Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJ96_LEIDO

TriTrypDb:

LdBPK_010410.1 , LdCL_010009100 , LDHU3_01.0440

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJ96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.551
CLV_NRD_NRD_1	146	148	PF00675	0.732
CLV_NRD_NRD_1	166	168	PF00675	0.454
CLV_NRD_NRD_1	181	183	PF00675	0.498
CLV_NRD_NRD_1	311	313	PF00675	0.351
CLV_NRD_NRD_1	378	380	PF00675	0.497
CLV_NRD_NRD_1	476	478	PF00675	0.446
CLV_NRD_NRD_1	499	501	PF00675	0.421
CLV_NRD_NRD_1	568	570	PF00675	0.530
CLV_NRD_NRD_1	622	624	PF00675	0.532
CLV_NRD_NRD_1	652	654	PF00675	0.403
CLV_NRD_NRD_1	777	779	PF00675	0.620
CLV_PCSK_KEX2_1	146	148	PF00082	0.623
CLV_PCSK_KEX2_1	166	168	PF00082	0.476
CLV_PCSK_KEX2_1	311	313	PF00082	0.351
CLV_PCSK_KEX2_1	348	350	PF00082	0.476
CLV_PCSK_KEX2_1	378	380	PF00082	0.497
CLV_PCSK_KEX2_1	476	478	PF00082	0.533
CLV_PCSK_KEX2_1	499	501	PF00082	0.483
CLV_PCSK_KEX2_1	568	570	PF00082	0.509
CLV_PCSK_KEX2_1	652	654	PF00082	0.418
CLV_PCSK_KEX2_1	777	779	PF00082	0.620
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.476
CLV_PCSK_PC7_1	162	168	PF00082	0.502
CLV_PCSK_SKI1_1	166	170	PF00082	0.621
CLV_PCSK_SKI1_1	171	175	PF00082	0.617
CLV_PCSK_SKI1_1	311	315	PF00082	0.431
CLV_PCSK_SKI1_1	340	344	PF00082	0.544
CLV_PCSK_SKI1_1	362	366	PF00082	0.419
CLV_PCSK_SKI1_1	368	372	PF00082	0.398
CLV_PCSK_SKI1_1	448	452	PF00082	0.516
CLV_PCSK_SKI1_1	467	471	PF00082	0.427
CLV_PCSK_SKI1_1	526	530	PF00082	0.559
CLV_PCSK_SKI1_1	553	557	PF00082	0.611
CLV_PCSK_SKI1_1	571	575	PF00082	0.503
CLV_PCSK_SKI1_1	641	645	PF00082	0.424
CLV_PCSK_SKI1_1	704	708	PF00082	0.447
CLV_PCSK_SKI1_1	802	806	PF00082	0.617
CLV_Separin_Metazoa	788	792	PF03568	0.467
DEG_APCC_DBOX_1	166	174	PF00400	0.618
DEG_APCC_DBOX_1	722	730	PF00400	0.493
DEG_Nend_UBRbox_3	1	3	PF02207	0.759
DOC_CKS1_1	121	126	PF01111	0.517
DOC_CKS1_1	754	759	PF01111	0.480
DOC_CYCLIN_RxL_1	550	560	PF00134	0.396
DOC_CYCLIN_RxL_1	638	648	PF00134	0.479
DOC_CYCLIN_RxL_1	799	807	PF00134	0.615
DOC_MAPK_gen_1	222	229	PF00069	0.607
DOC_MAPK_gen_1	348	356	PF00069	0.594
DOC_MAPK_gen_1	568	578	PF00069	0.680
DOC_MAPK_MEF2A_6	222	229	PF00069	0.673
DOC_MAPK_MEF2A_6	569	578	PF00069	0.476
DOC_MAPK_NFAT4_5	222	230	PF00069	0.536
DOC_PP1_RVXF_1	186	192	PF00149	0.615
DOC_PP1_RVXF_1	573	579	PF00149	0.466
DOC_PP2B_LxvP_1	769	772	PF13499	0.532
DOC_PP2B_LxvP_1	817	820	PF13499	0.571
DOC_PP4_FxxP_1	356	359	PF00568	0.449
DOC_USP7_MATH_1	287	291	PF00917	0.726
DOC_USP7_MATH_1	342	346	PF00917	0.435
DOC_USP7_MATH_1	37	41	PF00917	0.662
DOC_USP7_MATH_1	370	374	PF00917	0.534
DOC_USP7_MATH_1	408	412	PF00917	0.474
DOC_USP7_MATH_1	435	439	PF00917	0.550
DOC_USP7_MATH_1	50	54	PF00917	0.534
DOC_USP7_MATH_1	508	512	PF00917	0.594
DOC_USP7_MATH_1	619	623	PF00917	0.529
DOC_USP7_MATH_1	72	76	PF00917	0.680
DOC_USP7_MATH_1	812	816	PF00917	0.679
DOC_USP7_UBL2_3	291	295	PF12436	0.626
DOC_WW_Pin1_4	10	15	PF00397	0.622
DOC_WW_Pin1_4	120	125	PF00397	0.512
DOC_WW_Pin1_4	261	266	PF00397	0.688
DOC_WW_Pin1_4	64	69	PF00397	0.722
DOC_WW_Pin1_4	753	758	PF00397	0.498
LIG_14-3-3_CanoR_1	128	132	PF00244	0.533
LIG_14-3-3_CanoR_1	166	171	PF00244	0.603
LIG_14-3-3_CanoR_1	224	228	PF00244	0.598
LIG_14-3-3_CanoR_1	448	456	PF00244	0.530
LIG_14-3-3_CanoR_1	476	484	PF00244	0.498
LIG_14-3-3_CanoR_1	526	534	PF00244	0.596
LIG_14-3-3_CanoR_1	623	633	PF00244	0.606
LIG_14-3-3_CanoR_1	761	767	PF00244	0.538
LIG_Actin_WH2_2	594	611	PF00022	0.542
LIG_BIR_III_2	770	774	PF00653	0.507
LIG_BRCT_BRCA1_1	12	16	PF00533	0.617
LIG_BRCT_BRCA1_1	352	356	PF00533	0.532
LIG_Clathr_ClatBox_1	726	730	PF01394	0.383
LIG_deltaCOP1_diTrp_1	700	706	PF00928	0.496
LIG_FHA_1	112	118	PF00498	0.577
LIG_FHA_1	140	146	PF00498	0.568
LIG_FHA_1	192	198	PF00498	0.553
LIG_FHA_1	326	332	PF00498	0.431
LIG_FHA_1	420	426	PF00498	0.682
LIG_FHA_1	455	461	PF00498	0.482
LIG_FHA_1	577	583	PF00498	0.547
LIG_FHA_1	668	674	PF00498	0.394
LIG_FHA_2	167	173	PF00498	0.598
LIG_FHA_2	424	430	PF00498	0.550
LIG_FHA_2	527	533	PF00498	0.551
LIG_FHA_2	555	561	PF00498	0.521
LIG_FHA_2	597	603	PF00498	0.584
LIG_LIR_Apic_2	353	359	PF02991	0.508
LIG_LIR_Gen_1	130	137	PF02991	0.586
LIG_LIR_Gen_1	453	463	PF02991	0.388
LIG_LIR_Gen_1	688	696	PF02991	0.408
LIG_LIR_Gen_1	756	766	PF02991	0.533
LIG_LIR_Nem_3	130	134	PF02991	0.581
LIG_LIR_Nem_3	150	156	PF02991	0.542
LIG_LIR_Nem_3	453	459	PF02991	0.372
LIG_LIR_Nem_3	688	694	PF02991	0.401
LIG_LIR_Nem_3	730	736	PF02991	0.380
LIG_LIR_Nem_3	756	762	PF02991	0.540
LIG_MLH1_MIPbox_1	12	16	PF16413	0.617
LIG_MYND_3	343	347	PF01753	0.514
LIG_NRBOX	454	460	PF00104	0.418
LIG_NRBOX	628	634	PF00104	0.512
LIG_PCNA_PIPBox_1	589	598	PF02747	0.520
LIG_PCNA_yPIPBox_3	791	805	PF02747	0.577
LIG_Pex14_1	702	706	PF04695	0.504
LIG_Pex14_2	127	131	PF04695	0.527
LIG_Rb_pABgroove_1	638	646	PF01858	0.425
LIG_RPA_C_Fungi	618	630	PF08784	0.490
LIG_SH2_NCK_1	584	588	PF00017	0.581
LIG_SH2_SRC	584	587	PF00017	0.585
LIG_SH2_STAP1	687	691	PF00017	0.443
LIG_SH2_STAT3	15	18	PF00017	0.640
LIG_SH2_STAT5	121	124	PF00017	0.614
LIG_SH2_STAT5	15	18	PF00017	0.605
LIG_SH3_3	1	7	PF00018	0.734
LIG_SH3_3	751	757	PF00018	0.490
LIG_SH3_4	291	298	PF00018	0.558
LIG_SUMO_SIM_par_1	328	334	PF11976	0.569
LIG_SUMO_SIM_par_1	456	462	PF11976	0.366
LIG_SUMO_SIM_par_1	84	89	PF11976	0.554
LIG_TRAF2_1	530	533	PF00917	0.501
LIG_UBA3_1	313	319	PF00899	0.568
LIG_UBA3_1	459	467	PF00899	0.371
LIG_WW_3	3	7	PF00397	0.728
MOD_CK1_1	139	145	PF00069	0.606
MOD_CK1_1	243	249	PF00069	0.723
MOD_CK1_1	494	500	PF00069	0.554
MOD_CK1_1	698	704	PF00069	0.600
MOD_CK2_1	423	429	PF00069	0.613
MOD_CK2_1	435	441	PF00069	0.610
MOD_CK2_1	508	514	PF00069	0.537
MOD_CK2_1	526	532	PF00069	0.335
MOD_CK2_1	554	560	PF00069	0.477
MOD_CK2_1	596	602	PF00069	0.588
MOD_GlcNHglycan	138	141	PF01048	0.568
MOD_GlcNHglycan	245	248	PF01048	0.708
MOD_GlcNHglycan	258	261	PF01048	0.825
MOD_GlcNHglycan	410	413	PF01048	0.592
MOD_GlcNHglycan	47	50	PF01048	0.746
MOD_GlcNHglycan	477	480	PF01048	0.392
MOD_GlcNHglycan	564	568	PF01048	0.510
MOD_GlcNHglycan	626	629	PF01048	0.447
MOD_GlcNHglycan	697	700	PF01048	0.538
MOD_GlcNHglycan	708	711	PF01048	0.440
MOD_GlcNHglycan	78	81	PF01048	0.734
MOD_GSK3_1	107	114	PF00069	0.660
MOD_GSK3_1	123	130	PF00069	0.335
MOD_GSK3_1	223	230	PF00069	0.613
MOD_GSK3_1	419	426	PF00069	0.607
MOD_GSK3_1	430	437	PF00069	0.609
MOD_GSK3_1	487	494	PF00069	0.510
MOD_GSK3_1	60	67	PF00069	0.692
MOD_GSK3_1	68	75	PF00069	0.696
MOD_N-GLC_1	624	629	PF02516	0.480
MOD_N-GLC_1	717	722	PF02516	0.486
MOD_NEK2_1	227	232	PF00069	0.602
MOD_NEK2_1	320	325	PF00069	0.567
MOD_NEK2_1	491	496	PF00069	0.498
MOD_NEK2_1	534	539	PF00069	0.543
MOD_NEK2_1	545	550	PF00069	0.394
MOD_NEK2_1	596	601	PF00069	0.459
MOD_NEK2_1	76	81	PF00069	0.516
MOD_NEK2_1	762	767	PF00069	0.488
MOD_PIKK_1	277	283	PF00454	0.763
MOD_PIKK_1	585	591	PF00454	0.545
MOD_PKA_1	166	172	PF00069	0.515
MOD_PKA_2	106	112	PF00069	0.689
MOD_PKA_2	127	133	PF00069	0.552
MOD_PKA_2	166	172	PF00069	0.515
MOD_PKA_2	223	229	PF00069	0.712
MOD_PKA_2	320	326	PF00069	0.559
MOD_PKA_2	423	429	PF00069	0.464
MOD_PKA_2	475	481	PF00069	0.477
MOD_PKB_1	524	532	PF00069	0.621
MOD_Plk_1	227	233	PF00069	0.624
MOD_Plk_1	502	508	PF00069	0.512
MOD_Plk_1	534	540	PF00069	0.498
MOD_Plk_1	624	630	PF00069	0.371
MOD_Plk_2-3	223	229	PF00069	0.556
MOD_Plk_4	326	332	PF00069	0.439
MOD_Plk_4	350	356	PF00069	0.501
MOD_Plk_4	534	540	PF00069	0.558
MOD_Plk_4	812	818	PF00069	0.542
MOD_ProDKin_1	10	16	PF00069	0.619
MOD_ProDKin_1	120	126	PF00069	0.511
MOD_ProDKin_1	261	267	PF00069	0.686
MOD_ProDKin_1	64	70	PF00069	0.723
MOD_ProDKin_1	753	759	PF00069	0.491
MOD_SUMO_rev_2	203	212	PF00179	0.572
TRG_DiLeu_BaEn_1	758	763	PF01217	0.525
TRG_DiLeu_LyEn_5	758	763	PF01217	0.565
TRG_ENDOCYTIC_2	392	395	PF00928	0.534
TRG_ENDOCYTIC_2	691	694	PF00928	0.433
TRG_ER_diArg_1	145	147	PF00400	0.575
TRG_ER_diArg_1	165	167	PF00400	0.392
TRG_ER_diArg_1	310	312	PF00400	0.347
TRG_ER_diArg_1	378	380	PF00400	0.448
TRG_ER_diArg_1	524	527	PF00400	0.428
TRG_ER_diArg_1	568	571	PF00400	0.498
TRG_ER_diArg_1	652	654	PF00400	0.413
TRG_ER_diArg_1	777	779	PF00400	0.628
TRG_ER_FFAT_2	115	126	PF00635	0.524
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	641	645	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	802	807	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX8	Leptomonas seymouri	46%	100%
A0A0S4JLD6	Bodo saltans	25%	100%
A0A1X0P2X9	Trypanosomatidae	24%	100%
A4H365	Leishmania braziliensis	68%	97%
A4HRG2	Leishmania infantum	100%	100%
C9ZXI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AC30	Leishmania major	92%	100%
E9AJC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DD57	Trypanosoma cruzi	24%	100%