Acetyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A451EJL8_LEIDO

TriTrypDb:

LdBPK_030120.1 , LdCL_030006200 , LDHU3_03.0120

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031248	protein acetyltransferase complex	3	1
GO:0031414	N-terminal protein acetyltransferase complex	4	1
GO:0031415	NatA complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A451EJL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJL8

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0007062	sister chromatid cohesion	3	1
GO:0007064	mitotic sister chromatid cohesion	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0022402	cell cycle process	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016407	acetyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0008080	N-acetyltransferase activity	6	1
GO:0016410	N-acyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.384
CLV_NRD_NRD_1	167	169	PF00675	0.355
CLV_PCSK_KEX2_1	167	169	PF00082	0.442
CLV_PCSK_SKI1_1	78	82	PF00082	0.419
DOC_CYCLIN_yClb1_LxF_4	58	64	PF00134	0.323
DOC_MAPK_gen_1	120	128	PF00069	0.287
DOC_MAPK_MEF2A_6	120	128	PF00069	0.293
DOC_WW_Pin1_4	131	136	PF00397	0.287
LIG_14-3-3_CanoR_1	106	112	PF00244	0.316
LIG_14-3-3_CanoR_1	52	56	PF00244	0.333
LIG_Actin_WH2_2	87	104	PF00022	0.422
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_FHA_1	125	131	PF00498	0.343
LIG_FHA_1	71	77	PF00498	0.244
LIG_FHA_1	89	95	PF00498	0.244
LIG_FHA_2	154	160	PF00498	0.407
LIG_FHA_2	77	83	PF00498	0.264
LIG_GBD_Chelix_1	68	76	PF00786	0.323
LIG_LIR_Apic_2	34	39	PF02991	0.329
LIG_LIR_Gen_1	152	163	PF02991	0.443
LIG_LIR_Gen_1	54	63	PF02991	0.417
LIG_LIR_Nem_3	152	158	PF02991	0.365
LIG_LIR_Nem_3	44	50	PF02991	0.259
LIG_LIR_Nem_3	54	58	PF02991	0.306
LIG_LIR_Nem_3	7	13	PF02991	0.487
LIG_LIR_Nem_3	82	88	PF02991	0.238
LIG_LIR_Nem_3	96	101	PF02991	0.292
LIG_MAD2	31	39	PF02301	0.374
LIG_Pex14_2	139	143	PF04695	0.218
LIG_SH2_CRK	36	40	PF00017	0.369
LIG_SH2_GRB2like	46	49	PF00017	0.327
LIG_SH2_STAP1	42	46	PF00017	0.272
LIG_SH2_STAT3	5	8	PF00017	0.290
LIG_SH2_STAT5	155	158	PF00017	0.436
LIG_SH2_STAT5	36	39	PF00017	0.349
LIG_SH2_STAT5	42	45	PF00017	0.300
LIG_SH2_STAT5	50	53	PF00017	0.307
LIG_SH2_STAT5	85	88	PF00017	0.272
LIG_SH3_3	129	135	PF00018	0.287
LIG_SH3_3	167	173	PF00018	0.345
LIG_SUMO_SIM_par_1	122	127	PF11976	0.381
LIG_TRAF2_1	4	7	PF00917	0.412
MOD_CDK_SPxxK_3	131	138	PF00069	0.243
MOD_CK2_1	51	57	PF00069	0.444
MOD_CK2_1	78	84	PF00069	0.262
MOD_GlcNHglycan	112	115	PF01048	0.309
MOD_LATS_1	100	106	PF00433	0.294
MOD_N-GLC_1	116	121	PF02516	0.309
MOD_N-GLC_1	21	26	PF02516	0.450
MOD_NEK2_1	107	112	PF00069	0.287
MOD_NEK2_1	21	26	PF00069	0.476
MOD_NEK2_1	68	73	PF00069	0.271
MOD_NEK2_1	76	81	PF00069	0.254
MOD_NEK2_2	70	75	PF00069	0.244
MOD_PKA_2	51	57	PF00069	0.385
MOD_Plk_1	21	27	PF00069	0.403
MOD_Plk_1	6	12	PF00069	0.417
MOD_Plk_4	107	113	PF00069	0.269
MOD_Plk_4	42	48	PF00069	0.301
MOD_ProDKin_1	131	137	PF00069	0.287
TRG_DiLeu_BaEn_1	146	151	PF01217	0.449
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.264
TRG_ENDOCYTIC_2	140	143	PF00928	0.244
TRG_ENDOCYTIC_2	155	158	PF00928	0.343
TRG_ENDOCYTIC_2	64	67	PF00928	0.318
TRG_ENDOCYTIC_2	98	101	PF00928	0.284
TRG_ER_diArg_1	120	123	PF00400	0.381
TRG_ER_diArg_1	166	168	PF00400	0.418
TRG_ER_diLys_1	179	182	PF00400	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L1	Leptomonas seymouri	79%	100%
A0A0S4JJ81	Bodo saltans	49%	100%
A0A1X0P8P4	Trypanosomatidae	56%	88%
A0A422N7F8	Trypanosoma rangeli	56%	90%
A3KPA3	Danio rerio	28%	75%
A4H3I5	Leishmania braziliensis	94%	100%
A8E5V7	Xenopus tropicalis	28%	75%
D0A220	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	89%
E9ACG0	Leishmania major	98%	100%
E9AG32	Leishmania infantum	100%	100%
E9AJP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q0IIJ0	Bos taurus	33%	100%
Q17QK9	Bos taurus	26%	75%
Q3MHC1	Rattus norvegicus	26%	75%
Q5RF28	Pongo abelii	33%	100%
Q5XGA9	Xenopus tropicalis	34%	100%
Q6DBY2	Danio rerio	33%	100%
Q6GP53	Xenopus laevis	34%	100%
Q6PGB6	Mus musculus	33%	100%
Q9DBU2	Mus musculus	26%	75%
Q9GZZ1	Homo sapiens	33%	100%
Q9H7X0	Homo sapiens	26%	75%
Q9NHD5	Drosophila melanogaster	34%	99%