Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJI7_LEIDO

TriTrypDb:

LdBPK_020480.1 , LdCL_020010300 , LDHU3_02.0600

Length:

170

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	52	54	PF00675	0.661
CLV_NRD_NRD_1	58	60	PF00675	0.645
CLV_PCSK_KEX2_1	52	54	PF00082	0.679
CLV_PCSK_KEX2_1	58	60	PF00082	0.670
CLV_PCSK_SKI1_1	109	113	PF00082	0.696
DEG_Nend_Nbox_1	1	3	PF02207	0.656
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.617
DOC_USP7_MATH_1	12	16	PF00917	0.535
DOC_USP7_MATH_1	85	89	PF00917	0.643
DOC_WW_Pin1_4	27	32	PF00397	0.588
DOC_WW_Pin1_4	69	74	PF00397	0.745
LIG_14-3-3_CanoR_1	11	20	PF00244	0.630
LIG_14-3-3_CanoR_1	67	73	PF00244	0.600
LIG_Actin_WH2_2	44	60	PF00022	0.681
LIG_BIR_III_4	117	121	PF00653	0.631
LIG_deltaCOP1_diTrp_1	107	111	PF00928	0.575
LIG_DLG_GKlike_1	16	24	PF00625	0.527
LIG_FHA_1	12	18	PF00498	0.554
LIG_FHA_1	76	82	PF00498	0.647
LIG_FHA_2	143	149	PF00498	0.604
LIG_FHA_2	161	167	PF00498	0.611
LIG_FHA_2	91	97	PF00498	0.739
LIG_LIR_Gen_1	29	40	PF02991	0.605
LIG_LIR_Nem_3	107	111	PF02991	0.575
LIG_LIR_Nem_3	29	35	PF02991	0.653
LIG_SH2_STAT3	161	164	PF00017	0.586
LIG_TRAF2_1	93	96	PF00917	0.631
LIG_TRAF2_1	99	102	PF00917	0.533
LIG_WRC_WIRS_1	17	22	PF05994	0.526
MOD_CK1_1	69	75	PF00069	0.731
MOD_CK2_1	142	148	PF00069	0.669
MOD_CK2_1	23	29	PF00069	0.655
MOD_CK2_1	90	96	PF00069	0.637
MOD_GlcNHglycan	124	127	PF01048	0.574
MOD_GlcNHglycan	32	35	PF01048	0.613
MOD_GlcNHglycan	68	71	PF01048	0.740
MOD_GSK3_1	12	19	PF00069	0.551
MOD_GSK3_1	2	9	PF00069	0.654
MOD_GSK3_1	23	30	PF00069	0.511
MOD_GSK3_1	43	50	PF00069	0.464
MOD_GSK3_1	59	66	PF00069	0.498
MOD_GSK3_1	69	76	PF00069	0.727
MOD_NEK2_1	47	52	PF00069	0.656
MOD_PIKK_1	160	166	PF00454	0.598
MOD_PKA_2	2	8	PF00069	0.629
MOD_PKA_2	66	72	PF00069	0.601
MOD_PKA_2	90	96	PF00069	0.575
MOD_ProDKin_1	27	33	PF00069	0.590
MOD_ProDKin_1	69	75	PF00069	0.745
MOD_SUMO_rev_2	150	158	PF00179	0.426
TRG_DiLeu_BaEn_2	106	112	PF01217	0.579
TRG_ER_diArg_1	51	53	PF00400	0.667
TRG_ER_diArg_1	57	59	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3E2	Leishmania braziliensis	73%	100%
A4HRP6	Leishmania infantum	100%	100%
E9ACC5	Leishmania major	91%	100%
E9AJL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%