EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJB6_LEIDO

TriTrypDb:

LdBPK_010640.1 , LdCL_010011400 , LDHU3_01.0720

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.480
CLV_NRD_NRD_1	285	287	PF00675	0.764
CLV_NRD_NRD_1	320	322	PF00675	0.680
CLV_NRD_NRD_1	339	341	PF00675	0.818
CLV_NRD_NRD_1	413	415	PF00675	0.748
CLV_NRD_NRD_1	461	463	PF00675	0.714
CLV_NRD_NRD_1	486	488	PF00675	0.602
CLV_NRD_NRD_1	543	545	PF00675	0.623
CLV_PCSK_FUR_1	337	341	PF00082	0.679
CLV_PCSK_FUR_1	459	463	PF00082	0.714
CLV_PCSK_FUR_1	533	537	PF00082	0.589
CLV_PCSK_KEX2_1	284	286	PF00082	0.770
CLV_PCSK_KEX2_1	319	321	PF00082	0.682
CLV_PCSK_KEX2_1	339	341	PF00082	0.566
CLV_PCSK_KEX2_1	413	415	PF00082	0.696
CLV_PCSK_KEX2_1	446	448	PF00082	0.689
CLV_PCSK_KEX2_1	461	463	PF00082	0.696
CLV_PCSK_KEX2_1	486	488	PF00082	0.623
CLV_PCSK_KEX2_1	535	537	PF00082	0.588
CLV_PCSK_KEX2_1	541	543	PF00082	0.607
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.689
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.588
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.607
CLV_PCSK_PC7_1	457	463	PF00082	0.748
CLV_PCSK_PC7_1	531	537	PF00082	0.588
CLV_PCSK_SKI1_1	81	85	PF00082	0.395
DEG_APCC_DBOX_1	105	113	PF00400	0.463
DEG_APCC_DBOX_1	530	538	PF00400	0.645
DEG_APCC_DBOX_1	80	88	PF00400	0.403
DEG_Kelch_Keap1_1	253	258	PF01344	0.648
DEG_SCF_FBW7_1	304	311	PF00400	0.710
DEG_SCF_FBW7_1	383	389	PF00400	0.647
DEG_SPOP_SBC_1	249	253	PF00917	0.671
DOC_ANK_TNKS_1	570	577	PF00023	0.665
DOC_CDC14_PxL_1	45	53	PF14671	0.519
DOC_CKS1_1	383	388	PF01111	0.656
DOC_MAPK_gen_1	101	109	PF00069	0.482
DOC_MAPK_MEF2A_6	214	222	PF00069	0.430
DOC_MAPK_MEF2A_6	515	524	PF00069	0.552
DOC_PP2B_LxvP_1	384	387	PF13499	0.658
DOC_PP4_FxxP_1	505	508	PF00568	0.629
DOC_USP7_MATH_1	147	151	PF00917	0.670
DOC_USP7_MATH_1	24	28	PF00917	0.552
DOC_USP7_MATH_1	262	266	PF00917	0.657
DOC_USP7_MATH_1	379	383	PF00917	0.710
DOC_USP7_MATH_1	419	423	PF00917	0.669
DOC_USP7_MATH_1	437	441	PF00917	0.630
DOC_USP7_MATH_1	451	455	PF00917	0.643
DOC_USP7_MATH_1	508	512	PF00917	0.660
DOC_USP7_MATH_1	589	593	PF00917	0.695
DOC_USP7_UBL2_3	541	545	PF12436	0.604
DOC_WW_Pin1_4	18	23	PF00397	0.725
DOC_WW_Pin1_4	304	309	PF00397	0.770
DOC_WW_Pin1_4	332	337	PF00397	0.647
DOC_WW_Pin1_4	339	344	PF00397	0.655
DOC_WW_Pin1_4	382	387	PF00397	0.671
DOC_WW_Pin1_4	422	427	PF00397	0.671
DOC_WW_Pin1_4	515	520	PF00397	0.597
DOC_WW_Pin1_4	583	588	PF00397	0.706
LIG_14-3-3_CanoR_1	284	293	PF00244	0.777
LIG_14-3-3_CanoR_1	299	304	PF00244	0.594
LIG_14-3-3_CanoR_1	309	314	PF00244	0.670
LIG_14-3-3_CanoR_1	320	326	PF00244	0.690
LIG_14-3-3_CanoR_1	355	363	PF00244	0.727
LIG_14-3-3_CanoR_1	487	493	PF00244	0.546
LIG_14-3-3_CanoR_1	525	534	PF00244	0.597
LIG_14-3-3_CanoR_1	562	566	PF00244	0.649
LIG_14-3-3_CanoR_1	58	67	PF00244	0.485
LIG_APCC_ABBA_1	402	407	PF00400	0.512
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BIR_III_1	1	5	PF00653	0.557
LIG_BIR_III_3	1	5	PF00653	0.557
LIG_DLG_GKlike_1	299	307	PF00625	0.709
LIG_DLG_GKlike_1	309	317	PF00625	0.604
LIG_FHA_1	111	117	PF00498	0.500
LIG_FHA_1	217	223	PF00498	0.450
LIG_FHA_1	226	232	PF00498	0.444
LIG_FHA_1	305	311	PF00498	0.680
LIG_FHA_2	206	212	PF00498	0.489
LIG_FHA_2	250	256	PF00498	0.725
LIG_FHA_2	390	396	PF00498	0.610
LIG_GSK3_LRP6_1	386	392	PF00069	0.512
LIG_Integrin_isoDGR_2	370	372	PF01839	0.600
LIG_LIR_Apic_2	401	406	PF02991	0.496
LIG_LIR_Apic_2	504	508	PF02991	0.670
LIG_LIR_Apic_2	511	517	PF02991	0.648
LIG_LIR_Gen_1	113	123	PF02991	0.572
LIG_LIR_Gen_1	238	245	PF02991	0.423
LIG_LIR_Gen_1	61	67	PF02991	0.485
LIG_LIR_Nem_3	113	118	PF02991	0.564
LIG_LIR_Nem_3	159	163	PF02991	0.661
LIG_LIR_Nem_3	238	242	PF02991	0.424
LIG_LIR_Nem_3	407	412	PF02991	0.496
LIG_LIR_Nem_3	61	66	PF02991	0.430
LIG_NRBOX	299	305	PF00104	0.587
LIG_Pex14_2	242	246	PF04695	0.424
LIG_SH2_CRK	409	413	PF00017	0.521
LIG_SH2_CRK	514	518	PF00017	0.617
LIG_SH2_STAP1	565	569	PF00017	0.658
LIG_SH2_STAT5	115	118	PF00017	0.453
LIG_SH2_STAT5	13	16	PF00017	0.539
LIG_SH2_STAT5	239	242	PF00017	0.479
LIG_SH2_STAT5	403	406	PF00017	0.498
LIG_SH3_3	384	390	PF00018	0.601
LIG_SH3_3	510	516	PF00018	0.656
LIG_SUMO_SIM_par_1	108	113	PF11976	0.513
LIG_SUMO_SIM_par_1	218	224	PF11976	0.446
LIG_SUMO_SIM_par_1	392	401	PF11976	0.581
LIG_TRAF2_1	392	395	PF00917	0.617
LIG_UBA3_1	40	47	PF00899	0.518
MOD_CDK_SPK_2	304	309	PF00069	0.710
MOD_CDK_SPK_2	332	337	PF00069	0.729
MOD_CDK_SPxxK_3	332	339	PF00069	0.669
MOD_CDK_SPxxK_3	583	590	PF00069	0.708
MOD_CK1_1	247	253	PF00069	0.700
MOD_CK1_1	288	294	PF00069	0.689
MOD_CK1_1	349	355	PF00069	0.796
MOD_CK1_1	382	388	PF00069	0.777
MOD_CK1_1	422	428	PF00069	0.690
MOD_CK1_1	449	455	PF00069	0.673
MOD_CK1_1	61	67	PF00069	0.543
MOD_CK2_1	249	255	PF00069	0.715
MOD_CK2_1	262	268	PF00069	0.548
MOD_CK2_1	389	395	PF00069	0.565
MOD_CK2_1	89	95	PF00069	0.414
MOD_Cter_Amidation	484	487	PF01082	0.654
MOD_DYRK1A_RPxSP_1	515	519	PF00069	0.556
MOD_GlcNHglycan	149	152	PF01048	0.756
MOD_GlcNHglycan	163	166	PF01048	0.546
MOD_GlcNHglycan	197	203	PF01048	0.412
MOD_GlcNHglycan	233	236	PF01048	0.510
MOD_GlcNHglycan	255	258	PF01048	0.681
MOD_GlcNHglycan	28	31	PF01048	0.569
MOD_GlcNHglycan	289	293	PF01048	0.667
MOD_GlcNHglycan	421	424	PF01048	0.690
MOD_GlcNHglycan	439	442	PF01048	0.671
MOD_GlcNHglycan	453	456	PF01048	0.665
MOD_GlcNHglycan	470	473	PF01048	0.787
MOD_GlcNHglycan	474	477	PF01048	0.738
MOD_GlcNHglycan	63	66	PF01048	0.550
MOD_GSK3_1	147	154	PF00069	0.683
MOD_GSK3_1	18	25	PF00069	0.704
MOD_GSK3_1	221	228	PF00069	0.567
MOD_GSK3_1	244	251	PF00069	0.579
MOD_GSK3_1	284	291	PF00069	0.773
MOD_GSK3_1	304	311	PF00069	0.439
MOD_GSK3_1	339	346	PF00069	0.683
MOD_GSK3_1	351	358	PF00069	0.488
MOD_GSK3_1	371	378	PF00069	0.723
MOD_GSK3_1	382	389	PF00069	0.588
MOD_GSK3_1	449	456	PF00069	0.743
MOD_GSK3_1	468	475	PF00069	0.700
MOD_GSK3_1	520	527	PF00069	0.590
MOD_GSK3_1	54	61	PF00069	0.510
MOD_GSK3_1	561	568	PF00069	0.675
MOD_GSK3_1	577	584	PF00069	0.563
MOD_LATS_1	297	303	PF00433	0.696
MOD_N-GLC_1	468	473	PF02516	0.685
MOD_N-GLC_1	525	530	PF02516	0.603
MOD_NEK2_1	163	168	PF00069	0.637
MOD_NEK2_1	205	210	PF00069	0.485
MOD_NEK2_1	293	298	PF00069	0.728
MOD_NEK2_1	467	472	PF00069	0.687
MOD_NEK2_1	520	525	PF00069	0.592
MOD_PIKK_1	110	116	PF00454	0.474
MOD_PIKK_1	244	250	PF00454	0.623
MOD_PIKK_1	319	325	PF00454	0.748
MOD_PIKK_1	343	349	PF00454	0.664
MOD_PKA_1	284	290	PF00069	0.749
MOD_PKA_1	319	325	PF00069	0.684
MOD_PKA_1	446	452	PF00069	0.685
MOD_PKA_2	271	277	PF00069	0.706
MOD_PKA_2	284	290	PF00069	0.626
MOD_PKA_2	308	314	PF00069	0.656
MOD_PKA_2	319	325	PF00069	0.686
MOD_PKA_2	354	360	PF00069	0.727
MOD_PKA_2	371	377	PF00069	0.642
MOD_PKA_2	446	452	PF00069	0.724
MOD_PKA_2	477	483	PF00069	0.705
MOD_PKA_2	524	530	PF00069	0.599
MOD_PKA_2	561	567	PF00069	0.650
MOD_PKB_1	319	327	PF00069	0.612
MOD_Plk_1	184	190	PF00069	0.451
MOD_Plk_1	525	531	PF00069	0.578
MOD_Plk_1	54	60	PF00069	0.459
MOD_Plk_4	221	227	PF00069	0.547
MOD_Plk_4	299	305	PF00069	0.656
MOD_Plk_4	379	385	PF00069	0.686
MOD_Plk_4	439	445	PF00069	0.657
MOD_ProDKin_1	18	24	PF00069	0.724
MOD_ProDKin_1	304	310	PF00069	0.769
MOD_ProDKin_1	332	338	PF00069	0.648
MOD_ProDKin_1	339	345	PF00069	0.655
MOD_ProDKin_1	382	388	PF00069	0.661
MOD_ProDKin_1	422	428	PF00069	0.671
MOD_ProDKin_1	515	521	PF00069	0.593
MOD_ProDKin_1	583	589	PF00069	0.704
TRG_DiLeu_BaEn_1	394	399	PF01217	0.532
TRG_ENDOCYTIC_2	115	118	PF00928	0.394
TRG_ENDOCYTIC_2	160	163	PF00928	0.665
TRG_ENDOCYTIC_2	239	242	PF00928	0.418
TRG_ENDOCYTIC_2	409	412	PF00928	0.585
TRG_ER_diArg_1	283	286	PF00400	0.777
TRG_ER_diArg_1	318	321	PF00400	0.683
TRG_ER_diArg_1	336	339	PF00400	0.786
TRG_ER_diArg_1	412	414	PF00400	0.689
TRG_ER_diArg_1	459	462	PF00400	0.744
TRG_ER_diArg_1	530	533	PF00400	0.529
TRG_NES_CRM1_1	72	86	PF08389	0.436
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P577	Leptomonas seymouri	43%	93%
A4H333	Leishmania braziliensis	64%	100%
A4HRI5	Leishmania infantum	98%	99%
C9ZXL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AC53	Leishmania major	88%	99%
E9AJE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%