LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase
Gene product:
phosphoglycan beta 1,3 galactosyltransferase, putative (fragment)
Species:
Leishmania donovani
UniProt:
A0A451EJF4_LEIDO
TriTrypDb:
LdBPK_020140.1 * , LdBPK_020160.1 * , LdCL_020006700 , LDHU3_02.0230
Length:
817

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 52
NetGPI no yes: 0, no: 52
Cellular components
Term Name Level Count
GO:0016020 membrane 2 53
GO:0110165 cellular anatomical entity 1 53
GO:0000139 Golgi membrane 5 14
GO:0031090 organelle membrane 3 14
GO:0098588 bounding membrane of organelle 4 14

Expansion

Sequence features

A0A451EJF4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJF4

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 53
GO:0006807 nitrogen compound metabolic process 2 53
GO:0008152 metabolic process 1 53
GO:0019538 protein metabolic process 3 53
GO:0036211 protein modification process 4 53
GO:0043170 macromolecule metabolic process 3 53
GO:0043412 macromolecule modification 4 53
GO:0043413 macromolecule glycosylation 3 53
GO:0044238 primary metabolic process 2 53
GO:0070085 glycosylation 2 53
GO:0071704 organic substance metabolic process 2 53
GO:1901564 organonitrogen compound metabolic process 3 53
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 53
GO:0016740 transferase activity 2 53
GO:0016757 glycosyltransferase activity 3 53
GO:0016758 hexosyltransferase activity 4 53
GO:0008194 UDP-glycosyltransferase activity 4 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 62 66 PF00656 0.611
CLV_NRD_NRD_1 12 14 PF00675 0.421
CLV_NRD_NRD_1 314 316 PF00675 0.537
CLV_NRD_NRD_1 369 371 PF00675 0.613
CLV_NRD_NRD_1 411 413 PF00675 0.661
CLV_NRD_NRD_1 416 418 PF00675 0.650
CLV_NRD_NRD_1 435 437 PF00675 0.558
CLV_NRD_NRD_1 494 496 PF00675 0.668
CLV_NRD_NRD_1 562 564 PF00675 0.565
CLV_NRD_NRD_1 667 669 PF00675 0.539
CLV_NRD_NRD_1 733 735 PF00675 0.558
CLV_NRD_NRD_1 754 756 PF00675 0.526
CLV_NRD_NRD_1 93 95 PF00675 0.468
CLV_PCSK_KEX2_1 11 13 PF00082 0.424
CLV_PCSK_KEX2_1 314 316 PF00082 0.541
CLV_PCSK_KEX2_1 369 371 PF00082 0.628
CLV_PCSK_KEX2_1 411 413 PF00082 0.660
CLV_PCSK_KEX2_1 416 418 PF00082 0.648
CLV_PCSK_KEX2_1 435 437 PF00082 0.559
CLV_PCSK_KEX2_1 494 496 PF00082 0.601
CLV_PCSK_KEX2_1 564 566 PF00082 0.565
CLV_PCSK_KEX2_1 667 669 PF00082 0.589
CLV_PCSK_KEX2_1 733 735 PF00082 0.612
CLV_PCSK_KEX2_1 753 755 PF00082 0.530
CLV_PCSK_KEX2_1 777 779 PF00082 0.584
CLV_PCSK_KEX2_1 93 95 PF00082 0.476
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.423
CLV_PCSK_PC1ET2_1 564 566 PF00082 0.531
CLV_PCSK_PC1ET2_1 733 735 PF00082 0.612
CLV_PCSK_PC1ET2_1 753 755 PF00082 0.505
CLV_PCSK_PC1ET2_1 777 779 PF00082 0.567
CLV_PCSK_PC7_1 310 316 PF00082 0.513
CLV_PCSK_PC7_1 412 418 PF00082 0.538
CLV_PCSK_PC7_1 663 669 PF00082 0.500
CLV_PCSK_SKI1_1 306 310 PF00082 0.565
CLV_PCSK_SKI1_1 384 388 PF00082 0.577
CLV_PCSK_SKI1_1 435 439 PF00082 0.559
CLV_PCSK_SKI1_1 519 523 PF00082 0.579
CLV_PCSK_SKI1_1 595 599 PF00082 0.525
DEG_APCC_DBOX_1 138 146 PF00400 0.368
DEG_APCC_DBOX_1 369 377 PF00400 0.395
DEG_SCF_FBW7_1 455 462 PF00400 0.464
DEG_SCF_FBW7_2 424 431 PF00400 0.310
DOC_CKS1_1 288 293 PF01111 0.346
DOC_CKS1_1 456 461 PF01111 0.467
DOC_CYCLIN_yCln2_LP_2 183 189 PF00134 0.384
DOC_CYCLIN_yCln2_LP_2 4 10 PF00134 0.612
DOC_CYCLIN_yCln2_LP_2 453 459 PF00134 0.505
DOC_MAPK_gen_1 84 92 PF00069 0.616
DOC_MAPK_MEF2A_6 110 119 PF00069 0.359
DOC_MAPK_MEF2A_6 240 248 PF00069 0.354
DOC_MAPK_MEF2A_6 483 490 PF00069 0.427
DOC_MAPK_MEF2A_6 507 516 PF00069 0.323
DOC_PP1_RVXF_1 481 488 PF00149 0.325
DOC_PP1_RVXF_1 517 524 PF00149 0.420
DOC_PP2B_LxvP_1 453 456 PF13499 0.504
DOC_PP4_FxxP_1 461 464 PF00568 0.360
DOC_USP7_MATH_1 14 18 PF00917 0.620
DOC_USP7_MATH_1 232 236 PF00917 0.512
DOC_USP7_MATH_1 247 251 PF00917 0.361
DOC_USP7_MATH_1 349 353 PF00917 0.477
DOC_USP7_MATH_1 441 445 PF00917 0.411
DOC_WW_Pin1_4 182 187 PF00397 0.402
DOC_WW_Pin1_4 287 292 PF00397 0.388
DOC_WW_Pin1_4 3 8 PF00397 0.619
DOC_WW_Pin1_4 424 429 PF00397 0.494
DOC_WW_Pin1_4 455 460 PF00397 0.438
DOC_WW_Pin1_4 707 712 PF00397 0.296
DOC_WW_Pin1_4 75 80 PF00397 0.641
DOC_WW_Pin1_4 776 781 PF00397 0.346
LIG_14-3-3_CanoR_1 110 115 PF00244 0.208
LIG_14-3-3_CanoR_1 12 19 PF00244 0.621
LIG_14-3-3_CanoR_1 178 183 PF00244 0.378
LIG_14-3-3_CanoR_1 212 219 PF00244 0.450
LIG_14-3-3_CanoR_1 314 318 PF00244 0.459
LIG_14-3-3_CanoR_1 360 368 PF00244 0.448
LIG_14-3-3_CanoR_1 370 378 PF00244 0.387
LIG_14-3-3_CanoR_1 435 440 PF00244 0.429
LIG_14-3-3_CanoR_1 754 762 PF00244 0.346
LIG_14-3-3_CanoR_1 803 808 PF00244 0.309
LIG_14-3-3_CanoR_1 84 92 PF00244 0.645
LIG_Actin_WH2_2 175 190 PF00022 0.376
LIG_Actin_WH2_2 254 270 PF00022 0.370
LIG_Actin_WH2_2 653 669 PF00022 0.287
LIG_BIR_II_1 1 5 PF00653 0.616
LIG_EH1_1 607 615 PF00400 0.249
LIG_FHA_1 14 20 PF00498 0.661
LIG_FHA_1 174 180 PF00498 0.369
LIG_FHA_1 196 202 PF00498 0.537
LIG_FHA_1 250 256 PF00498 0.484
LIG_FHA_1 288 294 PF00498 0.345
LIG_FHA_1 3 9 PF00498 0.640
LIG_FHA_1 385 391 PF00498 0.373
LIG_FHA_1 441 447 PF00498 0.425
LIG_FHA_1 605 611 PF00498 0.279
LIG_FHA_1 71 77 PF00498 0.652
LIG_FHA_1 802 808 PF00498 0.309
LIG_FHA_2 317 323 PF00498 0.403
LIG_FHA_2 377 383 PF00498 0.496
LIG_FHA_2 499 505 PF00498 0.335
LIG_FHA_2 708 714 PF00498 0.283
LIG_FHA_2 755 761 PF00498 0.331
LIG_FHA_2 764 770 PF00498 0.291
LIG_FHA_2 803 809 PF00498 0.323
LIG_LIR_Apic_2 458 464 PF02991 0.365
LIG_LIR_Apic_2 505 511 PF02991 0.439
LIG_LIR_Gen_1 290 299 PF02991 0.331
LIG_LIR_Gen_1 319 324 PF02991 0.321
LIG_LIR_Gen_1 525 536 PF02991 0.354
LIG_LIR_Gen_1 542 552 PF02991 0.342
LIG_LIR_Gen_1 683 691 PF02991 0.334
LIG_LIR_Gen_1 700 706 PF02991 0.354
LIG_LIR_Nem_3 290 295 PF02991 0.325
LIG_LIR_Nem_3 316 320 PF02991 0.460
LIG_LIR_Nem_3 525 531 PF02991 0.405
LIG_LIR_Nem_3 542 548 PF02991 0.307
LIG_LIR_Nem_3 683 688 PF02991 0.333
LIG_LIR_Nem_3 700 704 PF02991 0.359
LIG_LIR_Nem_3 713 717 PF02991 0.271
LIG_LIR_Nem_3 808 814 PF02991 0.322
LIG_NRBOX 656 662 PF00104 0.274
LIG_Pex14_2 193 197 PF04695 0.373
LIG_PTB_Apo_2 596 603 PF02174 0.257
LIG_REV1ctd_RIR_1 718 727 PF16727 0.279
LIG_SH2_CRK 122 126 PF00017 0.377
LIG_SH2_CRK 811 815 PF00017 0.325
LIG_SH2_GRB2like 793 796 PF00017 0.299
LIG_SH2_NCK_1 122 126 PF00017 0.373
LIG_SH2_PTP2 545 548 PF00017 0.302
LIG_SH2_SRC 320 323 PF00017 0.332
LIG_SH2_SRC 526 529 PF00017 0.363
LIG_SH2_SRC 716 719 PF00017 0.265
LIG_SH2_STAP1 122 126 PF00017 0.377
LIG_SH2_STAP1 50 54 PF00017 0.605
LIG_SH2_STAP1 526 530 PF00017 0.447
LIG_SH2_STAP1 579 583 PF00017 0.314
LIG_SH2_STAP1 797 801 PF00017 0.364
LIG_SH2_STAT3 50 53 PF00017 0.600
LIG_SH2_STAT5 144 147 PF00017 0.391
LIG_SH2_STAT5 292 295 PF00017 0.379
LIG_SH2_STAT5 338 341 PF00017 0.405
LIG_SH2_STAT5 448 451 PF00017 0.368
LIG_SH2_STAT5 467 470 PF00017 0.328
LIG_SH2_STAT5 545 548 PF00017 0.326
LIG_SH2_STAT5 557 560 PF00017 0.356
LIG_SH2_STAT5 680 683 PF00017 0.339
LIG_SH2_STAT5 716 719 PF00017 0.429
LIG_SH3_3 285 291 PF00018 0.458
LIG_SH3_3 453 459 PF00018 0.478
LIG_SH3_3 543 549 PF00018 0.307
LIG_SH3_3 563 569 PF00018 0.341
LIG_SH3_3 615 621 PF00018 0.326
LIG_SUMO_SIM_anti_2 113 119 PF11976 0.263
LIG_TRAF2_1 319 322 PF00917 0.343
LIG_TYR_ITIM 318 323 PF00017 0.435
LIG_TYR_ITSM 288 295 PF00017 0.338
LIG_UBA3_1 145 149 PF00899 0.383
LIG_WW_3 78 82 PF00397 0.606
MOD_CDC14_SPxK_1 185 188 PF00782 0.388
MOD_CDC14_SPxK_1 78 81 PF00782 0.605
MOD_CDK_SPxK_1 182 188 PF00069 0.386
MOD_CDK_SPxK_1 75 81 PF00069 0.611
MOD_CK1_1 2 8 PF00069 0.626
MOD_CK1_1 352 358 PF00069 0.536
MOD_CK1_1 36 42 PF00069 0.655
MOD_CK1_1 444 450 PF00069 0.357
MOD_CK1_1 59 65 PF00069 0.675
MOD_CK2_1 214 220 PF00069 0.438
MOD_CK2_1 316 322 PF00069 0.400
MOD_CK2_1 361 367 PF00069 0.468
MOD_CK2_1 376 382 PF00069 0.514
MOD_CK2_1 460 466 PF00069 0.366
MOD_CK2_1 733 739 PF00069 0.410
MOD_CK2_1 754 760 PF00069 0.310
MOD_CK2_1 763 769 PF00069 0.297
MOD_GlcNHglycan 100 103 PF01048 0.407
MOD_GlcNHglycan 216 219 PF01048 0.710
MOD_GlcNHglycan 234 237 PF01048 0.702
MOD_GlcNHglycan 355 358 PF01048 0.687
MOD_GlcNHglycan 363 366 PF01048 0.648
MOD_GlcNHglycan 37 41 PF01048 0.497
MOD_GlcNHglycan 373 376 PF01048 0.592
MOD_GlcNHglycan 442 446 PF01048 0.659
MOD_GlcNHglycan 449 452 PF01048 0.625
MOD_GlcNHglycan 472 475 PF01048 0.640
MOD_GlcNHglycan 559 562 PF01048 0.512
MOD_GlcNHglycan 576 579 PF01048 0.578
MOD_GlcNHglycan 58 61 PF01048 0.484
MOD_GlcNHglycan 86 89 PF01048 0.445
MOD_GSK3_1 169 176 PF00069 0.393
MOD_GSK3_1 178 185 PF00069 0.412
MOD_GSK3_1 207 214 PF00069 0.470
MOD_GSK3_1 349 356 PF00069 0.542
MOD_GSK3_1 431 438 PF00069 0.445
MOD_GSK3_1 440 447 PF00069 0.402
MOD_GSK3_1 451 458 PF00069 0.400
MOD_GSK3_1 494 501 PF00069 0.325
MOD_GSK3_1 59 66 PF00069 0.666
MOD_GSK3_1 70 77 PF00069 0.686
MOD_GSK3_1 725 732 PF00069 0.336
MOD_GSK3_1 84 91 PF00069 0.630
MOD_GSK3_1 94 101 PF00069 0.598
MOD_N-GLC_1 169 174 PF02516 0.606
MOD_N-GLC_1 349 354 PF02516 0.633
MOD_N-GLC_1 360 365 PF02516 0.659
MOD_N-GLC_1 498 503 PF02516 0.532
MOD_N-GLC_1 583 588 PF02516 0.478
MOD_N-GLC_1 697 702 PF02516 0.500
MOD_NEK2_1 124 129 PF00069 0.385
MOD_NEK2_1 169 174 PF00069 0.472
MOD_NEK2_1 246 251 PF00069 0.349
MOD_NEK2_1 391 396 PF00069 0.367
MOD_NEK2_1 48 53 PF00069 0.625
MOD_NEK2_1 502 507 PF00069 0.393
MOD_NEK2_1 63 68 PF00069 0.630
MOD_NEK2_1 638 643 PF00069 0.295
MOD_NEK2_1 725 730 PF00069 0.310
MOD_NEK2_2 173 178 PF00069 0.367
MOD_NEK2_2 195 200 PF00069 0.548
MOD_NEK2_2 590 595 PF00069 0.268
MOD_NEK2_2 88 93 PF00069 0.611
MOD_PIKK_1 124 130 PF00454 0.386
MOD_PIKK_1 49 55 PF00454 0.604
MOD_PIKK_1 514 520 PF00454 0.432
MOD_PK_1 110 116 PF00069 0.208
MOD_PK_1 803 809 PF00069 0.271
MOD_PKA_1 12 18 PF00069 0.609
MOD_PKA_1 435 441 PF00069 0.357
MOD_PKA_1 494 500 PF00069 0.485
MOD_PKA_1 733 739 PF00069 0.328
MOD_PKA_1 753 759 PF00069 0.321
MOD_PKA_2 12 18 PF00069 0.659
MOD_PKA_2 211 217 PF00069 0.471
MOD_PKA_2 313 319 PF00069 0.461
MOD_PKA_2 371 377 PF00069 0.402
MOD_PKA_2 435 441 PF00069 0.437
MOD_PKA_2 494 500 PF00069 0.451
MOD_PKA_2 662 668 PF00069 0.289
MOD_PKA_2 733 739 PF00069 0.346
MOD_PKA_2 753 759 PF00069 0.331
MOD_PKA_2 802 808 PF00069 0.321
MOD_PKB_1 84 92 PF00069 0.614
MOD_Plk_1 441 447 PF00069 0.365
MOD_Plk_1 498 504 PF00069 0.330
MOD_Plk_1 638 644 PF00069 0.299
MOD_Plk_1 697 703 PF00069 0.340
MOD_Plk_4 110 116 PF00069 0.310
MOD_Plk_4 178 184 PF00069 0.396
MOD_Plk_4 444 450 PF00069 0.345
MOD_Plk_4 604 610 PF00069 0.278
MOD_Plk_4 700 706 PF00069 0.407
MOD_ProDKin_1 182 188 PF00069 0.404
MOD_ProDKin_1 287 293 PF00069 0.380
MOD_ProDKin_1 3 9 PF00069 0.620
MOD_ProDKin_1 424 430 PF00069 0.493
MOD_ProDKin_1 455 461 PF00069 0.436
MOD_ProDKin_1 707 713 PF00069 0.295
MOD_ProDKin_1 75 81 PF00069 0.641
MOD_ProDKin_1 776 782 PF00069 0.343
TRG_DiLeu_BaLyEn_6 609 614 PF01217 0.335
TRG_ENDOCYTIC_2 122 125 PF00928 0.379
TRG_ENDOCYTIC_2 292 295 PF00928 0.379
TRG_ENDOCYTIC_2 320 323 PF00928 0.461
TRG_ENDOCYTIC_2 528 531 PF00928 0.457
TRG_ENDOCYTIC_2 545 548 PF00928 0.241
TRG_ENDOCYTIC_2 714 717 PF00928 0.255
TRG_ENDOCYTIC_2 811 814 PF00928 0.311
TRG_ER_diArg_1 368 370 PF00400 0.430
TRG_ER_diArg_1 411 413 PF00400 0.455
TRG_ER_diArg_1 415 417 PF00400 0.438
TRG_ER_diArg_1 435 437 PF00400 0.359
TRG_ER_diArg_1 494 496 PF00400 0.383
TRG_ER_diArg_1 562 565 PF00400 0.353
TRG_ER_diArg_1 666 668 PF00400 0.355
TRG_ER_diArg_1 92 94 PF00400 0.666
TRG_NES_CRM1_1 136 152 PF08389 0.377
TRG_NLS_MonoExtC_3 562 567 PF00514 0.297
TRG_NLS_MonoExtC_3 732 737 PF00514 0.347
TRG_NLS_MonoExtN_4 733 738 PF00514 0.335
TRG_Pf-PMV_PEXEL_1 612 616 PF00026 0.570
TRG_Pf-PMV_PEXEL_1 812 816 PF00026 0.513

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 39% 100%
A0A3S5H4Y6 Leishmania donovani 74% 99%
A0A3S5H4Y9 Leishmania donovani 34% 100%
A0A3S7WT86 Leishmania donovani 44% 100%
A0A3S7WWA6 Leishmania donovani 39% 100%
A0A451EJD9 Leishmania donovani 38% 100%
A0A451EJF6 Leishmania donovani 75% 100%
A0A451EJF8 Leishmania donovani 58% 100%
A0A451EJF9 Leishmania donovani 61% 95%
A4H3A9 Leishmania braziliensis 65% 100%
A4H3B4 Leishmania braziliensis 67% 100%
A4H3B6 Leishmania braziliensis 64% 100%
A4H3B8 Leishmania braziliensis 61% 100%
A4H3B9 Leishmania braziliensis 40% 100%
A4H4W8 Leishmania braziliensis 38% 100%
A4HJ20 Leishmania braziliensis 63% 100%
A4HNK3 Leishmania braziliensis 41% 100%
A4HNK6 Leishmania braziliensis 37% 100%
A4HRL9 Leishmania infantum 98% 100%
A4HRM0 Leishmania infantum 74% 100%
A4HRM1 Leishmania infantum 75% 100%
A4HRS1 Leishmania infantum 61% 100%
A4HRS3 Leishmania infantum 34% 100%
A4HRS5 Leishmania infantum 58% 100%
A4HZM0 Leishmania infantum 38% 100%
A4I7C7 Leishmania infantum 39% 100%
A4IAQ2 Leishmania infantum 37% 100%
E9AC91 Leishmania major 87% 100%
E9AC92 Leishmania major 80% 100%
E9AC94 Leishmania major 34% 100%
E9AC95 Leishmania major 60% 100%
E9AC96 Leishmania major 65% 100%
E9AC98 Leishmania major 35% 100%
E9AEH8 Leishmania major 41% 100%
E9AHA6 Leishmania infantum 38% 100%
E9AIP8 Leishmania braziliensis 40% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
Q4Q5T6 Leishmania major 41% 100%
Q4QCL8 Leishmania major 41% 100%
Q4QFJ3 Leishmania major 43% 100%
Q4QIG9 Leishmania major 41% 100%
Q7YXU9 Leishmania major 40% 100%
Q7YXV1 Leishmania major 41% 100%
Q7YXV2 Leishmania major 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS