LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase
Gene product:
phosphoglycan beta 1,3 galactosyltransferase, putative (fragment)
Species:
Leishmania donovani
UniProt:
A0A451EJF8_LEIDO
TriTrypDb:
LdBPK_020150.1 , LdBPK_020170.1 * , LdCL_020007100 , LDHU3_02.0270
Length:
772

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0016020 membrane 2 54
GO:0110165 cellular anatomical entity 1 54
GO:0000139 Golgi membrane 5 13
GO:0031090 organelle membrane 3 13
GO:0098588 bounding membrane of organelle 4 13

Expansion

Sequence features

A0A451EJF8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJF8

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 54
GO:0006807 nitrogen compound metabolic process 2 54
GO:0008152 metabolic process 1 54
GO:0019538 protein metabolic process 3 54
GO:0036211 protein modification process 4 54
GO:0043170 macromolecule metabolic process 3 54
GO:0043412 macromolecule modification 4 54
GO:0043413 macromolecule glycosylation 3 54
GO:0044238 primary metabolic process 2 54
GO:0070085 glycosylation 2 54
GO:0071704 organic substance metabolic process 2 54
GO:1901564 organonitrogen compound metabolic process 3 54
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 54
GO:0016740 transferase activity 2 54
GO:0016757 glycosyltransferase activity 3 54
GO:0016758 hexosyltransferase activity 4 54
GO:0008194 UDP-glycosyltransferase activity 4 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.458
CLV_NRD_NRD_1 15 17 PF00675 0.481
CLV_NRD_NRD_1 233 235 PF00675 0.544
CLV_NRD_NRD_1 332 334 PF00675 0.667
CLV_NRD_NRD_1 416 418 PF00675 0.672
CLV_NRD_NRD_1 494 496 PF00675 0.621
CLV_NRD_NRD_1 56 58 PF00675 0.578
CLV_NRD_NRD_1 565 567 PF00675 0.569
CLV_NRD_NRD_1 594 596 PF00675 0.498
CLV_NRD_NRD_1 600 602 PF00675 0.495
CLV_NRD_NRD_1 733 735 PF00675 0.515
CLV_NRD_NRD_1 87 89 PF00675 0.541
CLV_PCSK_KEX2_1 10 12 PF00082 0.474
CLV_PCSK_KEX2_1 17 19 PF00082 0.486
CLV_PCSK_KEX2_1 233 235 PF00082 0.547
CLV_PCSK_KEX2_1 331 333 PF00082 0.670
CLV_PCSK_KEX2_1 416 418 PF00082 0.602
CLV_PCSK_KEX2_1 44 46 PF00082 0.599
CLV_PCSK_KEX2_1 494 496 PF00082 0.636
CLV_PCSK_KEX2_1 56 58 PF00082 0.547
CLV_PCSK_KEX2_1 565 567 PF00082 0.557
CLV_PCSK_KEX2_1 594 596 PF00082 0.503
CLV_PCSK_KEX2_1 600 602 PF00082 0.494
CLV_PCSK_KEX2_1 733 735 PF00082 0.553
CLV_PCSK_KEX2_1 87 89 PF00082 0.541
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.432
CLV_PCSK_PC1ET2_1 44 46 PF00082 0.576
CLV_PCSK_PC7_1 229 235 PF00082 0.519
CLV_PCSK_PC7_1 7 13 PF00082 0.426
CLV_PCSK_PC7_1 729 735 PF00082 0.519
CLV_PCSK_SKI1_1 225 229 PF00082 0.574
CLV_PCSK_SKI1_1 298 302 PF00082 0.520
CLV_PCSK_SKI1_1 333 337 PF00082 0.593
CLV_PCSK_SKI1_1 41 45 PF00082 0.554
CLV_PCSK_SKI1_1 441 445 PF00082 0.586
CLV_PCSK_SKI1_1 601 605 PF00082 0.485
CLV_PCSK_SKI1_1 686 690 PF00082 0.554
CLV_Separin_Metazoa 280 284 PF03568 0.435
DEG_APCC_DBOX_1 577 585 PF00400 0.297
DEG_Nend_UBRbox_1 1 4 PF02207 0.593
DEG_SCF_FBW7_1 377 384 PF00400 0.443
DOC_CKS1_1 207 212 PF01111 0.350
DOC_CKS1_1 268 273 PF01111 0.399
DOC_CKS1_1 378 383 PF01111 0.451
DOC_CYCLIN_RxL_1 370 380 PF00134 0.267
DOC_CYCLIN_yCln2_LP_2 375 381 PF00134 0.492
DOC_CYCLIN_yCln2_LP_2 61 67 PF00134 0.344
DOC_MAPK_gen_1 16 24 PF00069 0.683
DOC_MAPK_gen_1 575 583 PF00069 0.336
DOC_MAPK_JIP1_4 18 24 PF00069 0.583
DOC_MAPK_MEF2A_6 159 167 PF00069 0.338
DOC_MAPK_MEF2A_6 16 24 PF00069 0.703
DOC_MAPK_MEF2A_6 405 412 PF00069 0.432
DOC_MAPK_MEF2A_6 429 438 PF00069 0.332
DOC_MAPK_MEF2A_6 90 99 PF00069 0.372
DOC_PP1_RVXF_1 403 410 PF00149 0.332
DOC_PP1_RVXF_1 439 446 PF00149 0.429
DOC_PP1_RVXF_1 598 605 PF00149 0.262
DOC_PP2B_LxvP_1 375 378 PF13499 0.495
DOC_PP2B_LxvP_1 530 533 PF13499 0.400
DOC_PP4_FxxP_1 383 386 PF00568 0.328
DOC_USP7_MATH_1 151 155 PF00917 0.448
DOC_USP7_MATH_1 166 170 PF00917 0.352
DOC_USP7_MATH_1 264 268 PF00917 0.401
DOC_USP7_MATH_1 316 320 PF00917 0.386
DOC_USP7_MATH_1 335 339 PF00917 0.303
DOC_USP7_MATH_1 574 578 PF00917 0.372
DOC_USP7_MATH_1 664 668 PF00917 0.239
DOC_USP7_MATH_1 95 99 PF00917 0.376
DOC_WW_Pin1_4 106 111 PF00397 0.305
DOC_WW_Pin1_4 206 211 PF00397 0.384
DOC_WW_Pin1_4 267 272 PF00397 0.417
DOC_WW_Pin1_4 345 350 PF00397 0.487
DOC_WW_Pin1_4 362 367 PF00397 0.422
DOC_WW_Pin1_4 377 382 PF00397 0.421
LIG_14-3-3_CanoR_1 131 138 PF00244 0.398
LIG_14-3-3_CanoR_1 233 237 PF00244 0.472
LIG_14-3-3_CanoR_1 337 341 PF00244 0.346
LIG_14-3-3_CanoR_1 373 378 PF00244 0.281
LIG_14-3-3_CanoR_1 487 492 PF00244 0.430
LIG_14-3-3_CanoR_1 594 603 PF00244 0.315
LIG_14-3-3_CanoR_1 734 740 PF00244 0.346
LIG_Actin_WH2_2 173 189 PF00022 0.371
LIG_Actin_WH2_2 322 339 PF00022 0.317
LIG_APCC_ABBA_1 20 25 PF00400 0.408
LIG_deltaCOP1_diTrp_1 636 641 PF00928 0.256
LIG_eIF4E_1 29 35 PF01652 0.242
LIG_FHA_1 115 121 PF00498 0.458
LIG_FHA_1 169 175 PF00498 0.495
LIG_FHA_1 207 213 PF00498 0.349
LIG_FHA_1 34 40 PF00498 0.314
LIG_FHA_1 363 369 PF00498 0.408
LIG_FHA_1 647 653 PF00498 0.315
LIG_FHA_1 78 84 PF00498 0.347
LIG_FHA_2 236 242 PF00498 0.418
