LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A451EJM8_LEIDO
TriTrypDb:
LdBPK_030230.1 , LdCL_030007300 , LDHU3_03.0240
Length:
154

Annotations

LeishMANIAdb annotations

These Kinetoplastid-specific proteins have an unclear topology and structure. Might not be even embedded into the membrane.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A451EJM8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJM8

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 150 152 PF00675 0.508
CLV_NRD_NRD_1 3 5 PF00675 0.442
CLV_NRD_NRD_1 31 33 PF00675 0.313
CLV_NRD_NRD_1 7 9 PF00675 0.451
CLV_PCSK_FUR_1 28 32 PF00082 0.433
CLV_PCSK_KEX2_1 152 154 PF00082 0.565
CLV_PCSK_KEX2_1 28 30 PF00082 0.453
CLV_PCSK_KEX2_1 3 5 PF00082 0.442
CLV_PCSK_KEX2_1 31 33 PF00082 0.309
CLV_PCSK_KEX2_1 7 9 PF00082 0.452
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P4K8 Leptomonas seymouri 72% 100%
A0A0S4JRA9 Bodo saltans 42% 100%
A0A1X0P915 Trypanosomatidae 48% 100%
A0A422NQR6 Trypanosoma rangeli 51% 100%
A4H3J6 Leishmania braziliensis 87% 100%
A4HRT5 Leishmania infantum 99% 100%
D0A236 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9ACH1 Leishmania major 96% 100%
E9AJQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS