Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJK4_LEIDO

TriTrypDb:

LdBPK_020670.1 , LdCL_020012300 , LDHU3_27.3740

Length:

937

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A451EJK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.522
CLV_NRD_NRD_1	107	109	PF00675	0.533
CLV_NRD_NRD_1	197	199	PF00675	0.623
CLV_NRD_NRD_1	226	228	PF00675	0.522
CLV_NRD_NRD_1	279	281	PF00675	0.526
CLV_NRD_NRD_1	345	347	PF00675	0.464
CLV_NRD_NRD_1	366	368	PF00675	0.517
CLV_NRD_NRD_1	380	382	PF00675	0.457
CLV_NRD_NRD_1	598	600	PF00675	0.515
CLV_NRD_NRD_1	611	613	PF00675	0.473
CLV_NRD_NRD_1	646	648	PF00675	0.519
CLV_NRD_NRD_1	785	787	PF00675	0.524
CLV_NRD_NRD_1	884	886	PF00675	0.643
CLV_PCSK_KEX2_1	170	172	PF00082	0.533
CLV_PCSK_KEX2_1	197	199	PF00082	0.623
CLV_PCSK_KEX2_1	226	228	PF00082	0.504
CLV_PCSK_KEX2_1	279	281	PF00082	0.473
CLV_PCSK_KEX2_1	345	347	PF00082	0.464
CLV_PCSK_KEX2_1	366	368	PF00082	0.490
CLV_PCSK_KEX2_1	380	382	PF00082	0.417
CLV_PCSK_KEX2_1	414	416	PF00082	0.625
CLV_PCSK_KEX2_1	455	457	PF00082	0.568
CLV_PCSK_KEX2_1	580	582	PF00082	0.477
CLV_PCSK_KEX2_1	611	613	PF00082	0.493
CLV_PCSK_KEX2_1	646	648	PF00082	0.522
CLV_PCSK_KEX2_1	785	787	PF00082	0.494
CLV_PCSK_KEX2_1	884	886	PF00082	0.646
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.556
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.625
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.600
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.540
CLV_PCSK_SKI1_1	263	267	PF00082	0.582
CLV_PCSK_SKI1_1	367	371	PF00082	0.474
CLV_PCSK_SKI1_1	496	500	PF00082	0.485
CLV_PCSK_SKI1_1	583	587	PF00082	0.511
CLV_PCSK_SKI1_1	631	635	PF00082	0.557
CLV_PCSK_SKI1_1	660	664	PF00082	0.477
CLV_PCSK_SKI1_1	725	729	PF00082	0.537
CLV_PCSK_SKI1_1	802	806	PF00082	0.620
DEG_APCC_DBOX_1	455	463	PF00400	0.620
DEG_APCC_DBOX_1	860	868	PF00400	0.553
DEG_SCF_FBW7_1	39	45	PF00400	0.626
DOC_CKS1_1	39	44	PF01111	0.679
DOC_CKS1_1	892	897	PF01111	0.624
DOC_MAPK_gen_1	380	387	PF00069	0.567
DOC_MAPK_gen_1	580	589	PF00069	0.519
DOC_MAPK_MEF2A_6	580	589	PF00069	0.605
DOC_MAPK_MEF2A_6	720	728	PF00069	0.479
DOC_MAPK_RevD_3	770	786	PF00069	0.595
DOC_PP2B_LxvP_1	929	932	PF13499	0.687
DOC_PP4_FxxP_1	912	915	PF00568	0.645
DOC_USP7_MATH_1	192	196	PF00917	0.634
DOC_USP7_MATH_1	461	465	PF00917	0.545
DOC_USP7_MATH_1	795	799	PF00917	0.619
DOC_USP7_MATH_1	883	887	PF00917	0.513
DOC_USP7_MATH_1	918	922	PF00917	0.659
DOC_USP7_MATH_1	923	927	PF00917	0.682
DOC_WW_Pin1_4	2	7	PF00397	0.732
DOC_WW_Pin1_4	38	43	PF00397	0.659
DOC_WW_Pin1_4	888	893	PF00397	0.749
LIG_14-3-3_CanoR_1	147	155	PF00244	0.623
LIG_14-3-3_CanoR_1	215	220	PF00244	0.622
LIG_14-3-3_CanoR_1	24	29	PF00244	0.680
LIG_14-3-3_CanoR_1	314	322	PF00244	0.444
LIG_14-3-3_CanoR_1	415	425	PF00244	0.625
LIG_14-3-3_CanoR_1	543	547	PF00244	0.487
LIG_14-3-3_CanoR_1	563	567	PF00244	0.247
LIG_14-3-3_CanoR_1	677	683	PF00244	0.466
LIG_14-3-3_CanoR_1	884	892	PF00244	0.570
LIG_14-3-3_CanoR_1	917	921	PF00244	0.707
LIG_Actin_WH2_2	148	165	PF00022	0.594
LIG_APCC_ABBA_1	755	760	PF00400	0.661
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_BIR_III_4	621	625	PF00653	0.475
LIG_CaM_IQ_9	772	788	PF13499	0.594
LIG_Clathr_ClatBox_1	73	77	PF01394	0.465
LIG_FHA_1	209	215	PF00498	0.653
LIG_FHA_1	730	736	PF00498	0.530
LIG_FHA_1	766	772	PF00498	0.541
LIG_FHA_2	129	135	PF00498	0.522
LIG_FHA_2	215	221	PF00498	0.611
LIG_FHA_2	43	49	PF00498	0.570
LIG_FHA_2	465	471	PF00498	0.607
LIG_FHA_2	474	480	PF00498	0.560
LIG_FHA_2	521	527	PF00498	0.551
LIG_FHA_2	59	65	PF00498	0.472
LIG_FHA_2	762	768	PF00498	0.488
LIG_LIR_Gen_1	51	57	PF02991	0.489
LIG_LIR_Gen_1	548	557	PF02991	0.522
LIG_LIR_Gen_1	66	76	PF02991	0.436
LIG_LIR_Gen_1	767	775	PF02991	0.611
LIG_LIR_Nem_3	316	322	PF02991	0.451
LIG_LIR_Nem_3	51	55	PF02991	0.473
LIG_LIR_Nem_3	548	553	PF02991	0.515
LIG_LIR_Nem_3	61	65	PF02991	0.488
LIG_LIR_Nem_3	66	72	PF02991	0.472
LIG_LIR_Nem_3	747	753	PF02991	0.695
LIG_LIR_Nem_3	767	772	PF02991	0.330
LIG_LIR_Nem_3	88	92	PF02991	0.461
LIG_NRBOX	723	729	PF00104	0.592
LIG_OCRL_FandH_1	852	864	PF00620	0.584
LIG_PCNA_yPIPBox_3	288	300	PF02747	0.533
LIG_PCNA_yPIPBox_3	528	540	PF02747	0.470
LIG_REV1ctd_RIR_1	843	851	PF16727	0.578
LIG_SH2_CRK	319	323	PF00017	0.462
LIG_SH2_CRK	550	554	PF00017	0.459
LIG_SH2_CRK	702	706	PF00017	0.564
LIG_SH2_CRK	750	754	PF00017	0.713
LIG_SH2_CRK	769	773	PF00017	0.388
LIG_SH2_NCK_1	348	352	PF00017	0.520
LIG_SH2_SRC	69	72	PF00017	0.579
LIG_SH2_STAP1	348	352	PF00017	0.520
LIG_SH2_STAP1	65	69	PF00017	0.498
LIG_SH2_STAT3	284	287	PF00017	0.532
LIG_SH2_STAT3	65	68	PF00017	0.537
LIG_SH2_STAT3	690	693	PF00017	0.561
LIG_SH2_STAT5	284	287	PF00017	0.477
LIG_SH2_STAT5	368	371	PF00017	0.563
LIG_SH2_STAT5	546	549	PF00017	0.522
LIG_SH3_3	36	42	PF00018	0.691
LIG_SH3_3	889	895	PF00018	0.721
LIG_SH3_3	910	916	PF00018	0.635
LIG_TRAF2_1	187	190	PF00917	0.625
LIG_TRAF2_1	252	255	PF00917	0.514
LIG_TRAF2_1	332	335	PF00917	0.562
LIG_TRAF2_1	468	471	PF00917	0.521
LIG_TYR_ITIM	700	705	PF00017	0.571
LIG_Vh1_VBS_1	106	124	PF01044	0.512
LIG_WRC_WIRS_1	466	471	PF05994	0.569
LIG_WW_3	914	918	PF00397	0.617
MOD_CDK_SPK_2	891	896	PF00069	0.774
MOD_CK1_1	19	25	PF00069	0.616
MOD_CK1_1	2	8	PF00069	0.655
MOD_CK1_1	233	239	PF00069	0.581
MOD_CK1_1	464	470	PF00069	0.567
MOD_CK1_1	573	579	PF00069	0.577
MOD_CK1_1	921	927	PF00069	0.695
MOD_CK2_1	140	146	PF00069	0.560
MOD_CK2_1	249	255	PF00069	0.570
MOD_CK2_1	261	267	PF00069	0.492
MOD_CK2_1	42	48	PF00069	0.629
MOD_CK2_1	423	429	PF00069	0.707
MOD_CK2_1	464	470	PF00069	0.527
MOD_CK2_1	473	479	PF00069	0.509
MOD_CK2_1	503	509	PF00069	0.507
MOD_CK2_1	518	524	PF00069	0.419
MOD_CK2_1	58	64	PF00069	0.495
MOD_CK2_1	761	767	PF00069	0.527
MOD_GlcNHglycan	19	22	PF01048	0.728
MOD_GlcNHglycan	235	238	PF01048	0.562
MOD_GlcNHglycan	26	29	PF01048	0.719
MOD_GlcNHglycan	886	889	PF01048	0.702
MOD_GlcNHglycan	925	928	PF01048	0.650
MOD_GSK3_1	12	19	PF00069	0.717
MOD_GSK3_1	142	149	PF00069	0.603
MOD_GSK3_1	29	36	PF00069	0.639
MOD_GSK3_1	38	45	PF00069	0.608
MOD_GSK3_1	416	423	PF00069	0.636
MOD_GSK3_1	461	468	PF00069	0.586
MOD_GSK3_1	570	577	PF00069	0.505
MOD_GSK3_1	761	768	PF00069	0.619
MOD_GSK3_1	884	891	PF00069	0.678
MOD_GSK3_1	918	925	PF00069	0.657
MOD_GSK3_1	92	99	PF00069	0.478
MOD_N-GLC_1	30	35	PF02516	0.698
MOD_N-GLC_1	729	734	PF02516	0.570
MOD_NEK2_1	1	6	PF00069	0.717
MOD_NEK2_1	162	167	PF00069	0.553
MOD_NEK2_1	199	204	PF00069	0.591
MOD_NEK2_1	214	219	PF00069	0.503
MOD_NEK2_1	221	226	PF00069	0.524
MOD_NEK2_1	231	236	PF00069	0.423
MOD_NEK2_1	535	540	PF00069	0.486
MOD_NEK2_1	574	579	PF00069	0.560
MOD_NEK2_1	845	850	PF00069	0.471
MOD_NEK2_1	867	872	PF00069	0.582
MOD_NEK2_1	92	97	PF00069	0.462
MOD_NEK2_2	192	197	PF00069	0.709
MOD_PIKK_1	208	214	PF00454	0.629
MOD_PIKK_1	221	227	PF00454	0.543
MOD_PIKK_1	481	487	PF00454	0.561
MOD_PIKK_1	675	681	PF00454	0.516
MOD_PIKK_1	845	851	PF00454	0.595
MOD_PKA_1	884	890	PF00069	0.713
MOD_PKA_2	134	140	PF00069	0.634
MOD_PKA_2	146	152	PF00069	0.527
MOD_PKA_2	17	23	PF00069	0.753
MOD_PKA_2	214	220	PF00069	0.599
MOD_PKA_2	273	279	PF00069	0.482
MOD_PKA_2	313	319	PF00069	0.457
MOD_PKA_2	542	548	PF00069	0.485
MOD_PKA_2	562	568	PF00069	0.246
MOD_PKA_2	574	580	PF00069	0.360
MOD_PKA_2	610	616	PF00069	0.478
MOD_PKA_2	883	889	PF00069	0.676
MOD_PKA_2	916	922	PF00069	0.724
MOD_Plk_1	128	134	PF00069	0.553
