LeishMANIAdb
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NYN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NYN domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A451EJ97_LEIDO
TriTrypDb:
LdBPK_010420.1 * , LdCL_010009200 , LDHU3_01.0450
Length:
568

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A451EJ97
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ97

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0031123 RNA 3'-end processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1
GO:0016779 nucleotidyltransferase activity 4 1
GO:0050265 RNA uridylyltransferase activity 4 1
GO:0070569 uridylyltransferase activity 5 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 108 112 PF00656 0.522
CLV_NRD_NRD_1 160 162 PF00675 0.647
CLV_NRD_NRD_1 196 198 PF00675 0.414
CLV_NRD_NRD_1 273 275 PF00675 0.576
CLV_NRD_NRD_1 287 289 PF00675 0.553
CLV_NRD_NRD_1 351 353 PF00675 0.581
CLV_NRD_NRD_1 356 358 PF00675 0.479
CLV_NRD_NRD_1 375 377 PF00675 0.265
CLV_NRD_NRD_1 403 405 PF00675 0.606
CLV_NRD_NRD_1 433 435 PF00675 0.441
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IL81 Leptomonas seymouri 37% 96%
A4H366 Leishmania braziliensis 69% 100%
A4HRG3 Leishmania infantum 99% 100%
E9AC31 Leishmania major 88% 98%
E9AJC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 97%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS