NYN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJ97_LEIDO

TriTrypDb:

LdBPK_010420.1 , LdCL_010009200 , LDHU3_01.0450

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A451EJ97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ97

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0031123	RNA 3'-end processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071076	RNA 3' uridylation	8	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0050265	RNA uridylyltransferase activity	4	1
GO:0070569	uridylyltransferase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.522
CLV_NRD_NRD_1	160	162	PF00675	0.647
CLV_NRD_NRD_1	196	198	PF00675	0.414
CLV_NRD_NRD_1	273	275	PF00675	0.576
CLV_NRD_NRD_1	287	289	PF00675	0.553
CLV_NRD_NRD_1	351	353	PF00675	0.581
CLV_NRD_NRD_1	356	358	PF00675	0.479
CLV_NRD_NRD_1	375	377	PF00675	0.265
CLV_NRD_NRD_1	403	405	PF00675	0.606
CLV_NRD_NRD_1	433	435	PF00675	0.441
CLV_NRD_NRD_1	529	531	PF00675	0.585
CLV_PCSK_FUR_1	373	377	PF00082	0.436
CLV_PCSK_KEX2_1	160	162	PF00082	0.647
CLV_PCSK_KEX2_1	196	198	PF00082	0.414
CLV_PCSK_KEX2_1	273	275	PF00082	0.603
CLV_PCSK_KEX2_1	287	289	PF00082	0.580
CLV_PCSK_KEX2_1	350	352	PF00082	0.563
CLV_PCSK_KEX2_1	356	358	PF00082	0.489
CLV_PCSK_KEX2_1	375	377	PF00082	0.367
CLV_PCSK_KEX2_1	433	435	PF00082	0.448
CLV_PCSK_KEX2_1	528	530	PF00082	0.587
CLV_PCSK_PC7_1	156	162	PF00082	0.521
CLV_PCSK_PC7_1	352	358	PF00082	0.531
CLV_PCSK_SKI1_1	295	299	PF00082	0.711
CLV_PCSK_SKI1_1	357	361	PF00082	0.583
CLV_PCSK_SKI1_1	375	379	PF00082	0.319
CLV_PCSK_SKI1_1	439	443	PF00082	0.440
CLV_PCSK_SKI1_1	453	457	PF00082	0.349
DEG_APCC_DBOX_1	374	382	PF00400	0.422
DEG_APCC_DBOX_1	433	441	PF00400	0.370
DEG_Nend_UBRbox_1	1	4	PF02207	0.560
DEG_SPOP_SBC_1	88	92	PF00917	0.599
DEG_SPOP_SBC_1	94	98	PF00917	0.602
DOC_CYCLIN_RxL_1	448	461	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	116	119	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	181	187	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.615
DOC_PP1_RVXF_1	133	140	PF00149	0.605
DOC_PP2B_LxvP_1	116	119	PF13499	0.567
DOC_PP2B_LxvP_1	148	151	PF13499	0.431
DOC_PP2B_LxvP_1	181	184	PF13499	0.465
DOC_PP2B_LxvP_1	300	303	PF13499	0.633
DOC_PP2B_LxvP_1	77	80	PF13499	0.635
DOC_PP4_FxxP_1	139	142	PF00568	0.483
DOC_USP7_MATH_1	23	27	PF00917	0.550
DOC_USP7_MATH_1	249	253	PF00917	0.746
DOC_USP7_MATH_1	272	276	PF00917	0.658
DOC_USP7_MATH_1	306	310	PF00917	0.636
DOC_USP7_MATH_1	313	317	PF00917	0.640
DOC_USP7_MATH_1	359	363	PF00917	0.601
DOC_USP7_MATH_1	368	372	PF00917	0.509
DOC_USP7_MATH_1	377	381	PF00917	0.301
DOC_USP7_MATH_1	396	400	PF00917	0.442
DOC_USP7_MATH_1	84	88	PF00917	0.640
DOC_USP7_MATH_1	93	97	PF00917	0.682
DOC_WW_Pin1_4	364	369	PF00397	0.431
DOC_WW_Pin1_4	67	72	PF00397	0.592
LIG_14-3-3_CanoR_1	357	366	PF00244	0.525
LIG_14-3-3_CanoR_1	424	429	PF00244	0.559
LIG_14-3-3_CanoR_1	63	68	PF00244	0.577
LIG_BIR_III_4	248	252	PF00653	0.617
LIG_eIF4E_1	149	155	PF01652	0.446
LIG_FHA_1	100	106	PF00498	0.571
LIG_FHA_1	214	220	PF00498	0.488
LIG_FHA_1	462	468	PF00498	0.388
LIG_FHA_1	500	506	PF00498	0.579
LIG_FHA_1	64	70	PF00498	0.520
LIG_FHA_2	456	462	PF00498	0.335
LIG_LIR_Apic_2	114	118	PF02991	0.526
LIG_LIR_Nem_3	70	76	PF02991	0.546
LIG_NRBOX	177	183	PF00104	0.374
LIG_PCNA_yPIPBox_3	156	166	PF02747	0.398
LIG_SH2_CRK	149	153	PF00017	0.502
LIG_SH2_NCK_1	42	46	PF00017	0.539
LIG_SH2_SRC	149	152	PF00017	0.536
LIG_SH2_SRC	413	416	PF00017	0.448
LIG_SH2_STAP1	168	172	PF00017	0.387
LIG_SH2_STAT5	207	210	PF00017	0.336
LIG_SH2_STAT5	386	389	PF00017	0.366
LIG_SH2_STAT5	408	411	PF00017	0.440
LIG_SH2_STAT5	562	565	PF00017	0.489
LIG_SH3_1	412	418	PF00018	0.496
LIG_SH3_3	107	113	PF00018	0.568
LIG_SH3_3	261	267	PF00018	0.653
LIG_SH3_3	300	306	PF00018	0.631
LIG_SH3_3	390	396	PF00018	0.459
LIG_SH3_3	412	418	PF00018	0.499
LIG_TRAF2_1	318	321	PF00917	0.631
LIG_UBA3_1	557	565	PF00899	0.359
LIG_WW_3	421	425	PF00397	0.499
MOD_CK1_1	25	31	PF00069	0.582
MOD_CK1_1	252	258	PF00069	0.766
MOD_CK1_1	304	310	PF00069	0.619
MOD_CK1_1	358	364	PF00069	0.446
MOD_CK1_1	87	93	PF00069	0.543
MOD_CK2_1	118	124	PF00069	0.607
MOD_CK2_1	315	321	PF00069	0.613
MOD_CK2_1	396	402	PF00069	0.457
MOD_CK2_1	455	461	PF00069	0.325
MOD_GlcNHglycan	120	123	PF01048	0.598
MOD_GlcNHglycan	247	252	PF01048	0.626
MOD_GlcNHglycan	254	257	PF01048	0.665
MOD_GlcNHglycan	306	309	PF01048	0.686
MOD_GlcNHglycan	325	328	PF01048	0.672
MOD_GlcNHglycan	357	360	PF01048	0.436
MOD_GlcNHglycan	361	364	PF01048	0.398
MOD_GlcNHglycan	388	391	PF01048	0.474
MOD_GlcNHglycan	492	495	PF01048	0.555
MOD_GlcNHglycan	502	505	PF01048	0.587
MOD_GlcNHglycan	91	94	PF01048	0.652
MOD_GSK3_1	118	125	PF00069	0.617
MOD_GSK3_1	209	216	PF00069	0.412
MOD_GSK3_1	252	259	PF00069	0.736
MOD_GSK3_1	262	269	PF00069	0.580
MOD_GSK3_1	355	362	PF00069	0.515
MOD_GSK3_1	364	371	PF00069	0.405
MOD_GSK3_1	461	468	PF00069	0.373
MOD_GSK3_1	63	70	PF00069	0.632
MOD_GSK3_1	84	91	PF00069	0.626
MOD_GSK3_1	95	102	PF00069	0.609
MOD_LATS_1	522	528	PF00433	0.594
MOD_LATS_1	61	67	PF00433	0.508
MOD_N-GLC_1	499	504	PF02516	0.598
MOD_NEK2_1	123	128	PF00069	0.528
MOD_NEK2_1	345	350	PF00069	0.580
MOD_NEK2_1	407	412	PF00069	0.391
MOD_NEK2_1	455	460	PF00069	0.368
MOD_OFUCOSY	210	217	PF10250	0.376
MOD_PIKK_1	123	129	PF00454	0.540
MOD_PIKK_1	394	400	PF00454	0.508
MOD_PIKK_1	416	422	PF00454	0.417
MOD_PKA_2	272	278	PF00069	0.624
MOD_PKA_2	280	286	PF00069	0.520
MOD_PKA_2	355	361	PF00069	0.473
MOD_Plk_2-3	164	170	PF00069	0.396
MOD_Plk_4	111	117	PF00069	0.587
MOD_Plk_4	173	179	PF00069	0.450
MOD_Plk_4	377	383	PF00069	0.488
MOD_ProDKin_1	364	370	PF00069	0.426
MOD_ProDKin_1	67	73	PF00069	0.587
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.467
TRG_ER_diArg_1	160	162	PF00400	0.593
TRG_ER_diArg_1	287	290	PF00400	0.601
TRG_ER_diArg_1	341	344	PF00400	0.583
TRG_ER_diArg_1	349	352	PF00400	0.525
TRG_ER_diArg_1	372	375	PF00400	0.452
TRG_ER_diArg_1	432	434	PF00400	0.455
TRG_ER_diArg_1	51	54	PF00400	0.664
TRG_ER_diArg_1	528	530	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	559	564	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL81	Leptomonas seymouri	37%	96%
A4H366	Leishmania braziliensis	69%	100%
A4HRG3	Leishmania infantum	99%	100%
E9AC31	Leishmania major	88%	98%
E9AJC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	97%