Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania donovani

UniProt:

A0A451EJB3_LEIDO

TriTrypDb:

LdBPK_010600.1 , LdCL_010011000 , LDHU3_01.0680

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJB3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.642
CLV_C14_Caspase3-7	413	417	PF00656	0.504
CLV_C14_Caspase3-7	45	49	PF00656	0.698
CLV_C14_Caspase3-7	868	872	PF00656	0.769
CLV_C14_Caspase3-7	890	894	PF00656	0.732
CLV_NRD_NRD_1	399	401	PF00675	0.467
CLV_NRD_NRD_1	432	434	PF00675	0.501
CLV_NRD_NRD_1	464	466	PF00675	0.589
CLV_NRD_NRD_1	56	58	PF00675	0.742
CLV_NRD_NRD_1	563	565	PF00675	0.589
CLV_NRD_NRD_1	862	864	PF00675	0.773
CLV_PCSK_FUR_1	560	564	PF00082	0.535
CLV_PCSK_KEX2_1	432	434	PF00082	0.543
CLV_PCSK_KEX2_1	55	57	PF00082	0.759
CLV_PCSK_KEX2_1	559	561	PF00082	0.507
CLV_PCSK_KEX2_1	562	564	PF00082	0.553
CLV_PCSK_KEX2_1	862	864	PF00082	0.773
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.507
CLV_PCSK_SKI1_1	221	225	PF00082	0.544
CLV_PCSK_SKI1_1	285	289	PF00082	0.551
CLV_PCSK_SKI1_1	400	404	PF00082	0.416
CLV_PCSK_SKI1_1	435	439	PF00082	0.481
CLV_PCSK_SKI1_1	546	550	PF00082	0.455
CLV_PCSK_SKI1_1	60	64	PF00082	0.661
CLV_PCSK_SKI1_1	68	72	PF00082	0.559
CLV_PCSK_SKI1_1	735	739	PF00082	0.510
CLV_PCSK_SKI1_1	914	918	PF00082	0.610
DEG_APCC_DBOX_1	806	814	PF00400	0.554
DEG_MDM2_SWIB_1	800	808	PF02201	0.433
DEG_SCF_FBW7_1	348	355	PF00400	0.603
DEG_SCF_FBW7_1	422	428	PF00400	0.721
DEG_SPOP_SBC_1	145	149	PF00917	0.567
DEG_SPOP_SBC_1	328	332	PF00917	0.806
DOC_CKS1_1	349	354	PF01111	0.606
DOC_CKS1_1	422	427	PF01111	0.723
DOC_CKS1_1	737	742	PF01111	0.505
DOC_CYCLIN_RxL_1	279	292	PF00134	0.523
DOC_MAPK_DCC_7	807	815	PF00069	0.555
DOC_MAPK_gen_1	432	438	PF00069	0.528
DOC_MAPK_gen_1	63	71	PF00069	0.541
DOC_MAPK_gen_1	954	962	PF00069	0.497
DOC_MAPK_MEF2A_6	124	132	PF00069	0.584
DOC_MAPK_MEF2A_6	475	484	PF00069	0.466
DOC_MAPK_MEF2A_6	629	638	PF00069	0.532
DOC_MAPK_MEF2A_6	735	744	PF00069	0.479
DOC_MAPK_MEF2A_6	807	815	PF00069	0.555
DOC_MAPK_MEF2A_6	956	964	PF00069	0.533
DOC_PP1_RVXF_1	433	439	PF00149	0.573
DOC_PP1_RVXF_1	952	958	PF00149	0.407
DOC_PP2B_LxvP_1	179	182	PF13499	0.456
DOC_PP2B_PxIxI_1	127	133	PF00149	0.587
DOC_PP2B_PxIxI_1	739	745	PF00149	0.437
DOC_SPAK_OSR1_1	475	479	PF12202	0.505
DOC_SPAK_OSR1_1	66	70	PF12202	0.581
DOC_USP7_MATH_1	101	105	PF00917	0.667
DOC_USP7_MATH_1	141	145	PF00917	0.518
DOC_USP7_MATH_1	19	23	PF00917	0.767
DOC_USP7_MATH_1	255	259	PF00917	0.628
DOC_USP7_MATH_1	277	281	PF00917	0.619
DOC_USP7_MATH_1	313	317	PF00917	0.799
DOC_USP7_MATH_1	327	331	PF00917	0.795
DOC_USP7_MATH_1	389	393	PF00917	0.459
DOC_USP7_MATH_1	4	8	PF00917	0.733
DOC_USP7_MATH_1	512	516	PF00917	0.726
DOC_USP7_MATH_1	519	523	PF00917	0.740
DOC_USP7_MATH_1	582	586	PF00917	0.615
DOC_USP7_MATH_1	630	634	PF00917	0.532
DOC_USP7_MATH_1	825	829	PF00917	0.692
DOC_USP7_MATH_1	85	89	PF00917	0.715
DOC_USP7_MATH_1	875	879	PF00917	0.740
DOC_USP7_MATH_1	940	944	PF00917	0.454
DOC_WW_Pin1_4	15	20	PF00397	0.755
DOC_WW_Pin1_4	197	202	PF00397	0.608
DOC_WW_Pin1_4	240	245	PF00397	0.644
DOC_WW_Pin1_4	251	256	PF00397	0.639
DOC_WW_Pin1_4	278	283	PF00397	0.538
DOC_WW_Pin1_4	297	302	PF00397	0.531
DOC_WW_Pin1_4	31	36	PF00397	0.789
DOC_WW_Pin1_4	348	353	PF00397	0.628
DOC_WW_Pin1_4	421	426	PF00397	0.666
DOC_WW_Pin1_4	529	534	PF00397	0.507
DOC_WW_Pin1_4	730	735	PF00397	0.557
DOC_WW_Pin1_4	736	741	PF00397	0.493
LIG_14-3-3_CanoR_1	221	230	PF00244	0.570
LIG_14-3-3_CanoR_1	400	409	PF00244	0.404
LIG_14-3-3_CanoR_1	465	470	PF00244	0.510
LIG_14-3-3_CanoR_1	475	479	PF00244	0.470
LIG_14-3-3_CanoR_1	562	567	PF00244	0.529
LIG_14-3-3_CanoR_1	644	650	PF00244	0.516
LIG_14-3-3_CanoR_1	658	668	PF00244	0.678
LIG_14-3-3_CanoR_1	779	787	PF00244	0.692
LIG_14-3-3_CanoR_1	849	853	PF00244	0.424
LIG_AP2alpha_2	421	423	PF02296	0.721
LIG_APCC_ABBA_1	680	685	PF00400	0.562
LIG_BIR_II_1	1	5	PF00653	0.733
LIG_BRCT_BRCA1_1	372	376	PF00533	0.437
LIG_BRCT_BRCA1_1	902	906	PF00533	0.690
LIG_Clathr_ClatBox_1	673	677	PF01394	0.430
LIG_CtBP_PxDLS_1	94	98	PF00389	0.636
LIG_eIF4E_1	836	842	PF01652	0.516
LIG_EVH1_1	349	353	PF00568	0.638
LIG_EVH1_2	651	655	PF00568	0.522
LIG_FHA_1	229	235	PF00498	0.642
LIG_FHA_1	255	261	PF00498	0.633
LIG_FHA_1	385	391	PF00498	0.441
LIG_FHA_1	397	403	PF00498	0.463
LIG_FHA_1	547	553	PF00498	0.519
LIG_FHA_1	645	651	PF00498	0.531
LIG_FHA_1	669	675	PF00498	0.462
LIG_FHA_1	737	743	PF00498	0.493
LIG_FHA_1	757	763	PF00498	0.592
LIG_FHA_1	781	787	PF00498	0.753
LIG_FHA_1	906	912	PF00498	0.683
LIG_FHA_2	111	117	PF00498	0.684
LIG_FHA_2	204	210	PF00498	0.512
LIG_FHA_2	32	38	PF00498	0.799
LIG_FHA_2	333	339	PF00498	0.654
LIG_FHA_2	43	49	PF00498	0.487
LIG_FHA_2	652	658	PF00498	0.617
LIG_GBD_Chelix_1	260	268	PF00786	0.552
LIG_Integrin_RGD_1	218	220	PF01839	0.575
LIG_LIR_Apic_2	647	652	PF02991	0.525
LIG_LIR_Gen_1	167	176	PF02991	0.633
LIG_LIR_Gen_1	254	264	PF02991	0.462
LIG_LIR_Gen_1	367	377	PF02991	0.390
LIG_LIR_Gen_1	573	583	PF02991	0.582
LIG_LIR_Gen_1	640	650	PF02991	0.455
LIG_LIR_Gen_1	716	726	PF02991	0.459
LIG_LIR_Gen_1	753	763	PF02991	0.559
LIG_LIR_Gen_1	913	921	PF02991	0.567
LIG_LIR_Nem_3	148	154	PF02991	0.553
LIG_LIR_Nem_3	167	171	PF02991	0.417
LIG_LIR_Nem_3	254	259	PF02991	0.485
LIG_LIR_Nem_3	367	372	PF02991	0.404
LIG_LIR_Nem_3	420	426	PF02991	0.696
LIG_LIR_Nem_3	573	578	PF02991	0.598
LIG_LIR_Nem_3	585	591	PF02991	0.383
LIG_LIR_Nem_3	640	645	PF02991	0.475
LIG_LIR_Nem_3	716	721	PF02991	0.478
LIG_LIR_Nem_3	753	758	PF02991	0.474
LIG_LIR_Nem_3	850	855	PF02991	0.386
LIG_LIR_Nem_3	903	909	PF02991	0.643
LIG_LIR_Nem_3	913	918	PF02991	0.546
LIG_LYPXL_SIV_4	717	725	PF13949	0.475
LIG_LYPXL_yS_3	151	154	PF13949	0.592
LIG_MLH1_MIPbox_1	372	376	PF16413	0.437
LIG_NRBOX	283	289	PF00104	0.537
LIG_NRBOX	492	498	PF00104	0.433
LIG_NRBOX	757	763	PF00104	0.541
LIG_PAM2_1	637	649	PF00658	0.346
LIG_PCNA_PIPBox_1	498	507	PF02747	0.436
LIG_PDZ_Class_2	959	964	PF00595	0.530
LIG_Pex14_1	853	857	PF04695	0.479
LIG_Pex14_2	800	804	PF04695	0.453
LIG_PTAP_UEV_1	300	305	PF05743	0.766
LIG_PTB_Apo_2	620	627	PF02174	0.558
LIG_REV1ctd_RIR_1	449	459	PF16727	0.556
LIG_SH2_CRK	256	260	PF00017	0.463
LIG_SH2_CRK	386	390	PF00017	0.548
LIG_SH2_CRK	589	593	PF00017	0.488
LIG_SH2_CRK	718	722	PF00017	0.536
LIG_SH2_NCK_1	589	593	PF00017	0.510
LIG_SH2_NCK_1	718	722	PF00017	0.536
LIG_SH2_PTP2	915	918	PF00017	0.600
LIG_SH2_SRC	649	652	PF00017	0.552
LIG_SH2_STAP1	256	260	PF00017	0.566
LIG_SH2_STAP1	642	646	PF00017	0.482
LIG_SH2_STAT5	146	149	PF00017	0.572
LIG_SH2_STAT5	193	196	PF00017	0.653
LIG_SH2_STAT5	256	259	PF00017	0.651
LIG_SH2_STAT5	375	378	PF00017	0.480
LIG_SH2_STAT5	386	389	PF00017	0.519
LIG_SH2_STAT5	649	652	PF00017	0.544
LIG_SH2_STAT5	736	739	PF00017	0.521
LIG_SH2_STAT5	836	839	PF00017	0.531
LIG_SH2_STAT5	915	918	PF00017	0.600
LIG_SH3_2	427	432	PF14604	0.685
LIG_SH3_3	122	128	PF00018	0.597
LIG_SH3_3	185	191	PF00018	0.376
LIG_SH3_3	25	31	PF00018	0.827
LIG_SH3_3	298	304	PF00018	0.697
LIG_SH3_3	32	38	PF00018	0.668
LIG_SH3_3	344	350	PF00018	0.617
LIG_SH3_3	416	422	PF00018	0.665
LIG_SH3_3	424	430	PF00018	0.562
LIG_SH3_3	527	533	PF00018	0.477
LIG_SH3_3	633	639	PF00018	0.454
LIG_SH3_3	699	705	PF00018	0.494
LIG_SH3_3	810	816	PF00018	0.562
LIG_SH3_3	915	921	PF00018	0.534
LIG_SH3_3	923	929	PF00018	0.501
LIG_SUMO_SIM_anti_2	698	703	PF11976	0.413
LIG_SUMO_SIM_par_1	671	678	PF11976	0.378
LIG_SUMO_SIM_par_1	907	913	PF11976	0.626
LIG_TRAF2_1	444	447	PF00917	0.561
LIG_TRFH_1	736	740	PF08558	0.484
LIG_TRFH_1	925	929	PF08558	0.480
LIG_TYR_ITSM	147	154	PF00017	0.624
LIG_TYR_ITSM	714	721	PF00017	0.540
LIG_WRC_WIRS_1	165	170	PF05994	0.639
LIG_WRC_WIRS_1	638	643	PF05994	0.524
LIG_WRC_WIRS_1	86	91	PF05994	0.659
LIG_WW_2	347	350	PF00397	0.656
LIG_WW_3	429	433	PF00397	0.605
MOD_CDK_SPK_2	730	735	PF00069	0.481
MOD_CDK_SPxxK_3	278	285	PF00069	0.607
MOD_CK1_1	13	19	PF00069	0.792
MOD_CK1_1	144	150	PF00069	0.580
MOD_CK1_1	172	178	PF00069	0.471
MOD_CK1_1	2	8	PF00069	0.753
MOD_CK1_1	254	260	PF00069	0.613
MOD_CK1_1	299	305	PF00069	0.766
MOD_CK1_1	330	336	PF00069	0.794
MOD_CK1_1	365	371	PF00069	0.459
MOD_CK1_1	396	402	PF00069	0.532
MOD_CK1_1	454	460	PF00069	0.557
MOD_CK1_1	517	523	PF00069	0.576
MOD_CK1_1	532	538	PF00069	0.432
MOD_CK1_1	565	571	PF00069	0.603
MOD_CK1_1	766	772	PF00069	0.692
MOD_CK1_1	778	784	PF00069	0.674
MOD_CK1_1	803	809	PF00069	0.479
MOD_CK1_1	87	93	PF00069	0.712
MOD_CK1_1	878	884	PF00069	0.698
MOD_CK2_1	102	108	PF00069	0.657
MOD_CK2_1	174	180	PF00069	0.525
MOD_CK2_1	31	37	PF00069	0.809
MOD_CK2_1	332	338	PF00069	0.697
MOD_CK2_1	657	663	PF00069	0.706
MOD_CK2_1	778	784	PF00069	0.799
MOD_CK2_1	878	884	PF00069	0.762
MOD_GlcNHglycan	143	146	PF01048	0.509
MOD_GlcNHglycan	2	5	PF01048	0.735
MOD_GlcNHglycan	21	24	PF01048	0.804
MOD_GlcNHglycan	301	304	PF01048	0.701
MOD_GlcNHglycan	313	316	PF01048	0.731
MOD_GlcNHglycan	322	325	PF01048	0.560
MOD_GlcNHglycan	364	367	PF01048	0.491
MOD_GlcNHglycan	393	396	PF01048	0.536
MOD_GlcNHglycan	507	510	PF01048	0.551
MOD_GlcNHglycan	512	515	PF01048	0.588
MOD_GlcNHglycan	519	522	PF01048	0.625
MOD_GlcNHglycan	553	556	PF01048	0.502
MOD_GlcNHglycan	6	9	PF01048	0.745
MOD_GlcNHglycan	677	680	PF01048	0.472
MOD_GlcNHglycan	745	748	PF01048	0.470
MOD_GlcNHglycan	829	832	PF01048	0.682
MOD_GlcNHglycan	857	860	PF01048	0.639
MOD_GlcNHglycan	871	874	PF01048	0.719
MOD_GlcNHglycan	877	880	PF01048	0.748
MOD_GlcNHglycan	95	100	PF01048	0.637
MOD_GSK3_1	10	17	PF00069	0.791
MOD_GSK3_1	141	148	PF00069	0.508
MOD_GSK3_1	153	160	PF00069	0.512
MOD_GSK3_1	19	26	PF00069	0.668
MOD_GSK3_1	203	210	PF00069	0.496
MOD_GSK3_1	251	258	PF00069	0.597
MOD_GSK3_1	289	296	PF00069	0.576
MOD_GSK3_1	327	334	PF00069	0.731
MOD_GSK3_1	348	355	PF00069	0.678
MOD_GSK3_1	389	396	PF00069	0.420
MOD_GSK3_1	421	428	PF00069	0.671
MOD_GSK3_1	510	517	PF00069	0.567
MOD_GSK3_1	668	675	PF00069	0.508
MOD_GSK3_1	709	716	PF00069	0.529
MOD_GSK3_1	75	82	PF00069	0.730
MOD_GSK3_1	762	769	PF00069	0.516
MOD_GSK3_1	775	782	PF00069	0.746
MOD_GSK3_1	940	947	PF00069	0.513
MOD_N-GLC_1	505	510	PF02516	0.458
MOD_N-GLC_1	763	768	PF02516	0.608
MOD_N-GLC_1	775	780	PF02516	0.725
MOD_N-GLC_2	121	123	PF02516	0.607
MOD_NEK2_1	12	17	PF00069	0.711
MOD_NEK2_1	153	158	PF00069	0.598
MOD_NEK2_1	384	389	PF00069	0.487
MOD_NEK2_1	393	398	PF00069	0.436
MOD_NEK2_1	451	456	PF00069	0.570
MOD_NEK2_1	492	497	PF00069	0.368
MOD_NEK2_1	505	510	PF00069	0.478
MOD_NEK2_1	551	556	PF00069	0.490
MOD_NEK2_1	645	650	PF00069	0.526
MOD_NEK2_1	727	732	PF00069	0.428
MOD_NEK2_1	800	805	PF00069	0.411
MOD_NEK2_1	841	846	PF00069	0.373
MOD_NEK2_1	897	902	PF00069	0.745
MOD_NEK2_1	944	949	PF00069	0.383
MOD_NEK2_2	940	945	PF00069	0.491
MOD_OFUCOSY	531	536	PF10250	0.510
MOD_PIKK_1	266	272	PF00454	0.610
MOD_PIKK_1	756	762	PF00454	0.524
MOD_PK_1	956	962	PF00069	0.530
MOD_PKA_1	400	406	PF00069	0.412
MOD_PKA_1	465	471	PF00069	0.456
MOD_PKA_1	546	552	PF00069	0.489
MOD_PKA_1	562	568	PF00069	0.435
MOD_PKA_2	214	220	PF00069	0.442
MOD_PKA_2	431	437	PF00069	0.510
MOD_PKA_2	474	480	PF00069	0.522
MOD_PKA_2	510	516	PF00069	0.693
MOD_PKA_2	562	568	PF00069	0.574
MOD_PKA_2	657	663	PF00069	0.708
MOD_PKA_2	778	784	PF00069	0.789
MOD_PKA_2	848	854	PF00069	0.427
MOD_PKB_1	560	568	PF00069	0.514
MOD_Plk_1	134	140	PF00069	0.553
MOD_Plk_1	748	754	PF00069	0.402
MOD_Plk_1	775	781	PF00069	0.724
MOD_Plk_4	134	140	PF00069	0.478
MOD_Plk_4	164	170	PF00069	0.557
MOD_Plk_4	183	189	PF00069	0.352
MOD_Plk_4	207	213	PF00069	0.523
MOD_Plk_4	255	261	PF00069	0.557
MOD_Plk_4	359	365	PF00069	0.420
MOD_Plk_4	591	597	PF00069	0.369
MOD_Plk_4	637	643	PF00069	0.525
MOD_Plk_4	645	651	PF00069	0.512
MOD_Plk_4	669	675	PF00069	0.469
MOD_Plk_4	848	854	PF00069	0.407
MOD_Plk_4	891	897	PF00069	0.669
MOD_Plk_4	940	946	PF00069	0.492
MOD_ProDKin_1	15	21	PF00069	0.754
MOD_ProDKin_1	197	203	PF00069	0.605
MOD_ProDKin_1	240	246	PF00069	0.646
MOD_ProDKin_1	251	257	PF00069	0.632
MOD_ProDKin_1	278	284	PF00069	0.530
MOD_ProDKin_1	297	303	PF00069	0.532
MOD_ProDKin_1	31	37	PF00069	0.790
MOD_ProDKin_1	348	354	PF00069	0.631
MOD_ProDKin_1	421	427	PF00069	0.667
MOD_ProDKin_1	529	535	PF00069	0.506
MOD_ProDKin_1	730	736	PF00069	0.560
MOD_SUMO_rev_2	539	549	PF00179	0.477
TRG_DiLeu_BaEn_1	207	212	PF01217	0.520
TRG_DiLeu_BaEn_1	414	419	PF01217	0.630
TRG_DiLeu_BaEn_1	479	484	PF01217	0.419
TRG_DiLeu_BaEn_1	684	689	PF01217	0.525
TRG_ENDOCYTIC_2	151	154	PF00928	0.547
TRG_ENDOCYTIC_2	165	168	PF00928	0.494
TRG_ENDOCYTIC_2	256	259	PF00928	0.472
TRG_ENDOCYTIC_2	588	591	PF00928	0.504
TRG_ENDOCYTIC_2	642	645	PF00928	0.461
TRG_ENDOCYTIC_2	718	721	PF00928	0.536
TRG_ENDOCYTIC_2	836	839	PF00928	0.531
TRG_ENDOCYTIC_2	915	918	PF00928	0.576
TRG_ER_diArg_1	431	433	PF00400	0.537
TRG_ER_diArg_1	54	57	PF00400	0.727
TRG_ER_diArg_1	560	563	PF00400	0.580
TRG_ER_diArg_1	791	794	PF00400	0.487
TRG_NLS_Bipartite_1	546	563	PF00514	0.399
TRG_NLS_MonoExtC_3	558	563	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V6	Leptomonas seymouri	59%	91%
A0A1X0P2P9	Trypanosomatidae	29%	100%
A0A3S5IR38	Trypanosoma rangeli	30%	100%
A4H381	Leishmania braziliensis	70%	100%
A4HRI1	Leishmania infantum	99%	100%
C9ZXL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AC49	Leishmania major	89%	100%
E9AJE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5AX28	Trypanosoma cruzi	29%	100%