Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A451EJP7_LEIDO

TriTrypDb:

LdBPK_030440.1 , LdCL_030009400 , LDHU3_03.0450

Length:

1058

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	547	551	PF00656	0.629
CLV_C14_Caspase3-7	556	560	PF00656	0.559
CLV_C14_Caspase3-7	766	770	PF00656	0.651
CLV_C14_Caspase3-7	91	95	PF00656	0.775
CLV_NRD_NRD_1	123	125	PF00675	0.816
CLV_NRD_NRD_1	202	204	PF00675	0.786
CLV_NRD_NRD_1	459	461	PF00675	0.635
CLV_NRD_NRD_1	918	920	PF00675	0.781
CLV_PCSK_FUR_1	916	920	PF00082	0.718
CLV_PCSK_KEX2_1	123	125	PF00082	0.816
CLV_PCSK_KEX2_1	202	204	PF00082	0.838
CLV_PCSK_KEX2_1	459	461	PF00082	0.635
CLV_PCSK_KEX2_1	918	920	PF00082	0.781
CLV_PCSK_PC7_1	198	204	PF00082	0.817
CLV_PCSK_SKI1_1	136	140	PF00082	0.797
CLV_PCSK_SKI1_1	169	173	PF00082	0.715
CLV_PCSK_SKI1_1	549	553	PF00082	0.771
CLV_PCSK_SKI1_1	657	661	PF00082	0.604
CLV_PCSK_SKI1_1	918	922	PF00082	0.719
DEG_APCC_DBOX_1	583	591	PF00400	0.665
DEG_Nend_Nbox_1	1	3	PF02207	0.735
DEG_SPOP_SBC_1	569	573	PF00917	0.701
DOC_CKS1_1	231	236	PF01111	0.836
DOC_CKS1_1	455	460	PF01111	0.729
DOC_CKS1_1	46	51	PF01111	0.703
DOC_CKS1_1	533	538	PF01111	0.764
DOC_CKS1_1	76	81	PF01111	0.715
DOC_CKS1_1	779	784	PF01111	0.760
DOC_CYCLIN_RxL_1	133	143	PF00134	0.791
DOC_MAPK_gen_1	202	213	PF00069	0.741
DOC_MAPK_MEF2A_6	173	180	PF00069	0.702
DOC_MAPK_MEF2A_6	206	215	PF00069	0.734
DOC_PP2B_LxvP_1	1008	1011	PF13499	0.758
DOC_PP2B_LxvP_1	129	132	PF13499	0.792
DOC_PP2B_LxvP_1	215	218	PF13499	0.681
DOC_PP2B_LxvP_1	252	255	PF13499	0.710
DOC_PP2B_PxIxI_1	535	541	PF00149	0.734
DOC_PP4_MxPP_1	242	245	PF00568	0.702
DOC_USP7_MATH_1	134	138	PF00917	0.733
DOC_USP7_MATH_1	14	18	PF00917	0.629
DOC_USP7_MATH_1	270	274	PF00917	0.766
DOC_USP7_MATH_1	429	433	PF00917	0.752
DOC_USP7_MATH_1	520	524	PF00917	0.809
DOC_USP7_MATH_1	568	572	PF00917	0.720
DOC_USP7_MATH_1	591	595	PF00917	0.632
DOC_USP7_MATH_1	624	628	PF00917	0.794
DOC_USP7_MATH_1	692	696	PF00917	0.617
DOC_USP7_MATH_1	834	838	PF00917	0.646
DOC_USP7_MATH_1	850	854	PF00917	0.483
DOC_USP7_MATH_1	935	939	PF00917	0.730
DOC_USP7_MATH_1	958	962	PF00917	0.681
DOC_USP7_MATH_1	993	997	PF00917	0.682
DOC_WW_Pin1_4	100	105	PF00397	0.817
DOC_WW_Pin1_4	110	115	PF00397	0.830
DOC_WW_Pin1_4	230	235	PF00397	0.835
DOC_WW_Pin1_4	332	337	PF00397	0.688
DOC_WW_Pin1_4	357	362	PF00397	0.764
DOC_WW_Pin1_4	366	371	PF00397	0.657
DOC_WW_Pin1_4	382	387	PF00397	0.519
DOC_WW_Pin1_4	397	402	PF00397	0.732
DOC_WW_Pin1_4	41	46	PF00397	0.749
DOC_WW_Pin1_4	421	426	PF00397	0.699
DOC_WW_Pin1_4	443	448	PF00397	0.790
DOC_WW_Pin1_4	454	459	PF00397	0.806
DOC_WW_Pin1_4	479	484	PF00397	0.581
DOC_WW_Pin1_4	499	504	PF00397	0.663
DOC_WW_Pin1_4	509	514	PF00397	0.582
DOC_WW_Pin1_4	532	537	PF00397	0.811
DOC_WW_Pin1_4	541	546	PF00397	0.547
DOC_WW_Pin1_4	676	681	PF00397	0.777
DOC_WW_Pin1_4	688	693	PF00397	0.682
DOC_WW_Pin1_4	697	702	PF00397	0.663
DOC_WW_Pin1_4	717	722	PF00397	0.520
DOC_WW_Pin1_4	75	80	PF00397	0.779
DOC_WW_Pin1_4	758	763	PF00397	0.782
DOC_WW_Pin1_4	778	783	PF00397	0.489
DOC_WW_Pin1_4	795	800	PF00397	0.598
DOC_WW_Pin1_4	843	848	PF00397	0.742
DOC_WW_Pin1_4	863	868	PF00397	0.779
LIG_14-3-3_CanoR_1	1046	1052	PF00244	0.680
LIG_14-3-3_CanoR_1	110	114	PF00244	0.708
LIG_14-3-3_CanoR_1	123	133	PF00244	0.680
LIG_14-3-3_CanoR_1	136	141	PF00244	0.620
LIG_14-3-3_CanoR_1	144	148	PF00244	0.665
LIG_14-3-3_CanoR_1	37	43	PF00244	0.627
LIG_14-3-3_CanoR_1	431	436	PF00244	0.749
LIG_14-3-3_CanoR_1	519	525	PF00244	0.609
LIG_14-3-3_CanoR_1	584	588	PF00244	0.697
LIG_14-3-3_CanoR_1	657	666	PF00244	0.593
LIG_14-3-3_CanoR_1	686	692	PF00244	0.711
LIG_14-3-3_CanoR_1	737	743	PF00244	0.707
LIG_APCC_ABBA_1	608	613	PF00400	0.686
LIG_BIR_III_4	769	773	PF00653	0.690
LIG_BRCT_BRCA1_1	841	845	PF00533	0.576
LIG_deltaCOP1_diTrp_1	559	564	PF00928	0.589
LIG_deltaCOP1_diTrp_1	794	802	PF00928	0.779
LIG_EVH1_1	129	133	PF00568	0.788
LIG_FHA_1	110	116	PF00498	0.659
LIG_FHA_1	159	165	PF00498	0.746
LIG_FHA_1	291	297	PF00498	0.609
LIG_FHA_1	369	375	PF00498	0.617
LIG_FHA_1	533	539	PF00498	0.818
LIG_FHA_1	718	724	PF00498	0.742
LIG_FHA_1	737	743	PF00498	0.675
LIG_FHA_1	886	892	PF00498	0.766
LIG_FHA_1	957	963	PF00498	0.713
LIG_FHA_2	231	237	PF00498	0.730
LIG_FHA_2	500	506	PF00498	0.756
LIG_FHA_2	545	551	PF00498	0.705
LIG_FHA_2	554	560	PF00498	0.619
LIG_FHA_2	877	883	PF00498	0.622
LIG_LIR_Apic_2	369	375	PF02991	0.728
LIG_LIR_Apic_2	397	401	PF02991	0.730
LIG_LIR_Apic_2	695	701	PF02991	0.829
LIG_LIR_Apic_2	794	799	PF02991	0.778
LIG_LIR_Gen_1	846	857	PF02991	0.684
LIG_LIR_Gen_1	899	907	PF02991	0.698
LIG_LIR_Nem_3	246	250	PF02991	0.707
LIG_LIR_Nem_3	298	304	PF02991	0.776
LIG_LIR_Nem_3	846	852	PF02991	0.720
LIG_LIR_Nem_3	853	857	PF02991	0.601
LIG_LIR_Nem_3	899	903	PF02991	0.698
LIG_NRBOX	900	906	PF00104	0.698
LIG_PTAP_UEV_1	482	487	PF05743	0.578
LIG_SH2_CRK	372	376	PF00017	0.735
LIG_SH2_CRK	849	853	PF00017	0.647
LIG_SH2_NCK_1	849	853	PF00017	0.717
LIG_SH2_STAT3	117	120	PF00017	0.635
LIG_SH2_STAT3	415	418	PF00017	0.572
LIG_SH2_STAT3	699	702	PF00017	0.765
LIG_SH3_1	43	49	PF00018	0.733
LIG_SH3_2	455	460	PF14604	0.633
LIG_SH3_3	127	133	PF00018	0.793
LIG_SH3_3	17	23	PF00018	0.668
LIG_SH3_3	300	306	PF00018	0.716
LIG_SH3_3	43	49	PF00018	0.857
LIG_SH3_3	452	458	PF00018	0.717
LIG_SH3_3	462	468	PF00018	0.605
LIG_SH3_3	477	483	PF00018	0.517
LIG_SH3_3	739	745	PF00018	0.674
LIG_SH3_3	992	998	PF00018	0.778
LIG_SUMO_SIM_anti_2	899	905	PF11976	0.699
LIG_SUMO_SIM_par_1	678	685	PF11976	0.729
LIG_SUMO_SIM_par_1	887	892	PF11976	0.776
LIG_TRAF2_1	182	185	PF00917	0.794
LIG_TRAF2_1	489	492	PF00917	0.691
LIG_TRAF2_2	804	809	PF00917	0.725
LIG_UBA3_1	290	295	PF00899	0.712
LIG_WW_1	244	247	PF00397	0.702
LIG_WW_1	86	89	PF00397	0.788
MOD_CDC14_SPxK_1	360	363	PF00782	0.745
MOD_CDK_SPK_2	105	110	PF00069	0.734
MOD_CDK_SPK_2	332	337	PF00069	0.609
MOD_CDK_SPK_2	454	459	PF00069	0.806
MOD_CDK_SPK_2	75	80	PF00069	0.716
MOD_CDK_SPK_2	778	783	PF00069	0.584
MOD_CDK_SPxK_1	357	363	PF00069	0.749
MOD_CDK_SPxK_1	447	453	PF00069	0.797
MOD_CDK_SPxK_1	454	460	PF00069	0.564
MOD_CDK_SPxK_1	758	764	PF00069	0.738
MOD_CDK_SPxxK_3	100	107	PF00069	0.736
MOD_CDK_SPxxK_3	366	373	PF00069	0.768
MOD_CDK_SPxxK_3	45	52	PF00069	0.760
MOD_CDK_SPxxK_3	717	724	PF00069	0.693
MOD_CK1_1	274	280	PF00069	0.766
MOD_CK1_1	28	34	PF00069	0.733
MOD_CK1_1	41	47	PF00069	0.822
MOD_CK1_1	446	452	PF00069	0.791
MOD_CK1_1	484	490	PF00069	0.754
MOD_CK1_1	573	579	PF00069	0.633
MOD_CK1_1	589	595	PF00069	0.702
MOD_CK1_1	679	685	PF00069	0.846
MOD_CK1_1	687	693	PF00069	0.705
MOD_CK1_1	743	749	PF00069	0.736
MOD_CK1_1	841	847	PF00069	0.750
MOD_CK1_1	848	854	PF00069	0.646
MOD_CK1_1	885	891	PF00069	0.773
MOD_CK1_1	90	96	PF00069	0.795
MOD_CK1_1	939	945	PF00069	0.726
MOD_CK1_1	996	1002	PF00069	0.766
MOD_CK2_1	2	8	PF00069	0.691
MOD_CK2_1	351	357	PF00069	0.705
MOD_CK2_1	499	505	PF00069	0.758
MOD_CK2_1	788	794	PF00069	0.649
MOD_CK2_1	871	877	PF00069	0.842
MOD_CK2_1	94	100	PF00069	0.730
MOD_GlcNHglycan	1019	1022	PF01048	0.710
MOD_GlcNHglycan	1047	1050	PF01048	0.678
MOD_GlcNHglycan	165	169	PF01048	0.768
MOD_GlcNHglycan	187	190	PF01048	0.695
MOD_GlcNHglycan	215	218	PF01048	0.721
MOD_GlcNHglycan	27	30	PF01048	0.706
MOD_GlcNHglycan	313	316	PF01048	0.789
MOD_GlcNHglycan	353	356	PF01048	0.762
MOD_GlcNHglycan	391	394	PF01048	0.747
MOD_GlcNHglycan	4	7	PF01048	0.715
MOD_GlcNHglycan	483	486	PF01048	0.600
MOD_GlcNHglycan	514	517	PF01048	0.696
MOD_GlcNHglycan	566	569	PF01048	0.698
MOD_GlcNHglycan	593	596	PF01048	0.750
MOD_GlcNHglycan	626	629	PF01048	0.741
MOD_GlcNHglycan	686	689	PF01048	0.795
MOD_GlcNHglycan	711	714	PF01048	0.770
MOD_GlcNHglycan	749	752	PF01048	0.736
MOD_GlcNHglycan	783	786	PF01048	0.747
MOD_GlcNHglycan	790	793	PF01048	0.641
MOD_GlcNHglycan	913	916	PF01048	0.700
MOD_GlcNHglycan	923	927	PF01048	0.619
MOD_GlcNHglycan	941	944	PF01048	0.675
MOD_GlcNHglycan	96	99	PF01048	0.821
MOD_GlcNHglycan	971	976	PF01048	0.691
MOD_GSK3_1	105	112	PF00069	0.812
MOD_GSK3_1	134	141	PF00069	0.789
MOD_GSK3_1	185	192	PF00069	0.697
MOD_GSK3_1	2	9	PF00069	0.732
MOD_GSK3_1	202	209	PF00069	0.634
MOD_GSK3_1	270	277	PF00069	0.764
MOD_GSK3_1	347	354	PF00069	0.593
MOD_GSK3_1	378	385	PF00069	0.727
MOD_GSK3_1	41	48	PF00069	0.708
MOD_GSK3_1	420	427	PF00069	0.762
MOD_GSK3_1	431	438	PF00069	0.627
MOD_GSK3_1	443	450	PF00069	0.626
MOD_GSK3_1	564	571	PF00069	0.683
MOD_GSK3_1	582	589	PF00069	0.750
MOD_GSK3_1	682	689	PF00069	0.821
MOD_GSK3_1	693	700	PF00069	0.597
MOD_GSK3_1	709	716	PF00069	0.658
MOD_GSK3_1	736	743	PF00069	0.719
MOD_GSK3_1	749	756	PF00069	0.630
MOD_GSK3_1	777	784	PF00069	0.699
MOD_GSK3_1	834	841	PF00069	0.739
MOD_GSK3_1	876	883	PF00069	0.685
MOD_GSK3_1	90	97	PF00069	0.732
MOD_GSK3_1	935	942	PF00069	0.750
MOD_GSK3_1	946	953	PF00069	0.557
MOD_GSK3_1	996	1003	PF00069	0.733
MOD_LATS_1	122	128	PF00433	0.814
MOD_LATS_1	200	206	PF00433	0.816
MOD_LATS_1	869	875	PF00433	0.727
MOD_N-GLC_1	337	342	PF02516	0.646
MOD_N-GLC_1	911	916	PF02516	0.688
MOD_NEK2_1	1000	1005	PF00069	0.589
MOD_NEK2_1	1047	1052	PF00069	0.503
MOD_NEK2_1	2	7	PF00069	0.726
MOD_NEK2_1	213	218	PF00069	0.611
MOD_NEK2_1	290	295	PF00069	0.639
MOD_NEK2_1	30	35	PF00069	0.539
MOD_NEK2_1	389	394	PF00069	0.631
MOD_NEK2_1	430	435	PF00069	0.801
MOD_NEK2_1	552	557	PF00069	0.812
MOD_NEK2_1	564	569	PF00069	0.604
MOD_NEK2_1	622	627	PF00069	0.753
MOD_NEK2_1	668	673	PF00069	0.617
MOD_NEK2_1	709	714	PF00069	0.677
MOD_NEK2_1	763	768	PF00069	0.681
MOD_NEK2_2	38	43	PF00069	0.626
MOD_NEK2_2	6	11	PF00069	0.682