MOD_Plk_2-3	112	118	PF00069	0.589
MOD_Plk_2-3	58	64	PF00069	0.533
MOD_Plk_4	12	18	PF00069	0.661
MOD_Plk_4	461	467	PF00069	0.639
MOD_Plk_4	535	541	PF00069	0.489
MOD_Plk_4	542	548	PF00069	0.489
MOD_Plk_4	678	684	PF00069	0.470
MOD_Plk_4	92	98	PF00069	0.471
MOD_Plk_4	925	931	PF00069	0.739
MOD_ProDKin_1	2	8	PF00069	0.734
MOD_ProDKin_1	38	44	PF00069	0.651
MOD_ProDKin_1	888	894	PF00069	0.750
MOD_SUMO_for_1	141	144	PF00179	0.573
MOD_SUMO_for_1	169	172	PF00179	0.565
MOD_SUMO_for_1	403	406	PF00179	0.644
MOD_SUMO_for_1	585	588	PF00179	0.532
MOD_SUMO_rev_2	506	513	PF00179	0.522
TRG_DiLeu_BaEn_1	723	728	PF01217	0.535
TRG_DiLeu_BaEn_1	767	772	PF01217	0.633
TRG_DiLeu_BaEn_4	429	435	PF01217	0.522
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.455
TRG_ENDOCYTIC_2	319	322	PF00928	0.446
TRG_ENDOCYTIC_2	550	553	PF00928	0.444
TRG_ENDOCYTIC_2	69	72	PF00928	0.567
TRG_ENDOCYTIC_2	702	705	PF00928	0.568
TRG_ENDOCYTIC_2	750	753	PF00928	0.684
TRG_ENDOCYTIC_2	758	761	PF00928	0.684
TRG_ENDOCYTIC_2	769	772	PF00928	0.546
TRG_ENDOCYTIC_2	89	92	PF00928	0.257
TRG_ENDOCYTIC_2	909	912	PF00928	0.650
TRG_ER_diArg_1	196	198	PF00400	0.639
TRG_ER_diArg_1	226	228	PF00400	0.524
TRG_ER_diArg_1	279	281	PF00400	0.544
TRG_ER_diArg_1	345	347	PF00400	0.464
TRG_ER_diArg_1	366	368	PF00400	0.605
TRG_ER_diArg_1	739	742	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.670
TRG_Pf-PMV_PEXEL_1	733	738	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	780	784	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ56	Leptomonas seymouri	64%	100%
A0A0N1I2V1	Leptomonas seymouri	25%	91%
A0A0S4JDB4	Bodo saltans	25%	100%
A0A0S4JMK5	Bodo saltans	25%	100%
A0A0S4KGN1	Bodo saltans	33%	98%
A0A1X0NJT4	Trypanosomatidae	39%	100%
A0A381MLP4	Leishmania infantum	100%	100%
A0A3Q8IAS8	Leishmania donovani	100%	100%
A0A3S5H534	Leishmania donovani	24%	100%
A0A422NB26	Trypanosoma rangeli	36%	100%
A4H3K2	Leishmania braziliensis	25%	100%
A4HG33	Leishmania braziliensis	75%	100%
A4HRU2	Leishmania infantum	24%	100%
A8HUA1	Chlamydomonas reinhardtii	27%	100%
B2RW38	Mus musculus	26%	100%
C9ZJ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	91%
E9ACE4	Leishmania major	94%	100%
E9ACH7	Leishmania major	25%	100%
E9ACX3	Leishmania major	94%	100%
E9AJN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AJR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q5T655	Homo sapiens	25%	100%
V5D614	Trypanosoma cruzi	38%	100%