879 PF00017 0.299
LIG_UBA3_1 2 7 PF00899 0.693
LIG_WRC_WIRS_1 576 581 PF05994 0.473
LIG_WRC_WIRS_1 796 801 PF05994 0.444
MOD_CDK_SPK_2 456 461 PF00069 0.580
MOD_CDK_SPxxK_3 648 655 PF00069 0.674
MOD_CDK_SPxxK_3 701 708 PF00069 0.634
MOD_CK1_1 266 272 PF00069 0.536
MOD_CK1_1 346 352 PF00069 0.692
MOD_CK1_1 456 462 PF00069 0.710
MOD_CK1_1 552 558 PF00069 0.532
MOD_CK2_1 480 486 PF00069 0.650
MOD_CK2_1 56 62 PF00069 0.724
MOD_CK2_1 75 81 PF00069 0.447
MOD_CK2_1 801 807 PF00069 0.433
MOD_CK2_1 897 903 PF00069 0.590
MOD_CK2_1 909 915 PF00069 0.638
MOD_Cter_Amidation 986 989 PF01082 0.417
MOD_GlcNHglycan 189 192 PF01048 0.365
MOD_GlcNHglycan 379 383 PF01048 0.495
MOD_GlcNHglycan 467 470 PF01048 0.570
MOD_GlcNHglycan 527 530 PF01048 0.683
MOD_GlcNHglycan 541 544 PF01048 0.621
MOD_GlcNHglycan 551 554 PF01048 0.607
MOD_GlcNHglycan 834 837 PF01048 0.634
MOD_GlcNHglycan 876 879 PF01048 0.395
MOD_GSK3_1 1002 1009 PF00069 0.704
MOD_GSK3_1 153 160 PF00069 0.501
MOD_GSK3_1 283 290 PF00069 0.457
MOD_GSK3_1 316 323 PF00069 0.592
MOD_GSK3_1 339 346 PF00069 0.668
MOD_GSK3_1 349 356 PF00069 0.616
MOD_GSK3_1 378 385 PF00069 0.740
MOD_GSK3_1 456 463 PF00069 0.691
MOD_GSK3_1 480 487 PF00069 0.598
MOD_GSK3_1 548 555 PF00069 0.523
MOD_GSK3_1 575 582 PF00069 0.437
MOD_GSK3_1 588 595 PF00069 0.364
MOD_GSK3_1 640 647 PF00069 0.627
MOD_GSK3_1 697 704 PF00069 0.694
MOD_GSK3_1 773 780 PF00069 0.546
MOD_GSK3_1 841 848 PF00069 0.400
MOD_GSK3_1 940 947 PF00069 0.725
MOD_LATS_1 666 672 PF00433 0.647
MOD_N-GLC_1 113 118 PF02516 0.262
MOD_N-GLC_1 386 391 PF02516 0.510
MOD_N-GLC_1 411 416 PF02516 0.360
MOD_N-GLC_1 778 783 PF02516 0.634
MOD_NEK2_1 146 151 PF00069 0.450
MOD_NEK2_1 181 186 PF00069 0.526
MOD_NEK2_1 306 311 PF00069 0.536
MOD_NEK2_1 369 374 PF00069 0.709
MOD_NEK2_1 408 413 PF00069 0.621
MOD_NEK2_1 426 431 PF00069 0.568
MOD_NEK2_1 480 485 PF00069 0.603
MOD_NEK2_1 525 530 PF00069 0.446
MOD_NEK2_1 548 553 PF00069 0.542
MOD_NEK2_1 569 574 PF00069 0.475
MOD_NEK2_1 606 611 PF00069 0.435
MOD_NEK2_1 620 625 PF00069 0.311
MOD_NEK2_1 714 719 PF00069 0.328
MOD_NEK2_1 727 732 PF00069 0.310
MOD_NEK2_1 874 879 PF00069 0.289
MOD_NEK2_1 994 999 PF00069 0.707
MOD_NEK2_2 402 407 PF00069 0.653
MOD_PIKK_1 460 466 PF00454 0.734
MOD_PIKK_1 668 674 PF00454 0.634
MOD_PIKK_1 730 736 PF00454 0.438
MOD_PKA_2 460 466 PF00069 0.694
MOD_PKA_2 488 494 PF00069 0.647
MOD_PKA_2 640 646 PF00069 0.676
MOD_PKA_2 864 870 PF00069 0.463
MOD_Plk_1 113 119 PF00069 0.482
MOD_Plk_1 181 187 PF00069 0.597
MOD_Plk_1 382 388 PF00069 0.701
MOD_Plk_1 411 417 PF00069 0.604
MOD_Plk_1 777 783 PF00069 0.440
MOD_Plk_1 822 828 PF00069 0.390
MOD_Plk_4 114 120 PF00069 0.457
MOD_Plk_4 125 131 PF00069 0.497
MOD_Plk_4 253 259 PF00069 0.455
MOD_Plk_4 426 432 PF00069 0.639
MOD_Plk_4 438 444 PF00069 0.557
MOD_Plk_4 504 510 PF00069 0.330
MOD_Plk_4 569 575 PF00069 0.477
MOD_Plk_4 697 703 PF00069 0.660
MOD_Plk_4 785 791 PF00069 0.538
MOD_Plk_4 841 847 PF00069 0.492
MOD_Plk_4 864 870 PF00069 0.434
MOD_Plk_4 915 921 PF00069 0.631
MOD_ProDKin_1 1002 1008 PF00069 0.673
MOD_ProDKin_1 20 26 PF00069 0.726
MOD_ProDKin_1 263 269 PF00069 0.555
MOD_ProDKin_1 287 293 PF00069 0.461
MOD_ProDKin_1 456 462 PF00069 0.676
MOD_ProDKin_1 579 585 PF00069 0.447
MOD_ProDKin_1 592 598 PF00069 0.363
MOD_ProDKin_1 648 654 PF00069 0.594
MOD_ProDKin_1 701 707 PF00069 0.679
MOD_ProDKin_1 783 789 PF00069 0.475
TRG_DiLeu_BaEn_1 253 258 PF01217 0.473
TRG_DiLeu_BaEn_1 302 307 PF01217 0.536
TRG_DiLeu_BaLyEn_6 205 210 PF01217 0.704
TRG_DiLeu_BaLyEn_6 470 475 PF01217 0.651
TRG_DiLeu_BaLyEn_6 561 566 PF01217 0.447
TRG_DiLeu_BaLyEn_6 572 577 PF01217 0.370
TRG_DiLeu_BaLyEn_6 816 821 PF01217 0.395
TRG_ENDOCYTIC_2 242 245 PF00928 0.536
TRG_ENDOCYTIC_2 394 397 PF00928 0.603
TRG_ENDOCYTIC_2 40 43 PF00928 0.698
TRG_ENDOCYTIC_2 425 428 PF00928 0.565
TRG_ENDOCYTIC_2 442 445 PF00928 0.543
TRG_ENDOCYTIC_2 568 571 PF00928 0.481
TRG_ENDOCYTIC_2 662 665 PF00928 0.590
TRG_ENDOCYTIC_2 698 701 PF00928 0.604
TRG_ENDOCYTIC_2 818 821 PF00928 0.465
TRG_ENDOCYTIC_2 86 89 PF00928 0.430
TRG_ENDOCYTIC_2 876 879 PF00928 0.311
TRG_ENDOCYTIC_2 941 944 PF00928 0.751
TRG_ER_diArg_1 391 394 PF00400 0.667
TRG_ER_diArg_1 494 497 PF00400 0.605
TRG_ER_diArg_1 71 74 PF00400 0.597
TRG_NES_CRM1_1 498 512 PF08389 0.496
TRG_Pf-PMV_PEXEL_1 131 135 PF00026 0.273
TRG_Pf-PMV_PEXEL_1 164 168 PF00026 0.242
TRG_Pf-PMV_PEXEL_1 314 318 PF00026 0.296
TRG_Pf-PMV_PEXEL_1 575 580 PF00026 0.539
TRG_Pf-PMV_PEXEL_1 819 823 PF00026 0.594
TRG_Pf-PMV_PEXEL_1 966 971 PF00026 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1V5 Leptomonas seymouri 61% 100%
A0A1X0P8R3 Trypanosomatidae 34% 100%
A0A422NMJ8 Trypanosoma rangeli 35% 100%
A4HGI3 Leishmania braziliensis 79% 98%
D0A254 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9ACJ3 Leishmania major 94% 100%
E9AG37 Leishmania infantum 100% 100%
E9AJT1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5BST1 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS