Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJI4_LEIDO

TriTrypDb:

LdBPK_020450.1 , LdCL_020010000 , LDHU3_02.0570

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A451EJI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.687
CLV_NRD_NRD_1	121	123	PF00675	0.515
CLV_NRD_NRD_1	129	131	PF00675	0.521
CLV_NRD_NRD_1	18	20	PF00675	0.607
CLV_NRD_NRD_1	199	201	PF00675	0.603
CLV_PCSK_KEX2_1	100	102	PF00082	0.610
CLV_PCSK_KEX2_1	121	123	PF00082	0.515
CLV_PCSK_KEX2_1	128	130	PF00082	0.517
CLV_PCSK_KEX2_1	18	20	PF00082	0.622
CLV_PCSK_KEX2_1	198	200	PF00082	0.633
CLV_PCSK_KEX2_1	8	10	PF00082	0.609
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.610
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.571
CLV_PCSK_SKI1_1	121	125	PF00082	0.547
CLV_PCSK_SKI1_1	129	133	PF00082	0.485
CLV_PCSK_SKI1_1	66	70	PF00082	0.500
CLV_PCSK_SKI1_1	8	12	PF00082	0.561
DEG_APCC_DBOX_1	129	137	PF00400	0.601
DEG_SPOP_SBC_1	30	34	PF00917	0.626
DOC_CKS1_1	183	188	PF01111	0.538
DOC_MAPK_gen_1	75	84	PF00069	0.672
DOC_MAPK_RevD_3	186	199	PF00069	0.552
DOC_PP2B_LxvP_1	131	134	PF13499	0.531
DOC_USP7_MATH_1	134	138	PF00917	0.547
DOC_USP7_MATH_1	31	35	PF00917	0.617
DOC_USP7_UBL2_3	11	15	PF12436	0.590
DOC_WW_Pin1_4	182	187	PF00397	0.532
DOC_WW_Pin1_4	36	41	PF00397	0.674
LIG_14-3-3_CanoR_1	121	126	PF00244	0.604
LIG_14-3-3_CanoR_1	128	134	PF00244	0.616
LIG_14-3-3_CanoR_1	135	143	PF00244	0.467
LIG_14-3-3_CanoR_1	91	97	PF00244	0.630
LIG_AP2alpha_2	165	167	PF02296	0.471
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_FHA_1	115	121	PF00498	0.647
LIG_FHA_1	175	181	PF00498	0.516
LIG_FHA_1	183	189	PF00498	0.538
LIG_FHA_2	122	128	PF00498	0.479
LIG_FHA_2	53	59	PF00498	0.560
LIG_LIR_Gen_1	164	174	PF02991	0.462
LIG_LIR_Nem_3	164	170	PF02991	0.458
LIG_RPA_C_Fungi	117	129	PF08784	0.532
LIG_SH3_3	177	183	PF00018	0.523
LIG_SH3_4	111	118	PF00018	0.580
LIG_TRAF2_1	146	149	PF00917	0.455
MOD_CK1_1	114	120	PF00069	0.647
MOD_CK1_1	34	40	PF00069	0.648
MOD_CK2_1	121	127	PF00069	0.552
MOD_CK2_1	134	140	PF00069	0.487
MOD_GlcNHglycan	136	139	PF01048	0.531
MOD_GlcNHglycan	174	177	PF01048	0.503
MOD_GlcNHglycan	33	36	PF01048	0.653
MOD_GSK3_1	110	117	PF00069	0.685
MOD_GSK3_1	134	141	PF00069	0.509
MOD_GSK3_1	19	26	PF00069	0.653
MOD_GSK3_1	30	37	PF00069	0.619
MOD_PIKK_1	111	117	PF00454	0.702
MOD_PIKK_1	19	25	PF00454	0.661
MOD_PKA_1	121	127	PF00069	0.578
MOD_PKA_1	129	135	PF00069	0.523
MOD_PKA_2	121	127	PF00069	0.677
MOD_PKA_2	129	135	PF00069	0.575
MOD_PKA_2	141	147	PF00069	0.340
MOD_PKA_2	90	96	PF00069	0.740
MOD_Plk_4	121	127	PF00069	0.660
MOD_ProDKin_1	182	188	PF00069	0.535
MOD_ProDKin_1	36	42	PF00069	0.674
TRG_ER_diArg_1	120	122	PF00400	0.523
TRG_ER_diArg_1	128	130	PF00400	0.517
TRG_ER_diArg_1	198	200	PF00400	0.608
TRG_ER_diArg_1	69	72	PF00400	0.562
TRG_NLS_MonoExtN_4	5	12	PF00514	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P478	Leptomonas seymouri	52%	92%
A4H3D9	Leishmania braziliensis	60%	100%
A4HRP3	Leishmania infantum	100%	100%
E9ACC2	Leishmania major	91%	100%
E9AJL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%