Phosphoglycan beta 1,3 galactosyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycan beta 1,3 galactosyltransferase, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A451EJF6_LEIDO

TriTrypDb:

LdBPK_020140.1 , LdBPK_020160.1 , LdCL_020006900 , LDHU3_02.0250

Length:

654

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 60

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 47
NetGPI	no	yes: 0, no: 47

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Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	11
GO:0016020	membrane	2	48
GO:0031090	organelle membrane	3	11
GO:0098588	bounding membrane of organelle	4	11
GO:0110165	cellular anatomical entity	1	48

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Expansion

Sequence features

A0A451EJF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJF6

Function

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Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	48
GO:0006807	nitrogen compound metabolic process	2	48
GO:0008152	metabolic process	1	48
GO:0019538	protein metabolic process	3	48
GO:0036211	protein modification process	4	48
GO:0043170	macromolecule metabolic process	3	48
GO:0043412	macromolecule modification	4	48
GO:0043413	macromolecule glycosylation	3	48
GO:0044238	primary metabolic process	2	48
GO:0070085	glycosylation	2	48

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	48
GO:0008194	UDP-glycosyltransferase activity	4	11
GO:0016740	transferase activity	2	48
GO:0016757	glycosyltransferase activity	3	48
GO:0016758	hexosyltransferase activity	4	48

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	463	467	PF00656	0.363
CLV_NRD_NRD_1	133	135	PF00675	0.419
CLV_NRD_NRD_1	188	190	PF00675	0.508
CLV_NRD_NRD_1	230	232	PF00675	0.576
CLV_NRD_NRD_1	235	237	PF00675	0.560
CLV_NRD_NRD_1	254	256	PF00675	0.423
CLV_NRD_NRD_1	313	315	PF00675	0.615
CLV_NRD_NRD_1	411	413	PF00675	0.513
CLV_NRD_NRD_1	434	436	PF00675	0.349
CLV_NRD_NRD_1	451	453	PF00675	0.450

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGN9	Leishmania donovani	39%	100%
A0A3S5H4Y6	Leishmania donovani	75%	100%
A0A3S7WWA6	Leishmania donovani	39%	100%
A0A451EJD9	Leishmania donovani	41%	100%
A0A451EJF4	Leishmania donovani	75%	100%
A0A451EJF8	Leishmania donovani	61%	85%
A0A451EJF9	Leishmania donovani	96%	76%
A4H3A9	Leishmania braziliensis	55%	100%
A4H3B4	Leishmania braziliensis	60%	100%
A4H3B5	Leishmania braziliensis	51%	99%

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