LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase
Gene product:
phosphoglycan beta 1,3 galactosyltransferase, putative (fragment)
Species:
Leishmania donovani
UniProt:
A0A451EJF6_LEIDO
TriTrypDb:
LdBPK_020140.1 , LdBPK_020160.1 , LdCL_020006900 , LDHU3_02.0250
Length:
654

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 47
NetGPI no yes: 0, no: 47
Cellular components
Term Name Level Count
GO:0016020 membrane 2 48
GO:0110165 cellular anatomical entity 1 48
GO:0000139 Golgi membrane 5 11
GO:0031090 organelle membrane 3 11
GO:0098588 bounding membrane of organelle 4 11

Expansion

Sequence features

A0A451EJF6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJF6

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 48
GO:0006807 nitrogen compound metabolic process 2 48
GO:0008152 metabolic process 1 48
GO:0019538 protein metabolic process 3 48
GO:0036211 protein modification process 4 48
GO:0043170 macromolecule metabolic process 3 48
GO:0043412 macromolecule modification 4 48
GO:0043413 macromolecule glycosylation 3 48
GO:0044238 primary metabolic process 2 48
GO:0070085 glycosylation 2 48
GO:0071704 organic substance metabolic process 2 48
GO:1901564 organonitrogen compound metabolic process 3 48
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 48
GO:0016740 transferase activity 2 48
GO:0016757 glycosyltransferase activity 3 48
GO:0016758 hexosyltransferase activity 4 48
GO:0008194 UDP-glycosyltransferase activity 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 463 467 PF00656 0.363
CLV_NRD_NRD_1 133 135 PF00675 0.419
CLV_NRD_NRD_1 188 190 PF00675 0.508
CLV_NRD_NRD_1 230 232 PF00675 0.576
CLV_NRD_NRD_1 235 237 PF00675 0.560
CLV_NRD_NRD_1 254 256 PF00675 0.423
CLV_NRD_NRD_1 313 315 PF00675 0.615
CLV_NRD_NRD_1 411 413 PF00675 0.513
CLV_NRD_NRD_1 434 436 PF00675 0.349
CLV_NRD_NRD_1 451 453 PF00675 0.450
CLV_NRD_NRD_1 481 483 PF00675 0.377
CLV_PCSK_KEX2_1 133 135 PF00082 0.424
CLV_PCSK_KEX2_1 188 190 PF00082 0.533
CLV_PCSK_KEX2_1 230 232 PF00082 0.574
CLV_PCSK_KEX2_1 235 237 PF00082 0.558
CLV_PCSK_KEX2_1 254 256 PF00082 0.423
CLV_PCSK_KEX2_1 313 315 PF00082 0.500
CLV_PCSK_KEX2_1 382 384 PF00082 0.488
CLV_PCSK_KEX2_1 411 413 PF00082 0.513
CLV_PCSK_KEX2_1 434 436 PF00082 0.353
CLV_PCSK_KEX2_1 451 453 PF00082 0.437
CLV_PCSK_KEX2_1 481 483 PF00082 0.384
CLV_PCSK_PC1ET2_1 382 384 PF00082 0.460
CLV_PCSK_PC7_1 129 135 PF00082 0.377
CLV_PCSK_PC7_1 231 237 PF00082 0.412
CLV_PCSK_PC7_1 378 384 PF00082 0.359
CLV_PCSK_SKI1_1 125 129 PF00082 0.452
CLV_PCSK_SKI1_1 203 207 PF00082 0.429
CLV_PCSK_SKI1_1 254 258 PF00082 0.407
CLV_PCSK_SKI1_1 338 342 PF00082 0.450
CLV_PCSK_SKI1_1 434 438 PF00082 0.382
CLV_PCSK_SKI1_1 593 597 PF00082 0.383
DEG_APCC_DBOX_1 188 196 PF00400 0.455
DEG_APCC_DBOX_1 531 539 PF00400 0.320
DEG_Nend_Nbox_1 1 3 PF02207 0.439
DEG_SCF_FBW7_1 274 281 PF00400 0.593
