Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJM8_LEIDO

TriTrypDb:

LdBPK_030230.1 , LdCL_030007300 , LDHU3_03.0240

Length:

154

Annotations

LeishMANIAdb annotations

These Kinetoplastid-specific proteins have an unclear topology and structure. Might not be even embedded into the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A451EJM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.508
CLV_NRD_NRD_1	3	5	PF00675	0.442
CLV_NRD_NRD_1	31	33	PF00675	0.313
CLV_NRD_NRD_1	7	9	PF00675	0.451
CLV_PCSK_FUR_1	28	32	PF00082	0.433
CLV_PCSK_KEX2_1	152	154	PF00082	0.565
CLV_PCSK_KEX2_1	28	30	PF00082	0.453
CLV_PCSK_KEX2_1	3	5	PF00082	0.442
CLV_PCSK_KEX2_1	31	33	PF00082	0.309
CLV_PCSK_KEX2_1	7	9	PF00082	0.452
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.543
CLV_PCSK_PC7_1	3	9	PF00082	0.453
DEG_Nend_Nbox_1	1	3	PF02207	0.668
DOC_MAPK_gen_1	54	61	PF00069	0.358
DOC_MAPK_MEF2A_6	54	63	PF00069	0.383
DOC_PP2B_LxvP_1	121	124	PF13499	0.655
DOC_PP4_FxxP_1	53	56	PF00568	0.384
DOC_USP7_MATH_1	146	150	PF00917	0.737
LIG_14-3-3_CanoR_1	129	137	PF00244	0.700
LIG_14-3-3_CanoR_1	3	10	PF00244	0.736
LIG_14-3-3_CterR_2	151	154	PF00244	0.768
LIG_APCC_ABBA_1	47	52	PF00400	0.537
LIG_BIR_III_4	35	39	PF00653	0.447
LIG_eIF4E_1	68	74	PF01652	0.408
LIG_FHA_1	97	103	PF00498	0.710
LIG_LIR_Apic_2	51	56	PF02991	0.384
LIG_LIR_Gen_1	117	126	PF02991	0.666
LIG_LIR_LC3C_4	71	75	PF02991	0.266
LIG_LIR_Nem_3	117	123	PF02991	0.683
LIG_NRBOX	41	47	PF00104	0.434
LIG_PCNA_yPIPBox_3	32	46	PF02747	0.214
LIG_PTB_Apo_2	9	16	PF02174	0.735
LIG_Rb_pABgroove_1	44	52	PF01858	0.480
LIG_SH2_CRK	70	74	PF00017	0.319
LIG_SH2_NCK_1	34	38	PF00017	0.378
LIG_SH2_STAP1	70	74	PF00017	0.266
LIG_SH2_STAT5	107	110	PF00017	0.660
LIG_SH3_4	110	117	PF00018	0.636
LIG_TRAF2_1	78	81	PF00917	0.667
LIG_UBA3_1	45	54	PF00899	0.620
MOD_CK1_1	13	19	PF00069	0.749
MOD_CK1_1	138	144	PF00069	0.727
MOD_CK2_1	75	81	PF00069	0.621
MOD_GlcNHglycan	142	145	PF01048	0.511
MOD_GlcNHglycan	15	18	PF01048	0.517
MOD_GSK3_1	131	138	PF00069	0.683
MOD_NEK2_1	10	15	PF00069	0.765
MOD_NEK2_1	2	7	PF00069	0.692
MOD_PKA_2	13	19	PF00069	0.741
MOD_PKA_2	2	8	PF00069	0.687
MOD_PKA_2	96	102	PF00069	0.616
MOD_Plk_1	138	144	PF00069	0.745
MOD_SUMO_rev_2	149	154	PF00179	0.736
MOD_SUMO_rev_2	51	56	PF00179	0.463
TRG_DiLeu_BaEn_4	81	87	PF01217	0.679
TRG_ENDOCYTIC_2	50	53	PF00928	0.422
TRG_ENDOCYTIC_2	70	73	PF00928	0.150
TRG_ER_diArg_1	2	4	PF00400	0.662
TRG_ER_diArg_1	28	31	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K8	Leptomonas seymouri	72%	100%
A0A0S4JRA9	Bodo saltans	42%	100%
A0A1X0P915	Trypanosomatidae	48%	100%
A0A422NQR6	Trypanosoma rangeli	51%	100%
A4H3J6	Leishmania braziliensis	87%	100%
A4HRT5	Leishmania infantum	99%	100%
D0A236	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ACH1	Leishmania major	96%	100%
E9AJQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%