ARP2/3 complex subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ARP2/3 complex subunit, putative

Species:

Leishmania donovani

UniProt:

A0A451EJJ5_LEIDO

TriTrypDb:

LdBPK_020570.1 , LdCL_020011300 , LDHU3_02.0740

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005885	Arp2/3 protein complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A451EJJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJJ5

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	11
GO:0008064	regulation of actin polymerization or depolymerization	6	11
GO:0008154	actin polymerization or depolymerization	6	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0030041	actin filament polymerization	7	11
GO:0030832	regulation of actin filament length	5	11
GO:0030833	regulation of actin filament polymerization	7	11
GO:0032271	regulation of protein polymerization	6	11
GO:0032535	regulation of cellular component size	4	11
GO:0032956	regulation of actin cytoskeleton organization	5	11
GO:0032970	regulation of actin filament-based process	4	11
GO:0033043	regulation of organelle organization	5	11
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	11
GO:0043254	regulation of protein-containing complex assembly	5	11
GO:0043933	protein-containing complex organization	4	11
GO:0044087	regulation of cellular component biogenesis	4	11
GO:0045010	actin nucleation	6	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051128	regulation of cellular component organization	4	11
GO:0051258	protein polymerization	6	11
GO:0051493	regulation of cytoskeleton organization	6	11
GO:0065003	protein-containing complex assembly	5	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090066	regulation of anatomical structure size	3	11
GO:0097435	supramolecular fiber organization	4	11
GO:0110053	regulation of actin filament organization	6	11
GO:1902903	regulation of supramolecular fiber organization	5	11

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	5
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0008092	cytoskeletal protein binding	3	5
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.255
CLV_NRD_NRD_1	198	200	PF00675	0.222
CLV_PCSK_KEX2_1	136	138	PF00082	0.279
CLV_PCSK_KEX2_1	197	199	PF00082	0.224
CLV_PCSK_SKI1_1	14	18	PF00082	0.343
CLV_PCSK_SKI1_1	174	178	PF00082	0.359
DEG_APCC_DBOX_1	13	21	PF00400	0.530
DEG_APCC_DBOX_1	173	181	PF00400	0.419
DEG_COP1_1	27	38	PF00400	0.516
DOC_MAPK_gen_1	171	179	PF00069	0.395
DOC_PP1_RVXF_1	69	75	PF00149	0.513
DOC_PP1_RVXF_1	88	94	PF00149	0.452
DOC_PP4_FxxP_1	206	209	PF00568	0.608
LIG_14-3-3_CanoR_1	136	143	PF00244	0.498
LIG_14-3-3_CanoR_1	174	180	PF00244	0.505
LIG_14-3-3_CanoR_1	58	65	PF00244	0.520
LIG_14-3-3_CanoR_1	71	81	PF00244	0.457
LIG_14-3-3_CanoR_1	90	94	PF00244	0.460
LIG_Actin_WH2_2	176	193	PF00022	0.455
LIG_BIR_II_1	1	5	PF00653	0.431
LIG_BIR_III_3	1	5	PF00653	0.446
LIG_BIR_III_4	146	150	PF00653	0.407
LIG_BRCT_BRCA1_1	91	95	PF00533	0.435
LIG_eIF4E_1	153	159	PF01652	0.436
LIG_EVH1_2	50	54	PF00568	0.479
LIG_FHA_1	122	128	PF00498	0.512
LIG_FHA_1	150	156	PF00498	0.395
LIG_FHA_2	149	155	PF00498	0.460
LIG_HCF-1_HBM_1	162	165	PF13415	0.419
LIG_LIR_Gen_1	111	117	PF02991	0.548
LIG_LIR_Gen_1	154	165	PF02991	0.526
LIG_LIR_Nem_3	111	116	PF02991	0.548
LIG_LIR_Nem_3	154	160	PF02991	0.526
LIG_RPA_C_Fungi	53	65	PF08784	0.224
LIG_SH2_NCK_1	9	13	PF00017	0.407
LIG_SH2_STAP1	153	157	PF00017	0.280
LIG_SH2_STAT3	167	170	PF00017	0.341
LIG_SH2_STAT5	113	116	PF00017	0.254
LIG_WRC_WIRS_1	176	181	PF05994	0.294
LIG_WRC_WIRS_1	22	27	PF05994	0.407
MOD_CK1_1	175	181	PF00069	0.422
MOD_CK1_1	24	30	PF00069	0.405
MOD_CK1_1	85	91	PF00069	0.325
MOD_CK2_1	73	79	PF00069	0.308
MOD_GlcNHglycan	105	108	PF01048	0.418
MOD_GlcNHglycan	138	141	PF01048	0.238
MOD_GlcNHglycan	75	78	PF01048	0.428
MOD_GSK3_1	149	156	PF00069	0.232
MOD_GSK3_1	82	89	PF00069	0.309
MOD_NEK2_1	116	121	PF00069	0.427
MOD_NEK2_1	172	177	PF00069	0.304
MOD_NEK2_1	190	195	PF00069	0.362
MOD_NEK2_1	72	77	PF00069	0.347
MOD_OFUCOSY	80	86	PF10250	0.341
MOD_PKA_1	136	142	PF00069	0.341
MOD_PKA_2	135	141	PF00069	0.341
MOD_PKA_2	57	63	PF00069	0.264
MOD_PKA_2	89	95	PF00069	0.294
MOD_Plk_1	12	18	PF00069	0.404
MOD_Plk_1	153	159	PF00069	0.280
MOD_Plk_1	86	92	PF00069	0.301
MOD_Plk_4	153	159	PF00069	0.455
MOD_Plk_4	175	181	PF00069	0.324
MOD_Plk_4	50	56	PF00069	0.341
MOD_Plk_4	89	95	PF00069	0.331
TRG_ENDOCYTIC_2	113	116	PF00928	0.300
TRG_ENDOCYTIC_2	9	12	PF00928	0.300
TRG_ER_diArg_1	135	137	PF00400	0.341
TRG_ER_diArg_1	169	172	PF00400	0.224
TRG_ER_diArg_1	197	199	PF00400	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAU0	Leptomonas seymouri	48%	100%
A0A0S4KGM1	Bodo saltans	30%	100%
A0A1X0NJU3	Trypanosomatidae	33%	100%
A0A3R7MB12	Trypanosoma rangeli	31%	100%
A4H3F1	Leishmania braziliensis	72%	100%
A4HRQ5	Leishmania infantum	99%	100%
C9ZJ46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AJM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
F4JUL9	Arabidopsis thaliana	28%	100%
O96625	Dictyostelium discoideum	26%	100%
P33204	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P58798	Caenorhabditis elegans	28%	100%
P59998	Homo sapiens	28%	100%
P59999	Mus musculus	28%	100%
Q148J6	Bos taurus	28%	100%
Q19R45	Leishmania major	88%	100%
Q641G7	Xenopus laevis	27%	100%
Q92352	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%