LeishMANIAdb
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Gamma-glutamyl phosphate reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Gamma-glutamyl phosphate reductase-like protein
Gene product:
gamma-glutamyl phosphate reductase-like protein
Species:
Leishmania donovani
UniProt:
A0A451EJJ7_LEIDO
TriTrypDb:
LdBPK_020600.1 , LdCL_020011600 , LDHU3_02.0770
Length:
659

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJJ7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJJ7

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 5
GO:0006520 amino acid metabolic process 3 5
GO:0006560 proline metabolic process 6 5
GO:0006561 proline biosynthetic process 7 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0008652 amino acid biosynthetic process 4 5
GO:0009058 biosynthetic process 2 5
GO:0009064 glutamine family amino acid metabolic process 5 5
GO:0009084 glutamine family amino acid biosynthetic process 6 5
GO:0009987 cellular process 1 5
GO:0016053 organic acid biosynthetic process 4 5
GO:0018130 heterocycle biosynthetic process 4 5
GO:0019752 carboxylic acid metabolic process 5 5
GO:0043436 oxoacid metabolic process 4 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0044249 cellular biosynthetic process 3 5
GO:0044281 small molecule metabolic process 2 5
GO:0044283 small molecule biosynthetic process 3 5
GO:0046394 carboxylic acid biosynthetic process 5 5
GO:0046483 heterocycle metabolic process 3 5
GO:0055129 L-proline biosynthetic process 5 5
GO:0071704 organic substance metabolic process 2 5
GO:1901360 organic cyclic compound metabolic process 3 5
GO:1901362 organic cyclic compound biosynthetic process 4 5
GO:1901564 organonitrogen compound metabolic process 3 5
GO:1901566 organonitrogen compound biosynthetic process 4 5
GO:1901576 organic substance biosynthetic process 3 5
GO:1901605 alpha-amino acid metabolic process 4 5
GO:1901607 alpha-amino acid biosynthetic process 5 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016491 oxidoreductase activity 2 11
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4 11
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3 11
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 148 150 PF00675 0.680
CLV_NRD_NRD_1 333 335 PF00675 0.463
CLV_NRD_NRD_1 36 38 PF00675 0.446
CLV_NRD_NRD_1 395 397 PF00675 0.529
CLV_NRD_NRD_1 59 61 PF00675 0.470
CLV_NRD_NRD_1 643 645 PF00675 0.480
CLV_NRD_NRD_1 8 10 PF00675 0.527
CLV_PCSK_KEX2_1 148 150 PF00082 0.680
CLV_PCSK_KEX2_1 333 335 PF00082 0.463
CLV_PCSK_KEX2_1 36 38 PF00082 0.446
CLV_PCSK_KEX2_1 395 397 PF00082 0.429
CLV_PCSK_KEX2_1 59 61 PF00082 0.470
CLV_PCSK_KEX2_1 8 10 PF00082 0.527
CLV_PCSK_SKI1_1 37 41 PF00082 0.446
CLV_PCSK_SKI1_1 395 399 PF00082 0.430
DEG_APCC_DBOX_1 36 44 PF00400 0.436
DEG_COP1_1 219 229 PF00400 0.573
DEG_Nend_Nbox_1 1 3 PF02207 0.645
DEG_SPOP_SBC_1 624 628 PF00917 0.402
DOC_CKS1_1 247 252 PF01111 0.571
DOC_CYCLIN_yCln2_LP_2 255 261 PF00134 0.504
DOC_CYCLIN_yCln2_LP_2 343 349 PF00134 0.404
DOC_MAPK_gen_1 330 340 PF00069 0.663
DOC_MAPK_gen_1 355 362 PF00069 0.423
DOC_MAPK_gen_1 36 43 PF00069 0.396
DOC_MAPK_MEF2A_6 355 362 PF00069 0.456
DOC_MAPK_MEF2A_6 504 512 PF00069 0.405
DOC_MAPK_MEF2A_6 633 640 PF00069 0.435
DOC_MAPK_MEF2A_6 72 79 PF00069 0.629
DOC_PP2B_LxvP_1 343 346 PF13499 0.416
DOC_PP2B_PxIxI_1 357 363 PF00149 0.412
DOC_USP7_MATH_1 157 161 PF00917 0.597
DOC_USP7_MATH_1 194 198 PF00917 0.758
DOC_USP7_MATH_1 21 25 PF00917 0.463
DOC_USP7_MATH_1 216 220 PF00917 0.617
DOC_USP7_MATH_1 29 33 PF00917 0.403
DOC_USP7_MATH_1 297 301 PF00917 0.657
DOC_USP7_MATH_1 389 393 PF00917 0.511
DOC_USP7_MATH_1 417 421 PF00917 0.468
DOC_USP7_MATH_1 84 88 PF00917 0.668
DOC_USP7_MATH_1 94 98 PF00917 0.596
DOC_WW_Pin1_4 130 135 PF00397 0.675
DOC_WW_Pin1_4 143 148 PF00397 0.572
DOC_WW_Pin1_4 179 184 PF00397 0.632
DOC_WW_Pin1_4 207 212 PF00397 0.624
DOC_WW_Pin1_4 246 251 PF00397 0.641
DOC_WW_Pin1_4 254 259 PF00397 0.571
DOC_WW_Pin1_4 401 406 PF00397 0.392
DOC_WW_Pin1_4 71 76 PF00397 0.612
LIG_14-3-3_CanoR_1 148 154 PF00244 0.677
LIG_14-3-3_CanoR_1 217 226 PF00244 0.568
LIG_14-3-3_CanoR_1 3 11 PF00244 0.563
LIG_14-3-3_CanoR_1 333 341 PF00244 0.526
LIG_14-3-3_CanoR_1 36 40 PF00244 0.432
LIG_14-3-3_CanoR_1 395 405 PF00244 0.430
LIG_14-3-3_CanoR_1 419 427 PF00244 0.402
LIG_14-3-3_CanoR_1 448 455 PF00244 0.388
LIG_14-3-3_CanoR_1 49 55 PF00244 0.386
LIG_14-3-3_CanoR_1 504 512 PF00244 0.405
LIG_14-3-3_CanoR_1 610 617 PF00244 0.432
LIG_14-3-3_CanoR_1 633 639 PF00244 0.434
LIG_14-3-3_CanoR_1 649 658 PF00244 0.350
LIG_APCC_ABBA_1 496 501 PF00400 0.559
LIG_BIR_III_4 118 122 PF00653 0.647
LIG_BRCT_BRCA1_1 468 472 PF00533 0.405
LIG_Clathr_ClatBox_1 569 573 PF01394 0.413
LIG_DCNL_PONY_1 1 4 PF03556 0.636
LIG_eIF4E_1 449 455 PF01652 0.380
LIG_FHA_1 131 137 PF00498 0.593
LIG_FHA_1 333 339 PF00498 0.592
LIG_FHA_1 372 378 PF00498 0.384
LIG_FHA_1 398 404 PF00498 0.432
LIG_FHA_1 449 455 PF00498 0.419
LIG_FHA_1 492 498 PF00498 0.523
LIG_FHA_1 504 510 PF00498 0.384
LIG_FHA_1 554 560 PF00498 0.567
LIG_FHA_1 641 647 PF00498 0.490
LIG_FHA_1 72 78 PF00498 0.628
LIG_FHA_1 84 90 PF00498 0.575
LIG_FHA_2 233 239 PF00498 0.692
LIG_FHA_2 264 270 PF00498 0.581
LIG_FHA_2 584 590 PF00498 0.453
LIG_FXI_DFP_1 499 503 PF00024 0.413
LIG_LIR_Gen_1 421 431 PF02991 0.576
LIG_LIR_Gen_1 447 457 PF02991 0.407
LIG_LIR_Gen_1 458 466 PF02991 0.343
LIG_LIR_Gen_1 482 492 PF02991 0.468
LIG_LIR_Nem_3 421 427 PF02991 0.572
LIG_LIR_Nem_3 428 433 PF02991 0.462
LIG_LIR_Nem_3 447 452 PF02991 0.325
LIG_LIR_Nem_3 458 464 PF02991 0.354
LIG_LIR_Nem_3 482 487 PF02991 0.470
LIG_LIR_Nem_3 500 505 PF02991 0.269
LIG_LIR_Nem_3 539 545 PF02991 0.470
LIG_Pex14_2 571 575 PF04695 0.414
LIG_PTB_Apo_2 478 485 PF02174 0.406
LIG_RPA_C_Fungi 3 15 PF08784 0.499
LIG_SH2_CRK 449 453 PF00017 0.390
LIG_SH2_CRK 542 546 PF00017 0.507
LIG_SH2_NCK_1 449 453 PF00017 0.390
LIG_SH2_PTP2 430 433 PF00017 0.355
LIG_SH2_STAP1 341 345 PF00017 0.426
LIG_SH2_STAP1 505 509 PF00017 0.399
LIG_SH2_STAT3 465 468 PF00017 0.393
LIG_SH2_STAT5 155 158 PF00017 0.700
LIG_SH2_STAT5 270 273 PF00017 0.407
LIG_SH2_STAT5 430 433 PF00017 0.355
LIG_SH2_STAT5 465 468 PF00017 0.558
LIG_SH2_STAT5 505 508 PF00017 0.404
LIG_SH2_STAT5 594 597 PF00017 0.429
LIG_SH3_2 208 213 PF14604 0.609
LIG_SH3_3 205 211 PF00018 0.641
LIG_SH3_3 313 319 PF00018 0.648
LIG_SH3_3 433 439 PF00018 0.395
LIG_SH3_3 74 80 PF00018 0.642
LIG_SUMO_SIM_anti_2 432 437 PF11976 0.405
LIG_SUMO_SIM_anti_2 599 606 PF11976 0.415
LIG_SUMO_SIM_par_1 373 378 PF11976 0.384
LIG_SUMO_SIM_par_1 38 46 PF11976 0.401
LIG_SUMO_SIM_par_1 494 501 PF11976 0.398
LIG_SUMO_SIM_par_1 531 541 PF11976 0.439
LIG_SUMO_SIM_par_1 634 639 PF11976 0.441
LIG_SxIP_EBH_1 445 456 PF03271 0.567
LIG_TRAF2_1 537 540 PF00917 0.395
LIG_UBA3_1 255 263 PF00899 0.501
LIG_WRC_WIRS_1 572 577 PF05994 0.420
MOD_CDC14_SPxK_1 146 149 PF00782 0.679
MOD_CDC14_SPxK_1 210 213 PF00782 0.604
MOD_CDC14_SPxK_1 257 260 PF00782 0.519
MOD_CDK_SPK_2 143 148 PF00069 0.680
MOD_CDK_SPxK_1 143 149 PF00069 0.682
MOD_CDK_SPxK_1 207 213 PF00069 0.612
MOD_CDK_SPxK_1 254 260 PF00069 0.645
MOD_CK1_1 142 148 PF00069 0.682
MOD_CK1_1 197 203 PF00069 0.721
MOD_CK1_1 219 225 PF00069 0.646
MOD_CK1_1 447 453 PF00069 0.438
MOD_CK1_1 574 580 PF00069 0.552
MOD_CK1_1 7 13 PF00069 0.512
MOD_CK2_1 232 238 PF00069 0.691
MOD_CK2_1 263 269 PF00069 0.587
MOD_CK2_1 417 423 PF00069 0.457
MOD_CK2_1 535 541 PF00069 0.387
MOD_CK2_1 583 589 PF00069 0.450
MOD_GlcNHglycan 140 144 PF01048 0.665
MOD_GlcNHglycan 157 160 PF01048 0.597
MOD_GlcNHglycan 166 170 PF01048 0.639
MOD_GlcNHglycan 202 205 PF01048 0.686
MOD_GlcNHglycan 219 222 PF01048 0.571
MOD_GlcNHglycan 230 233 PF01048 0.604
MOD_GlcNHglycan 288 291 PF01048 0.722
MOD_GlcNHglycan 293 296 PF01048 0.702
MOD_GlcNHglycan 306 309 PF01048 0.562
MOD_GlcNHglycan 310 313 PF01048 0.564
MOD_GlcNHglycan 319 322 PF01048 0.620
MOD_GlcNHglycan 4 7 PF01048 0.577
MOD_GlcNHglycan 467 471 PF01048 0.404
MOD_GlcNHglycan 612 615 PF01048 0.479
MOD_GlcNHglycan 651 654 PF01048 0.455
MOD_GlcNHglycan 86 89 PF01048 0.674
MOD_GSK3_1 139 146 PF00069 0.662
MOD_GSK3_1 157 164 PF00069 0.513
MOD_GSK3_1 190 197 PF00069 0.767
MOD_GSK3_1 198 205 PF00069 0.645
MOD_GSK3_1 228 235 PF00069 0.631
MOD_GSK3_1 23 30 PF00069 0.479
MOD_GSK3_1 304 311 PF00069 0.603
MOD_GSK3_1 379 386 PF00069 0.484
MOD_GSK3_1 397 404 PF00069 0.407
MOD_GSK3_1 444 451 PF00069 0.474
MOD_GSK3_1 455 462 PF00069 0.352
MOD_GSK3_1 605 612 PF00069 0.417
MOD_GSK3_1 623 630 PF00069 0.274
MOD_GSK3_1 71 78 PF00069 0.623
MOD_GSK3_1 79 86 PF00069 0.606
MOD_GSK3_1 88 95 PF00069 0.540
MOD_N-GLC_1 605 610 PF02516 0.582
MOD_NEK2_1 165 170 PF00069 0.594
MOD_NEK2_1 190 195 PF00069 0.699
MOD_NEK2_1 2 7 PF00069 0.599
MOD_NEK2_1 28 33 PF00069 0.462
MOD_NEK2_1 383 388 PF00069 0.489
MOD_NEK2_1 390 395 PF00069 0.465
MOD_NEK2_1 455 460 PF00069 0.409
MOD_NEK2_1 571 576 PF00069 0.415
MOD_NEK2_1 623 628 PF00069 0.402
MOD_NEK2_1 640 645 PF00069 0.310
MOD_NEK2_2 297 302 PF00069 0.642
MOD_NEK2_2 379 384 PF00069 0.440
MOD_NEK2_2 94 99 PF00069 0.637
MOD_PIKK_1 543 549 PF00454 0.479
MOD_PKA_1 148 154 PF00069 0.658
MOD_PKA_2 148 154 PF00069 0.658
MOD_PKA_2 197 203 PF00069 0.671
MOD_PKA_2 2 8 PF00069 0.597
MOD_PKA_2 216 222 PF00069 0.509
MOD_PKA_2 329 335 PF00069 0.541
MOD_PKA_2 35 41 PF00069 0.442
MOD_PKA_2 358 364 PF00069 0.372
MOD_PKA_2 418 424 PF00069 0.430
MOD_PKA_2 447 453 PF00069 0.497
MOD_PKA_2 455 461 PF00069 0.391
MOD_PKA_2 48 54 PF00069 0.384
MOD_PKA_2 503 509 PF00069 0.412
MOD_PKA_2 609 615 PF00069 0.419
MOD_Plk_1 341 347 PF00069 0.421
MOD_Plk_2-3 535 541 PF00069 0.462
MOD_Plk_4 371 377 PF00069 0.358
MOD_Plk_4 379 385 PF00069 0.463
MOD_Plk_4 460 466 PF00069 0.401
MOD_Plk_4 492 498 PF00069 0.554
MOD_ProDKin_1 130 136 PF00069 0.678
MOD_ProDKin_1 143 149 PF00069 0.574
MOD_ProDKin_1 179 185 PF00069 0.633
MOD_ProDKin_1 207 213 PF00069 0.623
MOD_ProDKin_1 246 252 PF00069 0.639
MOD_ProDKin_1 254 260 PF00069 0.571
MOD_ProDKin_1 401 407 PF00069 0.386
MOD_ProDKin_1 71 77 PF00069 0.618
TRG_DiLeu_BaEn_1 515 520 PF01217 0.381
TRG_DiLeu_BaEn_4 540 546 PF01217 0.470
TRG_ENDOCYTIC_2 105 108 PF00928 0.638
TRG_ENDOCYTIC_2 430 433 PF00928 0.456
TRG_ENDOCYTIC_2 449 452 PF00928 0.312
TRG_ENDOCYTIC_2 505 508 PF00928 0.404
TRG_ENDOCYTIC_2 542 545 PF00928 0.471
TRG_ER_diArg_1 147 149 PF00400 0.680
TRG_ER_diArg_1 356 359 PF00400 0.441
TRG_ER_diArg_1 394 396 PF00400 0.429

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ITL0 Leishmania donovani 28% 100%
A4H3F4 Leishmania braziliensis 83% 100%
A4HKV9 Leishmania braziliensis 28% 100%
A4HRQ8 Leishmania infantum 99% 100%
A4I8D9 Leishmania infantum 28% 100%
E9ACD7 Leishmania major 95% 100%
E9AJM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B397 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q4V8 Leishmania major 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS