LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A451EJM0_LEIDO
TriTrypDb:
LdBPK_030140.1 * , LdCL_030006400 , LDHU3_03.0140
Length:
311

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJM0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJM0

PDB structure(s): 7aih_Ae , 7am2_Ae , 7ane_Ae

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 235 239 PF00656 0.406
CLV_NRD_NRD_1 108 110 PF00675 0.616
CLV_NRD_NRD_1 205 207 PF00675 0.409
CLV_PCSK_KEX2_1 108 110 PF00082 0.493
CLV_PCSK_KEX2_1 158 160 PF00082 0.437
CLV_PCSK_KEX2_1 205 207 PF00082 0.409
CLV_PCSK_KEX2_1 296 298 PF00082 0.544
CLV_PCSK_PC1ET2_1 108 110 PF00082 0.493
CLV_PCSK_PC1ET2_1 158 160 PF00082 0.437
CLV_PCSK_PC1ET2_1 296 298 PF00082 0.544
CLV_PCSK_PC7_1 104 110 PF00082 0.617
CLV_PCSK_SKI1_1 171 175 PF00082 0.412
CLV_PCSK_SKI1_1 198 202 PF00082 0.412
CLV_PCSK_SKI1_1 218 222 PF00082 0.200
CLV_PCSK_SKI1_1 296 300 PF00082 0.579
DEG_APCC_DBOX_1 108 116 PF00400 0.625
DEG_SCF_FBW7_1 148 155 PF00400 0.581
DEG_SCF_FBW7_2 228 233 PF00400 0.384
DEG_SIAH_1 159 167 PF03145 0.461
DOC_ANK_TNKS_1 268 275 PF00023 0.390
DOC_CKS1_1 62 67 PF01111 0.616
DOC_CYCLIN_yCln2_LP_2 41 47 PF00134 0.439
DOC_MAPK_DCC_7 180 190 PF00069 0.455
DOC_MAPK_gen_1 92 102 PF00069 0.428
DOC_PP2B_LxvP_1 135 138 PF13499 0.542
DOC_PP2B_LxvP_1 18 21 PF13499 0.534
DOC_PP2B_PxIxI_1 229 235 PF00149 0.369
DOC_USP7_MATH_1 166 170 PF00917 0.485
DOC_USP7_MATH_1 304 308 PF00917 0.569
DOC_USP7_UBL2_3 106 110 PF12436 0.500
DOC_USP7_UBL2_3 167 171 PF12436 0.577
DOC_USP7_UBL2_3 305 309 PF12436 0.636
DOC_WW_Pin1_4 148 153 PF00397 0.556
DOC_WW_Pin1_4 183 188 PF00397 0.381
DOC_WW_Pin1_4 209 214 PF00397 0.436
DOC_WW_Pin1_4 226 231 PF00397 0.313
DOC_WW_Pin1_4 61 66 PF00397 0.590
LIG_14-3-3_CanoR_1 205 215 PF00244 0.427
LIG_14-3-3_CanoR_1 269 277 PF00244 0.512
LIG_APCC_ABBA_1 174 179 PF00400 0.394
LIG_BIR_II_1 1 5 PF00653 0.501
LIG_BIR_III_1 1 5 PF00653 0.537
LIG_BIR_III_3 1 5 PF00653 0.611
LIG_Clathr_ClatBox_1 175 179 PF01394 0.382
LIG_deltaCOP1_diTrp_1 283 293 PF00928 0.401
LIG_eIF4E_1 285 291 PF01652 0.390
LIG_FHA_1 180 186 PF00498 0.327
LIG_FHA_1 227 233 PF00498 0.391
LIG_FHA_2 233 239 PF00498 0.401
LIG_LIR_Apic_2 114 120 PF02991 0.570
LIG_LIR_Apic_2 130 134 PF02991 0.367
LIG_LIR_Apic_2 240 245 PF02991 0.411
LIG_LIR_Gen_1 284 293 PF02991 0.403
LIG_LIR_Gen_1 9 18 PF02991 0.551
LIG_LIR_Gen_1 96 107 PF02991 0.450
LIG_LIR_Nem_3 217 223 PF02991 0.394
LIG_LIR_Nem_3 284 290 PF02991 0.399
LIG_LIR_Nem_3 9 13 PF02991 0.540
LIG_LIR_Nem_3 96 102 PF02991 0.435
LIG_MYND_1 29 33 PF01753 0.501
LIG_SH2_NCK_1 60 64 PF00017 0.586
LIG_SH2_PTP2 117 120 PF00017 0.572
LIG_SH2_PTP2 242 245 PF00017 0.393
LIG_SH2_SRC 242 245 PF00017 0.393
LIG_SH2_SRC 81 84 PF00017 0.492
LIG_SH2_STAT5 117 120 PF00017 0.526
LIG_SH2_STAT5 242 245 PF00017 0.393
LIG_SH2_STAT5 58 61 PF00017 0.502
LIG_SH2_STAT5 8 11 PF00017 0.502
LIG_SH3_3 142 148 PF00018 0.507
LIG_SH3_3 160 166 PF00018 0.293
LIG_SH3_3 238 244 PF00018 0.514
LIG_SH3_3 273 279 PF00018 0.435
LIG_SUMO_SIM_par_1 181 186 PF11976 0.306
LIG_SUMO_SIM_par_1 278 284 PF11976 0.423
LIG_UBA3_1 173 180 PF00899 0.382
MOD_CDK_SPK_2 226 231 PF00069 0.411
MOD_CDK_SPxK_1 61 67 PF00069 0.593
MOD_CK1_1 136 142 PF00069 0.502
MOD_CK1_1 209 215 PF00069 0.465
MOD_CK1_1 6 12 PF00069 0.509
MOD_CK2_1 136 142 PF00069 0.435
MOD_GlcNHglycan 135 138 PF01048 0.563
MOD_GlcNHglycan 208 211 PF01048 0.405
MOD_GlcNHglycan 270 273 PF01048 0.502
MOD_GlcNHglycan 306 309 PF01048 0.614
MOD_GSK3_1 148 155 PF00069 0.564
MOD_GSK3_1 179 186 PF00069 0.364
MOD_LATS_1 83 89 PF00433 0.444
MOD_NEK2_1 237 242 PF00069 0.429
MOD_PKA_2 268 274 PF00069 0.497
MOD_Plk_1 232 238 PF00069 0.375
MOD_Plk_4 136 142 PF00069 0.455
MOD_Plk_4 232 238 PF00069 0.366
MOD_Plk_4 72 78 PF00069 0.573
MOD_ProDKin_1 148 154 PF00069 0.563
MOD_ProDKin_1 183 189 PF00069 0.385
MOD_ProDKin_1 209 215 PF00069 0.431
MOD_ProDKin_1 226 232 PF00069 0.303
MOD_ProDKin_1 61 67 PF00069 0.593
MOD_SUMO_for_1 230 233 PF00179 0.461
TRG_DiLeu_BaLyEn_6 184 189 PF01217 0.489
TRG_DiLeu_BaLyEn_6 242 247 PF01217 0.456
TRG_ENDOCYTIC_2 222 225 PF00928 0.540
TRG_ENDOCYTIC_2 47 50 PF00928 0.404
TRG_ER_diArg_1 204 206 PF00400 0.416
TRG_ER_diArg_1 29 32 PF00400 0.475
TRG_NLS_MonoExtN_4 106 112 PF00514 0.619
TRG_NLS_MonoExtN_4 294 300 PF00514 0.571

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P502 Leptomonas seymouri 88% 99%
A0A0S4JH47 Bodo saltans 62% 100%
A0A1X0NTC0 Trypanosomatidae 75% 100%
A0A3R7M618 Trypanosoma rangeli 75% 100%
A4H3I7 Leishmania braziliensis 95% 100%
C9ZSG1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 100%
C9ZSK4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 74% 100%
E9ACG2 Leishmania major 98% 100%
E9AG34 Leishmania infantum 100% 100%
E9AJQ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
V5B5Z4 Trypanosoma cruzi 75% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS