Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJM6_LEIDO

TriTrypDb:

LdBPK_030210.1 , LdCL_030007100 , LDHU3_03.0220

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.558
CLV_NRD_NRD_1	110	112	PF00675	0.375
CLV_NRD_NRD_1	214	216	PF00675	0.416
CLV_NRD_NRD_1	23	25	PF00675	0.417
CLV_NRD_NRD_1	270	272	PF00675	0.519
CLV_NRD_NRD_1	284	286	PF00675	0.395
CLV_PCSK_FUR_1	268	272	PF00082	0.528
CLV_PCSK_KEX2_1	110	112	PF00082	0.375
CLV_PCSK_KEX2_1	214	216	PF00082	0.418
CLV_PCSK_KEX2_1	22	24	PF00082	0.431
CLV_PCSK_KEX2_1	268	270	PF00082	0.505
CLV_PCSK_KEX2_1	284	286	PF00082	0.392
CLV_PCSK_KEX2_1	72	74	PF00082	0.496
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.431
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.523
CLV_PCSK_SKI1_1	16	20	PF00082	0.494
CLV_PCSK_SKI1_1	166	170	PF00082	0.349
CLV_PCSK_SKI1_1	248	252	PF00082	0.528
CLV_PCSK_SKI1_1	284	288	PF00082	0.382
DOC_CDC14_PxL_1	304	312	PF14671	0.455
DOC_CKS1_1	30	35	PF01111	0.480
DOC_MAPK_gen_1	22	29	PF00069	0.383
DOC_MAPK_MEF2A_6	22	29	PF00069	0.383
DOC_MAPK_MEF2A_6	248	257	PF00069	0.384
DOC_MAPK_MEF2A_6	298	306	PF00069	0.393
DOC_PP1_RVXF_1	252	258	PF00149	0.378
DOC_PP1_RVXF_1	282	289	PF00149	0.384
DOC_PP4_FxxP_1	287	290	PF00568	0.375
DOC_PP4_FxxP_1	299	302	PF00568	0.358
DOC_USP7_MATH_1	157	161	PF00917	0.483
DOC_USP7_MATH_1	216	220	PF00917	0.366
DOC_USP7_UBL2_3	114	118	PF12436	0.450
DOC_USP7_UBL2_3	50	54	PF12436	0.425
DOC_WW_Pin1_4	175	180	PF00397	0.364
DOC_WW_Pin1_4	232	237	PF00397	0.397
DOC_WW_Pin1_4	273	278	PF00397	0.512
DOC_WW_Pin1_4	29	34	PF00397	0.392
DOC_WW_Pin1_4	308	313	PF00397	0.438
LIG_14-3-3_CanoR_1	214	224	PF00244	0.365
LIG_14-3-3_CanoR_1	56	64	PF00244	0.442
LIG_14-3-3_CanoR_1	8	13	PF00244	0.577
LIG_AP_GAE_1	88	94	PF02883	0.504
LIG_BRCT_BRCA1_1	217	221	PF00533	0.420
LIG_Clathr_ClatBox_1	242	246	PF01394	0.356
LIG_CSL_BTD_1	287	290	PF09270	0.375
LIG_FHA_1	44	50	PF00498	0.399
LIG_FHA_1	7	13	PF00498	0.610
LIG_Integrin_RGD_1	86	88	PF01839	0.401
LIG_LIR_Apic_2	235	240	PF02991	0.379
LIG_LIR_Gen_1	102	107	PF02991	0.369
LIG_LIR_Gen_1	123	134	PF02991	0.313
LIG_LIR_Gen_1	222	228	PF02991	0.341
LIG_LIR_Gen_1	88	98	PF02991	0.358
LIG_LIR_Nem_3	102	106	PF02991	0.368
LIG_LIR_Nem_3	123	129	PF02991	0.320
LIG_LIR_Nem_3	167	172	PF02991	0.348
LIG_LIR_Nem_3	178	184	PF02991	0.381
LIG_LIR_Nem_3	218	224	PF02991	0.350
LIG_LIR_Nem_3	88	94	PF02991	0.361
LIG_LYPXL_S_1	306	310	PF13949	0.421
LIG_LYPXL_yS_3	307	310	PF13949	0.424
LIG_MLH1_MIPbox_1	217	221	PF16413	0.420
LIG_MYND_1	308	312	PF01753	0.491
LIG_Pex14_2	239	243	PF04695	0.385
LIG_REV1ctd_RIR_1	255	264	PF16727	0.399
LIG_SH2_CRK	103	107	PF00017	0.385
LIG_SH2_CRK	224	228	PF00017	0.360
LIG_SH2_STAP1	103	107	PF00017	0.391
LIG_SH2_STAT5	220	223	PF00017	0.348
LIG_SH3_3	133	139	PF00018	0.333
LIG_SH3_3	173	179	PF00018	0.382
LIG_SH3_3	22	28	PF00018	0.406
LIG_SH3_3	30	36	PF00018	0.387
MOD_CDK_SPxxK_3	175	182	PF00069	0.368
MOD_CK1_1	273	279	PF00069	0.509
MOD_CK1_1	43	49	PF00069	0.429
MOD_CK2_1	216	222	PF00069	0.363
MOD_CK2_1	76	82	PF00069	0.454
MOD_Cter_Amidation	108	111	PF01082	0.369
MOD_Cter_Amidation	282	285	PF01082	0.400
MOD_GlcNHglycan	107	110	PF01048	0.386
MOD_GlcNHglycan	159	162	PF01048	0.436
MOD_GlcNHglycan	173	176	PF01048	0.346
MOD_GlcNHglycan	58	61	PF01048	0.435
MOD_GSK3_1	157	164	PF00069	0.454
MOD_GSK3_1	171	178	PF00069	0.360
MOD_GSK3_1	188	195	PF00069	0.341
MOD_GSK3_1	228	235	PF00069	0.390
MOD_NEK2_1	129	134	PF00069	0.318
MOD_NEK2_1	14	19	PF00069	0.499
MOD_NEK2_1	171	176	PF00069	0.362
MOD_NEK2_1	210	215	PF00069	0.368
MOD_NEK2_1	6	11	PF00069	0.557
MOD_PIKK_1	161	167	PF00454	0.399
MOD_PK_1	270	276	PF00069	0.633
MOD_PK_1	8	14	PF00069	0.531
MOD_PKA_1	270	276	PF00069	0.633
MOD_PKA_2	270	276	PF00069	0.570
MOD_PKA_2	55	61	PF00069	0.444
MOD_PKA_2	7	13	PF00069	0.545
MOD_PKB_1	268	276	PF00069	0.636
MOD_Plk_1	14	20	PF00069	0.496
MOD_Plk_2-3	117	123	PF00069	0.393
MOD_Plk_4	216	222	PF00069	0.363
MOD_Plk_4	270	276	PF00069	0.596
MOD_Plk_4	8	14	PF00069	0.596
MOD_ProDKin_1	175	181	PF00069	0.361
MOD_ProDKin_1	232	238	PF00069	0.396
MOD_ProDKin_1	273	279	PF00069	0.502
MOD_ProDKin_1	29	35	PF00069	0.385
TRG_DiLeu_BaEn_4	246	252	PF01217	0.382
TRG_ENDOCYTIC_2	103	106	PF00928	0.385
TRG_ENDOCYTIC_2	116	119	PF00928	0.344
TRG_ENDOCYTIC_2	181	184	PF00928	0.385
TRG_ENDOCYTIC_2	220	223	PF00928	0.348
TRG_ENDOCYTIC_2	224	227	PF00928	0.341
TRG_ENDOCYTIC_2	307	310	PF00928	0.424
TRG_ER_diArg_1	110	112	PF00400	0.375
TRG_ER_diArg_1	142	145	PF00400	0.385
TRG_ER_diArg_1	214	216	PF00400	0.413
TRG_ER_diArg_1	23	25	PF00400	0.417
TRG_ER_diArg_1	268	271	PF00400	0.509
TRG_ER_diArg_1	284	286	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I233	Leptomonas seymouri	91%	100%
A0A0S4JMI7	Bodo saltans	75%	100%
A0A1X0P9J8	Trypanosomatidae	85%	100%
A0A3R7MT70	Trypanosoma rangeli	84%	100%
A4H3J4	Leishmania braziliensis	97%	100%
A4HRT3	Leishmania infantum	100%	100%
D0A232	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
E9ACG9	Leishmania major	100%	100%
E9AJQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
V5AIL9	Trypanosoma cruzi	83%	100%