Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJD3_LEIDO

TriTrypDb:

LdBPK_010810.1 , LdCL_010013200 , LDHU3_01.0910

Length:

530

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.675
CLV_C14_Caspase3-7	64	68	PF00656	0.670
CLV_C14_Caspase3-7	91	95	PF00656	0.671
CLV_NRD_NRD_1	130	132	PF00675	0.736
CLV_NRD_NRD_1	210	212	PF00675	0.723
CLV_NRD_NRD_1	346	348	PF00675	0.775
CLV_NRD_NRD_1	386	388	PF00675	0.698
CLV_NRD_NRD_1	477	479	PF00675	0.715
CLV_NRD_NRD_1	69	71	PF00675	0.733
CLV_PCSK_KEX2_1	130	132	PF00082	0.741
CLV_PCSK_KEX2_1	210	212	PF00082	0.723
CLV_PCSK_KEX2_1	345	347	PF00082	0.769
CLV_PCSK_KEX2_1	386	388	PF00082	0.698
CLV_PCSK_KEX2_1	477	479	PF00082	0.715
CLV_PCSK_KEX2_1	484	486	PF00082	0.566
CLV_PCSK_KEX2_1	69	71	PF00082	0.733
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.649
CLV_PCSK_SKI1_1	131	135	PF00082	0.619
CLV_PCSK_SKI1_1	158	162	PF00082	0.603
CLV_PCSK_SKI1_1	512	516	PF00082	0.694
DEG_Nend_Nbox_1	1	3	PF02207	0.684
DEG_SCF_FBW7_1	201	206	PF00400	0.640
DEG_SPOP_SBC_1	423	427	PF00917	0.742
DEG_SPOP_SBC_1	53	57	PF00917	0.604
DOC_MAPK_gen_1	277	286	PF00069	0.669
DOC_MAPK_gen_1	386	393	PF00069	0.689
DOC_MAPK_gen_1	484	491	PF00069	0.641
DOC_PP1_RVXF_1	488	494	PF00149	0.637
DOC_PP4_MxPP_1	235	238	PF00568	0.605
DOC_USP7_MATH_1	113	117	PF00917	0.759
DOC_USP7_MATH_1	144	148	PF00917	0.715
DOC_USP7_MATH_1	167	171	PF00917	0.590
DOC_USP7_MATH_1	201	205	PF00917	0.741
DOC_USP7_MATH_1	254	258	PF00917	0.693
DOC_USP7_MATH_1	288	292	PF00917	0.699
DOC_USP7_MATH_1	321	325	PF00917	0.681
DOC_USP7_MATH_1	370	374	PF00917	0.756
DOC_USP7_MATH_1	423	427	PF00917	0.742
DOC_USP7_MATH_1	440	444	PF00917	0.660
DOC_USP7_MATH_1	454	458	PF00917	0.534
DOC_USP7_MATH_1	494	498	PF00917	0.666
DOC_USP7_MATH_1	53	57	PF00917	0.726
DOC_USP7_MATH_1	84	88	PF00917	0.706
DOC_WW_Pin1_4	107	112	PF00397	0.679
DOC_WW_Pin1_4	136	141	PF00397	0.753
DOC_WW_Pin1_4	199	204	PF00397	0.799
DOC_WW_Pin1_4	238	243	PF00397	0.827
DOC_WW_Pin1_4	301	306	PF00397	0.796
DOC_WW_Pin1_4	406	411	PF00397	0.739
LIG_14-3-3_CanoR_1	107	111	PF00244	0.699
LIG_14-3-3_CanoR_1	130	140	PF00244	0.780
LIG_14-3-3_CanoR_1	287	293	PF00244	0.666
LIG_14-3-3_CanoR_1	345	354	PF00244	0.686
LIG_14-3-3_CanoR_1	424	434	PF00244	0.839
LIG_14-3-3_CanoR_1	455	462	PF00244	0.718
LIG_14-3-3_CanoR_1	512	517	PF00244	0.693
LIG_14-3-3_CanoR_1	80	84	PF00244	0.679
LIG_BIR_III_4	364	368	PF00653	0.663
LIG_BIR_III_4	394	398	PF00653	0.697
LIG_FHA_1	1	7	PF00498	0.647
LIG_FHA_1	411	417	PF00498	0.691
LIG_FHA_1	430	436	PF00498	0.849
LIG_FHA_1	509	515	PF00498	0.695
LIG_FHA_2	215	221	PF00498	0.687
LIG_FHA_2	74	80	PF00498	0.608
LIG_LIR_Apic_2	163	169	PF02991	0.603
LIG_LIR_Apic_2	467	471	PF02991	0.681
LIG_LIR_Gen_1	175	183	PF02991	0.619
LIG_LIR_Nem_3	170	174	PF02991	0.632
LIG_LIR_Nem_3	175	181	PF02991	0.517
LIG_LIR_Nem_3	398	404	PF02991	0.718
LIG_LIR_Nem_3	446	450	PF02991	0.698
LIG_SH2_CRK	451	455	PF00017	0.672
LIG_SH2_GRB2like	227	230	PF00017	0.666
LIG_SH2_GRB2like	447	450	PF00017	0.699
LIG_SH2_PTP2	273	276	PF00017	0.645
LIG_SH2_SRC	468	471	PF00017	0.678
LIG_SH2_STAT5	273	276	PF00017	0.617
LIG_SH2_STAT5	468	471	PF00017	0.657
LIG_SH3_1	299	305	PF00018	0.716
LIG_SH3_2	239	244	PF14604	0.618
LIG_SH3_3	236	242	PF00018	0.755
LIG_SH3_3	299	305	PF00018	0.799
LIG_SH3_3	44	50	PF00018	0.714
LIG_TRAF2_1	217	220	PF00917	0.687
MOD_CDC14_SPxK_1	241	244	PF00782	0.619
MOD_CDK_SPxK_1	238	244	PF00069	0.617
MOD_CK1_1	116	122	PF00069	0.715
MOD_CK1_1	136	142	PF00069	0.754
MOD_CK1_1	147	153	PF00069	0.507
MOD_CK1_1	18	24	PF00069	0.650
MOD_CK1_1	26	32	PF00069	0.579
MOD_CK1_1	426	432	PF00069	0.744
MOD_CK1_1	443	449	PF00069	0.679
MOD_CK1_1	458	464	PF00069	0.580
MOD_CK1_1	497	503	PF00069	0.678
MOD_CK1_1	56	62	PF00069	0.744
MOD_CK1_1	8	14	PF00069	0.719
MOD_CK2_1	214	220	PF00069	0.691
MOD_GlcNHglycan	103	106	PF01048	0.769
MOD_GlcNHglycan	142	145	PF01048	0.764
MOD_GlcNHglycan	203	206	PF01048	0.761
MOD_GlcNHglycan	25	28	PF01048	0.686
MOD_GlcNHglycan	256	260	PF01048	0.662
MOD_GlcNHglycan	290	293	PF01048	0.793
MOD_GlcNHglycan	309	312	PF01048	0.789
MOD_GlcNHglycan	348	351	PF01048	0.810
MOD_GlcNHglycan	372	375	PF01048	0.708
MOD_GlcNHglycan	43	46	PF01048	0.690
MOD_GlcNHglycan	60	63	PF01048	0.566
MOD_GSK3_1	132	139	PF00069	0.749
MOD_GSK3_1	140	147	PF00069	0.642
MOD_GSK3_1	15	22	PF00069	0.738
MOD_GSK3_1	199	206	PF00069	0.773
MOD_GSK3_1	37	44	PF00069	0.767
MOD_GSK3_1	406	413	PF00069	0.736
MOD_GSK3_1	422	429	PF00069	0.610
MOD_GSK3_1	439	446	PF00069	0.666
MOD_GSK3_1	454	461	PF00069	0.592
MOD_GSK3_1	508	515	PF00069	0.691
MOD_GSK3_1	52	59	PF00069	0.588
MOD_GSK3_1	79	86	PF00069	0.757
MOD_GSK3_1	88	95	PF00069	0.654
MOD_NEK2_1	2	7	PF00069	0.642
MOD_NEK2_1	73	78	PF00069	0.692
MOD_NEK2_2	309	314	PF00069	0.648
MOD_OFUCOSY	453	459	PF10250	0.719
MOD_PIKK_1	321	327	PF00454	0.701
MOD_PIKK_1	497	503	PF00454	0.678
MOD_PKA_1	345	351	PF00069	0.771
MOD_PKA_2	106	112	PF00069	0.642
MOD_PKA_2	144	150	PF00069	0.625
MOD_PKA_2	196	202	PF00069	0.692
MOD_PKA_2	286	292	PF00069	0.716
MOD_PKA_2	345	351	PF00069	0.771
MOD_PKA_2	423	429	PF00069	0.742
MOD_PKA_2	454	460	PF00069	0.633
MOD_PKA_2	79	85	PF00069	0.731
MOD_PKA_2	92	98	PF00069	0.616
MOD_PKB_1	39	47	PF00069	0.644
MOD_PKB_1	510	518	PF00069	0.695
MOD_Plk_1	214	220	PF00069	0.691
MOD_Plk_4	167	173	PF00069	0.508
MOD_Plk_4	376	382	PF00069	0.622
MOD_Plk_4	412	418	PF00069	0.695
MOD_Plk_4	430	436	PF00069	0.695
MOD_Plk_4	464	470	PF00069	0.691
MOD_Plk_4	494	500	PF00069	0.665
MOD_Plk_4	61	67	PF00069	0.674
MOD_ProDKin_1	107	113	PF00069	0.679
MOD_ProDKin_1	136	142	PF00069	0.754
MOD_ProDKin_1	199	205	PF00069	0.798
MOD_ProDKin_1	238	244	PF00069	0.831
MOD_ProDKin_1	301	307	PF00069	0.797
MOD_ProDKin_1	406	412	PF00069	0.738
TRG_DiLeu_BaEn_1	256	261	PF01217	0.658
TRG_DiLeu_BaEn_1	487	492	PF01217	0.633
TRG_DiLeu_LyEn_5	487	492	PF01217	0.633
TRG_ENDOCYTIC_2	273	276	PF00928	0.723
TRG_ER_diArg_1	210	212	PF00400	0.723
TRG_ER_diArg_1	345	347	PF00400	0.775
TRG_ER_diArg_1	476	478	PF00400	0.692
TRG_ER_diArg_1	509	512	PF00400	0.698
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H394	Leishmania braziliensis	61%	100%
A4HRK2	Leishmania infantum	99%	100%
E9AC70	Leishmania major	89%	100%
E9AJG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	96%