LeishMANIAdb
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GPR1/FUN34/yaaH family, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GPR1/FUN34/yaaH family, putative
Gene product:
GPR1/FUN34/yaaH family, putative
Species:
Leishmania donovani
UniProt:
A0A451EJN9_LEIDO
TriTrypDb:
LdBPK_030350.1 , LdCL_030008500 , LDHU3_03.0360
Length:
310

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
GO:0005886 plasma membrane 3 2

Expansion

Sequence features

A0A451EJN9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJN9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006811 monoatomic ion transport 4 2
GO:0006820 monoatomic anion transport 5 2
GO:0006835 dicarboxylic acid transport 7 2
GO:0006846 acetate transport 6 2
GO:0009987 cellular process 1 2
GO:0015711 organic anion transport 5 2
GO:0015718 monocarboxylic acid transport 7 2
GO:0015740 C4-dicarboxylate transport 8 2
GO:0015744 succinate transport 6 2
GO:0015849 organic acid transport 5 2
GO:0034220 monoatomic ion transmembrane transport 3 2
GO:0035433 acetate transmembrane transport 5 2
GO:0046942 carboxylic acid transport 6 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
GO:0071422 succinate transmembrane transport 5 2
GO:0071702 organic substance transport 4 2
GO:0098656 monoatomic anion transmembrane transport 4 2
GO:1903825 organic acid transmembrane transport 3 2
GO:1905039 carboxylic acid transmembrane transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0005342 organic acid transmembrane transporter activity 3 2
GO:0008028 monocarboxylic acid transmembrane transporter activity 5 2
GO:0008324 monoatomic cation transmembrane transporter activity 4 2
GO:0008509 monoatomic anion transmembrane transporter activity 4 2
GO:0008514 organic anion transmembrane transporter activity 5 2
GO:0015075 monoatomic ion transmembrane transporter activity 3 2
GO:0015078 proton transmembrane transporter activity 5 2
GO:0015123 acetate transmembrane transporter activity 6 2
GO:0015291 secondary active transmembrane transporter activity 4 2
GO:0015293 symporter activity 5 2
GO:0015294 solute:monoatomic cation symporter activity 5 2
GO:0015295 solute:proton symporter activity 6 2
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 2
GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5 2
GO:0015360 acetate:proton symporter activity 7 2
GO:0022804 active transmembrane transporter activity 3 2
GO:0022853 active monoatomic ion transmembrane transporter activity 4 2
GO:0022857 transmembrane transporter activity 2 2
GO:0022890 inorganic cation transmembrane transporter activity 4 2
GO:0043893 acetate:monoatomic cation symporter activity 6 2
GO:0046943 carboxylic acid transmembrane transporter activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 207 211 PF00656 0.207
CLV_NRD_NRD_1 106 108 PF00675 0.406
CLV_NRD_NRD_1 48 50 PF00675 0.471
CLV_PCSK_KEX2_1 106 108 PF00082 0.541
CLV_PCSK_KEX2_1 303 305 PF00082 0.354
CLV_PCSK_PC1ET2_1 303 305 PF00082 0.354
CLV_PCSK_SKI1_1 294 298 PF00082 0.340
DEG_APCC_DBOX_1 293 301 PF00400 0.579
DOC_MAPK_DCC_7 120 129 PF00069 0.468
DOC_MAPK_gen_1 44 53 PF00069 0.661
DOC_MAPK_MEF2A_6 294 301 PF00069 0.589
DOC_PP4_FxxP_1 198 201 PF00568 0.326
DOC_PP4_FxxP_1 233 236 PF00568 0.475
DOC_PP4_FxxP_1 244 247 PF00568 0.326
DOC_USP7_MATH_1 201 205 PF00917 0.273
DOC_USP7_MATH_1 27 31 PF00917 0.746
DOC_WW_Pin1_4 112 117 PF00397 0.719
DOC_WW_Pin1_4 120 125 PF00397 0.490
DOC_WW_Pin1_4 232 237 PF00397 0.490
DOC_WW_Pin1_4 74 79 PF00397 0.598
LIG_14-3-3_CanoR_1 176 180 PF00244 0.471
LIG_14-3-3_CanoR_1 234 244 PF00244 0.435
LIG_14-3-3_CanoR_1 37 42 PF00244 0.607
LIG_Actin_WH2_2 275 291 PF00022 0.326
LIG_APCC_ABBA_1 5 10 PF00400 0.639
LIG_BRCT_BRCA1_1 225 229 PF00533 0.410
LIG_BRCT_BRCA1_1 253 257 PF00533 0.271
LIG_EH1_1 131 139 PF00400 0.254
LIG_FHA_1 133 139 PF00498 0.298
LIG_FHA_1 151 157 PF00498 0.289
LIG_FHA_1 162 168 PF00498 0.285
LIG_FHA_1 192 198 PF00498 0.298
LIG_FHA_1 266 272 PF00498 0.290
LIG_FHA_1 29 35 PF00498 0.670
LIG_FHA_2 285 291 PF00498 0.520
LIG_LIR_Apic_2 231 236 PF02991 0.435
LIG_LIR_Gen_1 235 245 PF02991 0.463
LIG_LIR_Nem_3 184 190 PF02991 0.316
LIG_Pex14_2 166 170 PF04695 0.312
LIG_Pex14_2 217 221 PF04695 0.276
LIG_Pex14_2 229 233 PF04695 0.291
LIG_SH2_STAT5 205 208 PF00017 0.235
LIG_SH2_STAT5 270 273 PF00017 0.363
LIG_SH2_STAT5 281 284 PF00017 0.290
LIG_SH2_STAT5 307 310 PF00017 0.665
LIG_SH2_STAT5 55 58 PF00017 0.687
LIG_SH3_2 91 96 PF14604 0.548
LIG_SH3_3 10 16 PF00018 0.658
LIG_SH3_3 110 116 PF00018 0.689
LIG_SH3_3 88 94 PF00018 0.683
LIG_TRAF2_1 78 81 PF00917 0.582
LIG_UBA3_1 296 303 PF00899 0.556
MOD_CK1_1 232 238 PF00069 0.435
MOD_CK1_1 74 80 PF00069 0.703
MOD_CK2_1 201 207 PF00069 0.227
MOD_CK2_1 55 61 PF00069 0.747
MOD_CK2_1 74 80 PF00069 0.666
MOD_DYRK1A_RPxSP_1 112 116 PF00069 0.596
MOD_GSK3_1 175 182 PF00069 0.443
MOD_GSK3_1 18 25 PF00069 0.734
MOD_GSK3_1 224 231 PF00069 0.419
MOD_GSK3_1 72 79 PF00069 0.610
MOD_N-GLC_1 23 28 PF02516 0.420
MOD_N-GLC_1 71 76 PF02516 0.498
MOD_N-GLC_2 145 147 PF02516 0.421
MOD_NEK2_1 132 137 PF00069 0.295
MOD_NEK2_1 179 184 PF00069 0.322
MOD_NEK2_1 224 229 PF00069 0.293
MOD_NEK2_1 251 256 PF00069 0.331
MOD_NEK2_1 284 289 PF00069 0.475
MOD_PIKK_1 161 167 PF00454 0.312
MOD_PKA_2 175 181 PF00069 0.435
MOD_Plk_1 201 207 PF00069 0.224
MOD_Plk_4 132 138 PF00069 0.286
MOD_Plk_4 201 207 PF00069 0.305
MOD_Plk_4 224 230 PF00069 0.269
MOD_Plk_4 277 283 PF00069 0.307
MOD_ProDKin_1 112 118 PF00069 0.717
MOD_ProDKin_1 120 126 PF00069 0.490
MOD_ProDKin_1 232 238 PF00069 0.490
MOD_ProDKin_1 74 80 PF00069 0.597
MOD_SUMO_rev_2 77 85 PF00179 0.592
TRG_DiLeu_BaEn_4 80 86 PF01217 0.636
TRG_ENDOCYTIC_2 187 190 PF00928 0.322
TRG_ENDOCYTIC_2 270 273 PF00928 0.339
TRG_ENDOCYTIC_2 281 284 PF00928 0.283
TRG_ER_diArg_1 304 307 PF00400 0.560
TRG_ER_diArg_1 41 44 PF00400 0.691

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0C8 Leptomonas seymouri 59% 97%
A0A3R7M294 Trypanosoma rangeli 35% 100%
A0A3R7MT82 Trypanosoma rangeli 30% 100%
A0A3S5H540 Leishmania donovani 25% 100%
A4HRU7 Leishmania infantum 99% 100%
A4HRU8 Leishmania infantum 23% 100%
A4HRV0 Leishmania infantum 25% 100%
E9ACI2 Leishmania major 87% 100%
E9ACI3 Leishmania major 24% 100%
E9ACI5 Leishmania major 26% 100%
E9AJS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9AJS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 83%
P32907 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS