Transmembrane amino acid transporter protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transmembrane amino acid transporter protein, putative

Species:

Leishmania donovani

UniProt:

A0A451EJH9_LEIDO

TriTrypDb:

LdCL_020009500

Length:

298

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	26
GO:0110165	cellular anatomical entity	1	26

Expansion

Sequence features

A0A451EJH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJH9

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	2
GO:0006810	transport	3	2
GO:0006865	amino acid transport	5	2
GO:0009987	cellular process	1	2
GO:0015849	organic acid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0015171	amino acid transmembrane transporter activity	5	2
GO:0015179	L-amino acid transmembrane transporter activity	6	2
GO:0016787	hydrolase activity	2	9
GO:0022857	transmembrane transporter activity	2	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.237
CLV_NRD_NRD_1	8	10	PF00675	0.197
CLV_PCSK_KEX2_1	262	264	PF00082	0.462
CLV_PCSK_KEX2_1	8	10	PF00082	0.169
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.462
CLV_PCSK_SKI1_1	85	89	PF00082	0.269
DEG_APCC_DBOX_1	233	241	PF00400	0.532
DEG_SPOP_SBC_1	33	37	PF00917	0.131
DOC_MAPK_MEF2A_6	14	23	PF00069	0.374
DOC_PP1_RVXF_1	227	233	PF00149	0.512
DOC_PP1_SILK_1	119	124	PF00149	0.174
DOC_PP2B_LxvP_1	191	194	PF13499	0.266
DOC_PP2B_LxvP_1	4	7	PF13499	0.418
DOC_PP2B_PxIxI_1	193	199	PF00149	0.186
DOC_PP4_FxxP_1	213	216	PF00568	0.288
DOC_USP7_MATH_1	33	37	PF00917	0.389
DOC_USP7_MATH_1	91	95	PF00917	0.268
LIG_14-3-3_CanoR_1	234	240	PF00244	0.329
LIG_14-3-3_CanoR_1	8	14	PF00244	0.387
LIG_APCC_ABBA_1	73	78	PF00400	0.136
LIG_BIR_III_4	90	94	PF00653	0.329
LIG_DCNL_PONY_1	1	4	PF03556	0.374
LIG_FHA_1	177	183	PF00498	0.175
LIG_FHA_1	20	26	PF00498	0.347
LIG_FHA_1	35	41	PF00498	0.309
LIG_FHA_1	58	64	PF00498	0.378
LIG_FHA_2	254	260	PF00498	0.131
LIG_FHA_2	49	55	PF00498	0.302
LIG_IRF3_LxIS_1	113	118	PF10401	0.129
LIG_LIR_Gen_1	238	247	PF02991	0.243
LIG_LIR_Nem_3	12	18	PF02991	0.478
LIG_LIR_Nem_3	217	221	PF02991	0.359
LIG_Pex14_2	103	107	PF04695	0.166
LIG_Pex14_2	62	66	PF04695	0.213
LIG_SH2_CRK	137	141	PF00017	0.188
LIG_SH2_GRB2like	239	242	PF00017	0.415
LIG_SH2_STAT5	15	18	PF00017	0.363
LIG_SH2_STAT5	161	164	PF00017	0.468
LIG_SH2_STAT5	221	224	PF00017	0.442
LIG_SH2_STAT5	239	242	PF00017	0.257
LIG_SH2_STAT5	48	51	PF00017	0.295
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.251
LIG_SUMO_SIM_anti_2	94	99	PF11976	0.400
LIG_TYR_ITIM	122	127	PF00017	0.226
LIG_TYR_ITIM	13	18	PF00017	0.459
LIG_UBA3_1	159	164	PF00899	0.374
LIG_WRC_WIRS_1	215	220	PF05994	0.296
MOD_GlcNHglycan	116	120	PF01048	0.361
MOD_GlcNHglycan	150	153	PF01048	0.131
MOD_GlcNHglycan	82	85	PF01048	0.157
MOD_NEK2_1	115	120	PF00069	0.209
MOD_NEK2_1	176	181	PF00069	0.327
MOD_NEK2_1	202	207	PF00069	0.299
MOD_NEK2_1	235	240	PF00069	0.435
MOD_NEK2_2	223	228	PF00069	0.374
MOD_PK_1	14	20	PF00069	0.462
MOD_Plk_4	117	123	PF00069	0.212
MOD_Plk_4	183	189	PF00069	0.305
MOD_Plk_4	19	25	PF00069	0.360
MOD_Plk_4	214	220	PF00069	0.312
MOD_Plk_4	235	241	PF00069	0.448
MOD_Plk_4	57	63	PF00069	0.295
MOD_Plk_4	93	99	PF00069	0.252
TRG_ENDOCYTIC_2	110	113	PF00928	0.296
TRG_ENDOCYTIC_2	124	127	PF00928	0.280
TRG_ENDOCYTIC_2	137	140	PF00928	0.287
TRG_ENDOCYTIC_2	15	18	PF00928	0.363
TRG_ENDOCYTIC_2	239	242	PF00928	0.255
TRG_ER_diArg_1	7	9	PF00400	0.397
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.129

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P613	Leptomonas seymouri	26%	73%
A0A0S4JEJ9	Bodo saltans	24%	100%
A0A0S4JQ87	Bodo saltans	30%	66%
A0A1X0NDW9	Trypanosomatidae	33%	100%
A0A1X0NNX9	Trypanosomatidae	35%	66%
A0A1X0NQH3	Trypanosomatidae	37%	67%
A0A1X0P4S1	Trypanosomatidae	24%	72%
A0A3Q8IN54	Leishmania donovani	28%	100%
A0A3R7KDS3	Trypanosoma rangeli	37%	73%
A0A3R7N2A2	Trypanosoma rangeli	42%	68%
A0A3S7XA86	Leishmania donovani	24%	73%
A0A422NBQ2	Trypanosoma rangeli	41%	68%
A4HNJ6	Leishmania braziliensis	24%	73%
A4IC53	Leishmania infantum	24%	73%
A4IC66	Leishmania infantum	28%	74%
D0A362	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	73%
E8NHF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	72%
E9AG08	Leishmania major	24%	73%
E9AG09	Leishmania major	28%	74%
E9AHD8	Leishmania infantum	38%	100%
E9B1I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B761	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	73%
E9B762	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	74%
O74327	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	71%
V5BH70	Trypanosoma cruzi	35%	67%
V5DET2	Trypanosoma cruzi	36%	85%
V5DKR4	Trypanosoma cruzi	40%	67%