LeishMANIAdb
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Transmembrane amino acid transporter protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane amino acid transporter protein, putative
Gene product:
Transmembrane amino acid transporter protein, putative
Species:
Leishmania donovani
UniProt:
A0A451EJH9_LEIDO
TriTrypDb:
LdCL_020009500
Length:
298

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 27
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0016020 membrane 2 26
GO:0110165 cellular anatomical entity 1 26

Expansion

Sequence features

A0A451EJH9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJH9

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 2
GO:0006810 transport 3 2
GO:0006865 amino acid transport 5 2
GO:0009987 cellular process 1 2
GO:0015849 organic acid transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
GO:1903825 organic acid transmembrane transport 3 2
GO:1905039 carboxylic acid transmembrane transport 4 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0005215 transporter activity 1 2
GO:0005342 organic acid transmembrane transporter activity 3 2
GO:0015171 amino acid transmembrane transporter activity 5 2
GO:0015179 L-amino acid transmembrane transporter activity 6 2
GO:0016787 hydrolase activity 2 9
GO:0022857 transmembrane transporter activity 2 2
GO:0046943 carboxylic acid transmembrane transporter activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 51 55 PF00656 0.237
CLV_NRD_NRD_1 8 10 PF00675 0.197
CLV_PCSK_KEX2_1 262 264 PF00082 0.462
CLV_PCSK_KEX2_1 8 10 PF00082 0.169
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.462
CLV_PCSK_SKI1_1 85 89 PF00082 0.269
DEG_APCC_DBOX_1 233 241 PF00400 0.532
DEG_SPOP_SBC_1 33 37 PF00917 0.131
DOC_MAPK_MEF2A_6 14 23 PF00069 0.374
DOC_PP1_RVXF_1 227 233 PF00149 0.512
DOC_PP1_SILK_1 119 124 PF00149 0.174
DOC_PP2B_LxvP_1 191 194 PF13499 0.266
DOC_PP2B_LxvP_1 4 7 PF13499 0.418
DOC_PP2B_PxIxI_1 193 199 PF00149 0.186
DOC_PP4_FxxP_1 213 216 PF00568 0.288
DOC_USP7_MATH_1 33 37 PF00917 0.389
DOC_USP7_MATH_1 91 95 PF00917 0.268
LIG_14-3-3_CanoR_1 234 240 PF00244 0.329
LIG_14-3-3_CanoR_1 8 14 PF00244 0.387
LIG_APCC_ABBA_1 73 78 PF00400 0.136
LIG_BIR_III_4 90 94 PF00653 0.329
LIG_DCNL_PONY_1 1 4 PF03556 0.374
LIG_FHA_1 177 183 PF00498 0.175
LIG_FHA_1 20 26 PF00498 0.347
LIG_FHA_1 35 41 PF00498 0.309
LIG_FHA_1 58 64 PF00498 0.378
LIG_FHA_2 254 260 PF00498 0.131
LIG_FHA_2 49 55 PF00498 0.302
LIG_IRF3_LxIS_1 113 118 PF10401 0.129
LIG_LIR_Gen_1 238 247 PF02991 0.243
LIG_LIR_Nem_3 12 18 PF02991 0.478
LIG_LIR_Nem_3 217 221 PF02991 0.359
LIG_Pex14_2 103 107 PF04695 0.166
LIG_Pex14_2 62 66 PF04695 0.213
LIG_SH2_CRK 137 141 PF00017 0.188
LIG_SH2_GRB2like 239 242 PF00017 0.415
LIG_SH2_STAT5 15 18 PF00017 0.363
LIG_SH2_STAT5 161 164 PF00017 0.468
LIG_SH2_STAT5 221 224 PF00017 0.442
LIG_SH2_STAT5 239 242 PF00017 0.257
LIG_SH2_STAT5 48 51 PF00017 0.295
LIG_SUMO_SIM_anti_2 283 288 PF11976 0.251
LIG_SUMO_SIM_anti_2 94 99 PF11976 0.400
LIG_TYR_ITIM 122 127 PF00017 0.226
LIG_TYR_ITIM 13 18 PF00017 0.459
LIG_UBA3_1 159 164 PF00899 0.374
LIG_WRC_WIRS_1 215 220 PF05994 0.296
MOD_GlcNHglycan 116 120 PF01048 0.361
MOD_GlcNHglycan 150 153 PF01048 0.131
MOD_GlcNHglycan 82 85 PF01048 0.157
MOD_NEK2_1 115 120 PF00069 0.209
MOD_NEK2_1 176 181 PF00069 0.327
MOD_NEK2_1 202 207 PF00069 0.299
MOD_NEK2_1 235 240 PF00069 0.435
MOD_NEK2_2 223 228 PF00069 0.374
MOD_PK_1 14 20 PF00069 0.462
MOD_Plk_4 117 123 PF00069 0.212
MOD_Plk_4 183 189 PF00069 0.305
MOD_Plk_4 19 25 PF00069 0.360
MOD_Plk_4 214 220 PF00069 0.312
MOD_Plk_4 235 241 PF00069 0.448
MOD_Plk_4 57 63 PF00069 0.295
MOD_Plk_4 93 99 PF00069 0.252
TRG_ENDOCYTIC_2 110 113 PF00928 0.296
TRG_ENDOCYTIC_2 124 127 PF00928 0.280
TRG_ENDOCYTIC_2 137 140 PF00928 0.287
TRG_ENDOCYTIC_2 15 18 PF00928 0.363
TRG_ENDOCYTIC_2 239 242 PF00928 0.255
TRG_ER_diArg_1 7 9 PF00400 0.397
TRG_Pf-PMV_PEXEL_1 85 90 PF00026 0.129

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P613 Leptomonas seymouri 26% 73%
A0A0S4JEJ9 Bodo saltans 24% 100%
A0A0S4JQ87 Bodo saltans 30% 66%
A0A1X0NDW9 Trypanosomatidae 33% 100%
A0A1X0NNX9 Trypanosomatidae 35% 66%
A0A1X0NQH3 Trypanosomatidae 37% 67%
A0A1X0P4S1 Trypanosomatidae 24% 72%
A0A3Q8IN54 Leishmania donovani 28% 100%
A0A3R7KDS3 Trypanosoma rangeli 37% 73%
A0A3R7N2A2 Trypanosoma rangeli 42% 68%
A0A3S7XA86 Leishmania donovani 24% 73%
A0A422NBQ2 Trypanosoma rangeli 41% 68%
A4HNJ6 Leishmania braziliensis 24% 73%
A4IC53 Leishmania infantum 24% 73%
A4IC66 Leishmania infantum 28% 74%
D0A362 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 73%
E8NHF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 72%
E9AG08 Leishmania major 24% 73%
E9AG09 Leishmania major 28% 74%
E9AHD8 Leishmania infantum 38% 100%
E9B1I3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B761 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 73%
E9B762 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 74%
O74327 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 71%
V5BH70 Trypanosoma cruzi 35% 67%
V5DET2 Trypanosoma cruzi 36% 85%
V5DKR4 Trypanosoma cruzi 40% 67%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS