LeishMANIAdb
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Mediator complex subunit 23

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Mediator complex subunit 23
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A451EJL3_LEIDO
TriTrypDb:
LdBPK_030060.1 , LdCL_030005600 , LDHU3_03.0060
Length:
833

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJL3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJL3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 667 671 PF00656 0.531
CLV_NRD_NRD_1 421 423 PF00675 0.471
CLV_NRD_NRD_1 435 437 PF00675 0.530
CLV_NRD_NRD_1 490 492 PF00675 0.583
CLV_NRD_NRD_1 544 546 PF00675 0.552
CLV_NRD_NRD_1 56 58 PF00675 0.448
CLV_NRD_NRD_1 765 767 PF00675 0.672
CLV_NRD_NRD_1 828 830 PF00675 0.585
CLV_PCSK_KEX2_1 435 437 PF00082 0.530
CLV_PCSK_KEX2_1 490 492 PF00082 0.583
CLV_PCSK_KEX2_1 543 545 PF00082 0.555
CLV_PCSK_KEX2_1 56 58 PF00082 0.448
CLV_PCSK_KEX2_1 765 767 PF00082 0.672
CLV_PCSK_KEX2_1 830 832 PF00082 0.677
CLV_PCSK_PC1ET2_1 830 832 PF00082 0.677
CLV_PCSK_PC7_1 486 492 PF00082 0.550
CLV_PCSK_SKI1_1 236 240 PF00082 0.706
CLV_PCSK_SKI1_1 247 251 PF00082 0.561
CLV_PCSK_SKI1_1 330 334 PF00082 0.467
CLV_PCSK_SKI1_1 347 351 PF00082 0.386
CLV_PCSK_SKI1_1 375 379 PF00082 0.391
CLV_PCSK_SKI1_1 422 426 PF00082 0.412
CLV_PCSK_SKI1_1 586 590 PF00082 0.440
CLV_PCSK_SKI1_1 605 609 PF00082 0.270
CLV_PCSK_SKI1_1 658 662 PF00082 0.488
CLV_PCSK_SKI1_1 751 755 PF00082 0.385
CLV_PCSK_SKI1_1 774 778 PF00082 0.539
CLV_Separin_Metazoa 487 491 PF03568 0.549
CLV_Separin_Metazoa 540 544 PF03568 0.583
DEG_APCC_DBOX_1 421 429 PF00400 0.469
DEG_APCC_DBOX_1 657 665 PF00400 0.510
DEG_APCC_DBOX_1 74 82 PF00400 0.580
DEG_APCC_DBOX_1 750 758 PF00400 0.416
DEG_Nend_UBRbox_2 1 3 PF02207 0.650
DOC_ANK_TNKS_1 489 496 PF00023 0.569
DOC_CDC14_PxL_1 251 259 PF14671 0.466
DOC_CYCLIN_RxL_1 372 382 PF00134 0.525
DOC_CYCLIN_RxL_1 610 620 PF00134 0.586
DOC_MAPK_gen_1 422 430 PF00069 0.470
DOC_MAPK_gen_1 505 512 PF00069 0.503
DOC_MAPK_gen_1 56 65 PF00069 0.403
DOC_MAPK_gen_1 749 758 PF00069 0.391
DOC_MAPK_MEF2A_6 462 469 PF00069 0.500
DOC_MAPK_MEF2A_6 505 514 PF00069 0.523
DOC_MAPK_MEF2A_6 56 65 PF00069 0.519
DOC_MAPK_MEF2A_6 658 665 PF00069 0.482
DOC_MAPK_MEF2A_6 749 758 PF00069 0.391
DOC_MAPK_NFAT4_5 751 759 PF00069 0.488
DOC_PP1_RVXF_1 345 351 PF00149 0.480
DOC_PP1_RVXF_1 584 590 PF00149 0.495
DOC_PP1_RVXF_1 611 618 PF00149 0.562
DOC_PP1_RVXF_1 728 734 PF00149 0.391
DOC_PP2B_LxvP_1 353 356 PF13499 0.467
DOC_PP2B_LxvP_1 688 691 PF13499 0.558
DOC_PP4_FxxP_1 135 138 PF00568 0.628
DOC_USP7_MATH_1 15 19 PF00917 0.627
DOC_USP7_MATH_1 588 592 PF00917 0.488
DOC_USP7_MATH_1 691 695 PF00917 0.635
DOC_USP7_MATH_1 87 91 PF00917 0.522
DOC_USP7_MATH_2 109 115 PF00917 0.654
DOC_USP7_UBL2_3 797 801 PF12436 0.617
DOC_USP7_UBL2_3 82 86 PF12436 0.572
DOC_USP7_UBL2_3 826 830 PF12436 0.666
DOC_WW_Pin1_4 136 141 PF00397 0.697
DOC_WW_Pin1_4 415 420 PF00397 0.483
DOC_WW_Pin1_4 450 455 PF00397 0.629
LIG_14-3-3_CanoR_1 16 22 PF00244 0.678
LIG_14-3-3_CanoR_1 414 419 PF00244 0.421
LIG_14-3-3_CanoR_1 593 600 PF00244 0.485
LIG_14-3-3_CanoR_1 605 612 PF00244 0.474
LIG_14-3-3_CanoR_1 647 655 PF00244 0.506
LIG_14-3-3_CanoR_1 693 697 PF00244 0.656
LIG_14-3-3_CanoR_1 771 777 PF00244 0.550
LIG_Actin_WH2_2 90 108 PF00022 0.575
LIG_BIR_III_4 36 40 PF00653 0.575
LIG_BRCT_BRCA1_1 465 469 PF00533 0.452
LIG_BRCT_BRCA1_1 636 640 PF00533 0.513
LIG_BRCT_BRCA1_1 809 813 PF00533 0.503
LIG_Clathr_ClatBox_1 191 195 PF01394 0.664
LIG_Clathr_ClatBox_1 464 468 PF01394 0.510
LIG_deltaCOP1_diTrp_1 468 474 PF00928 0.482
LIG_eIF4E_1 781 787 PF01652 0.403
LIG_FAT_LD_1 515 523 PF03623 0.530
LIG_FHA_1 25 31 PF00498 0.578
LIG_FHA_1 294 300 PF00498 0.447
LIG_FHA_1 546 552 PF00498 0.545
LIG_FHA_1 562 568 PF00498 0.423
LIG_FHA_1 606 612 PF00498 0.437
LIG_FHA_2 307 313 PF00498 0.525
LIG_FHA_2 657 663 PF00498 0.512
LIG_FHA_2 698 704 PF00498 0.536
LIG_FHA_2 802 808 PF00498 0.642
LIG_Integrin_RGD_1 668 670 PF01839 0.606
LIG_LIR_Apic_2 134 138 PF02991 0.627
LIG_LIR_Gen_1 127 137 PF02991 0.648
LIG_LIR_Gen_1 174 185 PF02991 0.620
LIG_LIR_Gen_1 262 273 PF02991 0.466
LIG_LIR_Gen_1 302 310 PF02991 0.408
LIG_LIR_Gen_1 364 374 PF02991 0.482
LIG_LIR_Gen_1 395 406 PF02991 0.556
LIG_LIR_Gen_1 507 515 PF02991 0.518
LIG_LIR_Gen_1 686 691 PF02991 0.561
LIG_LIR_LC3C_4 389 393 PF02991 0.538
LIG_LIR_Nem_3 127 132 PF02991 0.687
LIG_LIR_Nem_3 174 180 PF02991 0.584
LIG_LIR_Nem_3 187 192 PF02991 0.584
LIG_LIR_Nem_3 262 268 PF02991 0.455
LIG_LIR_Nem_3 302 308 PF02991 0.406
LIG_LIR_Nem_3 364 369 PF02991 0.488
LIG_LIR_Nem_3 395 401 PF02991 0.479
LIG_LIR_Nem_3 466 472 PF02991 0.506
LIG_LIR_Nem_3 507 511 PF02991 0.541
LIG_LIR_Nem_3 656 660 PF02991 0.426
LIG_LIR_Nem_3 686 690 PF02991 0.555
LIG_LIR_Nem_3 772 776 PF02991 0.441
LIG_LIR_Nem_3 778 784 PF02991 0.426
LIG_LIR_Nem_3 810 816 PF02991 0.665
LIG_LYPXL_yS_3 781 784 PF13949 0.431
LIG_NRBOX 424 430 PF00104 0.469
LIG_NRBOX 553 559 PF00104 0.503
LIG_NRBOX 753 759 PF00104 0.491
LIG_Pex14_1 181 185 PF04695 0.624
LIG_Pex14_1 585 589 PF04695 0.421
LIG_Pex14_1 594 598 PF04695 0.443
LIG_Pex14_2 470 474 PF04695 0.452
LIG_PTB_Apo_2 267 274 PF02174 0.497
LIG_PTB_Apo_2 611 618 PF02174 0.562
LIG_PTB_Phospho_1 267 273 PF10480 0.492
LIG_Rb_LxCxE_1 187 207 PF01857 0.688
LIG_REV1ctd_RIR_1 222 231 PF16727 0.575
LIG_SH2_CRK 273 277 PF00017 0.434
LIG_SH2_GRB2like 697 700 PF00017 0.372
LIG_SH2_PTP2 472 475 PF00017 0.530
LIG_SH2_STAP1 125 129 PF00017 0.679
LIG_SH2_STAP1 172 176 PF00017 0.686
LIG_SH2_STAP1 273 277 PF00017 0.419
LIG_SH2_STAT3 185 188 PF00017 0.573
LIG_SH2_STAT5 185 188 PF00017 0.585
LIG_SH2_STAT5 233 236 PF00017 0.541
LIG_SH2_STAT5 253 256 PF00017 0.438
LIG_SH2_STAT5 265 268 PF00017 0.411
LIG_SH2_STAT5 472 475 PF00017 0.456
LIG_SH2_STAT5 531 534 PF00017 0.512
LIG_SH2_STAT5 598 601 PF00017 0.449
LIG_SH2_STAT5 67 70 PF00017 0.502
LIG_SH2_STAT5 687 690 PF00017 0.548
LIG_SH2_STAT5 697 700 PF00017 0.405
LIG_SH3_3 177 183 PF00018 0.708
LIG_SH3_3 332 338 PF00018 0.476
LIG_SH3_3 507 513 PF00018 0.526
LIG_Sin3_3 426 433 PF02671 0.470
LIG_SUMO_SIM_anti_2 659 665 PF11976 0.517
LIG_SUMO_SIM_par_1 306 312 PF11976 0.473
LIG_SUMO_SIM_par_1 564 570 PF11976 0.551
LIG_TYR_ITIM 175 180 PF00017 0.620
LIG_TYR_ITIM 685 690 PF00017 0.486
LIG_UBA3_1 223 227 PF00899 0.615
LIG_UBA3_1 792 797 PF00899 0.541
LIG_WRC_WIRS_1 205 210 PF05994 0.554
LIG_WW_1 337 340 PF00397 0.535
MOD_CDK_SPxxK_3 415 422 PF00069 0.479
MOD_CDK_SPxxK_3 450 457 PF00069 0.508
MOD_CK1_1 136 142 PF00069 0.659
MOD_CK1_1 149 155 PF00069 0.464
MOD_CK1_1 206 212 PF00069 0.652
MOD_CK1_1 24 30 PF00069 0.531
MOD_CK1_1 376 382 PF00069 0.521
MOD_CK1_1 404 410 PF00069 0.529
MOD_CK1_1 705 711 PF00069 0.504
MOD_CK1_1 803 809 PF00069 0.678
MOD_CK2_1 193 199 PF00069 0.559
MOD_CK2_1 306 312 PF00069 0.452
MOD_CK2_1 656 662 PF00069 0.512
MOD_CK2_1 801 807 PF00069 0.691
MOD_Cter_Amidation 54 57 PF01082 0.544
MOD_GlcNHglycan 134 138 PF01048 0.715
MOD_GlcNHglycan 208 211 PF01048 0.649
MOD_GlcNHglycan 287 291 PF01048 0.556
MOD_GlcNHglycan 403 406 PF01048 0.550
MOD_GlcNHglycan 443 446 PF01048 0.685
MOD_GlcNHglycan 448 451 PF01048 0.673
MOD_GlcNHglycan 594 597 PF01048 0.475
MOD_GlcNHglycan 706 710 PF01048 0.497
MOD_GlcNHglycan 720 723 PF01048 0.380
MOD_GlcNHglycan 89 92 PF01048 0.589
MOD_GSK3_1 113 120 PF00069 0.712
MOD_GSK3_1 144 151 PF00069 0.689
MOD_GSK3_1 400 407 PF00069 0.556
MOD_GSK3_1 446 453 PF00069 0.645
MOD_GSK3_1 575 582 PF00069 0.610
MOD_GSK3_1 588 595 PF00069 0.369
MOD_GSK3_1 634 641 PF00069 0.506
MOD_GSK3_1 67 74 PF00069 0.475
MOD_GSK3_1 735 742 PF00069 0.504
MOD_GSK3_1 803 810 PF00069 0.585
MOD_GSK3_1 87 94 PF00069 0.286
MOD_LATS_1 245 251 PF00433 0.644
MOD_NEK2_1 113 118 PF00069 0.647
MOD_NEK2_1 159 164 PF00069 0.529
MOD_NEK2_1 219 224 PF00069 0.572
MOD_NEK2_1 306 311 PF00069 0.391
MOD_NEK2_1 373 378 PF00069 0.445
MOD_NEK2_1 401 406 PF00069 0.546
MOD_NEK2_1 480 485 PF00069 0.462
MOD_NEK2_1 501 506 PF00069 0.621
MOD_NEK2_1 592 597 PF00069 0.500
MOD_NEK2_1 634 639 PF00069 0.514
MOD_NEK2_1 645 650 PF00069 0.486
MOD_NEK2_1 717 722 PF00069 0.560
MOD_NEK2_1 739 744 PF00069 0.484
MOD_NEK2_1 777 782 PF00069 0.517
MOD_NEK2_2 588 593 PF00069 0.462
MOD_NEK2_2 77 82 PF00069 0.574
MOD_PIKK_1 15 21 PF00454 0.592
MOD_PIKK_1 529 535 PF00454 0.560
MOD_PIKK_1 647 653 PF00454 0.543
MOD_PIKK_1 739 745 PF00454 0.541
MOD_PIKK_1 91 97 PF00454 0.565
MOD_PKA_2 118 124 PF00069 0.655
MOD_PKA_2 15 21 PF00069 0.611
MOD_PKA_2 446 452 PF00069 0.636
MOD_PKA_2 592 598 PF00069 0.404
MOD_PKA_2 646 652 PF00069 0.536
MOD_PKA_2 692 698 PF00069 0.627
MOD_PKB_1 543 551 PF00069 0.500
MOD_Plk_1 194 200 PF00069 0.637
MOD_Plk_1 320 326 PF00069 0.538
MOD_Plk_1 545 551 PF00069 0.507
MOD_Plk_1 705 711 PF00069 0.408
MOD_Plk_2-3 463 469 PF00069 0.508
MOD_Plk_4 113 119 PF00069 0.680
MOD_Plk_4 219 225 PF00069 0.540
MOD_Plk_4 408 414 PF00069 0.491
MOD_Plk_4 634 640 PF00069 0.475
MOD_Plk_4 692 698 PF00069 0.588
MOD_ProDKin_1 136 142 PF00069 0.698
MOD_ProDKin_1 415 421 PF00069 0.480
MOD_ProDKin_1 450 456 PF00069 0.620
MOD_SUMO_for_1 796 799 PF00179 0.555
MOD_SUMO_rev_2 574 580 PF00179 0.613
MOD_SUMO_rev_2 825 832 PF00179 0.671
TRG_DiLeu_BaLyEn_6 187 192 PF01217 0.680
TRG_DiLeu_BaLyEn_6 472 477 PF01217 0.506
TRG_DiLeu_BaLyEn_6 563 568 PF01217 0.459
TRG_ENDOCYTIC_2 172 175 PF00928 0.605
TRG_ENDOCYTIC_2 177 180 PF00928 0.581
TRG_ENDOCYTIC_2 253 256 PF00928 0.477
TRG_ENDOCYTIC_2 265 268 PF00928 0.379
TRG_ENDOCYTIC_2 273 276 PF00928 0.227
TRG_ENDOCYTIC_2 340 343 PF00928 0.448
TRG_ENDOCYTIC_2 681 684 PF00928 0.391
TRG_ENDOCYTIC_2 687 690 PF00928 0.423
TRG_ENDOCYTIC_2 736 739 PF00928 0.385
TRG_ENDOCYTIC_2 781 784 PF00928 0.431
TRG_ER_diArg_1 40 43 PF00400 0.512
TRG_ER_diArg_1 489 491 PF00400 0.571
TRG_ER_diArg_1 542 545 PF00400 0.546
TRG_ER_diArg_1 56 59 PF00400 0.423
TRG_ER_diArg_1 628 631 PF00400 0.568
TRG_ER_diArg_1 829 832 PF00400 0.704
TRG_NES_CRM1_1 274 287 PF08389 0.445
TRG_NES_CRM1_1 297 312 PF08389 0.558
TRG_NES_CRM1_1 555 570 PF08389 0.559
TRG_Pf-PMV_PEXEL_1 32 36 PF00026 0.552
TRG_Pf-PMV_PEXEL_1 341 345 PF00026 0.468
TRG_Pf-PMV_PEXEL_1 347 351 PF00026 0.419
TRG_Pf-PMV_PEXEL_1 490 494 PF00026 0.579
TRG_Pf-PMV_PEXEL_1 597 601 PF00026 0.537
TRG_Pf-PMV_PEXEL_1 605 609 PF00026 0.527
TRG_Pf-PMV_PEXEL_1 737 741 PF00026 0.561

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAX1 Leptomonas seymouri 66% 93%
A0A0S4JH32 Bodo saltans 26% 96%
A0A1X0PA13 Trypanosomatidae 32% 100%
A0A422N7I6 Trypanosoma rangeli 33% 100%
A4H3H9 Leishmania braziliensis 90% 100%
D0A213 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9ACF4 Leishmania major 96% 100%
E9AG26 Leishmania infantum 100% 100%
E9AJP2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS