Metallo-peptidase, Clan ME, Family M16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial-processing peptidase subunit beta, putative

Species:

Leishmania donovani

UniProt:

A0A451EJB9_LEIDO

TriTrypDb:

LdBPK_010670.1 , LdCL_010011700 , LDHU3_01.0750

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0017087	mitochondrial processing peptidase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A451EJB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJB9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.279
CLV_C14_Caspase3-7	429	433	PF00656	0.371
CLV_NRD_NRD_1	145	147	PF00675	0.389
CLV_NRD_NRD_1	3	5	PF00675	0.608
CLV_NRD_NRD_1	313	315	PF00675	0.484
CLV_NRD_NRD_1	420	422	PF00675	0.335
CLV_PCSK_FUR_1	143	147	PF00082	0.389
CLV_PCSK_KEX2_1	145	147	PF00082	0.389
CLV_PCSK_KEX2_1	3	5	PF00082	0.608
CLV_PCSK_KEX2_1	313	315	PF00082	0.482
CLV_PCSK_KEX2_1	420	422	PF00082	0.335
CLV_PCSK_PC7_1	141	147	PF00082	0.315
CLV_PCSK_SKI1_1	122	126	PF00082	0.339
CLV_PCSK_SKI1_1	250	254	PF00082	0.303
CLV_PCSK_SKI1_1	350	354	PF00082	0.502
CLV_PCSK_SKI1_1	45	49	PF00082	0.252
DEG_APCC_DBOX_1	420	428	PF00400	0.407
DEG_SCF_FBW7_2	331	338	PF00400	0.321
DOC_CKS1_1	332	337	PF01111	0.303
DOC_PP4_FxxP_1	332	335	PF00568	0.301
DOC_USP7_MATH_1	110	114	PF00917	0.245
DOC_USP7_MATH_1	182	186	PF00917	0.279
DOC_USP7_MATH_1	452	456	PF00917	0.337
DOC_USP7_UBL2_3	122	126	PF12436	0.339
DOC_USP7_UBL2_3	200	204	PF12436	0.384
DOC_USP7_UBL2_3	390	394	PF12436	0.327
DOC_WW_Pin1_4	226	231	PF00397	0.339
DOC_WW_Pin1_4	30	35	PF00397	0.406
DOC_WW_Pin1_4	331	336	PF00397	0.306
DOC_WW_Pin1_4	432	437	PF00397	0.339
DOC_WW_Pin1_4	464	469	PF00397	0.607
LIG_14-3-3_CanoR_1	91	101	PF00244	0.287
LIG_Actin_WH2_2	424	442	PF00022	0.454
LIG_BRCT_BRCA1_1	481	485	PF00533	0.443
LIG_CtBP_PxDLS_1	436	440	PF00389	0.455
LIG_CtBP_PxDLS_1	468	472	PF00389	0.516
LIG_eIF4E_1	336	342	PF01652	0.288
LIG_eIF4E_1	466	472	PF01652	0.493
LIG_FHA_1	123	129	PF00498	0.406
LIG_FHA_1	182	188	PF00498	0.410
LIG_FHA_1	3	9	PF00498	0.569
LIG_FHA_1	31	37	PF00498	0.362
LIG_FHA_1	337	343	PF00498	0.329
LIG_FHA_1	351	357	PF00498	0.454
LIG_FHA_1	361	367	PF00498	0.394
LIG_FHA_1	46	52	PF00498	0.228
LIG_FHA_1	56	62	PF00498	0.201
LIG_FHA_2	110	116	PF00498	0.254
LIG_FHA_2	17	23	PF00498	0.446
LIG_FHA_2	332	338	PF00498	0.321
LIG_FHA_2	377	383	PF00498	0.388
LIG_GBD_Chelix_1	198	206	PF00786	0.304
LIG_LIR_Gen_1	208	218	PF02991	0.267
LIG_LIR_Gen_1	426	436	PF02991	0.334
LIG_LIR_Gen_1	444	454	PF02991	0.426
LIG_LIR_Gen_1	53	63	PF02991	0.297
LIG_LIR_Gen_1	67	77	PF02991	0.276
LIG_LIR_Nem_3	208	213	PF02991	0.267
LIG_LIR_Nem_3	238	244	PF02991	0.265
LIG_LIR_Nem_3	303	309	PF02991	0.304
LIG_LIR_Nem_3	426	431	PF02991	0.332
LIG_LIR_Nem_3	444	449	PF02991	0.478
LIG_LIR_Nem_3	53	59	PF02991	0.304
LIG_LIR_Nem_3	67	72	PF02991	0.302
LIG_PCNA_yPIPBox_3	358	369	PF02747	0.367
LIG_PCNA_yPIPBox_3	68	81	PF02747	0.245
LIG_Rb_pABgroove_1	368	376	PF01858	0.440
LIG_SH2_CRK	215	219	PF00017	0.245
LIG_SH2_CRK	344	348	PF00017	0.283
LIG_SH2_CRK	37	41	PF00017	0.324
LIG_SH2_CRK	466	470	PF00017	0.579
LIG_SH2_PTP2	210	213	PF00017	0.389
LIG_SH2_STAP1	336	340	PF00017	0.441
LIG_SH2_STAP1	374	378	PF00017	0.449
LIG_SH2_STAT3	289	292	PF00017	0.260
LIG_SH2_STAT5	111	114	PF00017	0.245
LIG_SH2_STAT5	120	123	PF00017	0.262
LIG_SH2_STAT5	210	213	PF00017	0.286
LIG_SH2_STAT5	215	218	PF00017	0.264
LIG_SH2_STAT5	240	243	PF00017	0.382
LIG_SH2_STAT5	333	336	PF00017	0.299
LIG_SH2_STAT5	368	371	PF00017	0.358
LIG_SH2_STAT5	446	449	PF00017	0.341
LIG_SH2_STAT5	50	53	PF00017	0.279
LIG_SH3_1	313	319	PF00018	0.489
LIG_SH3_3	273	279	PF00018	0.279
LIG_SH3_3	313	319	PF00018	0.430
LIG_SH3_3	446	452	PF00018	0.492
LIG_SH3_3	472	478	PF00018	0.547
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.586
LIG_SUMO_SIM_par_1	129	137	PF11976	0.346
LIG_SUMO_SIM_par_1	467	473	PF11976	0.591
LIG_TRAF2_1	335	338	PF00917	0.343
LIG_TRAF2_1	423	426	PF00917	0.424
LIG_TYR_ITIM	342	347	PF00017	0.278
LIG_TYR_ITIM	35	40	PF00017	0.312
MOD_CK1_1	242	248	PF00069	0.301
MOD_CK1_1	30	36	PF00069	0.385
MOD_CK1_1	467	473	PF00069	0.595
MOD_CK2_1	202	208	PF00069	0.315
MOD_CK2_1	331	337	PF00069	0.319
MOD_CK2_1	381	387	PF00069	0.405
MOD_CK2_1	64	70	PF00069	0.245
MOD_CK2_1	92	98	PF00069	0.397
MOD_Cter_Amidation	418	421	PF01082	0.333
MOD_GlcNHglycan	184	187	PF01048	0.279
MOD_GlcNHglycan	224	227	PF01048	0.286
MOD_GlcNHglycan	241	244	PF01048	0.226
MOD_GlcNHglycan	353	356	PF01048	0.488
MOD_GlcNHglycan	406	409	PF01048	0.372
MOD_GlcNHglycan	481	484	PF01048	0.590
MOD_GlcNHglycan	74	77	PF01048	0.371
MOD_GSK3_1	110	117	PF00069	0.245
MOD_GSK3_1	222	229	PF00069	0.319
MOD_GSK3_1	239	246	PF00069	0.389
MOD_GSK3_1	281	288	PF00069	0.285
MOD_GSK3_1	400	407	PF00069	0.433
MOD_GSK3_1	86	93	PF00069	0.245
MOD_N-GLC_1	16	21	PF02516	0.414
MOD_N-GLC_1	202	207	PF02516	0.366
MOD_NEK2_1	2	7	PF00069	0.550
MOD_NEK2_1	222	227	PF00069	0.260
MOD_NEK2_1	244	249	PF00069	0.310
MOD_NEK2_1	351	356	PF00069	0.570
MOD_NEK2_1	376	381	PF00069	0.354
MOD_NEK2_1	393	398	PF00069	0.377
MOD_NEK2_1	400	405	PF00069	0.354
MOD_PIKK_1	308	314	PF00454	0.515
MOD_PKA_2	152	158	PF00069	0.245
MOD_PKA_2	2	8	PF00069	0.532
MOD_PKA_2	400	406	PF00069	0.434
MOD_PKA_2	90	96	PF00069	0.287
MOD_Plk_1	114	120	PF00069	0.245
MOD_Plk_1	16	22	PF00069	0.429
MOD_Plk_1	202	208	PF00069	0.315
MOD_Plk_1	336	342	PF00069	0.290
MOD_Plk_1	381	387	PF00069	0.393
MOD_Plk_4	152	158	PF00069	0.245
MOD_Plk_4	187	193	PF00069	0.319
MOD_Plk_4	202	208	PF00069	0.350
MOD_Plk_4	259	265	PF00069	0.245
MOD_Plk_4	360	366	PF00069	0.430
MOD_Plk_4	369	375	PF00069	0.362
MOD_Plk_4	381	387	PF00069	0.407
MOD_Plk_4	393	399	PF00069	0.411
MOD_Plk_4	467	473	PF00069	0.585
MOD_ProDKin_1	226	232	PF00069	0.339
MOD_ProDKin_1	30	36	PF00069	0.402
MOD_ProDKin_1	331	337	PF00069	0.312
MOD_ProDKin_1	432	438	PF00069	0.339
MOD_ProDKin_1	464	470	PF00069	0.608
MOD_SUMO_for_1	389	392	PF00179	0.344
MOD_SUMO_rev_2	387	396	PF00179	0.357
TRG_DiLeu_BaEn_1	162	167	PF01217	0.245
TRG_DiLeu_BaEn_1	337	342	PF01217	0.306
TRG_DiLeu_BaEn_4	337	343	PF01217	0.322
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.384
TRG_ENDOCYTIC_2	210	213	PF00928	0.404
TRG_ENDOCYTIC_2	306	309	PF00928	0.318
TRG_ENDOCYTIC_2	344	347	PF00928	0.287
TRG_ENDOCYTIC_2	37	40	PF00928	0.312
TRG_ENDOCYTIC_2	446	449	PF00928	0.470
TRG_ENDOCYTIC_2	466	469	PF00928	0.579
TRG_ER_diArg_1	141	144	PF00400	0.399
TRG_ER_diArg_1	2	4	PF00400	0.585
TRG_ER_diArg_1	420	422	PF00400	0.330
TRG_NES_CRM1_1	414	426	PF08389	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P575	Leptomonas seymouri	83%	100%
A0A0N1PEB5	Leptomonas seymouri	30%	100%
A0A0S4IUJ1	Bodo saltans	53%	96%
A0A0S4KFV6	Bodo saltans	31%	98%
A0A1X0NHX2	Trypanosomatidae	29%	96%
A0A1X0P2L6	Trypanosomatidae	70%	96%
A0A3S7X938	Leishmania donovani	30%	100%
A0A422N9N5	Trypanosoma rangeli	28%	100%
A0A422NGW3	Trypanosoma rangeli	69%	100%
A4HMG0	Leishmania braziliensis	30%	100%
A4HRI8	Leishmania infantum	100%	100%
A4IB31	Leishmania infantum	30%	100%
C9ZNM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZXM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AC56	Leishmania major	97%	100%
E9AEW1	Leishmania major	30%	100%
E9AJF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B617	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O04308	Arabidopsis thaliana	25%	99%
O05945	Rickettsia prowazekii (strain Madrid E)	21%	100%
O32965	Mycobacterium leprae (strain TN)	25%	100%
O75439	Homo sapiens	35%	100%
O86835	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	22%	100%
O94745	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	98%
P07256	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P0A5S9	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	24%	100%
P10507	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P11913	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	33%	100%
P11914	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P20069	Rattus norvegicus	27%	94%
P22695	Homo sapiens	21%	100%
P23004	Bos taurus	22%	100%
P29677	Solanum tuberosum	25%	98%
P31800	Bos taurus	33%	100%
P31930	Homo sapiens	33%	100%
P32551	Rattus norvegicus	20%	100%
P43264	Euglena gracilis	40%	100%
P97997	Blastocladiella emersonii	25%	100%
P98080	Caenorhabditis elegans	28%	100%
P9WHT4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	24%	100%
P9WHT5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	24%	100%
Q00302	Blastocladiella emersonii	34%	100%
Q03346	Rattus norvegicus	36%	100%
Q04805	Bacillus subtilis (strain 168)	25%	100%
Q0P5M8	Bos taurus	28%	94%
Q10713	Homo sapiens	27%	94%
Q1RJ61	Rickettsia bellii (strain RML369-C)	22%	100%
Q23295	Caenorhabditis elegans	34%	100%
Q3SZ71	Bos taurus	37%	100%
Q42290	Arabidopsis thaliana	35%	93%
Q4UML9	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	22%	100%
Q4W6B5	Dictyostelium discoideum	32%	100%
Q54F93	Dictyostelium discoideum	23%	100%
Q5R513	Pongo abelii	28%	94%
Q5REK3	Pongo abelii	34%	100%
Q68FY0	Rattus norvegicus	32%	100%
Q92IX7	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	22%	100%
Q9CXT8	Mus musculus	36%	100%
Q9CZ13	Mus musculus	32%	100%
Q9DC61	Mus musculus	27%	94%
Q9P7X1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q9Y8B5	Lentinula edodes	36%	100%
Q9ZU25	Arabidopsis thaliana	25%	98%
V5BGV2	Trypanosoma cruzi	29%	100%
V5BH27	Trypanosoma cruzi	70%	100%