MOD_PIKK_1	275	281	PF00454	0.770
MOD_PIKK_1	668	674	PF00454	0.546
MOD_PIKK_1	740	746	PF00454	0.772
MOD_PIKK_1	882	888	PF00454	0.791
MOD_PK_1	431	437	PF00069	0.778
MOD_PK_1	880	886	PF00069	0.761
MOD_PKA_1	202	208	PF00069	0.787
MOD_PKA_2	1045	1051	PF00069	0.679
MOD_PKA_2	109	115	PF00069	0.691
MOD_PKA_2	125	131	PF00069	0.695
MOD_PKA_2	143	149	PF00069	0.568
MOD_PKA_2	202	208	PF00069	0.808
MOD_PKA_2	23	29	PF00069	0.680
MOD_PKA_2	319	325	PF00069	0.756
MOD_PKA_2	36	42	PF00069	0.576
MOD_PKA_2	430	436	PF00069	0.750
MOD_PKA_2	583	589	PF00069	0.693
MOD_PKA_2	736	742	PF00069	0.709
MOD_PKA_2	763	769	PF00069	0.682
MOD_Plk_1	880	886	PF00069	0.793
MOD_Plk_4	534	540	PF00069	0.766
MOD_Plk_4	693	699	PF00069	0.704
MOD_Plk_4	749	755	PF00069	0.668
MOD_Plk_4	958	964	PF00069	0.664
MOD_ProDKin_1	100	106	PF00069	0.817
MOD_ProDKin_1	110	116	PF00069	0.831
MOD_ProDKin_1	230	236	PF00069	0.837
MOD_ProDKin_1	332	338	PF00069	0.687
MOD_ProDKin_1	357	363	PF00069	0.766
MOD_ProDKin_1	366	372	PF00069	0.659
MOD_ProDKin_1	382	388	PF00069	0.518
MOD_ProDKin_1	397	403	PF00069	0.731
MOD_ProDKin_1	41	47	PF00069	0.768
MOD_ProDKin_1	421	427	PF00069	0.699
MOD_ProDKin_1	443	449	PF00069	0.789
MOD_ProDKin_1	454	460	PF00069	0.807
MOD_ProDKin_1	479	485	PF00069	0.580
MOD_ProDKin_1	499	505	PF00069	0.663
MOD_ProDKin_1	509	515	PF00069	0.582
MOD_ProDKin_1	532	538	PF00069	0.812
MOD_ProDKin_1	541	547	PF00069	0.547
MOD_ProDKin_1	676	682	PF00069	0.781
MOD_ProDKin_1	688	694	PF00069	0.681
MOD_ProDKin_1	697	703	PF00069	0.661
MOD_ProDKin_1	717	723	PF00069	0.519
MOD_ProDKin_1	75	81	PF00069	0.779
MOD_ProDKin_1	758	764	PF00069	0.783
MOD_ProDKin_1	778	784	PF00069	0.489
MOD_ProDKin_1	795	801	PF00069	0.598
MOD_ProDKin_1	843	849	PF00069	0.743
MOD_ProDKin_1	863	869	PF00069	0.781
MOD_SUMO_rev_2	221	229	PF00179	0.686
TRG_DiLeu_BaEn_1	899	904	PF01217	0.699
TRG_ENDOCYTIC_2	849	852	PF00928	0.681
TRG_ER_diArg_1	1037	1040	PF00400	0.718
TRG_ER_diArg_1	1044	1047	PF00400	0.511
TRG_ER_diArg_1	123	125	PF00400	0.816
TRG_ER_diArg_1	458	460	PF00400	0.633
TRG_ER_diArg_1	723	726	PF00400	0.682
TRG_ER_diArg_1	916	919	PF00400	0.771
TRG_Pf-PMV_PEXEL_1	919	923	PF00026	0.721

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3R6	Leishmania braziliensis	62%	97%
E9ACJ1	Leishmania major	86%	100%
E9AG35	Leishmania infantum	99%	100%
E9AJS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%