LIG_FHA_2 275 281 PF00498 0.442
LIG_FHA_2 421 427 PF00498 0.344
LIG_FHA_2 687 693 PF00498 0.336
LIG_FHA_2 736 742 PF00498 0.356
LIG_Integrin_isoDGR_2 628 630 PF01839 0.481
LIG_IRF3_LxIS_1 24 31 PF10401 0.216
LIG_LIR_Apic_2 380 386 PF02991 0.333
LIG_LIR_Apic_2 427 433 PF02991 0.455
LIG_LIR_Gen_1 209 218 PF02991 0.333
LIG_LIR_Gen_1 238 243 PF02991 0.332
LIG_LIR_Gen_1 447 458 PF02991 0.348
LIG_LIR_Gen_1 464 474 PF02991 0.360
LIG_LIR_Gen_1 62 69 PF02991 0.434
LIG_LIR_Gen_1 636 646 PF02991 0.360
LIG_LIR_Gen_1 653 659 PF02991 0.371
LIG_LIR_Nem_3 209 214 PF02991 0.346
LIG_LIR_Nem_3 235 239 PF02991 0.475
LIG_LIR_Nem_3 304 308 PF02991 0.294
LIG_LIR_Nem_3 36 40 PF02991 0.252
LIG_LIR_Nem_3 447 453 PF02991 0.391
LIG_LIR_Nem_3 464 470 PF02991 0.322
LIG_LIR_Nem_3 596 602 PF02991 0.396
LIG_LIR_Nem_3 62 68 PF02991 0.438
LIG_LIR_Nem_3 636 641 PF02991 0.344
LIG_LIR_Nem_3 653 657 PF02991 0.374
LIG_LIR_Nem_3 666 672 PF02991 0.281
LIG_LIR_Nem_3 764 769 PF02991 0.310
LIG_Pex14_1 637 641 PF04695 0.259
LIG_RPA_C_Fungi 560 572 PF08784 0.301
LIG_RPA_C_Fungi 590 602 PF08784 0.296
LIG_SH2_CRK 599 603 PF00017 0.345
LIG_SH2_CRK 616 620 PF00017 0.281
LIG_SH2_CRK 766 770 PF00017 0.379
LIG_SH2_GRB2like 523 526 PF00017 0.501
LIG_SH2_GRB2like 748 751 PF00017 0.362
LIG_SH2_NCK_1 308 312 PF00017 0.453
LIG_SH2_PTP2 467 470 PF00017 0.357
LIG_SH2_SRC 239 242 PF00017 0.412
LIG_SH2_SRC 448 451 PF00017 0.413
LIG_SH2_SRC 523 526 PF00017 0.501
LIG_SH2_STAP1 448 452 PF00017 0.537
LIG_SH2_STAP1 748 752 PF00017 0.476
LIG_SH2_STAT5 211 214 PF00017 0.463
LIG_SH2_STAT5 257 260 PF00017 0.497
LIG_SH2_STAT5 29 32 PF00017 0.265
LIG_SH2_STAT5 370 373 PF00017 0.426
LIG_SH2_STAT5 389 392 PF00017 0.366
LIG_SH2_STAT5 467 470 PF00017 0.394
LIG_SH2_STAT5 479 482 PF00017 0.427
LIG_SH2_STAT5 633 636 PF00017 0.409
LIG_SH2_STAT5 668 671 PF00017 0.536
LIG_SH2_STAT5 673 676 PF00017 0.474
LIG_SH3_3 204 210 PF00018 0.546
LIG_SH3_3 343 349 PF00018 0.363
LIG_SH3_3 375 381 PF00018 0.572
LIG_SH3_3 465 471 PF00018 0.367
LIG_TRAF2_1 238 241 PF00917 0.420
LIG_TRAF2_1 500 503 PF00917 0.471
LIG_TRAF2_1 688 691 PF00917 0.414
LIG_TYR_ITIM 237 242 PF00017 0.555
LIG_TYR_ITSM 207 214 PF00017 0.398
LIG_UBA3_1 39 44 PF00899 0.392
LIG_WRC_WIRS_1 302 307 PF05994 0.297
MOD_CDK_SPxxK_3 345 352 PF00069 0.325
MOD_CK1_1 267 273 PF00069 0.639
MOD_CK1_1 309 315 PF00069 0.329
MOD_CK2_1 133 139 PF00069 0.453
MOD_CK2_1 235 241 PF00069 0.502
MOD_CK2_1 274 280 PF00069 0.548
MOD_CK2_1 301 307 PF00069 0.577
MOD_CK2_1 354 360 PF00069 0.390
MOD_CK2_1 382 388 PF00069 0.390
MOD_CK2_1 686 692 PF00069 0.475
MOD_CK2_1 735 741 PF00069 0.386
MOD_GlcNHglycan 135 138 PF01048 0.564
MOD_GlcNHglycan 153 156 PF01048 0.546
MOD_GlcNHglycan 290 293 PF01048 0.463
MOD_GlcNHglycan 298 301 PF01048 0.407
MOD_GlcNHglycan 307 311 PF01048 0.354
MOD_GlcNHglycan 318 321 PF01048 0.440
MOD_GlcNHglycan 394 397 PF01048 0.552
MOD_GlcNHglycan 497 500 PF01048 0.499
MOD_GlcNHglycan 596 599 PF01048 0.288
MOD_GlcNHglycan 92 95 PF01048 0.473
MOD_GSK3_1 102 109 PF00069 0.428
MOD_GSK3_1 126 133 PF00069 0.531
MOD_GSK3_1 362 369 PF00069 0.473
MOD_GSK3_1 373 380 PF00069 0.453
MOD_GSK3_1 416 423 PF00069 0.369
MOD_GSK3_1 43 50 PF00069 0.451
MOD_GSK3_1 590 597 PF00069 0.363
MOD_GSK3_1 646 653 PF00069 0.438
MOD_GSK3_1 753 760 PF00069 0.332
MOD_N-GLC_1 102 107 PF02516 0.378
MOD_N-GLC_1 288 293 PF02516 0.512
MOD_N-GLC_1 296 301 PF02516 0.362
MOD_N-GLC_1 420 425 PF02516 0.389
MOD_N-GLC_1 650 655 PF02516 0.344
MOD_N-GLC_1 717 722 PF02516 0.353
MOD_N-GLC_1 729 734 PF02516 0.381
MOD_NEK2_1 165 170 PF00069 0.398
MOD_NEK2_1 28 33 PF00069 0.358
MOD_NEK2_1 3 8 PF00069 0.527
MOD_NEK2_1 336 341 PF00069 0.335
MOD_NEK2_1 424 429 PF00069 0.494
MOD_NEK2_1 43 48 PF00069 0.431
MOD_NEK2_1 717 722 PF00069 0.350
MOD_NEK2_2 114 119 PF00069 0.570
MOD_NEK2_2 543 548 PF00069 0.309
MOD_PIKK_1 309 315 PF00454 0.338
MOD_PIKK_1 436 442 PF00454 0.542
MOD_PIKK_1 550 556 PF00454 0.312
MOD_PKA_1 416 422 PF00069 0.612
MOD_PKA_1 594 600 PF00069 0.290
MOD_PKA_2 130 136 PF00069 0.511
MOD_PKA_2 232 238 PF00069 0.584
MOD_PKA_2 336 342 PF00069 0.387
MOD_PKA_2 354 360 PF00069 0.571
MOD_PKA_2 416 422 PF00069 0.561
MOD_PKA_2 593 599 PF00069 0.335
MOD_PKA_2 662 668 PF00069 0.272
MOD_PKB_1 88 96 PF00069 0.437
MOD_Plk_1 102 108 PF00069 0.366
MOD_Plk_1 296 302 PF00069 0.352
MOD_Plk_1 420 426 PF00069 0.391
MOD_Plk_1 650 656 PF00069 0.409
MOD_Plk_1 717 723 PF00069 0.336
MOD_Plk_4 102 108 PF00069 0.422
MOD_Plk_4 33 39 PF00069 0.317
MOD_Plk_4 366 372 PF00069 0.387
MOD_Plk_4 557 563 PF00069 0.342
MOD_Plk_4 653 659 PF00069 0.520
MOD_Plk_4 664 670 PF00069 0.336
MOD_ProDKin_1 106 112 PF00069 0.346
MOD_ProDKin_1 206 212 PF00069 0.447
MOD_ProDKin_1 267 273 PF00069 0.510
MOD_ProDKin_1 345 351 PF00069 0.606
MOD_ProDKin_1 362 368 PF00069 0.500
MOD_ProDKin_1 377 383 PF00069 0.506
TRG_ENDOCYTIC_2 211 214 PF00928 0.463
TRG_ENDOCYTIC_2 239 242 PF00928 0.598
TRG_ENDOCYTIC_2 450 453 PF00928 0.551
TRG_ENDOCYTIC_2 467 470 PF00928 0.264
TRG_ENDOCYTIC_2 599 602 PF00928 0.485
TRG_ENDOCYTIC_2 616 619 PF00928 0.298
TRG_ENDOCYTIC_2 638 641 PF00928 0.313
TRG_ENDOCYTIC_2 766 769 PF00928 0.351
TRG_ER_diArg_1 15 18 PF00400 0.579
TRG_ER_diArg_1 331 333 PF00400 0.576
TRG_ER_diArg_1 416 418 PF00400 0.458
TRG_ER_diArg_1 493 495 PF00400 0.500
TRG_ER_diArg_1 55 57 PF00400 0.388
TRG_ER_diArg_1 565 567 PF00400 0.412
TRG_ER_diArg_1 578 581 PF00400 0.406
TRG_ER_diArg_1 599 601 PF00400 0.335
TRG_ER_diArg_1 661 664 PF00400 0.321
TRG_ER_diArg_1 733 735 PF00400 0.361
TRG_ER_diArg_1 87 90 PF00400 0.418
TRG_ER_diArg_1 9 12 PF00400 0.571
TRG_Pf-PMV_PEXEL_1 767 771 PF00026 0.356
TRG_Pf-PMV_PEXEL_1 81 85 PF00026 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 38% 100%
A0A3S5H4Y6 Leishmania donovani 66% 100%
A0A3S5H4Y9 Leishmania donovani 34% 100%
A0A3S7WT86 Leishmania donovani 42% 100%
A0A3S7WWA6 Leishmania donovani 38% 100%
A0A451EJD9 Leishmania donovani 37% 100%
A0A451EJF4 Leishmania donovani 58% 100%
A0A451EJF6 Leishmania donovani 61% 97%
A0A451EJF9 Leishmania donovani 56% 89%
A4H3A9 Leishmania braziliensis 56% 100%
A4H3B4 Leishmania braziliensis 54% 100%
A4H3B5 Leishmania braziliensis 53% 95%
A4H3B6 Leishmania braziliensis 58% 95%
A4H3B7 Leishmania braziliensis 45% 72%
A4H3B8 Leishmania braziliensis 66% 100%
A4H3B9 Leishmania braziliensis 38% 100%
A4H4W8 Leishmania braziliensis 36% 100%
A4HJ20 Leishmania braziliensis 57% 100%
A4HNK3 Leishmania braziliensis 38% 95%
A4HNK6 Leishmania braziliensis 37% 100%
A4HRL9 Leishmania infantum 60% 100%
A4HRM0 Leishmania infantum 75% 96%
A4HRM1 Leishmania infantum 61% 97%
A4HRS1 Leishmania infantum 55% 100%
A4HRS3 Leishmania infantum 33% 100%
A4HRS5 Leishmania infantum 99% 100%
A4HZM0 Leishmania infantum 38% 100%
A4I7C7 Leishmania infantum 39% 100%
A4IAQ2 Leishmania infantum 38% 100%
E9AC91 Leishmania major 58% 100%
E9AC92 Leishmania major 55% 100%
E9AC95 Leishmania major 90% 100%
E9AC96 Leishmania major 56% 100%
E9AC98 Leishmania major 35% 100%
E9AEH8 Leishmania major 38% 100%
E9AHA6 Leishmania infantum 37% 100%
E9AIP8 Leishmania braziliensis 36% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 96%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
Q4Q5T6 Leishmania major 38% 100%
Q4QCL8 Leishmania major 37% 100%
Q4QFJ3 Leishmania major 42% 100%
Q4QIG9 Leishmania major 37% 100%
Q7YXU9 Leishmania major 37% 100%
Q7YXV1 Leishmania major 37% 100%
Q7YXV2 Leishmania major 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS