Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A451EJM2_LEIDO

TriTrypDb:

LdBPK_030160.1 , LdCL_030006600 , LDHU3_03.0160

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	70	74	PF00656	0.837
CLV_C14_Caspase3-7	84	88	PF00656	0.572
CLV_PCSK_KEX2_1	160	162	PF00082	0.684
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.684
CLV_PCSK_SKI1_1	24	28	PF00082	0.546
DOC_CDC14_PxL_1	173	181	PF14671	0.687
DOC_PP2B_LxvP_1	174	177	PF13499	0.565
DOC_USP7_MATH_1	75	79	PF00917	0.728
DOC_USP7_MATH_1	80	84	PF00917	0.640
DOC_WW_Pin1_4	140	145	PF00397	0.826
DOC_WW_Pin1_4	3	8	PF00397	0.712
DOC_WW_Pin1_4	62	67	PF00397	0.715
DOC_WW_Pin1_4	76	81	PF00397	0.590
LIG_BIR_II_1	1	5	PF00653	0.821
LIG_CtBP_PxDLS_1	167	171	PF00389	0.796
LIG_FHA_1	47	53	PF00498	0.721
LIG_FHA_1	96	102	PF00498	0.581
LIG_GBD_Chelix_1	22	30	PF00786	0.541
LIG_LIR_Apic_2	2	8	PF02991	0.754
LIG_LIR_Nem_3	48	53	PF02991	0.671
LIG_MYND_1	177	181	PF01753	0.572
LIG_SH2_CRK	5	9	PF00017	0.719
LIG_SH2_SRC	100	103	PF00017	0.743
LIG_SH2_STAT5	100	103	PF00017	0.743
LIG_SH3_2	4	9	PF14604	0.612
LIG_SH3_3	1	7	PF00018	0.756
LIG_SUMO_SIM_anti_2	25	30	PF11976	0.682
LIG_TRAF2_1	137	140	PF00917	0.610
LIG_TRAF2_1	45	48	PF00917	0.805
LIG_WW_3	6	10	PF00397	0.611
MOD_CDC14_SPxK_1	6	9	PF00782	0.613
MOD_CDK_SPxK_1	140	146	PF00069	0.827
MOD_CDK_SPxK_1	3	9	PF00069	0.611
MOD_CK1_1	3	9	PF00069	0.698
MOD_CK1_1	65	71	PF00069	0.790
MOD_CK1_1	83	89	PF00069	0.555
MOD_CK1_1	92	98	PF00069	0.607
MOD_GlcNHglycan	121	124	PF01048	0.662
MOD_GlcNHglycan	154	157	PF01048	0.813
MOD_GlcNHglycan	67	70	PF01048	0.794
MOD_GSK3_1	152	159	PF00069	0.755
MOD_GSK3_1	58	65	PF00069	0.815
MOD_GSK3_1	76	83	PF00069	0.527
MOD_GSK3_1	87	94	PF00069	0.623
MOD_N-GLC_1	35	40	PF02516	0.782
MOD_PKA_2	119	125	PF00069	0.761
MOD_PKA_2	75	81	PF00069	0.837
MOD_Plk_1	24	30	PF00069	0.541
MOD_Plk_4	24	30	PF00069	0.582
MOD_Plk_4	92	98	PF00069	0.555
MOD_ProDKin_1	140	146	PF00069	0.827
MOD_ProDKin_1	3	9	PF00069	0.715
MOD_ProDKin_1	62	68	PF00069	0.716
MOD_ProDKin_1	76	82	PF00069	0.587
TRG_ENDOCYTIC_2	53	56	PF00928	0.771
TRG_NES_CRM1_1	25	39	PF08389	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3I9	Leishmania braziliensis	62%	100%
A4HRS8	Leishmania infantum	99%	99%
E9ACG4	Leishmania major	84%	100%
E9AJQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%