LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A451EJM6_LEIDO
TriTrypDb:
LdBPK_030210.1 , LdCL_030007100 , LDHU3_03.0220
Length:
313

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJM6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJM6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 59 63 PF00656 0.558
CLV_NRD_NRD_1 110 112 PF00675 0.375
CLV_NRD_NRD_1 214 216 PF00675 0.416
CLV_NRD_NRD_1 23 25 PF00675 0.417
CLV_NRD_NRD_1 270 272 PF00675 0.519
CLV_NRD_NRD_1 284 286 PF00675 0.395
CLV_PCSK_FUR_1 268 272 PF00082 0.528
CLV_PCSK_KEX2_1 110 112 PF00082 0.375
CLV_PCSK_KEX2_1 214 216 PF00082 0.418
CLV_PCSK_KEX2_1 22 24 PF00082 0.431
CLV_PCSK_KEX2_1 268 270 PF00082 0.505
CLV_PCSK_KEX2_1 284 286 PF00082 0.392
CLV_PCSK_KEX2_1 72 74 PF00082 0.496
CLV_PCSK_PC1ET2_1 22 24 PF00082 0.431
CLV_PCSK_PC1ET2_1 72 74 PF00082 0.523
CLV_PCSK_SKI1_1 16 20 PF00082 0.494
CLV_PCSK_SKI1_1 166 170 PF00082 0.349
CLV_PCSK_SKI1_1 248 252 PF00082 0.528
CLV_PCSK_SKI1_1 284 288 PF00082 0.382
DOC_CDC14_PxL_1 304 312 PF14671 0.455
DOC_CKS1_1 30 35 PF01111 0.480
DOC_MAPK_gen_1 22 29 PF00069 0.383
DOC_MAPK_MEF2A_6 22 29 PF00069 0.383
DOC_MAPK_MEF2A_6 248 257 PF00069 0.384
DOC_MAPK_MEF2A_6 298 306 PF00069 0.393
DOC_PP1_RVXF_1 252 258 PF00149 0.378
DOC_PP1_RVXF_1 282 289 PF00149 0.384
DOC_PP4_FxxP_1 287 290 PF00568 0.375
DOC_PP4_FxxP_1 299 302 PF00568 0.358
DOC_USP7_MATH_1 157 161 PF00917 0.483
DOC_USP7_MATH_1 216 220 PF00917 0.366
DOC_USP7_UBL2_3 114 118 PF12436 0.450
DOC_USP7_UBL2_3 50 54 PF12436 0.425
DOC_WW_Pin1_4 175 180 PF00397 0.364
DOC_WW_Pin1_4 232 237 PF00397 0.397
DOC_WW_Pin1_4 273 278 PF00397 0.512
DOC_WW_Pin1_4 29 34 PF00397 0.392
DOC_WW_Pin1_4 308 313 PF00397 0.438
LIG_14-3-3_CanoR_1 214 224 PF00244 0.365
LIG_14-3-3_CanoR_1 56 64 PF00244 0.442
LIG_14-3-3_CanoR_1 8 13 PF00244 0.577
LIG_AP_GAE_1 88 94 PF02883 0.504
LIG_BRCT_BRCA1_1 217 221 PF00533 0.420
LIG_Clathr_ClatBox_1 242 246 PF01394 0.356
LIG_CSL_BTD_1 287 290 PF09270 0.375
LIG_FHA_1 44 50 PF00498 0.399
LIG_FHA_1 7 13 PF00498 0.610
LIG_Integrin_RGD_1 86 88 PF01839 0.401
LIG_LIR_Apic_2 235 240 PF02991 0.379
LIG_LIR_Gen_1 102 107 PF02991 0.369
LIG_LIR_Gen_1 123 134 PF02991 0.313
LIG_LIR_Gen_1 222 228 PF02991 0.341
LIG_LIR_Gen_1 88 98 PF02991 0.358
LIG_LIR_Nem_3 102 106 PF02991 0.368
LIG_LIR_Nem_3 123 129 PF02991 0.320
LIG_LIR_Nem_3 167 172 PF02991 0.348
LIG_LIR_Nem_3 178 184 PF02991 0.381
LIG_LIR_Nem_3 218 224 PF02991 0.350
LIG_LIR_Nem_3 88 94 PF02991 0.361
LIG_LYPXL_S_1 306 310 PF13949 0.421
LIG_LYPXL_yS_3 307 310 PF13949 0.424
LIG_MLH1_MIPbox_1 217 221 PF16413 0.420
LIG_MYND_1 308 312 PF01753 0.491
LIG_Pex14_2 239 243 PF04695 0.385
LIG_REV1ctd_RIR_1 255 264 PF16727 0.399
LIG_SH2_CRK 103 107 PF00017 0.385
LIG_SH2_CRK 224 228 PF00017 0.360
LIG_SH2_STAP1 103 107 PF00017 0.391
LIG_SH2_STAT5 220 223 PF00017 0.348
LIG_SH3_3 133 139 PF00018 0.333
LIG_SH3_3 173 179 PF00018 0.382
LIG_SH3_3 22 28 PF00018 0.406
LIG_SH3_3 30 36 PF00018 0.387
MOD_CDK_SPxxK_3 175 182 PF00069 0.368
MOD_CK1_1 273 279 PF00069 0.509
MOD_CK1_1 43 49 PF00069 0.429
MOD_CK2_1 216 222 PF00069 0.363
MOD_CK2_1 76 82 PF00069 0.454
MOD_Cter_Amidation 108 111 PF01082 0.369
MOD_Cter_Amidation 282 285 PF01082 0.400
MOD_GlcNHglycan 107 110 PF01048 0.386
MOD_GlcNHglycan 159 162 PF01048 0.436
MOD_GlcNHglycan 173 176 PF01048 0.346
MOD_GlcNHglycan 58 61 PF01048 0.435
MOD_GSK3_1 157 164 PF00069 0.454
MOD_GSK3_1 171 178 PF00069 0.360
MOD_GSK3_1 188 195 PF00069 0.341
MOD_GSK3_1 228 235 PF00069 0.390
MOD_NEK2_1 129 134 PF00069 0.318
MOD_NEK2_1 14 19 PF00069 0.499
MOD_NEK2_1 171 176 PF00069 0.362
MOD_NEK2_1 210 215 PF00069 0.368
MOD_NEK2_1 6 11 PF00069 0.557
MOD_PIKK_1 161 167 PF00454 0.399
MOD_PK_1 270 276 PF00069 0.633
MOD_PK_1 8 14 PF00069 0.531
MOD_PKA_1 270 276 PF00069 0.633
MOD_PKA_2 270 276 PF00069 0.570
MOD_PKA_2 55 61 PF00069 0.444
MOD_PKA_2 7 13 PF00069 0.545
MOD_PKB_1 268 276 PF00069 0.636
MOD_Plk_1 14 20 PF00069 0.496
MOD_Plk_2-3 117 123 PF00069 0.393
MOD_Plk_4 216 222 PF00069 0.363
MOD_Plk_4 270 276 PF00069 0.596
MOD_Plk_4 8 14 PF00069 0.596
MOD_ProDKin_1 175 181 PF00069 0.361
MOD_ProDKin_1 232 238 PF00069 0.396
MOD_ProDKin_1 273 279 PF00069 0.502
MOD_ProDKin_1 29 35 PF00069 0.385
TRG_DiLeu_BaEn_4 246 252 PF01217 0.382
TRG_ENDOCYTIC_2 103 106 PF00928 0.385
TRG_ENDOCYTIC_2 116 119 PF00928 0.344
TRG_ENDOCYTIC_2 181 184 PF00928 0.385
TRG_ENDOCYTIC_2 220 223 PF00928 0.348
TRG_ENDOCYTIC_2 224 227 PF00928 0.341
TRG_ENDOCYTIC_2 307 310 PF00928 0.424
TRG_ER_diArg_1 110 112 PF00400 0.375
TRG_ER_diArg_1 142 145 PF00400 0.385
TRG_ER_diArg_1 214 216 PF00400 0.413
TRG_ER_diArg_1 23 25 PF00400 0.417
TRG_ER_diArg_1 268 271 PF00400 0.509
TRG_ER_diArg_1 284 286 PF00400 0.392
TRG_Pf-PMV_PEXEL_1 113 117 PF00026 0.444
TRG_Pf-PMV_PEXEL_1 152 156 PF00026 0.363

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I233 Leptomonas seymouri 91% 100%
A0A0S4JMI7 Bodo saltans 75% 100%
A0A1X0P9J8 Trypanosomatidae 85% 100%
A0A3R7MT70 Trypanosoma rangeli 84% 100%
A4H3J4 Leishmania braziliensis 97% 100%
A4HRT3 Leishmania infantum 100% 100%
D0A232 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 83% 100%
E9ACG9 Leishmania major 100% 100%
E9AJQ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
V5AIL9 Trypanosoma cruzi 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS