Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJC9_LEIDO

TriTrypDb:

LdBPK_010780.1 , LdCL_010012800 , LDHU3_01.0880

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.768
CLV_NRD_NRD_1	38	40	PF00675	0.548
CLV_PCSK_KEX2_1	166	168	PF00082	0.781
CLV_PCSK_PC7_1	163	169	PF00082	0.784
CLV_PCSK_SKI1_1	325	329	PF00082	0.534
CLV_PCSK_SKI1_1	461	465	PF00082	0.614
CLV_PCSK_SKI1_1	74	78	PF00082	0.509
DEG_APCC_KENBOX_2	39	43	PF00400	0.548
DEG_SCF_FBW7_1	107	113	PF00400	0.539
DEG_SPOP_SBC_1	110	114	PF00917	0.534
DEG_SPOP_SBC_1	285	289	PF00917	0.404
DOC_CKS1_1	107	112	PF01111	0.524
DOC_CKS1_1	60	65	PF01111	0.520
DOC_CKS1_1	95	100	PF01111	0.501
DOC_CYCLIN_RxL_1	70	81	PF00134	0.508
DOC_MAPK_gen_1	200	209	PF00069	0.386
DOC_MAPK_MEF2A_6	245	252	PF00069	0.530
DOC_MAPK_MEF2A_6	410	419	PF00069	0.723
DOC_PP2B_LxvP_1	12	15	PF13499	0.501
DOC_PP2B_LxvP_1	141	144	PF13499	0.463
DOC_PP4_FxxP_1	402	405	PF00568	0.581
DOC_USP7_MATH_1	115	119	PF00917	0.544
DOC_USP7_MATH_1	144	148	PF00917	0.538
DOC_USP7_MATH_1	154	158	PF00917	0.658
DOC_USP7_MATH_1	162	166	PF00917	0.555
DOC_USP7_MATH_1	240	244	PF00917	0.601
DOC_USP7_MATH_1	284	288	PF00917	0.451
DOC_USP7_MATH_1	301	305	PF00917	0.505
DOC_USP7_MATH_1	312	316	PF00917	0.644
DOC_USP7_MATH_1	357	361	PF00917	0.764
DOC_USP7_MATH_1	370	374	PF00917	0.559
DOC_USP7_MATH_1	391	395	PF00917	0.674
DOC_USP7_MATH_1	86	90	PF00917	0.492
DOC_WW_Pin1_4	101	106	PF00397	0.512
DOC_WW_Pin1_4	111	116	PF00397	0.520
DOC_WW_Pin1_4	238	243	PF00397	0.735
DOC_WW_Pin1_4	316	321	PF00397	0.668
DOC_WW_Pin1_4	361	366	PF00397	0.775
DOC_WW_Pin1_4	59	64	PF00397	0.606
DOC_WW_Pin1_4	6	11	PF00397	0.502
DOC_WW_Pin1_4	94	99	PF00397	0.502
LIG_14-3-3_CanoR_1	445	454	PF00244	0.647
LIG_Actin_WH2_2	302	319	PF00022	0.449
LIG_APCC_ABBA_1	212	217	PF00400	0.552
LIG_BRCT_BRCA1_1	323	327	PF00533	0.478
LIG_BRCT_BRCA1_1	372	376	PF00533	0.720
LIG_FHA_1	286	292	PF00498	0.545
LIG_FHA_1	458	464	PF00498	0.531
LIG_FHA_2	462	468	PF00498	0.540
LIG_LIR_Apic_2	399	405	PF02991	0.597
LIG_LIR_Gen_1	171	181	PF02991	0.354
LIG_LIR_Gen_1	210	219	PF02991	0.535
LIG_LIR_Gen_1	260	269	PF02991	0.587
LIG_LIR_Gen_1	287	298	PF02991	0.336
LIG_LIR_Gen_1	330	337	PF02991	0.469
LIG_LIR_Gen_1	373	382	PF02991	0.670
LIG_LIR_Nem_3	171	177	PF02991	0.361
LIG_LIR_Nem_3	210	215	PF02991	0.532
LIG_LIR_Nem_3	216	221	PF02991	0.491
LIG_LIR_Nem_3	260	264	PF02991	0.577
LIG_LIR_Nem_3	330	334	PF02991	0.525
LIG_LIR_Nem_3	335	340	PF02991	0.607
LIG_LIR_Nem_3	373	379	PF02991	0.683
LIG_NRBOX	3	9	PF00104	0.489
LIG_SH2_CRK	174	178	PF00017	0.610
LIG_SH2_CRK	261	265	PF00017	0.580
LIG_SH2_CRK	331	335	PF00017	0.607
LIG_SH2_CRK	337	341	PF00017	0.553
LIG_SH2_NCK_1	331	335	PF00017	0.607
LIG_SH2_STAT3	172	175	PF00017	0.610
LIG_SH2_STAT3	473	476	PF00017	0.625
LIG_SH2_STAT5	27	30	PF00017	0.518
LIG_SH2_STAT5	446	449	PF00017	0.745
LIG_SH2_STAT5	473	476	PF00017	0.625
LIG_SH3_2	117	122	PF14604	0.545
LIG_SH3_3	114	120	PF00018	0.540
LIG_SH3_3	189	195	PF00018	0.575
LIG_SH3_3	236	242	PF00018	0.703
LIG_SH3_3	359	365	PF00018	0.787
LIG_SH3_3	483	489	PF00018	0.563
LIG_SH3_3	65	71	PF00018	0.515
LIG_SH3_3	92	98	PF00018	0.503
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.465
LIG_TRAF2_1	383	386	PF00917	0.505
LIG_TRAF2_1	456	459	PF00917	0.702
LIG_TYR_ITSM	333	340	PF00017	0.540
LIG_WW_3	36	40	PF00397	0.541
MOD_CDK_SPxxK_3	238	245	PF00069	0.611
MOD_CDK_SPxxK_3	316	323	PF00069	0.581
MOD_CK1_1	17	23	PF00069	0.521
MOD_CK1_1	275	281	PF00069	0.641
MOD_CK1_1	360	366	PF00069	0.780
MOD_CK2_1	380	386	PF00069	0.472
MOD_CK2_1	408	414	PF00069	0.718
MOD_CK2_1	453	459	PF00069	0.715
MOD_CK2_1	461	467	PF00069	0.441
MOD_GlcNHglycan	150	153	PF01048	0.669
MOD_GlcNHglycan	156	159	PF01048	0.602
MOD_GlcNHglycan	177	180	PF01048	0.564
MOD_GlcNHglycan	242	245	PF01048	0.552
MOD_GlcNHglycan	277	280	PF01048	0.570
MOD_GlcNHglycan	294	297	PF01048	0.422
MOD_GlcNHglycan	346	349	PF01048	0.665
MOD_GlcNHglycan	382	385	PF01048	0.556
MOD_GlcNHglycan	399	402	PF01048	0.646
MOD_GlcNHglycan	80	83	PF01048	0.574
MOD_GSK3_1	101	108	PF00069	0.528
MOD_GSK3_1	109	116	PF00069	0.527
MOD_GSK3_1	13	20	PF00069	0.520
MOD_GSK3_1	144	151	PF00069	0.525
MOD_GSK3_1	301	308	PF00069	0.578
MOD_GSK3_1	312	319	PF00069	0.688
MOD_GSK3_1	332	339	PF00069	0.462
MOD_GSK3_1	356	363	PF00069	0.777
MOD_GSK3_1	393	400	PF00069	0.682
MOD_GSK3_1	420	427	PF00069	0.556
MOD_GSK3_1	453	460	PF00069	0.542
MOD_N-GLC_1	41	46	PF02516	0.538
MOD_NEK2_1	292	297	PF00069	0.362
MOD_NEK2_1	307	312	PF00069	0.426
MOD_NEK2_1	397	402	PF00069	0.538
MOD_NEK2_1	77	82	PF00069	0.578
MOD_NEK2_2	312	317	PF00069	0.586
MOD_PIKK_1	307	313	PF00454	0.549
MOD_PKA_2	162	168	PF00069	0.593
MOD_PKA_2	17	23	PF00069	0.550
MOD_PKA_2	420	426	PF00069	0.658
MOD_PKA_2	78	84	PF00069	0.492
MOD_PKB_1	166	174	PF00069	0.536
MOD_Plk_1	391	397	PF00069	0.659
MOD_Plk_1	457	463	PF00069	0.539
MOD_Plk_4	135	141	PF00069	0.539
MOD_Plk_4	168	174	PF00069	0.510
MOD_Plk_4	286	292	PF00069	0.390
MOD_Plk_4	8	14	PF00069	0.512
MOD_ProDKin_1	101	107	PF00069	0.516
MOD_ProDKin_1	111	117	PF00069	0.518
MOD_ProDKin_1	238	244	PF00069	0.730
MOD_ProDKin_1	316	322	PF00069	0.668
MOD_ProDKin_1	361	367	PF00069	0.775
MOD_ProDKin_1	59	65	PF00069	0.606
MOD_ProDKin_1	6	12	PF00069	0.504
MOD_ProDKin_1	94	100	PF00069	0.501
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.487
TRG_ENDOCYTIC_2	174	177	PF00928	0.427
TRG_ENDOCYTIC_2	261	264	PF00928	0.578
TRG_ENDOCYTIC_2	331	334	PF00928	0.503
TRG_ENDOCYTIC_2	337	340	PF00928	0.588
TRG_ER_diArg_1	166	168	PF00400	0.781
TRG_ER_diArg_1	198	201	PF00400	0.383
TRG_ER_diArg_1	322	325	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H392	Leishmania braziliensis	50%	100%
E9AC67	Leishmania major	88%	99%
E9AJG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%