Mitochondrial_carrier_protein_putative/GeneDB:Lmj F.02.0670

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania donovani

UniProt:

A0A451EJK1_LEIDO

TriTrypDb:

LdBPK_020640.1 , LdCL_020012000 , LDHU3_02.0810

Length:

313

Annotations

LeishMANIAdb annotations

Homologous to Eukaryotic mitochondrial and chloroplast transporters for folate or nicotinic acid. Has no canonical mitochondrial target signal, only a Leishmaniid-specific C-terminal extension. Localization: Mitochondrial (by homology)

Annotations by Jardim et al.

Transporters, mitochondrial carrier

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A451EJK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJK1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0001409	guanine nucleotide transmembrane transporter activity	6	1
GO:0005215	transporter activity	1	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015216	purine nucleotide transmembrane transporter activity	5	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	259	261	PF00675	0.367
CLV_NRD_NRD_1	80	82	PF00675	0.433
CLV_PCSK_KEX2_1	124	126	PF00082	0.411
CLV_PCSK_KEX2_1	259	261	PF00082	0.373
CLV_PCSK_KEX2_1	45	47	PF00082	0.275
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.514
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.275
CLV_PCSK_PC7_1	120	126	PF00082	0.478
CLV_PCSK_SKI1_1	112	116	PF00082	0.434
CLV_PCSK_SKI1_1	219	223	PF00082	0.256
CLV_PCSK_SKI1_1	280	284	PF00082	0.276
CLV_PCSK_SKI1_1	292	296	PF00082	0.228
DEG_APCC_DBOX_1	167	175	PF00400	0.286
DOC_CDC14_PxL_1	287	295	PF14671	0.279
DOC_PP1_RVXF_1	290	296	PF00149	0.249
DOC_PP4_FxxP_1	149	152	PF00568	0.244
DOC_PP4_FxxP_1	36	39	PF00568	0.380
DOC_USP7_MATH_1	166	170	PF00917	0.266
DOC_USP7_MATH_1	7	11	PF00917	0.592
DOC_WW_Pin1_4	280	285	PF00397	0.260
LIG_14-3-3_CanoR_1	219	224	PF00244	0.256
LIG_14-3-3_CanoR_1	260	266	PF00244	0.317
LIG_AP2alpha_1	14	18	PF02296	0.419
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_Clathr_ClatBox_1	150	154	PF01394	0.245
LIG_eIF4E_1	218	224	PF01652	0.359
LIG_FHA_1	265	271	PF00498	0.317
LIG_FHA_1	281	287	PF00498	0.246
LIG_FHA_2	253	259	PF00498	0.338
LIG_FHA_2	296	302	PF00498	0.338
LIG_LIR_Apic_2	147	152	PF02991	0.244
LIG_LIR_Apic_2	33	39	PF02991	0.381
LIG_LIR_Gen_1	198	207	PF02991	0.245
LIG_LIR_Gen_1	222	232	PF02991	0.279
LIG_LIR_Gen_1	90	99	PF02991	0.432
LIG_LIR_Nem_3	121	126	PF02991	0.420
LIG_LIR_Nem_3	198	202	PF02991	0.253
LIG_LIR_Nem_3	277	282	PF02991	0.301
LIG_LIR_Nem_3	300	306	PF02991	0.283
LIG_LIR_Nem_3	90	95	PF02991	0.388
LIG_NRP_CendR_1	311	313	PF00754	0.417
LIG_PCNA_PIPBox_1	108	117	PF02747	0.349
LIG_PCNA_yPIPBox_3	101	115	PF02747	0.378
LIG_Pex14_2	14	18	PF04695	0.452
LIG_Pex14_2	36	40	PF04695	0.384
LIG_REV1ctd_RIR_1	276	283	PF16727	0.338
LIG_REV1ctd_RIR_1	301	309	PF16727	0.284
LIG_SH2_CRK	92	96	PF00017	0.315
LIG_SH2_NCK_1	92	96	PF00017	0.346
LIG_SH2_SRC	85	88	PF00017	0.297
LIG_SH2_STAP1	92	96	PF00017	0.313
LIG_SH2_STAT5	126	129	PF00017	0.556
LIG_SH2_STAT5	211	214	PF00017	0.395
LIG_SH2_STAT5	297	300	PF00017	0.304
LIG_SH2_STAT5	302	305	PF00017	0.304
LIG_SH2_STAT5	85	88	PF00017	0.327
LIG_UBA3_1	150	157	PF00899	0.262
LIG_WRC_WIRS_1	275	280	PF05994	0.309
MOD_CDK_SPK_2	280	285	PF00069	0.260
MOD_CK1_1	10	16	PF00069	0.318
MOD_CK1_1	2	8	PF00069	0.634
MOD_CK1_1	261	267	PF00069	0.226
MOD_CK2_1	252	258	PF00069	0.338
MOD_CK2_1	295	301	PF00069	0.260
MOD_CK2_1	55	61	PF00069	0.401
MOD_GlcNHglycan	1	4	PF01048	0.726
MOD_GlcNHglycan	168	171	PF01048	0.342
MOD_GlcNHglycan	260	263	PF01048	0.314
MOD_GlcNHglycan	288	291	PF01048	0.285
MOD_GSK3_1	55	62	PF00069	0.422
MOD_GSK3_1	87	94	PF00069	0.334
MOD_N-GLC_1	307	312	PF02516	0.455
MOD_N-GLC_2	226	228	PF02516	0.279
MOD_NEK2_1	114	119	PF00069	0.505
MOD_NEK2_1	18	23	PF00069	0.525
MOD_NEK2_1	202	207	PF00069	0.305
MOD_NEK2_1	227	232	PF00069	0.311
MOD_NEK2_1	295	300	PF00069	0.264
MOD_NEK2_1	307	312	PF00069	0.451
MOD_NEK2_1	40	45	PF00069	0.385
MOD_NEK2_1	55	60	PF00069	0.431
MOD_NEK2_1	91	96	PF00069	0.333
MOD_NEK2_2	274	279	PF00069	0.309
MOD_PIKK_1	157	163	PF00454	0.245
MOD_PKA_2	258	264	PF00069	0.388
MOD_PKA_2	55	61	PF00069	0.513
MOD_Plk_1	10	16	PF00069	0.452
MOD_Plk_4	184	190	PF00069	0.255
MOD_Plk_4	219	225	PF00069	0.253
MOD_Plk_4	274	280	PF00069	0.410
MOD_Plk_4	50	56	PF00069	0.548
MOD_Plk_4	87	93	PF00069	0.386
MOD_ProDKin_1	280	286	PF00069	0.260
MOD_SUMO_for_1	270	273	PF00179	0.390
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.309
TRG_ENDOCYTIC_2	92	95	PF00928	0.330
TRG_ENDOCYTIC_2	96	99	PF00928	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2W5	Leptomonas seymouri	46%	88%
A0A0N1IMP5	Leptomonas seymouri	22%	93%
A0A0S4IR49	Bodo saltans	50%	95%
A0A0S4IV98	Bodo saltans	25%	100%
A0A0S4JHF7	Bodo saltans	61%	99%
A0A1X0NJD2	Trypanosomatidae	27%	100%
A0A1X0NLB0	Trypanosomatidae	60%	98%
A0A1X0NUU7	Trypanosomatidae	21%	93%
A0A1X0P6S2	Trypanosomatidae	25%	96%
A0A3R7LCB2	Trypanosoma rangeli	20%	99%
A0A3R7RT89	Trypanosoma rangeli	25%	100%
A0A3S7WTS6	Leishmania donovani	24%	100%
A0A422N706	Trypanosoma rangeli	45%	90%
A0A422NAX9	Trypanosoma rangeli	62%	96%
A4H3F8	Leishmania braziliensis	85%	100%
A4HRR2	Leishmania infantum	100%	100%
A4HWR9	Leishmania infantum	24%	100%
A4I7S9	Leishmania infantum	20%	95%
A5DX39	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	22%	100%
B0DK57	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	26%	100%
B0G143	Dictyostelium discoideum	23%	100%
C9ZJ51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ACE1	Leishmania major	96%	100%
E9AJM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AQH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B2N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
F1R4U0	Danio rerio	22%	99%
O74439	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
O77792	Bos taurus	27%	100%
P38988	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P53007	Homo sapiens	21%	100%
P55851	Homo sapiens	26%	100%
P70406	Mus musculus	25%	100%
P79110	Bos taurus	22%	100%
Q03028	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q08CI8	Danio rerio	22%	100%
Q17QI7	Bos taurus	25%	87%
Q4QF00	Leishmania major	25%	100%
Q54B67	Dictyostelium discoideum	26%	100%
Q54FE6	Dictyostelium discoideum	24%	100%
Q55DY8	Dictyostelium discoideum	24%	100%
Q55E45	Dictyostelium discoideum	25%	100%
Q55GE2	Dictyostelium discoideum	22%	100%
Q59Q36	Candida albicans (strain SC5314 / ATCC MYA-2876)	22%	100%
Q5R5A8	Pongo abelii	26%	100%
Q5RFB7	Pongo abelii	25%	100%
Q6PGY3	Danio rerio	26%	87%
Q86AV5	Dictyostelium discoideum	25%	100%
Q8BZ09	Mus musculus	24%	100%
Q8JZU2	Mus musculus	22%	100%
Q94AG6	Arabidopsis thaliana	26%	96%
Q99297	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q99JD3	Rattus norvegicus	24%	100%
Q9BQT8	Homo sapiens	26%	100%
Q9DB41	Mus musculus	24%	98%
Q9FI73	Arabidopsis thaliana	22%	92%
Q9N2J1	Canis lupus familiaris	25%	100%
Q9P3T7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q9W720	Danio rerio	29%	100%
Q9W725	Cyprinus carpio	27%	100%
V5B5N3	Trypanosoma cruzi	60%	95%
V5BN90	Trypanosoma cruzi	45%	90%