Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJP9_LEIDO

TriTrypDb:

LdBPK_030450.1 , LdCL_030009600 , LDHU3_03.0470

Length:

957

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 2
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A451EJP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.692
CLV_NRD_NRD_1	330	332	PF00675	0.656
CLV_NRD_NRD_1	436	438	PF00675	0.667
CLV_NRD_NRD_1	455	457	PF00675	0.847
CLV_NRD_NRD_1	654	656	PF00675	0.363
CLV_NRD_NRD_1	685	687	PF00675	0.643
CLV_NRD_NRD_1	909	911	PF00675	0.384
CLV_PCSK_FUR_1	453	457	PF00082	0.725
CLV_PCSK_FUR_1	896	900	PF00082	0.450
CLV_PCSK_KEX2_1	116	118	PF00082	0.750
CLV_PCSK_KEX2_1	142	144	PF00082	0.692
CLV_PCSK_KEX2_1	263	265	PF00082	0.718
CLV_PCSK_KEX2_1	329	331	PF00082	0.671
CLV_PCSK_KEX2_1	435	437	PF00082	0.669
CLV_PCSK_KEX2_1	455	457	PF00082	0.846
CLV_PCSK_KEX2_1	654	656	PF00082	0.363
CLV_PCSK_KEX2_1	685	687	PF00082	0.643
CLV_PCSK_KEX2_1	898	900	PF00082	0.449
CLV_PCSK_KEX2_1	909	911	PF00082	0.373
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.706
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.718
CLV_PCSK_PC1ET2_1	898	900	PF00082	0.452
CLV_PCSK_SKI1_1	208	212	PF00082	0.628
CLV_PCSK_SKI1_1	331	335	PF00082	0.564
CLV_PCSK_SKI1_1	796	800	PF00082	0.311
CLV_PCSK_SKI1_1	909	913	PF00082	0.406
CLV_PCSK_SKI1_1	925	929	PF00082	0.520
DEG_APCC_DBOX_1	795	803	PF00400	0.315
DEG_APCC_DBOX_1	908	916	PF00400	0.605
DEG_MDM2_SWIB_1	583	591	PF02201	0.421
DEG_MDM2_SWIB_1	635	643	PF02201	0.294
DEG_SPOP_SBC_1	118	122	PF00917	0.519
DEG_SPOP_SBC_1	46	50	PF00917	0.560
DEG_SPOP_SBC_1	80	84	PF00917	0.508
DOC_CKS1_1	166	171	PF01111	0.486
DOC_CKS1_1	867	872	PF01111	0.656
DOC_CYCLIN_RxL_1	793	801	PF00134	0.395
DOC_CYCLIN_yCln2_LP_2	781	784	PF00134	0.380
DOC_MAPK_DCC_7	391	401	PF00069	0.440
DOC_MAPK_DCC_7	865	873	PF00069	0.693
DOC_MAPK_gen_1	25	32	PF00069	0.495
DOC_MAPK_gen_1	329	338	PF00069	0.422
DOC_MAPK_HePTP_8	326	338	PF00069	0.426
DOC_MAPK_JIP1_4	595	601	PF00069	0.381
DOC_MAPK_MEF2A_6	31	39	PF00069	0.441
DOC_MAPK_MEF2A_6	329	338	PF00069	0.422
DOC_MAPK_MEF2A_6	718	727	PF00069	0.627
DOC_MAPK_NFAT4_5	31	39	PF00069	0.429
DOC_PP1_RVXF_1	389	396	PF00149	0.406
DOC_PP1_RVXF_1	794	801	PF00149	0.345
DOC_PP1_RVXF_1	842	849	PF00149	0.640
DOC_PP2B_LxvP_1	781	784	PF13499	0.380
DOC_PP4_FxxP_1	836	839	PF00568	0.720
DOC_SPAK_OSR1_1	31	35	PF12202	0.427
DOC_USP7_MATH_1	118	122	PF00917	0.470
DOC_USP7_MATH_1	174	178	PF00917	0.547
DOC_USP7_MATH_1	194	198	PF00917	0.574
DOC_USP7_MATH_1	235	239	PF00917	0.501
DOC_USP7_MATH_1	283	287	PF00917	0.443
DOC_USP7_MATH_1	316	320	PF00917	0.494
DOC_USP7_MATH_1	410	414	PF00917	0.481
DOC_USP7_MATH_1	46	50	PF00917	0.607
DOC_USP7_MATH_1	603	607	PF00917	0.391
DOC_USP7_MATH_1	79	83	PF00917	0.492
DOC_USP7_MATH_1	872	876	PF00917	0.720
DOC_USP7_MATH_1	877	881	PF00917	0.735
DOC_WW_Pin1_4	165	170	PF00397	0.474
DOC_WW_Pin1_4	17	22	PF00397	0.521
DOC_WW_Pin1_4	463	468	PF00397	0.534
DOC_WW_Pin1_4	830	835	PF00397	0.656
DOC_WW_Pin1_4	866	871	PF00397	0.662
LIG_14-3-3_CanoR_1	117	125	PF00244	0.498
LIG_14-3-3_CanoR_1	220	225	PF00244	0.402
LIG_14-3-3_CanoR_1	25	30	PF00244	0.516
LIG_14-3-3_CanoR_1	302	312	PF00244	0.517
LIG_14-3-3_CanoR_1	391	396	PF00244	0.417
LIG_14-3-3_CanoR_1	560	569	PF00244	0.512
LIG_14-3-3_CanoR_1	655	665	PF00244	0.589
LIG_14-3-3_CanoR_1	788	793	PF00244	0.374
LIG_14-3-3_CanoR_1	809	816	PF00244	0.447
LIG_14-3-3_CanoR_1	842	847	PF00244	0.671
LIG_Actin_WH2_2	774	790	PF00022	0.527
LIG_Actin_WH2_2	795	811	PF00022	0.395
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_BRCT_BRCA1_1	269	273	PF00533	0.448
LIG_BRCT_BRCA1_1	844	848	PF00533	0.667
LIG_DLG_GKlike_1	220	227	PF00625	0.439
LIG_EH1_1	31	39	PF00400	0.491
LIG_FHA_1	245	251	PF00498	0.520
LIG_FHA_1	304	310	PF00498	0.483
LIG_FHA_1	422	428	PF00498	0.354
LIG_FHA_1	751	757	PF00498	0.579
LIG_FHA_2	107	113	PF00498	0.515
LIG_FHA_2	48	54	PF00498	0.473
LIG_FHA_2	941	947	PF00498	0.689
LIG_GBD_Chelix_1	661	669	PF00786	0.277
LIG_GBD_Chelix_1	815	823	PF00786	0.270
LIG_Integrin_RGD_1	494	496	PF01839	0.634
LIG_LIR_Apic_2	833	839	PF02991	0.703
LIG_LIR_Gen_1	181	191	PF02991	0.500
LIG_LIR_Gen_1	223	228	PF02991	0.442
LIG_LIR_Gen_1	26	37	PF02991	0.497
LIG_LIR_Gen_1	321	328	PF02991	0.461
LIG_LIR_Gen_1	632	643	PF02991	0.409
LIG_LIR_Gen_1	719	730	PF02991	0.634
LIG_LIR_Gen_1	757	767	PF02991	0.475
LIG_LIR_Gen_1	884	895	PF02991	0.595
LIG_LIR_Nem_3	177	182	PF02991	0.509
LIG_LIR_Nem_3	223	227	PF02991	0.492
LIG_LIR_Nem_3	26	32	PF02991	0.534
LIG_LIR_Nem_3	321	326	PF02991	0.410
LIG_LIR_Nem_3	394	398	PF02991	0.417
LIG_LIR_Nem_3	632	638	PF02991	0.409
LIG_LIR_Nem_3	719	725	PF02991	0.598
LIG_LIR_Nem_3	757	762	PF02991	0.475
LIG_LIR_Nem_3	790	795	PF02991	0.453
LIG_LIR_Nem_3	884	890	PF02991	0.613
LIG_NRBOX	672	678	PF00104	0.395
LIG_PCNA_PIPBox_1	658	667	PF02747	0.611
LIG_PCNA_yPIPBox_3	641	655	PF02747	0.283
LIG_Pex14_1	323	327	PF04695	0.401
LIG_Pex14_2	179	183	PF04695	0.481
LIG_Pex14_2	583	587	PF04695	0.425
LIG_Pex14_2	635	639	PF04695	0.294
LIG_RPA_C_Fungi	431	443	PF08784	0.581
LIG_SH2_CRK	224	228	PF00017	0.516
LIG_SH2_CRK	722	726	PF00017	0.454
LIG_SH2_CRK	887	891	PF00017	0.515
LIG_SH2_PTP2	867	870	PF00017	0.531
LIG_SH2_STAP1	114	118	PF00017	0.630
LIG_SH2_STAP1	907	911	PF00017	0.487
LIG_SH2_STAP1	926	930	PF00017	0.536
LIG_SH2_STAT5	182	185	PF00017	0.598
LIG_SH2_STAT5	682	685	PF00017	0.454
LIG_SH2_STAT5	867	870	PF00017	0.531
LIG_SH2_STAT5	907	910	PF00017	0.484
LIG_SH3_3	163	169	PF00018	0.556
LIG_SH3_3	277	283	PF00018	0.553
LIG_SH3_3	390	396	PF00018	0.599
LIG_SH3_3	461	467	PF00018	0.574
LIG_SH3_3	599	605	PF00018	0.466
LIG_SH3_3	847	853	PF00018	0.606
LIG_SUMO_SIM_anti_2	286	293	PF11976	0.458
LIG_SUMO_SIM_anti_2	670	676	PF11976	0.370
LIG_SUMO_SIM_anti_2	764	770	PF11976	0.322
LIG_SUMO_SIM_par_1	290	295	PF11976	0.544
LIG_SUMO_SIM_par_1	600	608	PF11976	0.425
LIG_SUMO_SIM_par_1	625	632	PF11976	0.610
LIG_SUMO_SIM_par_1	723	729	PF11976	0.486
LIG_SUMO_SIM_par_1	869	875	PF11976	0.607
LIG_TRAF2_1	109	112	PF00917	0.644
LIG_TRAF2_1	576	579	PF00917	0.541
LIG_TRAF2_1	628	631	PF00917	0.494
LIG_TRAF2_1	853	856	PF00917	0.574
LIG_TRAF2_1	911	914	PF00917	0.430
LIG_TRAF2_1	947	950	PF00917	0.685
LIG_TYR_ITIM	720	725	PF00017	0.475
LIG_UBA3_1	709	718	PF00899	0.437
MOD_CDK_SPK_2	830	835	PF00069	0.540
MOD_CDK_SPxxK_3	835	842	PF00069	0.579
MOD_CK1_1	119	125	PF00069	0.702
MOD_CK1_1	12	18	PF00069	0.656
MOD_CK1_1	197	203	PF00069	0.731
MOD_CK1_1	2	8	PF00069	0.559
MOD_CK1_1	238	244	PF00069	0.618
MOD_CK1_1	269	275	PF00069	0.572
MOD_CK1_1	404	410	PF00069	0.755
MOD_CK1_1	466	472	PF00069	0.570
MOD_CK1_1	490	496	PF00069	0.579
MOD_CK1_1	61	67	PF00069	0.623
MOD_CK1_1	751	757	PF00069	0.588
MOD_CK1_1	84	90	PF00069	0.639
MOD_CK1_1	880	886	PF00069	0.615
MOD_CK1_1	889	895	PF00069	0.490
MOD_CK1_1	944	950	PF00069	0.611
MOD_CK2_1	106	112	PF00069	0.650
MOD_CK2_1	148	154	PF00069	0.627
MOD_CK2_1	301	307	PF00069	0.653
MOD_CK2_1	47	53	PF00069	0.550
MOD_CK2_1	625	631	PF00069	0.501
MOD_CK2_1	723	729	PF00069	0.580
MOD_CK2_1	79	85	PF00069	0.574
MOD_CK2_1	940	946	PF00069	0.607
MOD_CMANNOS	647	650	PF00535	0.395
MOD_CMANNOS	800	803	PF00535	0.345
MOD_CMANNOS	821	824	PF00535	0.499
MOD_Cter_Amidation	261	264	PF01082	0.653
MOD_Cter_Amidation	453	456	PF01082	0.660
MOD_GlcNHglycan	11	14	PF01048	0.783
MOD_GlcNHglycan	125	128	PF01048	0.661
MOD_GlcNHglycan	137	141	PF01048	0.548
MOD_GlcNHglycan	151	154	PF01048	0.543
MOD_GlcNHglycan	200	203	PF01048	0.714
MOD_GlcNHglycan	240	243	PF01048	0.648
MOD_GlcNHglycan	293	297	PF01048	0.615
MOD_GlcNHglycan	303	306	PF01048	0.575
MOD_GlcNHglycan	318	321	PF01048	0.485
MOD_GlcNHglycan	341	344	PF01048	0.568
MOD_GlcNHglycan	385	388	PF01048	0.461
MOD_GlcNHglycan	489	492	PF01048	0.724
MOD_GlcNHglycan	512	515	PF01048	0.686
MOD_GlcNHglycan	520	523	PF01048	0.677
MOD_GlcNHglycan	591	594	PF01048	0.443
MOD_GlcNHglycan	60	63	PF01048	0.676
MOD_GlcNHglycan	607	610	PF01048	0.494
MOD_GlcNHglycan	669	672	PF01048	0.396
MOD_GlcNHglycan	731	734	PF01048	0.648
MOD_GlcNHglycan	753	756	PF01048	0.598
MOD_GlcNHglycan	763	766	PF01048	0.295
MOD_GlcNHglycan	773	776	PF01048	0.238
MOD_GlcNHglycan	87	90	PF01048	0.691
MOD_GlcNHglycan	879	882	PF01048	0.616
MOD_GlcNHglycan	892	895	PF01048	0.526
MOD_GlcNHglycan	91	94	PF01048	0.728
MOD_GSK3_1	119	126	PF00069	0.619
MOD_GSK3_1	132	139	PF00069	0.688
MOD_GSK3_1	174	181	PF00069	0.638
MOD_GSK3_1	190	197	PF00069	0.551
MOD_GSK3_1	269	276	PF00069	0.609
MOD_GSK3_1	337	344	PF00069	0.429
MOD_GSK3_1	362	369	PF00069	0.578
MOD_GSK3_1	379	386	PF00069	0.545
MOD_GSK3_1	410	417	PF00069	0.545
MOD_GSK3_1	458	465	PF00069	0.698
MOD_GSK3_1	504	511	PF00069	0.565
MOD_GSK3_1	611	618	PF00069	0.552
MOD_GSK3_1	625	632	PF00069	0.519
MOD_GSK3_1	725	732	PF00069	0.671
MOD_GSK3_1	750	757	PF00069	0.589
MOD_GSK3_1	80	87	PF00069	0.688
MOD_GSK3_1	842	849	PF00069	0.616
MOD_GSK3_1	872	879	PF00069	0.693
MOD_GSK3_1	882	889	PF00069	0.521
MOD_GSK3_1	940	947	PF00069	0.535
MOD_GSK3_1	95	102	PF00069	0.667
MOD_N-GLC_1	184	189	PF02516	0.595
MOD_NEK2_1	175	180	PF00069	0.592
MOD_NEK2_1	184	189	PF00069	0.610
MOD_NEK2_1	273	278	PF00069	0.556
MOD_NEK2_1	379	384	PF00069	0.587
MOD_NEK2_1	414	419	PF00069	0.597
MOD_NEK2_1	489	494	PF00069	0.583
MOD_NEK2_1	544	549	PF00069	0.658
MOD_NEK2_1	556	561	PF00069	0.477
MOD_NEK2_1	615	620	PF00069	0.660
MOD_NEK2_1	629	634	PF00069	0.434
MOD_NEK2_1	687	692	PF00069	0.663
MOD_NEK2_1	703	708	PF00069	0.225
MOD_NEK2_1	723	728	PF00069	0.381
MOD_NEK2_1	787	792	PF00069	0.490
MOD_NEK2_1	798	803	PF00069	0.292
MOD_NEK2_1	819	824	PF00069	0.524
MOD_NEK2_1	871	876	PF00069	0.609
MOD_NEK2_1	890	895	PF00069	0.377
MOD_NEK2_1	95	100	PF00069	0.621
MOD_NEK2_2	558	563	PF00069	0.577
MOD_NEK2_2	886	891	PF00069	0.515
MOD_PIKK_1	194	200	PF00454	0.615
MOD_PIKK_1	2	8	PF00454	0.603
MOD_PIKK_1	402	408	PF00454	0.592
MOD_PK_1	508	514	PF00069	0.599
MOD_PK_1	842	848	PF00069	0.581
MOD_PKA_1	116	122	PF00069	0.580
MOD_PKA_2	116	122	PF00069	0.664
MOD_PKA_2	132	138	PF00069	0.763
MOD_PKA_2	301	307	PF00069	0.642
MOD_PKA_2	579	585	PF00069	0.412
MOD_PKA_2	787	793	PF00069	0.436
MOD_PKA_2	808	814	PF00069	0.447
MOD_PKA_2	890	896	PF00069	0.502
MOD_PKA_2	95	101	PF00069	0.708
MOD_PKB_1	456	464	PF00069	0.682
MOD_Plk_1	266	272	PF00069	0.648
MOD_Plk_1	587	593	PF00069	0.509
MOD_Plk_1	71	77	PF00069	0.557
MOD_Plk_1	811	817	PF00069	0.299
MOD_Plk_1	846	852	PF00069	0.576
MOD_Plk_2-3	631	637	PF00069	0.395
MOD_Plk_4	178	184	PF00069	0.594
MOD_Plk_4	269	275	PF00069	0.597
MOD_Plk_4	283	289	PF00069	0.485
MOD_Plk_4	385	391	PF00069	0.503
MOD_Plk_4	410	416	PF00069	0.616
MOD_Plk_4	422	428	PF00069	0.428
MOD_Plk_4	473	479	PF00069	0.614
MOD_Plk_4	544	550	PF00069	0.634
MOD_Plk_4	579	585	PF00069	0.500
MOD_Plk_4	611	617	PF00069	0.513
MOD_Plk_4	657	663	PF00069	0.537
MOD_Plk_4	754	760	PF00069	0.345
MOD_Plk_4	788	794	PF00069	0.513
MOD_Plk_4	811	817	PF00069	0.287
MOD_ProDKin_1	165	171	PF00069	0.596
MOD_ProDKin_1	17	23	PF00069	0.514
MOD_ProDKin_1	463	469	PF00069	0.670
MOD_ProDKin_1	830	836	PF00069	0.570
MOD_ProDKin_1	866	872	PF00069	0.570
TRG_DiLeu_BaLyEn_6	484	489	PF01217	0.618
TRG_ENDOCYTIC_2	224	227	PF00928	0.513
TRG_ENDOCYTIC_2	722	725	PF00928	0.500
TRG_ENDOCYTIC_2	887	890	PF00928	0.505
TRG_ER_diArg_1	219	222	PF00400	0.520
TRG_ER_diArg_1	328	331	PF00400	0.587
TRG_ER_diArg_1	435	437	PF00400	0.584
TRG_ER_diArg_1	452	455	PF00400	0.545
TRG_ER_diArg_1	530	533	PF00400	0.518
TRG_ER_diArg_1	654	656	PF00400	0.453
TRG_ER_diArg_1	684	686	PF00400	0.551
TRG_NES_CRM1_1	282	293	PF08389	0.482
TRG_Pf-PMV_PEXEL_1	910	914	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE8	Leptomonas seymouri	34%	100%
A4HGI2	Leishmania braziliensis	66%	98%
E9ACJ2	Leishmania major	89%	100%
E9AG36	Leishmania infantum	99%	100%
E9AJT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%