RNase PH-like protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal RNA processing protein 41B, putative

Species:

Leishmania donovani

UniProt:

A0A451EJG9_LEIDO

TriTrypDb:

LdBPK_020290.1 , LdCL_020008300 , LDHU3_02.0400

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0000178	exosome (RNase complex)	4	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905354	exoribonuclease complex	3	1

Expansion

Sequence features

A0A451EJG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJG9

Function

Biological processes
Term	Name	Level	Count
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0016074	sno(s)RNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016180	snRNA processing	8	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031126	sno(s)RNA 3'-end processing	9	1
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	1
GO:0034470	ncRNA processing	7	1
GO:0034472	snRNA 3'-end processing	8	1
GO:0034475	U4 snRNA 3'-end processing	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034660	ncRNA metabolic process	6	1
GO:0034661	ncRNA catabolic process	6	1
GO:0043144	sno(s)RNA processing	8	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071028	nuclear mRNA surveillance	8	1
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	10	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.782
CLV_C14_Caspase3-7	93	97	PF00656	0.535
CLV_NRD_NRD_1	7	9	PF00675	0.415
CLV_NRD_NRD_1	86	88	PF00675	0.312
CLV_PCSK_KEX2_1	7	9	PF00082	0.439
CLV_PCSK_SKI1_1	11	15	PF00082	0.467
CLV_PCSK_SKI1_1	119	123	PF00082	0.309
DEG_SPOP_SBC_1	172	176	PF00917	0.596
DEG_SPOP_SBC_1	232	236	PF00917	0.643
DOC_MAPK_DCC_7	130	140	PF00069	0.530
DOC_MAPK_gen_1	114	123	PF00069	0.546
DOC_MAPK_gen_1	7	16	PF00069	0.524
DOC_MAPK_MEF2A_6	119	128	PF00069	0.511
DOC_PP4_FxxP_1	265	268	PF00568	0.412
DOC_USP7_MATH_1	142	146	PF00917	0.545
DOC_USP7_MATH_1	205	209	PF00917	0.575
DOC_USP7_MATH_1	216	220	PF00917	0.560
DOC_USP7_MATH_1	233	237	PF00917	0.453
DOC_USP7_MATH_1	247	251	PF00917	0.447
DOC_USP7_MATH_1	99	103	PF00917	0.566
LIG_14-3-3_CanoR_1	155	159	PF00244	0.422
LIG_14-3-3_CanoR_1	182	187	PF00244	0.712
LIG_14-3-3_CanoR_1	22	29	PF00244	0.269
LIG_14-3-3_CanoR_1	308	316	PF00244	0.488
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_FHA_1	57	63	PF00498	0.531
LIG_FHA_1	93	99	PF00498	0.569
LIG_FHA_2	10	16	PF00498	0.450
LIG_FHA_2	201	207	PF00498	0.369
LIG_FHA_2	25	31	PF00498	0.406
LIG_FHA_2	91	97	PF00498	0.535
LIG_LIR_Gen_1	194	202	PF02991	0.500
LIG_LIR_Nem_3	194	199	PF02991	0.536
LIG_NRBOX	99	105	PF00104	0.535
LIG_PCNA_yPIPBox_3	141	155	PF02747	0.454
LIG_REV1ctd_RIR_1	314	322	PF16727	0.385
LIG_SH2_CRK	213	217	PF00017	0.670
LIG_SH2_NCK_1	213	217	PF00017	0.670
LIG_SH2_STAP1	196	200	PF00017	0.489
LIG_SH2_STAP1	299	303	PF00017	0.496
LIG_SH2_STAP1	57	61	PF00017	0.530
LIG_SH2_STAT5	198	201	PF00017	0.467
LIG_SH3_3	235	241	PF00018	0.547
LIG_SH3_3	289	295	PF00018	0.539
LIG_SH3_3	68	74	PF00018	0.538
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.535
LIG_SUMO_SIM_par_1	120	125	PF11976	0.516
LIG_SUMO_SIM_par_1	301	307	PF11976	0.419
LIG_TRAF2_1	204	207	PF00917	0.446
LIG_TRFH_1	198	202	PF08558	0.470
MOD_CK1_1	176	182	PF00069	0.634
MOD_CK1_1	191	197	PF00069	0.651
MOD_CK1_1	231	237	PF00069	0.681
MOD_CK1_1	24	30	PF00069	0.472
MOD_CK1_1	281	287	PF00069	0.624
MOD_CK2_1	191	197	PF00069	0.510
MOD_CK2_1	200	206	PF00069	0.295
MOD_CK2_1	216	222	PF00069	0.568
MOD_CK2_1	9	15	PF00069	0.477
MOD_CK2_1	99	105	PF00069	0.496
MOD_GlcNHglycan	144	147	PF01048	0.341
MOD_GlcNHglycan	175	178	PF01048	0.711
MOD_GlcNHglycan	190	193	PF01048	0.538
MOD_GlcNHglycan	203	206	PF01048	0.470
MOD_GlcNHglycan	218	221	PF01048	0.573
MOD_GlcNHglycan	235	238	PF01048	0.636
MOD_GlcNHglycan	283	286	PF01048	0.634
MOD_GlcNHglycan	309	312	PF01048	0.503
MOD_GSK3_1	172	179	PF00069	0.636
MOD_GSK3_1	182	189	PF00069	0.692
MOD_GSK3_1	201	208	PF00069	0.423
MOD_GSK3_1	224	231	PF00069	0.771
MOD_GSK3_1	99	106	PF00069	0.535
MOD_NEK2_1	103	108	PF00069	0.497
MOD_NEK2_1	263	268	PF00069	0.362
MOD_NEK2_1	278	283	PF00069	0.279
MOD_NEK2_1	29	34	PF00069	0.461
MOD_PIKK_1	176	182	PF00454	0.697
MOD_PK_1	182	188	PF00069	0.709
MOD_PK_1	256	262	PF00069	0.330
MOD_PKA_2	154	160	PF00069	0.360
MOD_PKA_2	181	187	PF00069	0.777
MOD_PKA_2	21	27	PF00069	0.257
MOD_PKA_2	307	313	PF00069	0.430
MOD_Plk_1	104	110	PF00069	0.535
MOD_Plk_1	205	211	PF00069	0.485
MOD_Plk_1	24	30	PF00069	0.497
MOD_Plk_4	191	197	PF00069	0.635
MOD_Plk_4	30	36	PF00069	0.491
MOD_Plk_4	99	105	PF00069	0.504
MOD_SUMO_rev_2	80	89	PF00179	0.516
TRG_ENDOCYTIC_2	196	199	PF00928	0.496
TRG_ENDOCYTIC_2	299	302	PF00928	0.502
TRG_ER_diArg_1	242	245	PF00400	0.645
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIN2	Leptomonas seymouri	65%	94%
A0A0S4JHC4	Bodo saltans	36%	100%
A0A3R7MES5	Trypanosoma rangeli	40%	100%
A4HRM9	Leishmania infantum	100%	100%
C9ZIZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ACA7	Leishmania major	92%	100%
E9AJJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%