Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat/DHHC palmitoyltransferase, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/DHHC palmitoyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A451EJQ0_LEIDO

TriTrypDb:

LdBPK_030460.1 , LdCL_030009700 , LDHU3_03.0480

Length:

1009

Annotations

LeishMANIAdb annotations

This small but fast-evolving family of Kinetoplastid proteins likely serves either as a transporter or a lipid-related enzyme (e.g. palmitoyltransferase).

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	10
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A0A451EJQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJQ0

Function

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Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	3
GO:0044237	cellular metabolic process	2	3

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016301	kinase activity	4	3
GO:0016409	palmitoyltransferase activity	5	3
GO:0016417	S-acyltransferase activity	5	1
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	1
GO:0019707	protein-cysteine S-acyltransferase activity	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.453
CLV_C14_Caspase3-7	317	321	PF00656	0.575
CLV_C14_Caspase3-7	355	359	PF00656	0.729
CLV_C14_Caspase3-7	368	372	PF00656	0.671
CLV_C14_Caspase3-7	528	532	PF00656	0.409
CLV_C14_Caspase3-7	555	559	PF00656	0.456
CLV_C14_Caspase3-7	700	704	PF00656	0.615
CLV_NRD_NRD_1	106	108	PF00675	0.282
CLV_NRD_NRD_1	400	402	PF00675	0.405
CLV_NRD_NRD_1	73	75	PF00675	0.362

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V5	Leptomonas seymouri	61%	100%
A0A1X0P8R3	Trypanosomatidae	34%	100%
A0A422NMJ8	Trypanosoma rangeli	35%	100%
A4HGI3	Leishmania braziliensis	79%	98%
D0A254	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ACJ3	Leishmania major	94%	100%
E9AG37	Leishmania infantum	100%	100%
E9AJT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BST1	Trypanosoma cruzi	33%	100%

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