DEG_SCF_FBW7_2 243 250 PF00400 0.355
DEG_SPOP_SBC_1 461 465 PF00917 0.390
DOC_CKS1_1 107 112 PF01111 0.409
DOC_CKS1_1 275 280 PF01111 0.601
DOC_CYCLIN_yCln2_LP_2 2 8 PF00134 0.394
DOC_CYCLIN_yCln2_LP_2 272 278 PF00134 0.621
DOC_MAPK_gen_1 434 441 PF00069 0.323
DOC_MAPK_gen_1 451 458 PF00069 0.284
DOC_MAPK_gen_1 502 511 PF00069 0.310
DOC_MAPK_MEF2A_6 302 309 PF00069 0.560
DOC_MAPK_MEF2A_6 326 335 PF00069 0.392
DOC_MAPK_MEF2A_6 434 441 PF00069 0.302
DOC_MAPK_MEF2A_6 59 67 PF00069 0.397
DOC_PP1_RVXF_1 300 307 PF00149 0.406
DOC_PP1_RVXF_1 336 343 PF00149 0.519
DOC_PP2B_LxvP_1 272 275 PF13499 0.620
DOC_PP2B_LxvP_1 458 461 PF13499 0.340
DOC_PP4_FxxP_1 280 283 PF00568 0.401
DOC_PP4_FxxP_1 386 389 PF00568 0.372
DOC_USP7_MATH_1 168 172 PF00917 0.612
DOC_USP7_MATH_1 260 264 PF00917 0.482
DOC_USP7_MATH_1 461 465 PF00917 0.438
DOC_USP7_MATH_1 51 55 PF00917 0.561
DOC_USP7_MATH_1 66 70 PF00917 0.385
DOC_WW_Pin1_4 1 6 PF00397 0.469
DOC_WW_Pin1_4 106 111 PF00397 0.455
DOC_WW_Pin1_4 243 248 PF00397 0.626
DOC_WW_Pin1_4 274 279 PF00397 0.546
DOC_WW_Pin1_4 399 404 PF00397 0.532
DOC_WW_Pin1_4 406 411 PF00397 0.507
LIG_14-3-3_CanoR_1 133 137 PF00244 0.584
LIG_14-3-3_CanoR_1 179 187 PF00244 0.555
LIG_14-3-3_CanoR_1 189 197 PF00244 0.421
LIG_14-3-3_CanoR_1 254 259 PF00244 0.521
LIG_14-3-3_CanoR_1 31 38 PF00244 0.541
LIG_14-3-3_CanoR_1 481 485 PF00244 0.405
LIG_14-3-3_CanoR_1 504 510 PF00244 0.373
LIG_14-3-3_CterR_2 651 654 PF00244 0.323
LIG_Actin_WH2_2 73 89 PF00022 0.429
LIG_BRCT_BRCA1_1 641 645 PF00533 0.294
LIG_EVH1_1 386 390 PF00568 0.380
LIG_FHA_1 107 113 PF00498 0.400
LIG_FHA_1 15 21 PF00498 0.548
LIG_FHA_1 204 210 PF00498 0.434
LIG_FHA_1 260 266 PF00498 0.527
LIG_FHA_1 566 572 PF00498 0.351
LIG_FHA_1 69 75 PF00498 0.603
LIG_FHA_2 136 142 PF00498 0.522
LIG_FHA_2 196 202 PF00498 0.569
LIG_FHA_2 318 324 PF00498 0.413
LIG_FHA_2 623 629 PF00498 0.392
LIG_Integrin_RGD_1 573 575 PF01839 0.395
LIG_LIR_Apic_2 277 283 PF02991 0.412
LIG_LIR_Apic_2 324 330 PF02991 0.604
LIG_LIR_Gen_1 109 118 PF02991 0.366
LIG_LIR_Gen_1 138 143 PF02991 0.386
LIG_LIR_Gen_1 344 355 PF02991 0.399
LIG_LIR_Gen_1 361 371 PF02991 0.433
LIG_LIR_Gen_1 522 530 PF02991 0.395
LIG_LIR_Gen_1 537 545 PF02991 0.451
LIG_LIR_Nem_3 109 114 PF02991 0.364
LIG_LIR_Nem_3 135 139 PF02991 0.588
LIG_LIR_Nem_3 344 350 PF02991 0.475
LIG_LIR_Nem_3 361 367 PF02991 0.354
LIG_LIR_Nem_3 522 527 PF02991 0.397
LIG_LIR_Nem_3 537 543 PF02991 0.456
LIG_LIR_Nem_3 552 558 PF02991 0.308
LIG_LIR_Nem_3 644 650 PF02991 0.325
LIG_NRP_CendR_1 651 654 PF00754 0.372
LIG_Pex14_2 12 16 PF04695 0.311
LIG_PTB_Apo_2 630 637 PF02174 0.284
LIG_PTB_Phospho_1 630 636 PF10480 0.278
LIG_RPA_C_Fungi 446 458 PF08784 0.301
LIG_SH2_CRK 417 421 PF00017 0.423
LIG_SH2_GRB2like 477 480 PF00017 0.336
LIG_SH2_PTP2 364 367 PF00017 0.330
LIG_SH2_SRC 139 142 PF00017 0.418
LIG_SH2_SRC 345 348 PF00017 0.412
LIG_SH2_STAP1 345 349 PF00017 0.555
LIG_SH2_STAP1 634 638 PF00017 0.456
LIG_SH2_STAT3 558 561 PF00017 0.261
LIG_SH2_STAT3 634 637 PF00017 0.285
LIG_SH2_STAT5 111 114 PF00017 0.441
LIG_SH2_STAT5 157 160 PF00017 0.531
LIG_SH2_STAT5 267 270 PF00017 0.440
LIG_SH2_STAT5 286 289 PF00017 0.393
LIG_SH2_STAT5 364 367 PF00017 0.385
LIG_SH2_STAT5 376 379 PF00017 0.424
LIG_SH2_STAT5 519 522 PF00017 0.424
LIG_SH2_STAT5 554 557 PF00017 0.537
LIG_SH2_STAT5 559 562 PF00017 0.486
LIG_SH2_STAT5 621 624 PF00017 0.473
LIG_SH3_1 385 391 PF00018 0.379
LIG_SH3_2 387 392 PF14604 0.382
LIG_SH3_3 104 110 PF00018 0.574
LIG_SH3_3 272 278 PF00018 0.610
LIG_SH3_3 362 368 PF00018 0.371
LIG_SH3_3 384 390 PF00018 0.478
LIG_SH3_CIN85_PxpxPR_1 387 392 PF14604 0.385
LIG_SUMO_SIM_par_1 470 476 PF11976 0.388
LIG_TRAF2_1 138 141 PF00917 0.433
LIG_TYR_ITIM 137 142 PF00017 0.569
LIG_TYR_ITSM 107 114 PF00017 0.393
LIG_WW_3 389 393 PF00397 0.410
MOD_CDC14_SPxK_1 4 7 PF00782 0.384
MOD_CDK_SPK_2 406 411 PF00069 0.517
MOD_CDK_SPxK_1 1 7 PF00069 0.413
MOD_CDK_SPxK_1 406 412 PF00069 0.514
MOD_CK1_1 171 177 PF00069 0.712
MOD_CK1_1 263 269 PF00069 0.405
MOD_CK1_1 402 408 PF00069 0.538
MOD_CK1_1 565 571 PF00069 0.351
MOD_CK2_1 135 141 PF00069 0.522
MOD_CK2_1 180 186 PF00069 0.589
MOD_CK2_1 195 201 PF00069 0.603
MOD_CK2_1 279 285 PF00069 0.418
MOD_CK2_1 33 39 PF00069 0.519
MOD_CK2_1 564 570 PF00069 0.386
MOD_Cter_Amidation 432 435 PF01082 0.285
MOD_GlcNHglycan 174 177 PF01048 0.637
MOD_GlcNHglycan 182 185 PF01048 0.567
MOD_GlcNHglycan 192 195 PF01048 0.407
MOD_GlcNHglycan 261 265 PF01048 0.539
MOD_GlcNHglycan 268 271 PF01048 0.515
MOD_GlcNHglycan 291 294 PF01048 0.553
MOD_GlcNHglycan 35 38 PF01048 0.654
MOD_GlcNHglycan 431 434 PF01048 0.277
MOD_GlcNHglycan 53 56 PF01048 0.571
MOD_GlcNHglycan 563 567 PF01048 0.340
MOD_GlcNHglycan 615 618 PF01048 0.405
MOD_GSK3_1 168 175 PF00069 0.721
MOD_GSK3_1 250 257 PF00069 0.567
MOD_GSK3_1 259 266 PF00069 0.482
MOD_GSK3_1 26 33 PF00069 0.552
MOD_GSK3_1 270 277 PF00069 0.487
MOD_GSK3_1 313 320 PF00069 0.402
MOD_GSK3_1 402 409 PF00069 0.539
MOD_GSK3_1 534 541 PF00069 0.389
MOD_GSK3_1 605 612 PF00069 0.347
MOD_N-GLC_1 168 173 PF02516 0.540
MOD_N-GLC_1 179 184 PF02516 0.574
MOD_N-GLC_1 317 322 PF02516 0.409
MOD_N-GLC_1 505 510 PF02516 0.310
MOD_N-GLC_1 632 637 PF02516 0.325
MOD_NEK2_1 210 215 PF00069 0.411
MOD_NEK2_1 321 326 PF00069 0.513
MOD_NEK2_1 65 70 PF00069 0.409
MOD_NEK2_2 14 19 PF00069 0.555
MOD_PIKK_1 333 339 PF00454 0.549
MOD_PIKK_1 402 408 PF00454 0.523
MOD_PKA_1 254 260 PF00069 0.402
MOD_PKA_1 313 319 PF00069 0.644
MOD_PKA_2 132 138 PF00069 0.586
MOD_PKA_2 190 196 PF00069 0.423
MOD_PKA_2 254 260 PF00069 0.552
MOD_PKA_2 30 36 PF00069 0.571
MOD_PKA_2 313 319 PF00069 0.585
MOD_PKA_2 480 486 PF00069 0.372
MOD_PKA_2 639 645 PF00069 0.378
MOD_Plk_1 260 266 PF00069 0.404
MOD_Plk_1 317 323 PF00069 0.407
MOD_Plk_1 505 511 PF00069 0.309
MOD_Plk_1 513 519 PF00069 0.291
MOD_Plk_1 632 638 PF00069 0.330
MOD_Plk_1 640 646 PF00069 0.339
MOD_Plk_4 263 269 PF00069 0.414
MOD_Plk_4 513 519 PF00069 0.299
MOD_Plk_4 539 545 PF00069 0.540
MOD_Plk_4 605 611 PF00069 0.393
MOD_Plk_4 641 647 PF00069 0.365
MOD_ProDKin_1 1 7 PF00069 0.456
MOD_ProDKin_1 106 112 PF00069 0.444
MOD_ProDKin_1 243 249 PF00069 0.625
MOD_ProDKin_1 274 280 PF00069 0.541
MOD_ProDKin_1 399 405 PF00069 0.531
MOD_ProDKin_1 406 412 PF00069 0.505
TRG_ENDOCYTIC_2 111 114 PF00928 0.441
TRG_ENDOCYTIC_2 139 142 PF00928 0.592
TRG_ENDOCYTIC_2 347 350 PF00928 0.561
TRG_ENDOCYTIC_2 364 367 PF00928 0.266
TRG_ENDOCYTIC_2 417 420 PF00928 0.433
TRG_ENDOCYTIC_2 524 527 PF00928 0.323
TRG_ER_diArg_1 187 189 PF00400 0.536
TRG_ER_diArg_1 230 232 PF00400 0.571
TRG_ER_diArg_1 234 236 PF00400 0.549
TRG_ER_diArg_1 254 256 PF00400 0.423
TRG_ER_diArg_1 313 315 PF00400 0.495
TRG_ER_diArg_1 383 386 PF00400 0.421
TRG_ER_diArg_1 410 412 PF00400 0.531
TRG_ER_diArg_1 434 436 PF00400 0.332
TRG_ER_diArg_1 451 453 PF00400 0.432
TRG_ER_diArg_1 501 504 PF00400 0.384
TRG_ER_diArg_1 547 550 PF00400 0.312
TRG_Pf-PMV_PEXEL_1 451 455 PF00026 0.460
TRG_Pf-PMV_PEXEL_1 482 487 PF00026 0.368

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 39% 100%
A0A3S5H4Y6 Leishmania donovani 75% 100%
A0A3S7WWA6 Leishmania donovani 39% 100%
A0A451EJD9 Leishmania donovani 41% 100%
A0A451EJF4 Leishmania donovani 75% 100%
A0A451EJF8 Leishmania donovani 61% 85%
A0A451EJF9 Leishmania donovani 96% 76%
A4H3A9 Leishmania braziliensis 55% 100%
A4H3B4 Leishmania braziliensis 60% 100%
A4H3B5 Leishmania braziliensis 51% 99%
A4H3B6 Leishmania braziliensis 55% 100%
A4H3B8 Leishmania braziliensis 62% 100%
A4H3B9 Leishmania braziliensis 39% 100%
A4H4W8 Leishmania braziliensis 39% 100%
A4HJ20 Leishmania braziliensis 55% 100%
A4HNK3 Leishmania braziliensis 41% 96%
A4HNK6 Leishmania braziliensis 40% 100%
A4HRL9 Leishmania infantum 75% 100%
A4HRM0 Leishmania infantum 63% 100%
A4HRM1 Leishmania infantum 99% 100%
A4HRS1 Leishmania infantum 95% 100%
A4HRS5 Leishmania infantum 61% 100%
A4HZM0 Leishmania infantum 40% 100%
A4I7C7 Leishmania infantum 41% 100%
A4IAQ2 Leishmania infantum 41% 100%
E9AC91 Leishmania major 69% 100%
E9AC92 Leishmania major 67% 100%
E9AC95 Leishmania major 60% 100%
E9AC96 Leishmania major 90% 100%
E9AEH8 Leishmania major 41% 100%
E9AHA6 Leishmania infantum 40% 100%
E9AIP8 Leishmania braziliensis 41% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 100%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 69% 100%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 66%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
Q4Q5T6 Leishmania major 41% 100%
Q4QCL8 Leishmania major 41% 100%
Q4QIG9 Leishmania major 41% 100%
Q7YXU9 Leishmania major 39% 100%
Q7YXV1 Leishmania major 40% 100%
Q7YXV2 Leishmania major 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS