Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJI8_LEIDO

TriTrypDb:

LdBPK_020500.1 , LdCL_020010600 , LDHU3_02.0640

Length:

863

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.623
CLV_C14_Caspase3-7	628	632	PF00656	0.667
CLV_C14_Caspase3-7	696	700	PF00656	0.700
CLV_MEL_PAP_1	62	68	PF00089	0.644
CLV_NRD_NRD_1	205	207	PF00675	0.647
CLV_NRD_NRD_1	300	302	PF00675	0.742
CLV_NRD_NRD_1	503	505	PF00675	0.731
CLV_NRD_NRD_1	600	602	PF00675	0.744
CLV_NRD_NRD_1	623	625	PF00675	0.686
CLV_NRD_NRD_1	742	744	PF00675	0.694
CLV_NRD_NRD_1	853	855	PF00675	0.687
CLV_PCSK_KEX2_1	205	207	PF00082	0.647
CLV_PCSK_KEX2_1	299	301	PF00082	0.750
CLV_PCSK_KEX2_1	500	502	PF00082	0.743
CLV_PCSK_KEX2_1	600	602	PF00082	0.743
CLV_PCSK_KEX2_1	623	625	PF00082	0.686
CLV_PCSK_KEX2_1	853	855	PF00082	0.687
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.743
CLV_PCSK_SKI1_1	129	133	PF00082	0.683
CLV_PCSK_SKI1_1	265	269	PF00082	0.611
CLV_PCSK_SKI1_1	554	558	PF00082	0.707
CLV_PCSK_SKI1_1	770	774	PF00082	0.627
DEG_APCC_DBOX_1	205	213	PF00400	0.657
DEG_SCF_FBW7_1	112	117	PF00400	0.606
DEG_SPOP_SBC_1	389	393	PF00917	0.661
DEG_SPOP_SBC_1	625	629	PF00917	0.597
DOC_CKS1_1	10	15	PF01111	0.636
DOC_CKS1_1	18	23	PF01111	0.632
DOC_CKS1_1	361	366	PF01111	0.623
DOC_MAPK_DCC_7	205	214	PF00069	0.656
DOC_MAPK_gen_1	205	212	PF00069	0.656
DOC_MAPK_HePTP_8	202	214	PF00069	0.553
DOC_MAPK_MEF2A_6	205	214	PF00069	0.656
DOC_MAPK_MEF2A_6	705	713	PF00069	0.695
DOC_PP2B_LxvP_1	11	14	PF13499	0.581
DOC_PP2B_LxvP_1	152	155	PF13499	0.641
DOC_PP2B_LxvP_1	357	360	PF13499	0.682
DOC_PP4_MxPP_1	538	541	PF00568	0.665
DOC_SPAK_OSR1_1	726	730	PF12202	0.674
DOC_USP7_MATH_1	163	167	PF00917	0.703
DOC_USP7_MATH_1	169	173	PF00917	0.686
DOC_USP7_MATH_1	182	186	PF00917	0.538
DOC_USP7_MATH_1	19	23	PF00917	0.671
DOC_USP7_MATH_1	191	195	PF00917	0.588
DOC_USP7_MATH_1	219	223	PF00917	0.653
DOC_USP7_MATH_1	26	30	PF00917	0.593
DOC_USP7_MATH_1	304	308	PF00917	0.626
DOC_USP7_MATH_1	325	329	PF00917	0.597
DOC_USP7_MATH_1	373	377	PF00917	0.696
DOC_USP7_MATH_1	405	409	PF00917	0.656
DOC_USP7_MATH_1	431	435	PF00917	0.626
DOC_USP7_MATH_1	452	456	PF00917	0.630
DOC_USP7_MATH_1	476	480	PF00917	0.734
DOC_USP7_MATH_1	565	569	PF00917	0.684
DOC_USP7_MATH_1	625	629	PF00917	0.679
DOC_USP7_MATH_1	671	675	PF00917	0.747
DOC_USP7_MATH_1	684	688	PF00917	0.598
DOC_USP7_MATH_1	692	696	PF00917	0.675
DOC_USP7_MATH_1	761	765	PF00917	0.681
DOC_USP7_MATH_1	772	776	PF00917	0.558
DOC_USP7_MATH_1	842	846	PF00917	0.715
DOC_WW_Pin1_4	110	115	PF00397	0.736
DOC_WW_Pin1_4	147	152	PF00397	0.678
DOC_WW_Pin1_4	17	22	PF00397	0.543
DOC_WW_Pin1_4	173	178	PF00397	0.692
DOC_WW_Pin1_4	2	7	PF00397	0.726
DOC_WW_Pin1_4	288	293	PF00397	0.665
DOC_WW_Pin1_4	360	365	PF00397	0.717
DOC_WW_Pin1_4	390	395	PF00397	0.662
DOC_WW_Pin1_4	427	432	PF00397	0.706
DOC_WW_Pin1_4	499	504	PF00397	0.737
DOC_WW_Pin1_4	573	578	PF00397	0.690
DOC_WW_Pin1_4	676	681	PF00397	0.735
DOC_WW_Pin1_4	752	757	PF00397	0.590
DOC_WW_Pin1_4	9	14	PF00397	0.628
LIG_14-3-3_CanoR_1	317	323	PF00244	0.572
LIG_14-3-3_CanoR_1	525	529	PF00244	0.691
LIG_14-3-3_CanoR_1	600	604	PF00244	0.739
LIG_14-3-3_CanoR_1	623	633	PF00244	0.688
LIG_14-3-3_CanoR_1	726	730	PF00244	0.648
LIG_14-3-3_CanoR_1	74	84	PF00244	0.639
LIG_Actin_WH2_2	332	350	PF00022	0.628
LIG_Actin_WH2_2	510	527	PF00022	0.663
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BIR_III_2	428	432	PF00653	0.672
LIG_BIR_III_2	631	635	PF00653	0.658
LIG_BRCT_BRCA1_1	723	727	PF00533	0.674
LIG_eIF4E_1	204	210	PF01652	0.653
LIG_eIF4E_1	550	556	PF01652	0.705
LIG_EVH1_1	539	543	PF00568	0.656
LIG_EVH1_2	13	17	PF00568	0.581
LIG_FHA_1	13	19	PF00498	0.710
LIG_FHA_1	147	153	PF00498	0.579
LIG_FHA_1	325	331	PF00498	0.607
LIG_FHA_1	356	362	PF00498	0.660
LIG_FHA_1	391	397	PF00498	0.587
LIG_FHA_1	428	434	PF00498	0.525
LIG_FHA_1	49	55	PF00498	0.663
LIG_FHA_1	530	536	PF00498	0.693
LIG_FHA_1	555	561	PF00498	0.709
LIG_FHA_1	726	732	PF00498	0.662
LIG_FHA_1	733	739	PF00498	0.608
LIG_FHA_1	766	772	PF00498	0.636
LIG_FHA_1	827	833	PF00498	0.660
LIG_FHA_2	361	367	PF00498	0.690
LIG_FHA_2	694	700	PF00498	0.700
LIG_FHA_2	778	784	PF00498	0.602
LIG_GBD_Chelix_1	335	343	PF00786	0.624
LIG_Integrin_isoDGR_2	588	590	PF01839	0.671
LIG_LIR_Apic_2	793	799	PF02991	0.604
LIG_LIR_Gen_1	32	37	PF02991	0.677
LIG_LIR_Gen_1	341	352	PF02991	0.629
LIG_LIR_Gen_1	408	418	PF02991	0.679
LIG_LIR_Gen_1	811	821	PF02991	0.608
LIG_LIR_Nem_3	32	36	PF02991	0.677
LIG_LIR_Nem_3	341	347	PF02991	0.625
LIG_LIR_Nem_3	350	356	PF02991	0.554
LIG_LIR_Nem_3	408	414	PF02991	0.672
LIG_LIR_Nem_3	786	792	PF02991	0.596
LIG_LIR_Nem_3	811	816	PF02991	0.601
LIG_MYND_1	151	155	PF01753	0.636
LIG_MYND_1	537	541	PF01753	0.664
LIG_PCNA_yPIPBox_3	216	228	PF02747	0.610
LIG_PDZ_Class_2	858	863	PF00595	0.670
LIG_Rb_LxCxE_1	410	428	PF01857	0.701
LIG_RPA_C_Fungi	218	230	PF08784	0.607
LIG_SH2_CRK	813	817	PF00017	0.600
LIG_SH2_PTP2	411	414	PF00017	0.684
LIG_SH2_STAP1	781	785	PF00017	0.629
LIG_SH2_STAP1	813	817	PF00017	0.600
LIG_SH2_STAT5	37	40	PF00017	0.668
LIG_SH2_STAT5	411	414	PF00017	0.684
LIG_SH3_1	109	115	PF00018	0.610
LIG_SH3_1	534	540	PF00018	0.661
LIG_SH3_3	1	7	PF00018	0.678
LIG_SH3_3	109	115	PF00018	0.610
LIG_SH3_3	159	165	PF00018	0.663
LIG_SH3_3	183	189	PF00018	0.660
LIG_SH3_3	358	364	PF00018	0.640
LIG_SH3_3	534	540	PF00018	0.699
LIG_SH3_3	674	680	PF00018	0.700
LIG_SH3_3	706	712	PF00018	0.694
LIG_SUMO_SIM_anti_2	783	790	PF11976	0.634
LIG_SUMO_SIM_par_1	732	740	PF11976	0.592
LIG_TRAF2_1	420	423	PF00917	0.667
LIG_WW_2	540	543	PF00397	0.650
MOD_CDC14_SPxK_1	502	505	PF00782	0.733
MOD_CDK_SPK_2	499	504	PF00069	0.737
MOD_CDK_SPxK_1	499	505	PF00069	0.737
MOD_CDK_SPxxK_3	288	295	PF00069	0.669
MOD_CK1_1	103	109	PF00069	0.722
MOD_CK1_1	172	178	PF00069	0.700
MOD_CK1_1	2	8	PF00069	0.724
MOD_CK1_1	222	228	PF00069	0.644
MOD_CK1_1	276	282	PF00069	0.679
MOD_CK1_1	29	35	PF00069	0.591
MOD_CK1_1	311	317	PF00069	0.668
MOD_CK1_1	321	327	PF00069	0.560
MOD_CK1_1	378	384	PF00069	0.703
MOD_CK1_1	401	407	PF00069	0.666
MOD_CK1_1	518	524	PF00069	0.667
MOD_CK1_1	679	685	PF00069	0.732
MOD_CK1_1	693	699	PF00069	0.595
MOD_CK1_1	732	738	PF00069	0.632
MOD_CK1_1	755	761	PF00069	0.714
MOD_CK1_1	835	841	PF00069	0.627
MOD_CK2_1	360	366	PF00069	0.780
MOD_CK2_1	454	460	PF00069	0.650
MOD_CK2_1	599	605	PF00069	0.739
MOD_CK2_1	64	70	PF00069	0.652
MOD_GlcNHglycan	1	4	PF01048	0.734
MOD_GlcNHglycan	102	105	PF01048	0.554
MOD_GlcNHglycan	136	139	PF01048	0.668
MOD_GlcNHglycan	142	145	PF01048	0.639
MOD_GlcNHglycan	193	196	PF01048	0.627
MOD_GlcNHglycan	21	24	PF01048	0.542
MOD_GlcNHglycan	259	262	PF01048	0.585
MOD_GlcNHglycan	26	29	PF01048	0.475
MOD_GlcNHglycan	310	313	PF01048	0.684
MOD_GlcNHglycan	323	326	PF01048	0.532
MOD_GlcNHglycan	327	330	PF01048	0.482
MOD_GlcNHglycan	373	376	PF01048	0.799
MOD_GlcNHglycan	377	380	PF01048	0.762
MOD_GlcNHglycan	400	403	PF01048	0.677
MOD_GlcNHglycan	407	410	PF01048	0.585
MOD_GlcNHglycan	425	428	PF01048	0.540
MOD_GlcNHglycan	440	443	PF01048	0.546
MOD_GlcNHglycan	456	459	PF01048	0.531
MOD_GlcNHglycan	491	494	PF01048	0.629
MOD_GlcNHglycan	562	565	PF01048	0.660
MOD_GlcNHglycan	567	570	PF01048	0.653
MOD_GlcNHglycan	577	580	PF01048	0.528
MOD_GlcNHglycan	611	614	PF01048	0.675
MOD_GlcNHglycan	616	619	PF01048	0.660
MOD_GlcNHglycan	687	690	PF01048	0.727
MOD_GlcNHglycan	692	695	PF01048	0.694
MOD_GlcNHglycan	7	10	PF01048	0.640
MOD_GlcNHglycan	713	716	PF01048	0.682
MOD_GlcNHglycan	765	768	PF01048	0.633
MOD_GlcNHglycan	836	840	PF01048	0.664
MOD_GlcNHglycan	85	88	PF01048	0.694
MOD_GSK3_1	110	117	PF00069	0.560
MOD_GSK3_1	169	176	PF00069	0.722
MOD_GSK3_1	178	185	PF00069	0.623
MOD_GSK3_1	269	276	PF00069	0.609
MOD_GSK3_1	304	311	PF00069	0.637
MOD_GSK3_1	316	323	PF00069	0.596
MOD_GSK3_1	338	345	PF00069	0.616
MOD_GSK3_1	367	374	PF00069	0.701
MOD_GSK3_1	375	382	PF00069	0.653
MOD_GSK3_1	401	408	PF00069	0.632
MOD_GSK3_1	423	430	PF00069	0.782
MOD_GSK3_1	438	445	PF00069	0.560
MOD_GSK3_1	44	51	PF00069	0.608
MOD_GSK3_1	482	489	PF00069	0.735
MOD_GSK3_1	5	12	PF00069	0.637
MOD_GSK3_1	524	531	PF00069	0.653
MOD_GSK3_1	556	563	PF00069	0.676
MOD_GSK3_1	571	578	PF00069	0.563
MOD_GSK3_1	721	728	PF00069	0.634
MOD_GSK3_1	730	737	PF00069	0.590
MOD_GSK3_1	752	759	PF00069	0.720
MOD_GSK3_1	761	768	PF00069	0.620
MOD_GSK3_1	96	103	PF00069	0.681
MOD_N-GLC_1	24	29	PF02516	0.618
MOD_N-GLC_1	276	281	PF02516	0.636
MOD_N-GLC_1	614	619	PF02516	0.576
MOD_N-GLC_1	756	761	PF02516	0.695
MOD_NEK2_1	146	151	PF00069	0.636
MOD_NEK2_1	24	29	PF00069	0.653
MOD_NEK2_1	347	352	PF00069	0.695
MOD_NEK2_1	524	529	PF00069	0.680
MOD_NEK2_1	560	565	PF00069	0.661
MOD_PIKK_1	338	344	PF00454	0.653
MOD_PIKK_1	431	437	PF00454	0.653
MOD_PIKK_1	515	521	PF00454	0.664
MOD_PIKK_1	737	743	PF00454	0.638
MOD_PKA_1	140	146	PF00069	0.664
MOD_PKA_2	222	228	PF00069	0.606
MOD_PKA_2	316	322	PF00069	0.553
MOD_PKA_2	347	353	PF00069	0.729
MOD_PKA_2	524	530	PF00069	0.693
MOD_PKA_2	580	586	PF00069	0.636
MOD_PKA_2	599	605	PF00069	0.640
MOD_PKA_2	64	70	PF00069	0.652
MOD_PKA_2	725	731	PF00069	0.645
MOD_PKA_2	73	79	PF00069	0.591
MOD_PKB_1	419	427	PF00069	0.609
MOD_Plk_1	421	427	PF00069	0.614
MOD_Plk_1	467	473	PF00069	0.667
MOD_Plk_1	657	663	PF00069	0.721
MOD_Plk_1	783	789	PF00069	0.594
MOD_Plk_1	811	817	PF00069	0.602
MOD_Plk_2-3	777	783	PF00069	0.609
MOD_Plk_4	210	216	PF00069	0.660
MOD_Plk_4	29	35	PF00069	0.679
MOD_Plk_4	407	413	PF00069	0.668
MOD_Plk_4	442	448	PF00069	0.667
MOD_Plk_4	657	663	PF00069	0.697
MOD_Plk_4	783	789	PF00069	0.594
MOD_Plk_4	811	817	PF00069	0.602
MOD_Plk_4	827	833	PF00069	0.494
MOD_ProDKin_1	110	116	PF00069	0.738
MOD_ProDKin_1	147	153	PF00069	0.680
MOD_ProDKin_1	17	23	PF00069	0.539
MOD_ProDKin_1	173	179	PF00069	0.692
MOD_ProDKin_1	2	8	PF00069	0.724
MOD_ProDKin_1	288	294	PF00069	0.665
MOD_ProDKin_1	360	366	PF00069	0.718
MOD_ProDKin_1	390	396	PF00069	0.663
MOD_ProDKin_1	427	433	PF00069	0.704
MOD_ProDKin_1	499	505	PF00069	0.737
MOD_ProDKin_1	573	579	PF00069	0.688
MOD_ProDKin_1	676	682	PF00069	0.735
MOD_ProDKin_1	752	758	PF00069	0.591
MOD_ProDKin_1	9	15	PF00069	0.627
TRG_DiLeu_BaEn_1	657	662	PF01217	0.695
TRG_DiLeu_BaEn_1	812	817	PF01217	0.601
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.628
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.637
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.700
TRG_ENDOCYTIC_2	411	414	PF00928	0.684
TRG_ENDOCYTIC_2	813	816	PF00928	0.597
TRG_ER_diArg_1	127	130	PF00400	0.686
TRG_ER_diArg_1	204	206	PF00400	0.661
TRG_ER_diArg_1	298	301	PF00400	0.744
TRG_ER_diArg_1	622	624	PF00400	0.692
TRG_ER_diArg_1	852	854	PF00400	0.685
TRG_NLS_MonoExtN_4	501	508	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.739
TRG_Pf-PMV_PEXEL_1	854	859	PF00026	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3E3	Leishmania braziliensis	63%	98%
A4HRP8	Leishmania infantum	99%	100%
E9ACC7	Leishmania major	91%	100%
E9AJL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%