Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJI9_LEIDO

TriTrypDb:

LdBPK_020510.1 , LdCL_020010700 , LDHU3_02.0650

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A451EJI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.624
CLV_NRD_NRD_1	139	141	PF00675	0.459
CLV_NRD_NRD_1	225	227	PF00675	0.493
CLV_NRD_NRD_1	229	231	PF00675	0.557
CLV_PCSK_FUR_1	137	141	PF00082	0.461
CLV_PCSK_FUR_1	223	227	PF00082	0.448
CLV_PCSK_KEX2_1	139	141	PF00082	0.459
CLV_PCSK_KEX2_1	204	206	PF00082	0.391
CLV_PCSK_KEX2_1	225	227	PF00082	0.493
CLV_PCSK_KEX2_1	228	230	PF00082	0.536
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.409
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.455
CLV_PCSK_PC7_1	221	227	PF00082	0.447
CLV_PCSK_SKI1_1	201	205	PF00082	0.375
CLV_PCSK_SKI1_1	276	280	PF00082	0.299
CLV_PCSK_SKI1_1	305	309	PF00082	0.573
DEG_SPOP_SBC_1	25	29	PF00917	0.475
DOC_MAPK_gen_1	201	210	PF00069	0.610
DOC_MAPK_JIP1_4	49	55	PF00069	0.299
DOC_MAPK_MEF2A_6	155	162	PF00069	0.292
DOC_MAPK_MEF2A_6	49	57	PF00069	0.299
DOC_PP2B_LxvP_1	22	25	PF13499	0.515
DOC_PP2B_LxvP_1	299	302	PF13499	0.406
DOC_USP7_MATH_1	126	130	PF00917	0.616
DOC_USP7_MATH_1	25	29	PF00917	0.460
DOC_USP7_MATH_1	312	316	PF00917	0.346
DOC_USP7_UBL2_3	305	309	PF12436	0.411
DOC_WW_Pin1_4	116	121	PF00397	0.764
DOC_WW_Pin1_4	124	129	PF00397	0.680
LIG_14-3-3_CanoR_1	115	120	PF00244	0.644
LIG_14-3-3_CanoR_1	140	150	PF00244	0.649
LIG_14-3-3_CanoR_1	213	217	PF00244	0.639
LIG_BH_BH3_1	141	157	PF00452	0.617
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_BIR_III_3	1	5	PF00653	0.499
LIG_BRCT_BRCA1_1	117	121	PF00533	0.642
LIG_BRCT_BRCA1_1	126	130	PF00533	0.616
LIG_BRCT_BRCA1_1	198	202	PF00533	0.498
LIG_BRCT_BRCA1_1	254	258	PF00533	0.630
LIG_BRCT_BRCA1_1	274	278	PF00533	0.606
LIG_BRCT_BRCA1_2	198	204	PF00533	0.501
LIG_EH1_1	281	289	PF00400	0.312
LIG_eIF4E_1	17	23	PF01652	0.568
LIG_FHA_1	183	189	PF00498	0.292
LIG_GBD_Chelix_1	288	296	PF00786	0.384
LIG_GBD_Chelix_1	55	63	PF00786	0.346
LIG_LIR_Gen_1	154	162	PF02991	0.460
LIG_LIR_Gen_1	51	60	PF02991	0.406
LIG_LIR_Gen_1	90	99	PF02991	0.639
LIG_LIR_Nem_3	154	160	PF02991	0.460
LIG_LIR_Nem_3	164	170	PF02991	0.292
LIG_LIR_Nem_3	199	203	PF02991	0.503
LIG_LIR_Nem_3	279	285	PF02991	0.346
LIG_LIR_Nem_3	51	57	PF02991	0.406
LIG_LIR_Nem_3	61	67	PF02991	0.180
LIG_LIR_Nem_3	83	89	PF02991	0.633
LIG_LIR_Nem_3	9	13	PF02991	0.359
LIG_LIR_Nem_3	90	95	PF02991	0.600
LIG_PCNA_PIPBox_1	271	280	PF02747	0.609
LIG_PDZ_Class_3	324	329	PF00595	0.436
LIG_Pex14_2	278	282	PF04695	0.315
LIG_SH2_CRK	138	142	PF00017	0.659
LIG_SH2_CRK	157	161	PF00017	0.188
LIG_SH2_CRK	195	199	PF00017	0.292
LIG_SH2_CRK	200	204	PF00017	0.575
LIG_SH2_STAP1	92	96	PF00017	0.616
LIG_SH2_STAT5	195	198	PF00017	0.292
LIG_SH3_3	125	131	PF00018	0.678
LIG_SUMO_SIM_anti_2	189	194	PF11976	0.370
LIG_SUMO_SIM_anti_2	264	269	PF11976	0.634
LIG_SUMO_SIM_par_1	148	154	PF11976	0.609
LIG_SUMO_SIM_par_1	184	189	PF11976	0.292
LIG_SUMO_SIM_par_1	266	272	PF11976	0.624
LIG_SUMO_SIM_par_1	55	61	PF11976	0.346
LIG_TYR_ITIM	136	141	PF00017	0.660
LIG_TYR_ITIM	193	198	PF00017	0.292
LIG_UBA3_1	63	72	PF00899	0.292
LIG_WRC_WIRS_1	7	12	PF05994	0.346
MOD_CK1_1	27	33	PF00069	0.460
MOD_CK1_1	58	64	PF00069	0.346
MOD_GlcNHglycan	10	13	PF01048	0.381
MOD_GlcNHglycan	132	135	PF01048	0.463
MOD_GlcNHglycan	210	213	PF01048	0.427
MOD_GlcNHglycan	216	219	PF01048	0.401
MOD_GlcNHglycan	254	257	PF01048	0.448
MOD_GlcNHglycan	314	317	PF01048	0.481
MOD_GlcNHglycan	35	38	PF01048	0.719
MOD_GlcNHglycan	45	48	PF01048	0.584
MOD_GlcNHglycan	64	67	PF01048	0.346
MOD_GSK3_1	126	133	PF00069	0.637
MOD_GSK3_1	182	189	PF00069	0.260
MOD_GSK3_1	208	215	PF00069	0.628
MOD_GSK3_1	23	30	PF00069	0.453
MOD_GSK3_1	272	279	PF00069	0.702
MOD_GSK3_1	58	65	PF00069	0.458
MOD_N-GLC_1	182	187	PF02516	0.460
MOD_NEK2_1	143	148	PF00069	0.687
MOD_NEK2_1	16	21	PF00069	0.640
MOD_NEK2_1	188	193	PF00069	0.346
MOD_NEK2_1	208	213	PF00069	0.625
MOD_NEK2_1	216	221	PF00069	0.592
MOD_NEK2_1	277	282	PF00069	0.416
MOD_NEK2_1	294	299	PF00069	0.430
MOD_NEK2_1	33	38	PF00069	0.420
MOD_NEK2_1	55	60	PF00069	0.346
MOD_PKA_2	208	214	PF00069	0.675
MOD_PKA_2	48	54	PF00069	0.428
MOD_Plk_4	182	188	PF00069	0.372
MOD_Plk_4	193	199	PF00069	0.416
MOD_Plk_4	48	54	PF00069	0.523
MOD_Plk_4	55	61	PF00069	0.221
MOD_ProDKin_1	116	122	PF00069	0.762
MOD_ProDKin_1	124	130	PF00069	0.680
MOD_SUMO_rev_2	73	80	PF00179	0.626
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.634
TRG_ENDOCYTIC_2	13	16	PF00928	0.394
TRG_ENDOCYTIC_2	138	141	PF00928	0.768
TRG_ENDOCYTIC_2	157	160	PF00928	0.188
TRG_ENDOCYTIC_2	195	198	PF00928	0.292
TRG_ENDOCYTIC_2	200	203	PF00928	0.575
TRG_ENDOCYTIC_2	92	95	PF00928	0.641
TRG_ER_diArg_1	138	140	PF00400	0.663
TRG_ER_diArg_1	223	226	PF00400	0.683
TRG_ER_diArg_1	229	231	PF00400	0.620
TRG_NLS_MonoExtN_4	225	232	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5IR47	Trypanosoma rangeli	36%	100%
A4HRP9	Leishmania infantum	98%	99%
E9ACC8	Leishmania major	95%	100%
E9AJL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%