Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A451EJC2_LEIDO

TriTrypDb:

LdBPK_010700.1 , LdCL_010012000 , LDHU3_01.0790

Length:

804

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.669
CLV_C14_Caspase3-7	182	186	PF00656	0.637
CLV_C14_Caspase3-7	324	328	PF00656	0.698
CLV_C14_Caspase3-7	644	648	PF00656	0.627
CLV_NRD_NRD_1	213	215	PF00675	0.687
CLV_NRD_NRD_1	248	250	PF00675	0.800
CLV_NRD_NRD_1	260	262	PF00675	0.665
CLV_NRD_NRD_1	306	308	PF00675	0.595
CLV_NRD_NRD_1	35	37	PF00675	0.619
CLV_NRD_NRD_1	611	613	PF00675	0.715
CLV_NRD_NRD_1	62	64	PF00675	0.644
CLV_NRD_NRD_1	729	731	PF00675	0.659
CLV_NRD_NRD_1	86	88	PF00675	0.717
CLV_NRD_NRD_1	99	101	PF00675	0.623
CLV_PCSK_FUR_1	211	215	PF00082	0.688
CLV_PCSK_FUR_1	97	101	PF00082	0.679
CLV_PCSK_KEX2_1	213	215	PF00082	0.687
CLV_PCSK_KEX2_1	247	249	PF00082	0.787
CLV_PCSK_KEX2_1	260	262	PF00082	0.657
CLV_PCSK_KEX2_1	306	308	PF00082	0.595
CLV_PCSK_KEX2_1	34	36	PF00082	0.617
CLV_PCSK_KEX2_1	611	613	PF00082	0.715
CLV_PCSK_KEX2_1	714	716	PF00082	0.650
CLV_PCSK_KEX2_1	729	731	PF00082	0.562
CLV_PCSK_KEX2_1	86	88	PF00082	0.717
CLV_PCSK_KEX2_1	99	101	PF00082	0.623
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.625
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.650
CLV_PCSK_PC7_1	243	249	PF00082	0.696
CLV_PCSK_SKI1_1	28	32	PF00082	0.549
CLV_PCSK_SKI1_1	676	680	PF00082	0.679
CLV_PCSK_SKI1_1	777	781	PF00082	0.601
DEG_SCF_FBW7_1	542	549	PF00400	0.677
DEG_SPOP_SBC_1	368	372	PF00917	0.643
DEG_SPOP_SBC_1	386	390	PF00917	0.502
DEG_SPOP_SBC_1	541	545	PF00917	0.687
DEG_SPOP_SBC_1	578	582	PF00917	0.648
DEG_SPOP_SBC_1	758	762	PF00917	0.677
DOC_CKS1_1	300	305	PF01111	0.703
DOC_CYCLIN_RxL_1	774	783	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.664
DOC_MAPK_gen_1	633	642	PF00069	0.586
DOC_MAPK_gen_1	713	721	PF00069	0.675
DOC_PP2B_LxvP_1	187	190	PF13499	0.657
DOC_USP7_MATH_1	179	183	PF00917	0.636
DOC_USP7_MATH_1	217	221	PF00917	0.733
DOC_USP7_MATH_1	234	238	PF00917	0.484
DOC_USP7_MATH_1	274	278	PF00917	0.647
DOC_USP7_MATH_1	368	372	PF00917	0.673
DOC_USP7_MATH_1	373	377	PF00917	0.615
DOC_USP7_MATH_1	386	390	PF00917	0.505
DOC_USP7_MATH_1	445	449	PF00917	0.594
DOC_USP7_MATH_1	50	54	PF00917	0.697
DOC_USP7_MATH_1	518	522	PF00917	0.652
DOC_USP7_MATH_1	724	728	PF00917	0.653
DOC_USP7_MATH_1	757	761	PF00917	0.678
DOC_WW_Pin1_4	1	6	PF00397	0.647
DOC_WW_Pin1_4	122	127	PF00397	0.679
DOC_WW_Pin1_4	131	136	PF00397	0.656
DOC_WW_Pin1_4	148	153	PF00397	0.615
DOC_WW_Pin1_4	299	304	PF00397	0.673
DOC_WW_Pin1_4	336	341	PF00397	0.698
DOC_WW_Pin1_4	357	362	PF00397	0.615
DOC_WW_Pin1_4	382	387	PF00397	0.650
DOC_WW_Pin1_4	417	422	PF00397	0.641
DOC_WW_Pin1_4	52	57	PF00397	0.646
DOC_WW_Pin1_4	542	547	PF00397	0.678
DOC_WW_Pin1_4	602	607	PF00397	0.644
DOC_WW_Pin1_4	661	666	PF00397	0.714
DOC_WW_Pin1_4	98	103	PF00397	0.655
LIG_14-3-3_CanoR_1	129	137	PF00244	0.642
LIG_14-3-3_CanoR_1	155	160	PF00244	0.690
LIG_14-3-3_CanoR_1	248	258	PF00244	0.598
LIG_14-3-3_CanoR_1	394	398	PF00244	0.626
LIG_14-3-3_CanoR_1	413	421	PF00244	0.606
LIG_14-3-3_CanoR_1	450	456	PF00244	0.657
LIG_14-3-3_CanoR_1	599	607	PF00244	0.641
LIG_14-3-3_CanoR_1	633	642	PF00244	0.691
LIG_14-3-3_CanoR_1	670	678	PF00244	0.688
LIG_14-3-3_CanoR_1	715	721	PF00244	0.710
LIG_14-3-3_CanoR_1	734	740	PF00244	0.538
LIG_APCC_ABBA_1	784	789	PF00400	0.621
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BIR_III_2	185	189	PF00653	0.650
LIG_BIR_III_2	474	478	PF00653	0.621
LIG_BIR_III_2	740	744	PF00653	0.650
LIG_BRCT_BRCA1_1	271	275	PF00533	0.641
LIG_BRCT_BRCA1_1	38	42	PF00533	0.550
LIG_CaM_NSCaTE_8	439	446	PF13499	0.644
LIG_FHA_1	163	169	PF00498	0.567
LIG_FHA_1	182	188	PF00498	0.686
LIG_FHA_1	286	292	PF00498	0.697
LIG_FHA_1	299	305	PF00498	0.711
LIG_FHA_1	314	320	PF00498	0.688
LIG_FHA_1	333	339	PF00498	0.606
LIG_FHA_1	460	466	PF00498	0.699
LIG_FHA_1	578	584	PF00498	0.675
LIG_FHA_1	771	777	PF00498	0.658
LIG_FHA_2	194	200	PF00498	0.705
LIG_FHA_2	228	234	PF00498	0.558
LIG_FHA_2	313	319	PF00498	0.667
LIG_FHA_2	64	70	PF00498	0.663
LIG_FHA_2	769	775	PF00498	0.599
LIG_Integrin_RGD_1	76	78	PF01839	0.618
LIG_LIR_Gen_1	4	12	PF02991	0.618
LIG_LIR_Gen_1	480	489	PF02991	0.562
LIG_LIR_Gen_1	500	507	PF02991	0.382
LIG_LIR_Nem_3	158	163	PF02991	0.788
LIG_LIR_Nem_3	4	9	PF02991	0.644
LIG_LIR_Nem_3	480	484	PF02991	0.601
LIG_LIR_Nem_3	486	492	PF02991	0.567
LIG_LIR_Nem_3	500	505	PF02991	0.402
LIG_PTAP_UEV_1	101	106	PF05743	0.695
LIG_Rb_LxCxE_1	106	125	PF01857	0.601
LIG_SH2_CRK	481	485	PF00017	0.562
LIG_SH2_SRC	787	790	PF00017	0.632
LIG_SH2_STAP1	183	187	PF00017	0.637
LIG_SH2_STAT5	183	186	PF00017	0.617
LIG_SH2_STAT5	502	505	PF00017	0.587
LIG_SH3_1	99	105	PF00018	0.670
LIG_SH3_2	255	260	PF14604	0.728
LIG_SH3_2	665	670	PF14604	0.695
LIG_SH3_3	146	152	PF00018	0.671
LIG_SH3_3	252	258	PF00018	0.718
LIG_SH3_3	294	300	PF00018	0.705
LIG_SH3_3	462	468	PF00018	0.627
LIG_SH3_3	662	668	PF00018	0.705
LIG_SH3_3	686	692	PF00018	0.586
LIG_SH3_3	99	105	PF00018	0.670
LIG_SH3_CIN85_PxpxPR_1	150	155	PF14604	0.639
LIG_SUMO_SIM_anti_2	422	428	PF11976	0.560
LIG_SUMO_SIM_par_1	116	122	PF11976	0.632
LIG_SUMO_SIM_par_1	638	645	PF11976	0.628
LIG_TYR_ITIM	479	484	PF00017	0.568
MOD_CDC14_SPxK_1	667	670	PF00782	0.695
MOD_CDK_SPK_2	150	155	PF00069	0.639
MOD_CDK_SPxK_1	664	670	PF00069	0.698
MOD_CDK_SPxxK_3	122	129	PF00069	0.633
MOD_CDK_SPxxK_3	148	155	PF00069	0.641
MOD_CDK_SPxxK_3	299	306	PF00069	0.588
MOD_CK1_1	119	125	PF00069	0.615
MOD_CK1_1	138	144	PF00069	0.667
MOD_CK1_1	181	187	PF00069	0.683
MOD_CK1_1	220	226	PF00069	0.595
MOD_CK1_1	263	269	PF00069	0.712
MOD_CK1_1	277	283	PF00069	0.568
MOD_CK1_1	4	10	PF00069	0.660
MOD_CK1_1	414	420	PF00069	0.713
MOD_CK1_1	448	454	PF00069	0.687
MOD_CK1_1	459	465	PF00069	0.580
MOD_CK1_1	521	527	PF00069	0.722
MOD_CK1_1	536	542	PF00069	0.593
MOD_CK1_1	565	571	PF00069	0.661
MOD_CK1_1	576	582	PF00069	0.614
MOD_CK1_1	602	608	PF00069	0.694
MOD_CK1_1	638	644	PF00069	0.688
MOD_CK1_1	652	658	PF00069	0.566
MOD_CK1_1	663	669	PF00069	0.611
MOD_CK1_1	732	738	PF00069	0.685
MOD_CK1_1	761	767	PF00069	0.664
MOD_CK2_1	107	113	PF00069	0.626
MOD_CK2_1	193	199	PF00069	0.820
MOD_CK2_1	227	233	PF00069	0.594
MOD_CK2_1	234	240	PF00069	0.545
MOD_CK2_1	528	534	PF00069	0.621
MOD_CK2_1	625	631	PF00069	0.652
MOD_CK2_1	63	69	PF00069	0.667
MOD_Cter_Amidation	211	214	PF01082	0.609
MOD_GlcNHglycan	1	4	PF01048	0.649
MOD_GlcNHglycan	102	105	PF01048	0.715
MOD_GlcNHglycan	131	134	PF01048	0.674
MOD_GlcNHglycan	140	143	PF01048	0.650
MOD_GlcNHglycan	191	194	PF01048	0.699
MOD_GlcNHglycan	208	211	PF01048	0.581
MOD_GlcNHglycan	219	222	PF01048	0.545
MOD_GlcNHglycan	251	254	PF01048	0.705
MOD_GlcNHglycan	371	374	PF01048	0.633
MOD_GlcNHglycan	38	41	PF01048	0.599
MOD_GlcNHglycan	382	385	PF01048	0.565
MOD_GlcNHglycan	389	392	PF01048	0.521
MOD_GlcNHglycan	443	446	PF01048	0.653
MOD_GlcNHglycan	447	450	PF01048	0.708
MOD_GlcNHglycan	459	462	PF01048	0.646
MOD_GlcNHglycan	52	55	PF01048	0.608
MOD_GlcNHglycan	521	524	PF01048	0.723
MOD_GlcNHglycan	538	541	PF01048	0.576
MOD_GlcNHglycan	564	567	PF01048	0.694
MOD_GlcNHglycan	6	9	PF01048	0.635
MOD_GlcNHglycan	635	638	PF01048	0.608
MOD_GlcNHglycan	652	655	PF01048	0.617
MOD_GlcNHglycan	731	734	PF01048	0.685
MOD_GlcNHglycan	755	758	PF01048	0.712
MOD_GlcNHglycan	761	764	PF01048	0.652
MOD_GlcNHglycan	78	83	PF01048	0.607
MOD_GSK3_1	118	125	PF00069	0.658
MOD_GSK3_1	131	138	PF00069	0.544
MOD_GSK3_1	189	196	PF00069	0.810
MOD_GSK3_1	198	205	PF00069	0.676
MOD_GSK3_1	262	269	PF00069	0.684
MOD_GSK3_1	270	277	PF00069	0.638
MOD_GSK3_1	298	305	PF00069	0.676
MOD_GSK3_1	332	339	PF00069	0.722
MOD_GSK3_1	363	370	PF00069	0.746
MOD_GSK3_1	382	389	PF00069	0.546
MOD_GSK3_1	411	418	PF00069	0.660
MOD_GSK3_1	441	448	PF00069	0.705
MOD_GSK3_1	450	457	PF00069	0.617
MOD_GSK3_1	518	525	PF00069	0.689
MOD_GSK3_1	536	543	PF00069	0.605
MOD_GSK3_1	572	579	PF00069	0.718
MOD_GSK3_1	602	609	PF00069	0.580
MOD_GSK3_1	625	632	PF00069	0.682
MOD_GSK3_1	638	645	PF00069	0.615
MOD_GSK3_1	64	71	PF00069	0.697
MOD_GSK3_1	660	667	PF00069	0.664
MOD_GSK3_1	676	683	PF00069	0.541
MOD_GSK3_1	709	716	PF00069	0.654
MOD_GSK3_1	729	736	PF00069	0.597
MOD_GSK3_1	749	756	PF00069	0.588
MOD_GSK3_1	757	764	PF00069	0.656
MOD_GSK3_1	766	773	PF00069	0.522
MOD_N-GLC_1	197	202	PF02516	0.678
MOD_N-GLC_1	266	271	PF02516	0.662
MOD_N-GLC_1	325	330	PF02516	0.657
MOD_N-GLC_1	428	433	PF02516	0.520
MOD_NEK2_1	118	123	PF00069	0.642
MOD_NEK2_1	227	232	PF00069	0.565
MOD_NEK2_1	275	280	PF00069	0.662
MOD_NEK2_1	291	296	PF00069	0.543
MOD_NEK2_1	312	317	PF00069	0.734
MOD_NEK2_1	380	385	PF00069	0.649
MOD_NEK2_1	393	398	PF00069	0.677
MOD_NEK2_1	443	448	PF00069	0.719
MOD_NEK2_1	456	461	PF00069	0.657
MOD_NEK2_1	488	493	PF00069	0.723
MOD_NEK2_1	669	674	PF00069	0.698
MOD_NEK2_1	780	785	PF00069	0.648
MOD_NEK2_2	606	611	PF00069	0.579
MOD_PIKK_1	22	28	PF00454	0.539
MOD_PIKK_1	373	379	PF00454	0.693
MOD_PIKK_1	567	573	PF00454	0.694
MOD_PIKK_1	625	631	PF00454	0.699
MOD_PIKK_1	724	730	PF00454	0.656
MOD_PK_1	116	122	PF00069	0.621
MOD_PK_1	782	788	PF00069	0.591
MOD_PKA_1	248	254	PF00069	0.670
MOD_PKA_1	260	266	PF00069	0.630
MOD_PKA_1	611	617	PF00069	0.692
MOD_PKA_1	63	69	PF00069	0.644
MOD_PKA_1	713	719	PF00069	0.650
MOD_PKA_1	729	735	PF00069	0.562
MOD_PKA_2	128	134	PF00069	0.600
MOD_PKA_2	248	254	PF00069	0.747
MOD_PKA_2	260	266	PF00069	0.733
MOD_PKA_2	291	297	PF00069	0.613
MOD_PKA_2	393	399	PF00069	0.676
MOD_PKA_2	414	420	PF00069	0.602
MOD_PKA_2	536	542	PF00069	0.735
MOD_PKA_2	610	616	PF00069	0.688
MOD_PKA_2	669	675	PF00069	0.638
MOD_PKA_2	714	720	PF00069	0.685
MOD_PKA_2	729	735	PF00069	0.579
MOD_PKB_1	34	42	PF00069	0.569
MOD_PKB_1	413	421	PF00069	0.641
MOD_PKB_1	633	641	PF00069	0.588
MOD_Plk_1	197	203	PF00069	0.679
MOD_Plk_1	227	233	PF00069	0.609
MOD_Plk_1	266	272	PF00069	0.660
MOD_Plk_1	325	331	PF00069	0.659
MOD_Plk_4	422	428	PF00069	0.642
MOD_Plk_4	451	457	PF00069	0.652
MOD_Plk_4	635	641	PF00069	0.650
MOD_Plk_4	782	788	PF00069	0.645
MOD_ProDKin_1	1	7	PF00069	0.651
MOD_ProDKin_1	122	128	PF00069	0.679
MOD_ProDKin_1	131	137	PF00069	0.658
MOD_ProDKin_1	148	154	PF00069	0.612
MOD_ProDKin_1	299	305	PF00069	0.672
MOD_ProDKin_1	336	342	PF00069	0.698
MOD_ProDKin_1	357	363	PF00069	0.616
MOD_ProDKin_1	382	388	PF00069	0.649
MOD_ProDKin_1	417	423	PF00069	0.642
MOD_ProDKin_1	52	58	PF00069	0.648
MOD_ProDKin_1	542	548	PF00069	0.677
MOD_ProDKin_1	602	608	PF00069	0.644
MOD_ProDKin_1	661	667	PF00069	0.714
MOD_ProDKin_1	98	104	PF00069	0.653
MOD_SUMO_rev_2	110	118	PF00179	0.615
TRG_DiLeu_BaEn_1	113	118	PF01217	0.612
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.698
TRG_ENDOCYTIC_2	160	163	PF00928	0.720
TRG_ENDOCYTIC_2	481	484	PF00928	0.569
TRG_ENDOCYTIC_2	502	505	PF00928	0.585
TRG_ER_diArg_1	211	214	PF00400	0.691
TRG_ER_diArg_1	259	261	PF00400	0.718
TRG_ER_diArg_1	34	36	PF00400	0.571
TRG_ER_diArg_1	535	538	PF00400	0.687
TRG_ER_diArg_1	610	612	PF00400	0.716
TRG_NES_CRM1_1	774	789	PF08389	0.588
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H386	Leishmania braziliensis	51%	100%
A4HRJ1	Leishmania infantum	99%	100%
E9AC59	Leishmania major	86%	98%
E9AJF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	98%